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Coexpression cluster:C217

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Full id: C217_carcinoid_neuroectodermal_mature_mesodermal_colon_acute_occipital



Phase1 CAGE Peaks

Hg19::chr10:1608256..1608259,-p@chr10:1608256..1608259
-
Hg19::chr10:4832445..4832452,-p@chr10:4832445..4832452
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Hg19::chr12:119551986..119552003,+p@chr12:119551986..119552003
+
Hg19::chr12:54995823..54995832,+p@chr12:54995823..54995832
+
Hg19::chr15:78110669..78110682,-p@chr15:78110669..78110682
-
Hg19::chr15:90017749..90017754,+p@chr15:90017749..90017754
+
Hg19::chr19:49607884..49607918,+p8@SNRNP70
Hg19::chr1:62644259..62644263,-p@chr1:62644259..62644263
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Hg19::chr1:91173989..91173995,-p@chr1:91173989..91173995
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Hg19::chr1:91182854..91182860,-p1@BARHL2
Hg19::chr1:91183462..91183477,-p@chr1:91183462..91183477
-
Hg19::chr20:61408204..61408211,-p@chr20:61408204..61408211
-
Hg19::chr2:288759..288775,-p5@FAM150B
Hg19::chr3:163217650..163217656,+p@chr3:163217650..163217656
+
Hg19::chr3:163246025..163246029,+p@chr3:163246025..163246029
+
Hg19::chr3:164914157..164914179,-p1@SLITRK3
Hg19::chr3:164914186..164914209,-p2@SLITRK3
Hg19::chr3:164924775..164924801,+p1@ENST00000494915
Hg19::chr3:164978158..164978160,+p@chr3:164978158..164978160
+
Hg19::chr3:165528391..165528411,+p@chr3:165528391..165528411
+
Hg19::chr4:107889427..107889438,-p@chr4:107889427..107889438
-
Hg19::chr4:164245890..164245892,-p@chr4:164245890..164245892
-
Hg19::chr4:164253724..164253729,-p6@NPY1R
Hg19::chr4:164253738..164253756,-p1@NPY1R
Hg19::chr4:164265035..164265079,+p1@NPY5R
Hg19::chr6:140362987..140362992,-p@chr6:140362987..140362992
-
Hg19::chr7:100963860..100963864,+p@chr7:100963860..100963864
+
Hg19::chr7:108255447..108255485,-p@chr7:108255447..108255485
-
Hg19::chr7:16761415..16761424,+p@chr7:16761415..16761424
+
Hg19::chr7:8110627..8110644,+p@chr7:8110627..8110644
+
Hg19::chr8:128736275..128736278,+p@chr8:128736275..128736278
+
Hg19::chr8:128740714..128740717,+p@chr8:128740714..128740717
+
Hg19::chr8:128744545..128744550,+p@chr8:128744545..128744550
+
Hg19::chr8:128750912..128750928,-p@chr8:128750912..128750928
-
Hg19::chr8:128753103..128753122,-p@chr8:128753103..128753122
-
Hg19::chr8:128808429..128808430,+p@chr8:128808429..128808430
+
Hg19::chr8:128808502..128808513,+p@chr8:128808502..128808513
+
Hg19::chr8:128816803..128816806,+p@chr8:128816803..128816806
+
Hg19::chr8:128838281..128838284,+p@chr8:128838281..128838284
+
Hg19::chr8:128854517..128854521,+p@chr8:128854517..128854521
+
Hg19::chr8:128871079..128871082,+p@chr8:128871079..128871082
+
Hg19::chr8:128913834..128913842,+p@chr8:128913834..128913842
+
Hg19::chr8:128914686..128914701,+p@chr8:128914686..128914701
+
Hg19::chr8:128941462..128941471,+p@chr8:128941462..128941471
+
Hg19::chr8:128966560..128966563,+p@chr8:128966560..128966563
+
Hg19::chr8:128997045..128997048,+p@chr8:128997045..128997048
+
Hg19::chr8:129008161..129008165,+p@chr8:129008161..129008165
+
Hg19::chr8:129009316..129009319,+p@chr8:129009316..129009319
+
Hg19::chr8:129010478..129010491,+p@chr8:129010478..129010491
+
Hg19::chr8:129010495..129010500,+p@chr8:129010495..129010500
+
Hg19::chr8:129010508..129010517,+p@chr8:129010508..129010517
+
Hg19::chr8:129010544..129010566,+p@chr8:129010544..129010566
+
Hg19::chr8:129010580..129010588,+p@chr8:129010580..129010588
+
Hg19::chr8:129010639..129010644,+p@chr8:129010639..129010644
+
Hg19::chr8:129010662..129010678,+p@chr8:129010662..129010678
+
Hg19::chr8:129010681..129010688,+p@chr8:129010681..129010688
+
Hg19::chr8:129010691..129010716,+p@chr8:129010691..129010716
+
Hg19::chr8:129010718..129010746,+p@chr8:129010718..129010746
+
Hg19::chr8:130552836..130552878,+p@chr8:130552836..130552878
+
Hg19::chr8:130561090..130561130,+p@chr8:130561090..130561130
+
Hg19::chr8:130561422..130561452,+p@chr8:130561422..130561452
+
Hg19::chr8:130561498..130561517,+p@chr8:130561498..130561517
+
Hg19::chr8:130597061..130597068,+p@chr8:130597061..130597068
+
Hg19::chr8:130605044..130605052,+p@chr8:130605044..130605052
+
Hg19::chr8:130619499..130619504,+p@chr8:130619499..130619504
+
Hg19::chr8:130695085..130695088,+p@chr8:130695085..130695088
+
Hg19::chr9:15868281..15868293,+p@chr9:15868281..15868293
+
Hg19::chrX:2716941..2716946,+p@chrX:2716941..2716946
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0001602pancreatic polypeptide receptor activity4.55398731382268e-06
GO:0001601peptide YY receptor activity4.55398731382268e-06
GO:0004983neuropeptide Y receptor activity3.33854210183063e-05
GO:0008188neuropeptide receptor activity0.000356402276119086
GO:0042923neuropeptide binding0.000356402276119086
GO:0007409axonogenesis0.00117282651970566
GO:0048667neuron morphogenesis during differentiation0.00117282651970566
GO:0048812neurite morphogenesis0.00117282651970566
GO:0000904cellular morphogenesis during differentiation0.00117282651970566
GO:0031175neurite development0.00117282651970566
GO:0030594neurotransmitter receptor activity0.00117282651970566
GO:0042165neurotransmitter binding0.00117282651970566
GO:0001653peptide receptor activity0.00117282651970566
GO:0008528peptide receptor activity, G-protein coupled0.00117282651970566
GO:0048666neuron development0.00118522585057282
GO:0032501multicellular organismal process0.00145984201655562
GO:0032990cell part morphogenesis0.00157350799159451
GO:0048858cell projection morphogenesis0.00157350799159451
GO:0030030cell projection organization and biogenesis0.00157350799159451
GO:0042277peptide binding0.00157350799159451
GO:0030182neuron differentiation0.00157350799159451
GO:0048699generation of neurons0.00199335571415066
GO:0022008neurogenesis0.00223381212475117
GO:0000902cell morphogenesis0.0067941250701111
GO:0032989cellular structure morphogenesis0.0067941250701111
GO:0030516regulation of axon extension0.00793028288399281
GO:0019233sensory perception of pain0.00954444637888664
GO:0048675axon extension0.0104297952116351
GO:0007193G-protein signaling, adenylate cyclase inhibiting pathway0.0106620378517675
GO:0040014regulation of multicellular organism growth0.0120228164603318
GO:0007399nervous system development0.0121866909190908
GO:0035264multicellular organism growth0.01287988259275
GO:0050770regulation of axonogenesis0.0135291867260136
GO:0001709cell fate determination0.0146444756340622
GO:0001764neuron migration0.0176264153211654
GO:0007631feeding behavior0.0176264153211654
GO:0050767regulation of neurogenesis0.0176264153211654
GO:0009653anatomical structure morphogenesis0.0209891357403477
GO:0045727positive regulation of translation0.0233080356963457
GO:0008217regulation of blood pressure0.023580811498767
GO:0001584rhodopsin-like receptor activity0.0240144591641738
GO:0031328positive regulation of cellular biosynthetic process0.0244941344852801
GO:0048468cell development0.0259020651756324
GO:0050877neurological system process0.0263977756741457
GO:0009891positive regulation of biosynthetic process0.026451459743057
GO:0045165cell fate commitment0.026451459743057
GO:0005887integral to plasma membrane0.0270803626016344
GO:0031226intrinsic to plasma membrane0.027140803467409
GO:0004930G-protein coupled receptor activity0.0285449509077174
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messenger0.0285449509077174
GO:0051247positive regulation of protein metabolic process0.0285449509077174
GO:0019933cAMP-mediated signaling0.0286522076736371
GO:0003008system process0.0318891306803883
GO:0048731system development0.0339510465476914
GO:0007186G-protein coupled receptor protein signaling pathway0.0357325844498906
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messenger0.0357325844498906
GO:0019935cyclic-nucleotide-mediated signaling0.0365978547929813
GO:0048869cellular developmental process0.0391952391971702
GO:0030154cell differentiation0.0391952391971702
GO:0008015blood circulation0.0447745868544492
GO:0003013circulatory system process0.0447745868544492
GO:0048856anatomical structure development0.0454101387301649
GO:0004888transmembrane receptor activity0.0454622754135308
GO:0007626locomotory behavior0.0482321915530359
GO:0006417regulation of translation0.0482708870795632
GO:0006006glucose metabolic process0.0495889089312643



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
sympathetic nervous system7.49e-085
autonomic nervous system7.49e-085
Disease
Ontology termp-valuen
neuroectodermal tumor8.32e-8210
germ cell and embryonal cancer1.25e-3722
germ cell cancer1.25e-3722
neuroendocrine tumor9.49e-076


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.68912e-11
MA0004.10.302529
MA0006.10.0297369
MA0007.10.0467421
MA0009.11.00868
MA0014.15.16551e-07
MA0017.10.223058
MA0019.10.994221
MA0024.10.120483
MA0025.10.728045
MA0027.11.60746
MA0028.10.0368956
MA0029.11.90677
MA0030.10.392846
MA0031.10.094053
MA0038.10.0284609
MA0040.10.415512
MA0041.13.01427
MA0042.19.0892
MA0043.11.00944
MA0046.10.171104
MA0048.10.000919965
MA0050.12.23917
MA0051.11.62003
MA0052.10.135254
MA0055.10.0312761
MA0056.10
MA0057.10.183774
MA0058.10.448435
MA0059.10.272043
MA0060.10.11068
MA0061.10.00148092
MA0063.10
MA0066.10.118571
MA0067.10.400371
MA0068.10.238262
MA0069.10.168868
MA0070.10.162448
MA0071.10.228212
MA0072.10.482446
MA0073.16.90995e-06
MA0074.10.27621
MA0076.10.00432033
MA0077.10.155571
MA0078.10.199944
MA0081.10.44493
MA0083.10.181949
MA0084.10.555931
MA0087.10.47903
MA0088.10.0222455
MA0089.10
MA0090.11.43486
MA0091.10.793218
MA0092.10.651594
MA0093.10.275542
MA0095.10
MA0098.10
MA0100.10.128828
MA0101.10.00910474
MA0103.10.0673755
MA0105.10.00337407
MA0106.10.038444
MA0107.10.00228563
MA0108.22.15797
MA0109.10
MA0111.10.0989757
MA0113.10.165308
MA0114.10.0263885
MA0115.10.341187
MA0116.10.0104708
MA0117.10.200286
MA0119.10.395774
MA0122.10.61946
MA0124.10.310325
MA0125.10.251003
MA0130.10
MA0131.10.217941
MA0132.10
MA0133.10
MA0135.11.0819
MA0136.10.54188
MA0139.10.00382957
MA0140.10.428952
MA0141.10.143592
MA0142.10.580707
MA0143.10.376424
MA0144.10.172262
MA0145.10.0195803
MA0146.11.39904e-06
MA0147.10.0323713
MA0148.10.881312
MA0149.10.990634
MA0062.20.0310787
MA0035.20.0891444
MA0039.22.15299e-06
MA0138.20.0546513
MA0002.20.35822
MA0137.20.0975954
MA0104.20.0273024
MA0047.21.80618
MA0112.24.34295e-05
MA0065.20.00549678
MA0150.10.0828285
MA0151.10
MA0152.10.233552
MA0153.10.239658
MA0154.10.0512269
MA0155.10.000111282
MA0156.10.988444
MA0157.10.0700329
MA0158.10
MA0159.10.0739945
MA0160.10.197076
MA0161.10
MA0162.10.00440094
MA0163.10.00131631
MA0164.10.176498
MA0080.22.13896
MA0018.20.350937
MA0099.20.021518
MA0079.26.0078e-08
MA0102.20.588272
MA0258.10.0847589
MA0259.10.0370316
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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