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Coexpression cluster:C152

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Full id: C152_peripheral_neuroectodermal_neuroepithelioma_neuroblastoma_testicular_carcinoid_lung



Phase1 CAGE Peaks

Hg19::chr10:108310875..108310884,-p@chr10:108310875..108310884
-
Hg19::chr10:118927879..118927891,+p@chr10:118927879..118927891
+
Hg19::chr10:134906467..134906473,+p@chr10:134906467..134906473
+
Hg19::chr10:48439100..48439189,-p1@GDF10
Hg19::chr10:48439197..48439208,-p3@GDF10
Hg19::chr10:48439285..48439302,-p4@GDF10
Hg19::chr10:6261377..6261401,+p@chr10:6261377..6261401
+
Hg19::chr10:6261416..6261419,+p@chr10:6261416..6261419
+
Hg19::chr10:78646980..78646993,+p@chr10:78646980..78646993
+
Hg19::chr10:78647047..78647056,+p@chr10:78647047..78647056
+
Hg19::chr10:90749902..90749913,+p14@FAS
Hg19::chr10:90749936..90749994,+p5@FAS
Hg19::chr10:90750010..90750015,+p15@FAS
Hg19::chr11:16919073..16919082,-p@chr11:16919073..16919082
-
Hg19::chr11:69471441..69471453,-p@chr11:69471441..69471453
-
Hg19::chr11:74145723..74145725,+p@chr11:74145723..74145725
+
Hg19::chr12:114836635..114836650,-p@chr12:114836635..114836650
-
Hg19::chr12:114837411..114837414,-p@chr12:114837411..114837414
-
Hg19::chr12:114837457..114837465,-p@chr12:114837457..114837465
-
Hg19::chr12:114843910..114843921,-p6@TBX5
Hg19::chr12:114843940..114843955,-p2@TBX5
Hg19::chr12:114844068..114844089,+p@chr12:114844068..114844089
+
Hg19::chr12:117799095..117799111,-p9@NOS1
Hg19::chr12:117799113..117799134,-p3@NOS1
Hg19::chr12:117799378..117799392,-p10@NOS1
Hg19::chr12:117799419..117799440,-p5@NOS1
Hg19::chr12:117799446..117799471,-p4@NOS1
Hg19::chr12:130841945..130841985,+p@chr12:130841945..130841985
+
Hg19::chr12:20848257..20848271,+p7@SLCO1C1
Hg19::chr12:26733687..26733698,-p@chr12:26733687..26733698
-
Hg19::chr12:26733721..26733726,-p@chr12:26733721..26733726
-
Hg19::chr13:112721457..112721482,+p1@SOX1
Hg19::chr13:112721490..112721504,+p2@SOX1
Hg19::chr13:112721521..112721535,+p3@SOX1
Hg19::chr13:112721551..112721560,+p4@SOX1
Hg19::chr13:75900519..75900574,-p10@TBC1D4
Hg19::chr14:104405379..104405383,+p@chr14:104405379..104405383
+
Hg19::chr14:104405388..104405397,+p@chr14:104405388..104405397
+
Hg19::chr16:22309943..22309949,-p@chr16:22309943..22309949
-
Hg19::chr16:23912540..23912551,+p@chr16:23912540..23912551
+
Hg19::chr16:49891694..49891706,-p10@ZNF423
Hg19::chr16:52484467..52484485,-p@chr16:52484467..52484485
-
Hg19::chr16:52484576..52484584,-p@chr16:52484576..52484584
-
Hg19::chr16:5566803..5566806,+p@chr16:5566803..5566806
+
Hg19::chr16:8627066..8627076,+p@chr16:8627066..8627076
+
Hg19::chr16:8627360..8627377,+p@chr16:8627360..8627377
+
Hg19::chr17:46806193..46806200,+p@chr17:46806193..46806200
+
Hg19::chr18:44181418..44181441,-p3@LOXHD1
Hg19::chr18:44181442..44181462,-p2@LOXHD1
Hg19::chr18:61254221..61254236,+p4@SERPINB13
Hg19::chr19:42384711..42384739,+p3@CD79A
Hg19::chr1:146373572..146373600,+p1@NBPF12
Hg19::chr1:146643708..146643719,-p7@PRKAB2
Hg19::chr1:146643723..146643782,-p2@PRKAB2
Hg19::chr1:146644036..146644086,-p1@PRKAB2
Hg19::chr1:185670947..185670956,+p@chr1:185670947..185670956
+
Hg19::chr1:185703364..185703371,-p@chr1:185703364..185703371
-
Hg19::chr1:242020592..242020602,+p5@EXO1
Hg19::chr1:242020623..242020630,+p12@EXO1
Hg19::chr1:242020631..242020643,+p9@EXO1
Hg19::chr1:242020659..242020669,+p7@EXO1
Hg19::chr1:78879438..78879441,-p@chr1:78879438..78879441
-
Hg19::chr1:78958304..78958311,+p8@PTGFR
Hg19::chr1:78958320..78958332,+p2@PTGFR
Hg19::chr1:78958342..78958353,+p3@PTGFR
Hg19::chr1:78958355..78958362,+p4@PTGFR
Hg19::chr21:46172488..46172503,-p@chr21:46172488..46172503
-
Hg19::chr21:46172506..46172545,-p@chr21:46172506..46172545
-
Hg19::chr21:46276385..46276396,-p13@PTTG1IP
Hg19::chr2:11706154..11706185,+p@chr2:11706154..11706185
+
Hg19::chr2:218876066..218876078,-p@chr2:218876066..218876078
-
Hg19::chr2:218876166..218876177,-p@chr2:218876166..218876177
-
Hg19::chr2:224467409..224467423,-p3@SCG2
Hg19::chr2:224467467..224467472,-p9@SCG2
Hg19::chr2:224467481..224467491,-p5@SCG2
Hg19::chr2:23647036..23647041,-p@chr2:23647036..23647041
-
Hg19::chr2:857378..857381,-p@chr2:857378..857381
-
Hg19::chr3:8407443..8407453,-p@chr3:8407443..8407453
-
Hg19::chr3:8407458..8407469,-p@chr3:8407458..8407469
-
Hg19::chr3:8407493..8407496,-p@chr3:8407493..8407496
-
Hg19::chr4:16685601..16685611,-p@chr4:16685601..16685611
-
Hg19::chr4:3124552..3124561,+p@chr4:3124552..3124561
+
Hg19::chr5:37840113..37840126,-p3@GDNF
Hg19::chr5:37840137..37840156,-p2@GDNF
Hg19::chr5:37840160..37840165,-p6@GDNF
Hg19::chr5:43039771..43039781,-p3@AB463523
Hg19::chr6:110540042..110540046,+p@chr6:110540042..110540046
+
Hg19::chr6:110546668..110546681,+p@chr6:110546668..110546681
+
Hg19::chr6:123337191..123337197,+p@chr6:123337191..123337197
+
Hg19::chr6:153240124..153240130,-p@chr6:153240124..153240130
-
Hg19::chr6:159420667..159420681,-p5@RSPH3
Hg19::chr6:40331129..40331139,-p@chr6:40331129..40331139
-
Hg19::chr7:115879301..115879308,-p1@ENST00000456289
Hg19::chr7:123726231..123726235,+p@chr7:123726231..123726235
+
Hg19::chr7:3515955..3515958,+p@chr7:3515955..3515958
+
Hg19::chr8:12612962..12613049,-p1@LONRF1
Hg19::chr8:12803204..12803216,+p10@KIAA1456
Hg19::chr8:12803327..12803377,+p21@KIAA1456
Hg19::chr8:143694142..143694155,-p@chr8:143694142..143694155
-
Hg19::chr8:143694177..143694197,-p@chr8:143694177..143694197
-
Hg19::chr8:143694204..143694215,-p@chr8:143694204..143694215
-
Hg19::chr8:27041770..27041779,+p4@ENST00000521408
Hg19::chr8:27080771..27080783,+p@chr8:27080771..27080783
+
Hg19::chr8:6062830..6062834,-p@chr8:6062830..6062834
-
Hg19::chr8:6081804..6081807,-p@chr8:6081804..6081807
-
Hg19::chr8:6115044..6115061,-p1@ENST00000519555
Hg19::chr8:6262267..6262273,-p@chr8:6262267..6262273
-
Hg19::chr8:6264222..6264257,-p2@LOC100287015
Hg19::chr8:71053573..71053617,-p25@NCOA2
Hg19::chr8:71053651..71053662,-p24@NCOA2
Hg19::chr8:71053689..71053698,-p31@NCOA2
Hg19::chr8:81787006..81787031,-p2@ZNF704


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0048518positive regulation of biological process0.00883372854427476
GO:0048523negative regulation of cellular process0.00883372854427476
GO:0048519negative regulation of biological process0.00883372854427476
GO:0007154cell communication0.0108053691275168
GO:0048522positive regulation of cellular process0.0108053691275168
GO:0007275multicellular organismal development0.0108053691275168
GO:0048731system development0.0108053691275168
GO:0043066negative regulation of apoptosis0.0108053691275168
GO:0043069negative regulation of programmed cell death0.0108053691275168
GO:0042981regulation of apoptosis0.0108053691275168
GO:0016477cell migration0.0108053691275168
GO:0043067regulation of programmed cell death0.0108053691275168
GO:0032502developmental process0.0108053691275168
GO:0048869cellular developmental process0.0108053691275168
GO:0030154cell differentiation0.0108053691275168
GO:0045145single-stranded DNA specific 5'-3' exodeoxyribonuclease activity0.0108053691275168
GO:0051580regulation of neurotransmitter uptake0.0108053691275168
GO:0031588AMP-activated protein kinase complex0.0108053691275168
GO:0051940regulation of catecholamine uptake during transmission of nerve impulse0.0108053691275168
GO:0060044negative regulation of cardiac muscle cell proliferation0.0108053691275168
GO:0051584regulation of dopamine uptake0.0108053691275168
GO:0060039pericardium development0.0108053691275168
GO:0051588regulation of neurotransmitter transport0.0108053691275168
GO:0048245eosinophil chemotaxis0.0108053691275168
GO:0051908double-stranded DNA specific 5'-3' exodeoxyribonuclease activity0.0108053691275168
GO:0045941positive regulation of transcription0.0109783992484107
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0117075890696853
GO:0048856anatomical structure development0.0142134057431183
GO:0048256flap endonuclease activity0.0142134057431183
GO:0051890regulation of cardioblast differentiation0.0142134057431183
GO:0008297single-stranded DNA specific exodeoxyribonuclease activity0.0142134057431183
GO:0051891positive regulation of cardioblast differentiation0.0142134057431183
GO:0051934catecholamine uptake during transmission of nerve impulse0.0142134057431183
GO:00353125'-3' exodeoxyribonuclease activity0.0142134057431183
GO:0051583dopamine uptake0.0142134057431183
GO:0008309double-stranded DNA specific exodeoxyribonuclease activity0.0142134057431183
GO:0060043regulation of cardiac muscle cell proliferation0.0142134057431183
GO:0051937catecholamine transport0.0142134057431183
GO:0032501multicellular organismal process0.0150050967142505
GO:0031325positive regulation of cellular metabolic process0.0154808719383287
GO:0006928cell motility0.0161985131820893
GO:0051674localization of cell0.0161985131820893
GO:0006915apoptosis0.0161985131820893
GO:0009893positive regulation of metabolic process0.0161985131820893
GO:0012501programmed cell death0.0161985131820893
GO:0050789regulation of biological process0.0161985131820893
GO:0019814immunoglobulin complex0.0161985131820893
GO:0035117embryonic arm morphogenesis0.0161985131820893
GO:0035140arm morphogenesis0.0161985131820893
GO:0019815B cell receptor complex0.0161985131820893
GO:0016265death0.0176861445070775
GO:0008219cell death0.0176861445070775
GO:0007165signal transduction0.0176861445070775
GO:0010002cardioblast differentiation0.0186135006843351
GO:0004958prostaglandin F receptor activity0.0186135006843351
GO:0015872dopamine transport0.0186135006843351
GO:0005771multivesicular body0.0186135006843351
GO:00084095'-3' exonuclease activity0.0186135006843351
GO:0035136forelimb morphogenesis0.0224846941476318
GO:0035115embryonic forelimb morphogenesis0.0224846941476318
GO:0005515protein binding0.0239348000934181
GO:0005102receptor binding0.0240458941701157
GO:0001938positive regulation of endothelial cell proliferation0.0248987934679273
GO:0060038cardiac muscle cell proliferation0.0248987934679273
GO:0014855striated muscle cell proliferation0.0248987934679273
GO:0065007biological regulation0.0250294907536934
GO:0004517nitric-oxide synthase activity0.0273565638859108
GO:0001963synaptic transmission, dopaminergic0.0273565638859108
GO:0030375thyroid hormone receptor coactivator activity0.0273565638859108
GO:0048513organ development0.0280081264378309
GO:0006916anti-apoptosis0.0280081264378309
GO:0001504neurotransmitter uptake0.0280081264378309
GO:0035051cardiac cell differentiation0.0280081264378309
GO:0004529exodeoxyribonuclease activity0.0280081264378309
GO:0016895exodeoxyribonuclease activity, producing 5'-phosphomonoesters0.0280081264378309
GO:0007567parturition0.0280081264378309
GO:0050930induction of positive chemotaxis0.0280081264378309
GO:0006510ATP-dependent proteolysis0.0310960275236025
GO:0050926regulation of positive chemotaxis0.0324601955437952
GO:0001755neural crest cell migration0.0324601955437952
GO:0004960thromboxane receptor activity0.0324601955437952
GO:0050927positive regulation of positive chemotaxis0.0324601955437952
GO:0050918positive chemotaxis0.0324601955437952
GO:0048468cell development0.0336533321008129
GO:0050853B cell receptor signaling pathway0.0340545295881786
GO:0043524negative regulation of neuron apoptosis0.0340545295881786
GO:0050921positive regulation of chemotaxis0.0340545295881786
GO:0007267cell-cell signaling0.0341347283659012
GO:0050920regulation of chemotaxis0.0355069644778001
GO:0001937negative regulation of endothelial cell proliferation0.0355069644778001
GO:0043542endothelial cell migration0.0355069644778001
GO:0006917induction of apoptosis0.0356361027681849
GO:0012502induction of programmed cell death0.0356361027681849
GO:0016564transcription repressor activity0.0356361027681849
GO:0045893positive regulation of transcription, DNA-dependent0.0380549399575205
GO:0008285negative regulation of cell proliferation0.0380549399575205
GO:0014032neural crest cell development0.0380549399575205
GO:0014033neural crest cell differentiation0.0380549399575205
GO:0004176ATP-dependent peptidase activity0.0380549399575205
GO:0002376immune system process0.0413852875303107
GO:0008283cell proliferation0.0439491641186795
GO:0030162regulation of proteolysis0.0439491641186795
GO:0001936regulation of endothelial cell proliferation0.0439491641186795
GO:0001772immunological synapse0.0439491641186795
GO:0008083growth factor activity0.0439821776891054
GO:0043065positive regulation of apoptosis0.0445591050977236
GO:0043068positive regulation of programmed cell death0.0447977380904846
GO:0042100B cell proliferation0.0447977380904846
GO:0007270nerve-nerve synaptic transmission0.0459949624042042
GO:0001935endothelial cell proliferation0.0459949624042042
GO:0030336negative regulation of cell migration0.0459949624042042
GO:0033002muscle cell proliferation0.0479693615694716



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
neurectoderm7.10e-0886
Disease
Ontology termp-valuen
neuroectodermal tumor1.10e-5910
germ cell and embryonal cancer7.08e-2822
germ cell cancer7.08e-2822


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0194449
MA0004.10.251921
MA0006.10.122271
MA0007.10.0562575
MA0009.10.570094
MA0014.10.000779911
MA0017.10.0313753
MA0019.10.425032
MA0024.10.169313
MA0025.10.428679
MA0027.11.39425
MA0028.10.046389
MA0029.10.73162
MA0030.10.176065
MA0031.10.124699
MA0038.10.322492
MA0040.11.14467
MA0041.10.0847574
MA0042.10.359676
MA0043.10.5707
MA0046.10.258624
MA0048.10.0416367
MA0050.10.126433
MA0051.10.171728
MA0052.10.756911
MA0055.17.55824e-05
MA0056.10
MA0057.10.107997
MA0058.10.0935274
MA0059.10.00599665
MA0060.10.00170862
MA0061.10.581331
MA0063.10
MA0066.10.0265383
MA0067.10.247007
MA0068.10.606841
MA0069.10.922676
MA0070.10.8914
MA0071.10.0027962
MA0072.10.23852
MA0073.17.4987e-07
MA0074.10.0250788
MA0076.10.113788
MA0077.10.0647289
MA0078.10.164775
MA0081.10.951103
MA0083.10.0814601
MA0084.10.381714
MA0087.10.872181
MA0088.10.419167
MA0089.10
MA0090.10.134335
MA0091.10.40661
MA0092.10.300454
MA0093.10.304462
MA0095.10
MA0098.10
MA0100.10.196399
MA0101.10.212643
MA0103.10.0297417
MA0105.11.36661
MA0106.10.237129
MA0107.10.255624
MA0108.20.538441
MA0109.10
MA0111.10.155428
MA0113.10.0456672
MA0114.10.00709112
MA0115.10.198631
MA0116.10.00890274
MA0117.10.0936537
MA0119.10.220499
MA0122.10.104876
MA0124.10.174251
MA0125.11.31069
MA0130.10
MA0131.10.0152848
MA0132.10
MA0133.10
MA0135.12.13328
MA0136.11.79306
MA0139.10.286965
MA0140.10.398928
MA0141.10.00126048
MA0142.11.11719
MA0143.10.127628
MA0144.10.0242569
MA0145.10.000970742
MA0146.11.77678e-06
MA0147.11.23786
MA0148.10.476514
MA0149.182.0515
MA0062.20.0158062
MA0035.20.397043
MA0039.20.000617653
MA0138.20.166094
MA0002.20.0837095
MA0137.20.00889358
MA0104.20.824085
MA0047.20.607609
MA0112.20.000112837
MA0065.20.00441862
MA0150.10.0648423
MA0151.10
MA0152.11.16911
MA0153.10.121169
MA0154.10.219848
MA0155.10.575615
MA0156.12.61443
MA0157.10.681581
MA0158.10
MA0159.10.0223514
MA0160.10.043501
MA0161.10
MA0162.10.0012209
MA0163.10.224934
MA0164.10.487335
MA0080.20.580679
MA0018.20.113942
MA0099.20.134579
MA0079.20.141619
MA0102.21.05711
MA0258.10.00351876
MA0259.10.220623
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SUZ12#23512135.81701028431984.21795873082e-072.02724064375568e-05



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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