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Coexpression cluster:C849

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Full id: C849_papillotubular_lung_mucinous_oral_Renal_clear_gall



Phase1 CAGE Peaks

Hg19::chr19:51471362..51471380,-p7@KLK6
Hg19::chr19:51471381..51471383,-p14@KLK6
Hg19::chr19:51471909..51471917,-p10@KLK6
Hg19::chr19:51471925..51471946,-p4@KLK6
Hg19::chr19:51471965..51471976,-p5@KLK6
Hg19::chr19:51472031..51472042,-p6@KLK6
Hg19::chr19:51472081..51472088,-p8@KLK6
Hg19::chr19:51472185..51472197,-p11@KLK6
Hg19::chr19:51472222..51472234,-p9@KLK6
Hg19::chr8:143317560..143317581,-p@chr8:143317560..143317581
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
nephron tubule epithelium3.42e-1710
renal cortex tubule8.74e-123
region of nephron tubule8.74e-123
proximal tubule8.74e-123
cavitated compound organ1.28e-1131
nephron epithelium4.28e-1115
renal tubule4.28e-1115
nephron tubule4.28e-1115
nephron4.28e-1115
uriniferous tubule4.28e-1115
nephrogenic mesenchyme4.28e-1115
excretory tube2.47e-1016
kidney epithelium2.47e-1016
trunk region element2.53e-10101
kidney1.16e-0926
kidney mesenchyme1.16e-0926
upper urinary tract1.16e-0926
kidney rudiment1.16e-0926
kidney field1.16e-0926
urinary system structure1.18e-0947
renal system2.15e-0948
cortex3.02e-0815
abdomen element3.26e-0854
abdominal segment element3.26e-0854
cortex of kidney1.63e-0712
renal parenchyma1.63e-0712
abdominal segment of trunk4.08e-0760
abdomen4.08e-0760
compound organ4.70e-0768
anatomical conduit7.13e-07240
Disease
Ontology termp-valuen
carcinoma1.02e-17106
adenocarcinoma1.64e-1525
cell type cancer2.04e-12143
pancreas adenocarcinoma1.60e-082
pancreatic carcinoma1.60e-082
pancreatic ductal adenocarcinoma1.60e-082
signet ring cell adenocarcinoma2.56e-082


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.456919
MA0004.10.380329
MA0006.10.236135
MA0007.10.363007
MA0009.10.828613
MA0014.10.0679667
MA0017.18.00519
MA0019.10.520264
MA0024.10.725404
MA0025.10.960689
MA0027.12.43535
MA0028.10.25013
MA0029.10.744375
MA0030.10.733118
MA0031.10.669876
MA0038.10.477043
MA0040.10.750125
MA0041.10.397617
MA0042.10.367902
MA0043.10.828925
MA0046.10.817858
MA0048.10.0613414
MA0050.10.368721
MA0051.10.473017
MA0052.10.753928
MA0055.10.174262
MA0056.10
MA0057.10.46253
MA0058.10.293055
MA0059.11.44436
MA0060.10.138988
MA0061.10.118318
MA0063.10
MA0066.10.477449
MA0067.11.1435
MA0068.11.56182
MA0069.10.814052
MA0070.10.803003
MA0071.10.440254
MA0072.10.798564
MA0073.11.63429
MA0074.13.0664
MA0076.10.307383
MA0077.10.790956
MA0078.10.568317
MA0081.10.292043
MA0083.10.836033
MA0084.11.32998
MA0087.10.79615
MA0088.12.74176
MA0089.10
MA0090.16.35095
MA0091.10.382762
MA0092.11.64377
MA0093.10.238771
MA0095.10
MA0098.10
MA0100.10.49029
MA0101.10.241637
MA0103.10.228129
MA0105.10.189717
MA0106.10.516528
MA0107.10.179177
MA0108.20.666881
MA0109.10
MA0111.10.33284
MA0113.10.532314
MA0114.11.5848
MA0115.12.42332
MA0116.10.182037
MA0117.10.865782
MA0119.10.277531
MA0122.10.891407
MA0124.11.0263
MA0125.10.942948
MA0130.10
MA0131.10.585907
MA0132.10
MA0133.10
MA0135.10.858623
MA0136.10.483775
MA0139.10.109245
MA0140.10.437738
MA0141.10.290336
MA0142.10.638837
MA0143.10.532484
MA0144.12.89805
MA0145.11.35344
MA0146.13.10317
MA0147.10.184931
MA0148.10.403564
MA0149.10.428597
MA0062.20.114378
MA0035.20.437071
MA0039.20.138005
MA0138.20.569505
MA0002.20.129981
MA0137.20.710884
MA0104.20.138396
MA0047.20.504873
MA0112.20.573053
MA0065.23.55646
MA0150.10.315136
MA0151.10
MA0152.10.443956
MA0153.10.926242
MA0154.13.28929
MA0155.14.58734
MA0156.10.257809
MA0157.10.612166
MA0158.10
MA0159.13.9329
MA0160.10.417847
MA0161.10
MA0162.12.45203
MA0163.10.162989
MA0164.10.544294
MA0080.20.238846
MA0018.20.517858
MA0099.20.444294
MA0079.28.83835
MA0102.21.36707
MA0258.10.155735
MA0259.10.191914
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EGR1#195873.49172536636710.0008771692339228240.0065426851608103



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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