MCL coexpression mm9:993
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0006679 | glucosylceramide biosynthetic process | 0.0183511363443851 |
| GO:0046476 | glycosylceramide biosynthetic process | 0.0183511363443851 |
| GO:0008120 | ceramide glucosyltransferase activity | 0.0183511363443851 |
| GO:0006678 | glucosylceramide metabolic process | 0.0183511363443851 |
| GO:0046513 | ceramide biosynthetic process | 0.0244574589523605 |
| GO:0006688 | glycosphingolipid biosynthetic process | 0.0244574589523605 |
| GO:0006677 | glycosylceramide metabolic process | 0.0244574589523605 |
| GO:0035251 | UDP-glucosyltransferase activity | 0.0244574589523605 |
| GO:0046520 | sphingoid biosynthetic process | 0.0244574589523605 |
| GO:0046527 | glucosyltransferase activity | 0.0256775179255801 |
| GO:0009247 | glycolipid biosynthetic process | 0.0266750174125593 |
| GO:0017053 | transcriptional repressor complex | 0.0282077778601329 |
| GO:0006687 | glycosphingolipid metabolic process | 0.0282077778601329 |
| GO:0030148 | sphingolipid biosynthetic process | 0.0359484775696386 |
| GO:0006664 | glycolipid metabolic process | 0.0359484775696386 |
| GO:0043231 | intracellular membrane-bound organelle | 0.0359484775696386 |
| GO:0043227 | membrane-bound organelle | 0.0359484775696386 |
| GO:0006672 | ceramide metabolic process | 0.0467895503180661 |
| GO:0046519 | sphingoid metabolic process | 0.0481709005625808 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| endoderm-derived structure | 9.33e-17 | 118 |
| endoderm | 9.33e-17 | 118 |
| presumptive endoderm | 9.33e-17 | 118 |
| digestive system | 3.65e-16 | 116 |
| digestive tract | 3.65e-16 | 116 |
| primitive gut | 3.65e-16 | 116 |
| subdivision of digestive tract | 3.85e-15 | 114 |
| gastrointestinal system | 2.79e-10 | 47 |
| intestine | 2.03e-09 | 31 |
| hemolymphoid system | 2.90e-08 | 48 |
| immune system | 2.90e-08 | 48 |
| mixed endoderm/mesoderm-derived structure | 3.14e-08 | 35 |
| organ component layer | 1.55e-07 | 24 |
| hematopoietic system | 6.07e-07 | 45 |
| blood island | 6.07e-07 | 45 |
| hemopoietic organ | 8.75e-07 | 29 |
| immune organ | 8.75e-07 | 29 |
| mucosa | 9.13e-07 | 15 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 3.57432 |
| MA0004.1 | 1.10905 |
| MA0006.1 | 1.37063 |
| MA0007.1 | 1.07722 |
| MA0009.1 | 0.870101 |
| MA0014.1 | 4.67229 |
| MA0017.1 | 0.296816 |
| MA0019.1 | 0.688051 |
| MA0024.1 | 0.826339 |
| MA0025.1 | 1.10341 |
| MA0027.1 | 2.51754 |
| MA0028.1 | 0.769859 |
| MA0029.1 | 0.804619 |
| MA0030.1 | 0.811181 |
| MA0031.1 | 0.775627 |
| MA0038.1 | 0.577528 |
| MA0040.1 | 0.882616 |
| MA0041.1 | 0.360875 |
| MA0042.1 | 0.348174 |
| MA0043.1 | 0.966833 |
| MA0046.1 | 0.906029 |
| MA0048.1 | 1.13456 |
| MA0050.1 | 0.472794 |
| MA0051.1 | 0.586414 |
| MA0052.1 | 0.890676 |
| MA0055.1 | 2.65362 |
| MA0056.1 | 0 |
| MA0057.1 | 1.58436 |
| MA0058.1 | 0.341628 |
| MA0059.1 | 0.353484 |
| MA0060.1 | 0.197678 |
| MA0061.1 | 0.224905 |
| MA0063.1 | 0 |
| MA0066.1 | 1.39085 |
| MA0067.1 | 1.21448 |
| MA0068.1 | 0.0965831 |
| MA0069.1 | 0.891016 |
| MA0070.1 | 0.881319 |
| MA0071.1 | 0.471969 |
| MA0072.1 | 0.872842 |
| MA0073.1 | 0.312272 |
| MA0074.1 | 0.531046 |
| MA0076.1 | 0.845594 |
| MA0077.1 | 0.851175 |
| MA0078.1 | 0.61926 |
| MA0081.1 | 0.375851 |
| MA0083.1 | 0.96604 |
| MA0084.1 | 1.54225 |
| MA0087.1 | 0.922929 |
| MA0088.1 | 0.229377 |
| MA0089.1 | 0 |
| MA0090.1 | 0.401197 |
| MA0091.1 | 0.447561 |
| MA0092.1 | 0.401504 |
| MA0093.1 | 0.787675 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.519598 |
| MA0101.1 | 0.362124 |
| MA0103.1 | 0.307078 |
| MA0105.1 | 0.133231 |
| MA0106.1 | 0.626997 |
| MA0107.1 | 0.301222 |
| MA0108.2 | 0.710846 |
| MA0109.1 | 0 |
| MA0111.1 | 1.06639 |
| MA0113.1 | 0.598933 |
| MA0114.1 | 0.222763 |
| MA0115.1 | 0.969632 |
| MA0116.1 | 1.36991 |
| MA0117.1 | 0.937363 |
| MA0119.1 | 0.951747 |
| MA0122.1 | 0.957212 |
| MA0124.1 | 1.16127 |
| MA0125.1 | 1.0872 |
| MA0130.1 | 0 |
| MA0131.1 | 0.683521 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.00325 |
| MA0136.1 | 0.550755 |
| MA0139.1 | 0.977634 |
| MA0140.1 | 0.519484 |
| MA0141.1 | 0.325895 |
| MA0142.1 | 0.761136 |
| MA0143.1 | 0.615203 |
| MA0144.1 | 0.640537 |
| MA0145.1 | 1.87609 |
| MA0146.1 | 0.946874 |
| MA0147.1 | 2.70055 |
| MA0148.1 | 0.450593 |
| MA0149.1 | 0.367458 |
| MA0062.2 | 2.64619 |
| MA0035.2 | 0.524137 |
| MA0039.2 | 2.84599 |
| MA0138.2 | 1.61926 |
| MA0002.2 | 0.172399 |
| MA0137.2 | 0.32312 |
| MA0104.2 | 3.099 |
| MA0047.2 | 0.576767 |
| MA0112.2 | 1.87605 |
| MA0065.2 | 0.528619 |
| MA0150.1 | 1.07698 |
| MA0151.1 | 0 |
| MA0152.1 | 0.576873 |
| MA0153.1 | 1.01988 |
| MA0154.1 | 0.100744 |
| MA0155.1 | 1.45843 |
| MA0156.1 | 0.843735 |
| MA0157.1 | 0.729116 |
| MA0158.1 | 0 |
| MA0159.1 | 0.688775 |
| MA0160.1 | 0.453546 |
| MA0161.1 | 0 |
| MA0162.1 | 11.6633 |
| MA0163.1 | 1.79588 |
| MA0164.1 | 0.551114 |
| MA0080.2 | 0.816435 |
| MA0018.2 | 0.560731 |
| MA0099.2 | 0.669311 |
| MA0079.2 | 12.7454 |
| MA0102.2 | 1.59466 |
| MA0258.1 | 0.60477 |
| MA0259.1 | 2.63282 |
| MA0442.1 | 0 |
