Coexpression cluster:C226
From FANTOM5_SSTAR
Full id: C226_Corneal_Keratinocyte_Esophageal_Urothelial_Mammary_Bronchial_Tracheal
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 7.90940612888754e-05 | 0.0166888469319527 | 3 | 85 | ECM-receptor interaction (KEGG):04512 |
| 6.12511642504549e-07 | 0.000387719869705379 | 4 | 69 | Alpha6-Beta4 Integrin Signaling Pathway (Wikipathways):WP244 |
| 2.40906544721509e-06 | 0.000762469214043575 | 4 | 97 | Cell junction organization (Reactome):REACT_20676 |
| 0.000171638888981101 | 0.0271618541812592 | 4 | 288 | {ACTB,297} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0009888 | tissue development | 0.000467859320844482 |
| GO:0007398 | ectoderm development | 0.000467859320844482 |
| GO:0014704 | intercalated disc | 0.000494265234320962 |
| GO:0048731 | system development | 0.00501723215290283 |
| GO:0007275 | multicellular organismal development | 0.00501723215290283 |
| GO:0048513 | organ development | 0.00501723215290283 |
| GO:0008544 | epidermis development | 0.0050388845571958 |
| GO:0005922 | connexon complex | 0.00705063890640088 |
| GO:0032502 | developmental process | 0.00733551717943004 |
| GO:0005911 | intercellular junction | 0.00733551717943004 |
| GO:0005921 | gap junction | 0.00749484253179777 |
| GO:0048856 | anatomical structure development | 0.00749484253179777 |
| GO:0022610 | biological adhesion | 0.00964929591541734 |
| GO:0007155 | cell adhesion | 0.00964929591541734 |
| GO:0032501 | multicellular organismal process | 0.0122266281545092 |
| GO:0005604 | basement membrane | 0.0247177030320746 |
| GO:0005610 | laminin-5 complex | 0.0273908549258614 |
| GO:0008426 | protein kinase C inhibitor activity | 0.038791147396166 |
| GO:0005515 | protein binding | 0.0448481256440162 |
| GO:0043403 | skeletal muscle regeneration | 0.0465343065901034 |
| GO:0030054 | cell junction | 0.0468426097393087 |
| GO:0017049 | GTP-Rho binding | 0.0468426097393087 |
| GO:0005916 | fascia adherens | 0.0468426097393087 |
| GO:0005243 | gap junction channel activity | 0.0468426097393087 |
| GO:0044459 | plasma membrane part | 0.0468426097393087 |
| GO:0044420 | extracellular matrix part | 0.0468426097393087 |
| GO:0022829 | wide pore channel activity | 0.0481077772224277 |
| GO:0043588 | skin development | 0.0481077772224277 |
| GO:0009898 | internal side of plasma membrane | 0.0481077772224277 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| epithelial cell | 9.61e-43 | 253 |
| endo-epithelial cell | 4.58e-31 | 42 |
| endodermal cell | 2.07e-22 | 58 |
| epithelial cell of alimentary canal | 1.41e-16 | 20 |
| respiratory epithelial cell | 9.45e-14 | 13 |
| kidney tubule cell | 1.30e-09 | 10 |
| nephron tubule epithelial cell | 1.30e-09 | 10 |
| epithelial cell of tracheobronchial tree | 3.17e-09 | 9 |
| epithelial cell of lower respiratory tract | 3.17e-09 | 9 |
| general ecto-epithelial cell | 8.82e-09 | 14 |
| acinar cell | 4.50e-07 | 5 |
| epithelial cell of nephron | 4.83e-07 | 15 |
| Ontology term | p-value | n |
|---|---|---|
| carcinoma | 5.95e-21 | 106 |
| squamous cell carcinoma | 2.76e-13 | 14 |
| cell type cancer | 9.42e-13 | 143 |
| adenocarcinoma | 1.01e-10 | 25 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 6.92399 |
| MA0004.1 | 0.0148246 |
| MA0006.1 | 0.508799 |
| MA0007.1 | 1.14479 |
| MA0009.1 | 0.570861 |
| MA0014.1 | 3.02673 |
| MA0017.1 | 1.57736 |
| MA0019.1 | 0.180053 |
| MA0024.1 | 0.835639 |
| MA0025.1 | 0.285416 |
| MA0027.1 | 1.64023 |
| MA0028.1 | 1.75024 |
| MA0029.1 | 0.44873 |
| MA0030.1 | 0.140185 |
| MA0031.1 | 0.10769 |
| MA0038.1 | 0.0351241 |
| MA0040.1 | 0.149577 |
| MA0041.1 | 0.0176845 |
| MA0042.1 | 0.0620436 |
| MA0043.1 | 0.196415 |
| MA0046.1 | 0.189523 |
| MA0048.1 | 4.17868 |
| MA0050.1 | 0.0130821 |
| MA0051.1 | 0.0340651 |
| MA0052.1 | 0.151713 |
| MA0055.1 | 3.01012 |
| MA0056.1 | 0 |
| MA0057.1 | 1.34293 |
| MA0058.1 | 0.0277371 |
| MA0059.1 | 0.18173 |
| MA0060.1 | 0.907462 |
| MA0061.1 | 5.50548 |
| MA0063.1 | 0 |
| MA0066.1 | 0.328394 |
| MA0067.1 | 0.426099 |
| MA0068.1 | 0.32078 |
| MA0069.1 | 0.187175 |
| MA0070.1 | 0.180428 |
| MA0071.1 | 0.0261486 |
| MA0072.1 | 0.177746 |
| MA0073.1 | 9.65778 |
| MA0074.1 | 0.319683 |
| MA0076.1 | 1.15934 |
| MA0077.1 | 0.99124 |
| MA0078.1 | 0.85365 |
| MA0081.1 | 0.329859 |
| MA0083.1 | 0.200894 |
| MA0084.1 | 0.58417 |
| MA0087.1 | 0.176294 |
| MA0088.1 | 1.04664 |
| MA0089.1 | 0 |
| MA0090.1 | 2.46989 |
| MA0091.1 | 0.184212 |
| MA0092.1 | 0.140498 |
| MA0093.1 | 0.00192412 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.038743 |
| MA0101.1 | 0.533246 |
| MA0103.1 | 4.5849 |
| MA0105.1 | 6.27447 |
| MA0106.1 | 1.53344 |
| MA0107.1 | 1.33584 |
| MA0108.2 | 0.106251 |
| MA0109.1 | 0 |
| MA0111.1 | 0.982123 |
| MA0113.1 | 0.74825 |
| MA0114.1 | 1.02124 |
| MA0115.1 | 0.365583 |
| MA0116.1 | 2.01536 |
| MA0117.1 | 1.17644 |
| MA0119.1 | 2.90501 |
| MA0122.1 | 0.667475 |
| MA0124.1 | 0.333911 |
| MA0125.1 | 0.272745 |
| MA0130.1 | 0 |
| MA0131.1 | 0.248636 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.215386 |
| MA0136.1 | 0.0369375 |
| MA0139.1 | 0.999742 |
| MA0140.1 | 0.492673 |
| MA0141.1 | 0.0812823 |
| MA0142.1 | 0.0932211 |
| MA0143.1 | 0.0516412 |
| MA0144.1 | 0.225549 |
| MA0145.1 | 8.68779 |
| MA0146.1 | 6.73774 |
| MA0147.1 | 0.300661 |
| MA0148.1 | 0.0187432 |
| MA0149.1 | 0.249619 |
| MA0062.2 | 0.852077 |
| MA0035.2 | 0.107918 |
| MA0039.2 | 15.7093 |
| MA0138.2 | 0.498427 |
| MA0002.2 | 0.319182 |
| MA0137.2 | 0.0538152 |
| MA0104.2 | 0.514016 |
| MA0047.2 | 0.042965 |
| MA0112.2 | 5.7829 |
| MA0065.2 | 0.102375 |
| MA0150.1 | 0.393541 |
| MA0151.1 | 0 |
| MA0152.1 | 0.0269807 |
| MA0153.1 | 0.260996 |
| MA0154.1 | 2.28524 |
| MA0155.1 | 4.41302 |
| MA0156.1 | 0.0552371 |
| MA0157.1 | 0.0816079 |
| MA0158.1 | 0 |
| MA0159.1 | 1.11902 |
| MA0160.1 | 0.233502 |
| MA0161.1 | 0 |
| MA0162.1 | 2.00053 |
| MA0163.1 | 4.76601 |
| MA0164.1 | 0.055624 |
| MA0080.2 | 0.0426084 |
| MA0018.2 | 0.177725 |
| MA0099.2 | 1.18243 |
| MA0079.2 | 13.6984 |
| MA0102.2 | 0.616902 |
| MA0258.1 | 0.845592 |
| MA0259.1 | 0.0193094 |
| MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| CTCF#10664 | 21 | 1.78675212435834 | 0.00395645447998033 | 0.0189928364329227 |
| E2F1#1869 | 23 | 1.79158653876547 | 0.00225427379515551 | 0.012804378141744 |
| MYC#4609 | 22 | 1.82365398691122 | 0.00234023697568195 | 0.0132673981925549 |
| POLR2A#5430 | 59 | 2.01110694312581 | 1.33117697459636e-15 | 2.46939239875433e-13 |
| SMARCC1#6599 | 6 | 4.15841517329824 | 0.00320606301401661 | 0.0168167352278078 |
| STAT3#6774 | 15 | 2.50463452313196 | 0.000678719432485891 | 0.00547457358737983 |
| TFAP2A#7020 | 10 | 2.62200545603888 | 0.00439187349915724 | 0.0208132714574137 |
| TFAP2C#7022 | 17 | 2.91677597408927 | 4.14543338165909e-05 | 0.00075229351337462 |
| ZEB1#6935 | 20 | 5.36140698969646 | 3.10677472077757e-10 | 3.12891461006065e-08 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
