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Coexpression cluster:C768

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Full id: C768_Hepatocyte_liver_cervical_Hep2_epitheloid_large_nonsmall



Phase1 CAGE Peaks

Hg19::chr2:211421314..211421335,+p1@CPS1
Hg19::chr2:211441064..211441083,+p@chr2:211441064..211441083
+
Hg19::chr2:211466992..211467008,+p@chr2:211466992..211467008
+
Hg19::chr2:211476909..211476924,+p7@CPS1
Hg19::chr2:211512735..211512749,+p@chr2:211512735..211512749
+
Hg19::chr2:211523350..211523365,+p10@CPS1
Hg19::chr2:211540478..211540490,+p@chr2:211540478..211540490
+
Hg19::chr2:211542663..211542679,+p@chr2:211542663..211542679
+
Hg19::chr2:211542948..211542962,+p@chr2:211542948..211542962
+
Hg19::chr2:211543284..211543294,+p@chr2:211543284..211543294
+
Hg19::chr2:211543338..211543342,+p@chr2:211543338..211543342
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
metabolising cell9.59e-1212
endopolyploid cell9.59e-1212
parenchymal cell9.59e-1212
polyploid cell9.59e-1212
hepatocyte9.59e-1212
epithelial cell4.22e-09253
Uber Anatomy
Ontology termp-valuen
larynx6.69e-539
upper respiratory tract2.87e-2419
subdivision of digestive tract4.57e-19118
foregut4.55e-1887
respiratory primordium6.20e-1738
endoderm of foregut6.20e-1738
digestive system2.92e-16145
digestive tract2.92e-16145
primitive gut2.92e-16145
endoderm-derived structure2.71e-14160
endoderm2.71e-14160
presumptive endoderm2.71e-14160
liver4.20e-1419
digestive gland4.20e-1419
liver bud4.20e-1419
epithelium of foregut-midgut junction1.34e-1325
anatomical boundary1.34e-1325
hepatobiliary system1.34e-1325
foregut-midgut junction1.34e-1325
septum transversum1.34e-1325
segment of respiratory tract2.77e-1347
hepatic diverticulum4.64e-1222
liver primordium4.64e-1222
digestive tract diverticulum1.69e-1123
respiratory tract2.75e-1154
small intestine8.93e-114
epithelial sac1.66e-1025
primordium2.35e-10160
sac4.55e-1026
organ system subdivision9.65e-09223
exocrine gland2.66e-0831
exocrine system2.66e-0831
respiratory system1.12e-0774
endocrine gland2.98e-0735
Disease
Ontology termp-valuen
carcinoma1.49e-19106
cell type cancer2.44e-13143
cancer3.27e-07235
disease of cellular proliferation5.71e-07239


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.000103786
MA0004.10.349539
MA0006.10.210781
MA0007.10.332734
MA0009.10.79061
MA0014.10.00227771
MA0017.10.24363
MA0019.10.486183
MA0024.10.688373
MA0025.10.921763
MA0027.12.39404
MA0028.10.224112
MA0029.10.707146
MA0030.11.6617
MA0031.10.633489
MA0038.11.12886
MA0040.10.712837
MA0041.10.366339
MA0042.11.60736
MA0043.10.790919
MA0046.10.779945
MA0048.10.0494179
MA0050.10.338274
MA0051.10.439895
MA0052.11.70446
MA0055.10.00989454
MA0056.10
MA0057.10.0465155
MA0058.10.265212
MA0059.10.2641
MA0060.10.119532
MA0061.10.100525
MA0063.10
MA0066.10.444231
MA0067.11.1037
MA0068.10.0758327
MA0069.10.776171
MA0070.10.765217
MA0071.10.40788
MA0072.10.760818
MA0073.13.85623e-06
MA0074.10.439193
MA0076.10.278993
MA0077.10.753278
MA0078.10.533387
MA0081.10.26424
MA0083.10.79797
MA0084.11.28962
MA0087.10.758426
MA0088.10.10094
MA0089.10
MA0090.10.291627
MA0091.10.351901
MA0092.10.318032
MA0093.10.213288
MA0095.10
MA0098.10
MA0100.10.456802
MA0101.10.216017
MA0103.10.203171
MA0105.10.0403209
MA0106.10.482519
MA0107.10.156959
MA0108.20.630531
MA0109.10
MA0111.10.303543
MA0113.10.498009
MA0114.10.153042
MA0115.11.02805
MA0116.10.159642
MA0117.10.827487
MA0119.10.250314
MA0122.10.852927
MA0124.10.98702
MA0125.10.904129
MA0130.10
MA0131.10.550695
MA0132.10
MA0133.10
MA0135.10.820382
MA0136.10.450422
MA0139.10.0922451
MA0140.10.405425
MA0141.10.2626
MA0142.11.46715
MA0143.10.498176
MA0144.10.438224
MA0145.10.02761
MA0146.10.00165539
MA0147.10.162359
MA0148.10.372124
MA0149.10.396509
MA0062.20.0969238
MA0035.20.404774
MA0039.20.000152622
MA0138.20.534556
MA0002.20.111226
MA0137.20.229531
MA0104.20.118985
MA0047.20.47109
MA0112.20.0251803
MA0065.20.0286783
MA0150.10.286461
MA0151.10
MA0152.11.86388
MA0153.10.887528
MA0154.10.0391503
MA0155.10.0230394
MA0156.10.231442
MA0157.10.576556
MA0158.10
MA0159.10.162854
MA0160.10.386031
MA0161.10
MA0162.10.00470038
MA0163.10.00253231
MA0164.10.509774
MA0080.20.21336
MA0018.20.483823
MA0099.20.411824
MA0079.28.76424e-07
MA0102.21.32663
MA0258.10.135061
MA0259.10.168926
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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