MCL coexpression mm9:326
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0045740 | positive regulation of DNA replication | 0.0402497060598641 |
| GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity | 0.0402497060598641 |
| GO:0045741 | positive regulation of epidermal growth factor receptor activity | 0.0402497060598641 |
| GO:0005588 | collagen type V | 0.0402497060598641 |
| GO:0045840 | positive regulation of mitosis | 0.0402497060598641 |
| GO:0048661 | positive regulation of smooth muscle cell proliferation | 0.0402497060598641 |
| GO:0048660 | regulation of smooth muscle cell proliferation | 0.0402497060598641 |
| GO:0051054 | positive regulation of DNA metabolic process | 0.0402497060598641 |
| GO:0007176 | regulation of epidermal growth factor receptor activity | 0.0402497060598641 |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway | 0.0425893257526012 |
| GO:0005583 | fibrillar collagen | 0.0425893257526012 |
| GO:0030036 | actin cytoskeleton organization and biogenesis | 0.0425893257526012 |
| GO:0048659 | smooth muscle cell proliferation | 0.0425893257526012 |
| GO:0030029 | actin filament-based process | 0.0425893257526012 |
| GO:0045410 | positive regulation of interleukin-6 biosynthetic process | 0.0425893257526012 |
| GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 0.0425893257526012 |
| GO:0004720 | protein-lysine 6-oxidase activity | 0.0425893257526012 |
| GO:0008284 | positive regulation of cell proliferation | 0.0433274084684527 |
| GO:0005154 | epidermal growth factor receptor binding | 0.0444475374244391 |
| GO:0051018 | protein kinase A binding | 0.0482467528778367 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| cardiovascular system | 9.60e-12 | 23 |
| circulatory system | 9.60e-12 | 23 |
| splanchnic layer of lateral plate mesoderm | 5.89e-10 | 33 |
| primary circulatory organ | 2.75e-09 | 18 |
| heart | 2.75e-09 | 18 |
| primitive heart tube | 2.75e-09 | 18 |
| primary heart field | 2.75e-09 | 18 |
| anterior lateral plate mesoderm | 2.75e-09 | 18 |
| heart tube | 2.75e-09 | 18 |
| heart primordium | 2.75e-09 | 18 |
| cardiac mesoderm | 2.75e-09 | 18 |
| cardiogenic plate | 2.75e-09 | 18 |
| heart rudiment | 2.75e-09 | 18 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.0978048 |
| MA0004.1 | 0.118549 |
| MA0006.1 | 0.161227 |
| MA0007.1 | 1.73673 |
| MA0009.1 | 1.11793 |
| MA0014.1 | 0.110955 |
| MA0017.1 | 0.190692 |
| MA0019.1 | 0.290797 |
| MA0024.1 | 1.03781 |
| MA0025.1 | 0.645374 |
| MA0027.1 | 2.02409 |
| MA0028.1 | 0.0452573 |
| MA0029.1 | 0.383872 |
| MA0030.1 | 1.01026 |
| MA0031.1 | 0.946067 |
| MA0038.1 | 0.209603 |
| MA0040.1 | 0.449452 |
| MA0041.1 | 0.0795363 |
| MA0042.1 | 0.0734808 |
| MA0043.1 | 0.522621 |
| MA0046.1 | 0.469568 |
| MA0048.1 | 0.918827 |
| MA0050.1 | 0.141024 |
| MA0051.1 | 1.81275 |
| MA0052.1 | 0.456356 |
| MA0055.1 | 0.600243 |
| MA0056.1 | 0 |
| MA0057.1 | 0.390656 |
| MA0058.1 | 0.0704409 |
| MA0059.1 | 0.0759876 |
| MA0060.1 | 0.0191397 |
| MA0061.1 | 0.269352 |
| MA0063.1 | 0 |
| MA0066.1 | 0.20204 |
| MA0067.1 | 0.748059 |
| MA0068.1 | 0.246947 |
| MA0069.1 | 0.456647 |
| MA0070.1 | 0.448343 |
| MA0071.1 | 0.140522 |
| MA0072.1 | 0.44111 |
| MA0073.1 | 0.0586171 |
| MA0074.1 | 0.526923 |
| MA0076.1 | 0.0586682 |
| MA0077.1 | 0.422739 |
| MA0078.1 | 0.672666 |
| MA0081.1 | 0.293354 |
| MA0083.1 | 0.521922 |
| MA0084.1 | 1.0607 |
| MA0087.1 | 0.484199 |
| MA0088.1 | 1.00693 |
| MA0089.1 | 0 |
| MA0090.1 | 0.32897 |
| MA0091.1 | 0.125983 |
| MA0092.1 | 1.11922 |
| MA0093.1 | 0.0482497 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.508591 |
| MA0101.1 | 0.274567 |
| MA0103.1 | 0.447794 |
| MA0105.1 | 0.61924 |
| MA0106.1 | 0.685785 |
| MA0107.1 | 0.196036 |
| MA0108.2 | 0.830865 |
| MA0109.1 | 0 |
| MA0111.1 | 1.71244 |
| MA0113.1 | 1.86061 |
| MA0114.1 | 0.265028 |
| MA0115.1 | 0.525089 |
| MA0116.1 | 0.0415661 |
| MA0117.1 | 0.496768 |
| MA0119.1 | 0.275337 |
| MA0122.1 | 0.514153 |
| MA0124.1 | 1.66708 |
| MA0125.1 | 0.630583 |
| MA0130.1 | 0 |
| MA0131.1 | 0.287321 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.554905 |
| MA0136.1 | 0.191208 |
| MA0139.1 | 1.5573 |
| MA0140.1 | 0.170444 |
| MA0141.1 | 0.846766 |
| MA0142.1 | 0.34839 |
| MA0143.1 | 0.236381 |
| MA0144.1 | 1.17278 |
| MA0145.1 | 0.414538 |
| MA0146.1 | 0.485808 |
| MA0147.1 | 0.0299713 |
| MA0148.1 | 0.127756 |
| MA0149.1 | 0.0827548 |
| MA0062.2 | 0.00745981 |
| MA0035.2 | 0.173482 |
| MA0039.2 | 0.37693 |
| MA0138.2 | 2.15544 |
| MA0002.2 | 0.336716 |
| MA0137.2 | 0.223304 |
| MA0104.2 | 0.0744814 |
| MA0047.2 | 0.601531 |
| MA0112.2 | 0.831988 |
| MA0065.2 | 0.0291578 |
| MA0150.1 | 0.110236 |
| MA0151.1 | 0 |
| MA0152.1 | 0.209147 |
| MA0153.1 | 0.569763 |
| MA0154.1 | 0.140391 |
| MA0155.1 | 0.0945236 |
| MA0156.1 | 0.464199 |
| MA0157.1 | 0.863107 |
| MA0158.1 | 0 |
| MA0159.1 | 0.313465 |
| MA0160.1 | 0.807296 |
| MA0161.1 | 0 |
| MA0162.1 | 0.00177304 |
| MA0163.1 | 0.112891 |
| MA0164.1 | 0.559407 |
| MA0080.2 | 0.197063 |
| MA0018.2 | 0.197998 |
| MA0099.2 | 0.276491 |
| MA0079.2 | 0.0137477 |
| MA0102.2 | 1.11159 |
| MA0258.1 | 0.240529 |
| MA0259.1 | 0.113327 |
| MA0442.1 | 0 |
