Novel motif:63

name:	motif63_GTNCCA

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0046655	folic acid metabolic process	4.647283e-10
GO:0010891	negative regulation of sequestering of triglyceride	1.491502e-9
GO:0015705	iodide transport	6.120519e-9
GO:0045820	negative regulation of glycolysis	1.537799e-8
GO:0043249	erythrocyte maturation	1.661584e-8
GO:0003009	skeletal muscle contraction	1.910765e-8
GO:0051241	negative regulation of multicellular organismal process	2.017385e-8
GO:0051412	response to corticosterone stimulus	2.309338e-8
GO:0007585	respiratory gaseous exchange	2.522161e-8
GO:0006544	glycine metabolic process	3.115249e-8
GO:0009142	nucleoside triphosphate biosynthetic process	3.914456e-8
GO:0009201	ribonucleoside triphosphate biosynthetic process	4.192059e-8
GO:2000119	negative regulation of sodium-dependent phosphate transport	4.682865e-8
GO:0006449	regulation of translational termination	5.644451e-8
GO:0003016	respiratory system process	5.775123e-8
GO:0009145	purine nucleoside triphosphate biosynthetic process	6.485054e-8
GO:0060535	trachea cartilage morphogenesis	7.287085e-8
GO:0060669	embryonic placenta morphogenesis	7.524484e-8
GO:0006575	cellular modified amino acid metabolic process	7.781067e-8
GO:0060749	mammary gland alveolus development	8.130647e-8
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	8.552175e-8
GO:0032312	regulation of ARF GTPase activity	1.126553e-7
GO:0007165	signal transduction	1.391611e-7
GO:0050881	musculoskeletal movement	1.540223e-7
GO:2000249	regulation of actin cytoskeleton reorganization	1.917627e-7
GO:0072363	regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter	2.125935e-7
GO:0072366	regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter	2.125935e-7
GO:0051716	cellular response to stimulus	2.366565e-7
GO:0033599	regulation of mammary gland epithelial cell proliferation	2.475580e-7
GO:0046939	nucleotide phosphorylation	2.891255e-7
GO:0051385	response to mineralocorticoid stimulus	2.899901e-7
GO:0046131	pyrimidine ribonucleoside metabolic process	3.541017e-7
GO:0060482	lobar bronchus development	5.005591e-7
GO:0009629	response to gravity	6.083802e-7
GO:0006304	DNA modification	1.084551e-6
GO:0002923	regulation of humoral immune response mediated by circulating immunoglobulin	1.113514e-6
GO:0031330	negative regulation of cellular catabolic process	1.139902e-6
GO:0009071	serine family amino acid catabolic process	1.207045e-6
GO:0006695	cholesterol biosynthetic process	1.334047e-6
GO:0007568	aging	1.517336e-6
GO:0019918	peptidyl-arginine methylation, to symmetrical-dimethyl arginine	1.556578e-6
GO:0044281	small molecule metabolic process	1.579422e-6
GO:0072369	regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter	1.682002e-6
GO:0006754	ATP biosynthetic process	1.682060e-6
GO:0006760	folic acid-containing compound metabolic process	2.008680e-6
GO:0060534	trachea cartilage development	2.049976e-6
GO:0060706	cell differentiation involved in embryonic placenta development	2.160088e-6
GO:0006213	pyrimidine nucleoside metabolic process	2.272584e-6
GO:0010889	regulation of sequestering of triglyceride	2.387859e-6
GO:0051001	negative regulation of nitric-oxide synthase activity	2.443691e-6
GO:0030277	maintenance of gastrointestinal epithelium	2.573680e-6
GO:0008215	spermine metabolic process	3.037449e-6
GO:0001974	blood vessel remodeling	3.047252e-6
GO:0060764	cell-cell signaling involved in mammary gland development	3.184120e-6
GO:0048144	fibroblast proliferation	3.426544e-6
GO:0045056	transcytosis	3.470385e-6
GO:0072361	regulation of glycolysis by regulation of transcription from RNA polymerase II promoter	3.582778e-6
GO:0016126	sterol biosynthetic process	3.624737e-6
GO:0034340	response to type I interferon	3.758095e-6
GO:0035556	intracellular signal transduction	4.538975e-6
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	4.560195e-6
GO:0006982	response to lipid hydroperoxide	4.851808e-6
GO:0006820	anion transport	5.288589e-6
GO:0015698	inorganic anion transport	5.564004e-6
GO:0060337	type I interferon-mediated signaling pathway	6.140621e-6
GO:0019388	galactose catabolic process	6.354155e-6
GO:0002069	columnar/cuboidal epithelial cell maturation	6.536762e-6
GO:0030195	negative regulation of blood coagulation	6.571694e-6
GO:0006546	glycine catabolic process	6.652125e-6
GO:0002238	response to molecule of fungal origin	6.730650e-6
GO:0010288	response to lead ion	6.775922e-6
GO:0044275	cellular carbohydrate catabolic process	7.569650e-6
GO:0046208	spermine catabolic process	7.728913e-6
GO:0016052	carbohydrate catabolic process	7.830774e-6
GO:0006955	immune response	8.188092e-6
GO:0060708	spongiotrophoblast differentiation	8.431392e-6
GO:0006720	isoprenoid metabolic process	8.724797e-6
GO:0046365	monosaccharide catabolic process	9.239685e-6
GO:0032526	response to retinoic acid	9.479356e-6
GO:0009069	serine family amino acid metabolic process	9.557874e-6
GO:0060707	trophoblast giant cell differentiation	9.804061e-6
GO:0006621	protein retention in ER lumen	1.027659e-5
GO:0008299	isoprenoid biosynthetic process	1.127677e-5
GO:0072061	inner medullary collecting duct development	1.199551e-5
GO:0072060	outer medullary collecting duct development	1.199551e-5
GO:0016332	establishment or maintenance of polarity of embryonic epithelium	1.199551e-5
GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter	1.213678e-5
GO:0032203	telomere formation via telomerase	1.233744e-5
GO:0048631	regulation of skeletal muscle tissue growth	1.291485e-5
GO:0050902	leukocyte adhesive activation	1.308674e-5
GO:0051041	positive regulation of calcium-independent cell-cell adhesion	1.308674e-5
GO:0006220	pyrimidine nucleotide metabolic process	1.340511e-5
GO:0042403	thyroid hormone metabolic process	1.426182e-5
GO:0032689	negative regulation of interferon-gamma production	1.441501e-5
GO:0030641	regulation of cellular pH	1.525230e-5
GO:0045606	positive regulation of epidermal cell differentiation	1.558972e-5
GO:0072527	pyrimidine-containing compound metabolic process	1.584104e-5
GO:0051453	regulation of intracellular pH	1.607359e-5
GO:0030225	macrophage differentiation	1.637280e-5
GO:0006885	regulation of pH	1.651216e-5
GO:0051452	intracellular pH reduction	1.676251e-5
GO:0046135	pyrimidine nucleoside catabolic process	1.768994e-5
GO:0045123	cellular extravasation	1.821068e-5
GO:0048771	tissue remodeling	1.842875e-5
GO:0042908	xenobiotic transport	1.940119e-5
GO:0023052	signaling	1.947717e-5
GO:0072528	pyrimidine-containing compound biosynthetic process	1.967411e-5
GO:0009116	nucleoside metabolic process	1.993555e-5
GO:0043542	endothelial cell migration	2.006618e-5
GO:0019320	hexose catabolic process	2.042277e-5
GO:0032796	uropod organization	2.150416e-5
GO:0006826	iron ion transport	2.260611e-5
GO:0031960	response to corticosteroid stimulus	2.288156e-5
GO:0043320	natural killer cell degranulation	2.319650e-5
GO:0006520	cellular amino acid metabolic process	2.346979e-5
GO:0032414	positive regulation of ion transmembrane transporter activity	2.527881e-5
GO:0034097	response to cytokine stimulus	2.571169e-5
GO:0070885	negative regulation of calcineurin-NFAT signaling pathway	2.593252e-5
GO:0032202	telomere assembly	2.597044e-5
GO:0009298	GDP-mannose biosynthetic process	2.618671e-5
GO:0018094	protein polyglycylation	2.625439e-5
GO:0045604	regulation of epidermal cell differentiation	2.948007e-5
GO:0009268	response to pH	2.965769e-5
GO:0045851	pH reduction	3.006168e-5
GO:0042398	cellular modified amino acid biosynthetic process	3.084245e-5
GO:0060574	intestinal epithelial cell maturation	3.175529e-5
GO:0009308	amine metabolic process	3.188754e-5
GO:0030719	P granule organization	3.362108e-5
GO:0006810	transport	3.445400e-5
GO:0009199	ribonucleoside triphosphate metabolic process	3.623057e-5
GO:0051248	negative regulation of protein metabolic process	3.742603e-5
GO:0006066	alcohol metabolic process	3.869969e-5
GO:0012502	induction of programmed cell death	3.935948e-5
GO:0006694	steroid biosynthetic process	4.049105e-5
GO:0003059	positive regulation of the force of heart contraction by epinephrine	4.124777e-5
GO:0043243	positive regulation of protein complex disassembly	4.183483e-5
GO:0002920	regulation of humoral immune response	4.211533e-5
GO:0048246	macrophage chemotaxis	4.286750e-5
GO:0051384	response to glucocorticoid stimulus	4.465616e-5
GO:0015893	drug transport	4.492495e-5
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	4.551903e-5
GO:0009205	purine ribonucleoside triphosphate metabolic process	4.625886e-5
GO:0071347	cellular response to interleukin-1	4.765048e-5
GO:0051289	protein homotetramerization	4.765048e-5
GO:0030198	extracellular matrix organization	4.859912e-5
GO:0009119	ribonucleoside metabolic process	4.890129e-5
GO:0021754	facial nucleus development	4.927583e-5
GO:0010631	epithelial cell migration	4.958835e-5
GO:0051234	establishment of localization	5.042381e-5
GO:0001977	renal system process involved in regulation of blood volume	5.081878e-5
GO:0060711	labyrinthine layer development	5.143362e-5
GO:0006821	chloride transport	5.192132e-5
GO:0009144	purine nucleoside triphosphate metabolic process	5.232962e-5
GO:0006917	induction of apoptosis	5.245925e-5
GO:0060056	mammary gland involution	5.579178e-5
GO:0007028	cytoplasm organization	5.626114e-5
GO:0035811	negative regulation of urine volume	5.640340e-5
GO:0050896	response to stimulus	5.656005e-5
GO:0009698	phenylpropanoid metabolic process	6.030516e-5
GO:0032269	negative regulation of cellular protein metabolic process	6.231490e-5
GO:0050909	sensory perception of taste	6.288705e-5
GO:0030878	thyroid gland development	6.294151e-5
GO:0042446	hormone biosynthetic process	6.325796e-5
GO:0032012	regulation of ARF protein signal transduction	6.555901e-5
GO:0060712	spongiotrophoblast layer development	6.733908e-5
GO:0060670	branching involved in embryonic placenta morphogenesis	6.832823e-5
GO:0000093	mitotic telophase	6.850888e-5
GO:0009628	response to abiotic stimulus	6.889308e-5
GO:0018293	protein-FAD linkage	6.994383e-5
GO:0006121	mitochondrial electron transport, succinate to ubiquinone	6.994383e-5
GO:0002502	peptide antigen assembly with MHC class I protein complex	6.994383e-5
GO:0072110	glomerular mesangial cell proliferation	7.196203e-5
GO:0007154	cell communication	7.245305e-5
GO:0072364	regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter	7.293092e-5
GO:0031442	positive regulation of mRNA 3'-end processing	7.458694e-5
GO:0006617	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	7.925076e-5
GO:0006616	SRP-dependent cotranslational protein targeting to membrane, translocation	7.925076e-5
GO:0045947	negative regulation of translational initiation	7.952733e-5
GO:0006446	regulation of translational initiation	8.053219e-5
GO:0032793	positive regulation of CREB transcription factor activity	8.142137e-5
GO:0046474	glycerophospholipid biosynthetic process	8.232427e-5
GO:0015684	ferrous iron transport	8.667661e-5
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	8.861599e-5
GO:0006096	glycolysis	8.931102e-5
GO:0048790	maintenance of presynaptic active zone structure	9.222312e-5
GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane	9.222312e-5
GO:0031440	regulation of mRNA 3'-end processing	9.236996e-5
GO:0050819	negative regulation of coagulation	9.449375e-5
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	9.767032e-5
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	1.015401e-4
GO:0042730	fibrinolysis	1.034737e-4
GO:0060713	labyrinthine layer morphogenesis	1.048656e-4
GO:0006458	'de novo' protein folding	1.053558e-4
GO:0009416	response to light stimulus	1.057217e-4
GO:0016525	negative regulation of angiogenesis	1.066964e-4
GO:0009141	nucleoside triphosphate metabolic process	1.075836e-4
GO:0051045	negative regulation of membrane protein ectodomain proteolysis	1.078690e-4
GO:0051917	regulation of fibrinolysis	1.080131e-4
GO:0090026	positive regulation of monocyte chemotaxis	1.109508e-4
GO:0070988	demethylation	1.152686e-4
GO:0002891	positive regulation of immunoglobulin mediated immune response	1.261141e-4
GO:0003105	negative regulation of glomerular filtration	1.319636e-4
GO:0071356	cellular response to tumor necrosis factor	1.320010e-4
GO:0060668	regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling	1.335864e-4
GO:0042886	amide transport	1.382746e-4
GO:0045343	regulation of MHC class I biosynthetic process	1.382746e-4
GO:0006766	vitamin metabolic process	1.393923e-4
GO:0048873	homeostasis of number of cells within a tissue	1.400141e-4
GO:0009260	ribonucleotide biosynthetic process	1.401845e-4
GO:0001300	chronological cell aging	1.406764e-4
GO:0016311	dephosphorylation	1.457853e-4
GO:0002922	positive regulation of humoral immune response	1.536347e-4
GO:0006749	glutathione metabolic process	1.540519e-4
GO:0051918	negative regulation of fibrinolysis	1.570297e-4
GO:0044106	cellular amine metabolic process	1.597321e-4
GO:0045017	glycerolipid biosynthetic process	1.625550e-4
GO:0006241	CTP biosynthetic process	1.678454e-4
GO:0030421	defecation	1.681429e-4
GO:0046022	positive regulation of transcription from RNA polymerase II promoter during mitosis	1.683839e-4
GO:0001893	maternal placenta development	1.695328e-4
GO:0050779	RNA destabilization	1.697222e-4
GO:0031400	negative regulation of protein modification process	1.799519e-4
GO:0006598	polyamine catabolic process	1.836298e-4
GO:0032754	positive regulation of interleukin-5 production	1.881547e-4
GO:0006590	thyroid hormone generation	1.901801e-4
GO:0061037	negative regulation of cartilage development	1.903939e-4
GO:0033209	tumor necrosis factor-mediated signaling pathway	1.930004e-4
GO:0035510	DNA dealkylation	1.962552e-4
GO:0022009	central nervous system vasculogenesis	1.999876e-4
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	1.999876e-4
GO:0006897	endocytosis	2.006811e-4
GO:0007283	spermatogenesis	2.024344e-4
GO:0042558	pteridine-containing compound metabolic process	2.053336e-4
GO:0070498	interleukin-1-mediated signaling pathway	2.076217e-4
GO:0010529	negative regulation of transposition	2.116321e-4
GO:0051084	'de novo' posttranslational protein folding	2.135833e-4
GO:0031338	regulation of vesicle fusion	2.214794e-4
GO:0008612	peptidyl-lysine modification to hypusine	2.215620e-4
GO:0009070	serine family amino acid biosynthetic process	2.219625e-4
GO:0048016	inositol phosphate-mediated signaling	2.243620e-4
GO:0070059	apoptosis in response to endoplasmic reticulum stress	2.251573e-4
GO:0044027	hypermethylation of CpG island	2.278000e-4
GO:0032703	negative regulation of interleukin-2 production	2.287892e-4
GO:0015840	urea transport	2.315836e-4
GO:0045345	positive regulation of MHC class I biosynthetic process	2.317079e-4
GO:0003071	renal system process involved in regulation of systemic arterial blood pressure	2.338913e-4
GO:0043462	regulation of ATPase activity	2.380737e-4
GO:0006090	pyruvate metabolic process	2.386166e-4
GO:0048545	response to steroid hormone stimulus	2.488544e-4
GO:0015884	folic acid transport	2.564794e-4
GO:0045777	positive regulation of blood pressure	2.623915e-4
GO:0010669	epithelial structure maintenance	2.633612e-4
GO:0006937	regulation of muscle contraction	2.636066e-4
GO:0016973	poly(A)+ mRNA export from nucleus	2.791588e-4
GO:0070633	transepithelial transport	2.794964e-4
GO:0006417	regulation of translation	2.870251e-4
GO:0034329	cell junction assembly	2.919359e-4
GO:0090257	regulation of muscle system process	2.927567e-4
GO:0006470	protein dephosphorylation	2.954613e-4
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	2.980977e-4
GO:0035039	male pronucleus assembly	3.062523e-4
GO:0048469	cell maturation	3.082647e-4
GO:0090084	negative regulation of inclusion body assembly	3.083002e-4
GO:0001894	tissue homeostasis	3.103981e-4
GO:0003257	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	3.310246e-4
GO:0007274	neuromuscular synaptic transmission	3.354699e-4
GO:0010887	negative regulation of cholesterol storage	3.385055e-4
GO:0060591	chondroblast differentiation	3.387811e-4
GO:0009812	flavonoid metabolic process	3.397549e-4
GO:0071529	cementum mineralization	3.429571e-4
GO:0001986	negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure	3.429571e-4
GO:0033189	response to vitamin A	3.468925e-4
GO:0060876	semicircular canal formation	3.519288e-4
GO:0014041	regulation of neuron maturation	3.532939e-4
GO:0060306	regulation of membrane repolarization	3.563216e-4
GO:0000956	nuclear-transcribed mRNA catabolic process	3.591333e-4
GO:0007296	vitellogenesis	3.617912e-4
GO:0006457	protein folding	3.655832e-4
GO:0072334	UDP-galactose transmembrane transport	3.681503e-4
GO:0048633	positive regulation of skeletal muscle tissue growth	3.749731e-4
GO:0009148	pyrimidine nucleoside triphosphate biosynthetic process	3.759447e-4
GO:0050710	negative regulation of cytokine secretion	3.764398e-4
GO:0035269	protein O-linked mannosylation	3.765722e-4
GO:0010608	posttranscriptional regulation of gene expression	3.901778e-4
GO:0034505	tooth mineralization	3.980304e-4
GO:0009152	purine ribonucleotide biosynthetic process	4.067183e-4
GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	4.172312e-4
GO:0045109	intermediate filament organization	4.206022e-4
GO:0032411	positive regulation of transporter activity	4.215831e-4
GO:0090343	positive regulation of cell aging	4.264928e-4
GO:0070170	regulation of tooth mineralization	4.376610e-4
GO:0042512	negative regulation of tyrosine phosphorylation of Stat1 protein	4.406416e-4
GO:0010871	negative regulation of receptor biosynthetic process	4.437995e-4
GO:0072109	glomerular mesangium development	4.442515e-4
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	4.489757e-4
GO:0022417	protein maturation by protein folding	4.538955e-4
GO:0055067	monovalent inorganic cation homeostasis	4.568693e-4
GO:0008652	cellular amino acid biosynthetic process	4.616782e-4
GO:0015949	nucleobase-containing small molecule interconversion	4.699986e-4
GO:0070172	positive regulation of tooth mineralization	4.754585e-4
GO:0006221	pyrimidine nucleotide biosynthetic process	4.836231e-4
GO:0043046	DNA methylation involved in gamete generation	4.891015e-4
GO:0042711	maternal behavior	4.908372e-4
GO:0043163	cell envelope organization	4.931865e-4
GO:0042503	tyrosine phosphorylation of Stat3 protein	4.983481e-4
GO:0090398	cellular senescence	5.140900e-4
GO:0046618	drug export	5.175894e-4
GO:0003106	negative regulation of glomerular filtration by angiotensin	5.175894e-4
GO:0014895	smooth muscle hypertrophy	5.175894e-4
GO:0050709	negative regulation of protein secretion	5.243666e-4
GO:0032606	type I interferon production	5.300401e-4
GO:0002682	regulation of immune system process	5.370441e-4
GO:0045006	DNA deamination	5.495522e-4
GO:0002376	immune system process	5.549137e-4
GO:0048260	positive regulation of receptor-mediated endocytosis	5.577087e-4
GO:0001937	negative regulation of endothelial cell proliferation	5.593408e-4
GO:0050860	negative regulation of T cell receptor signaling pathway	5.607330e-4
GO:0002086	diaphragm contraction	5.629396e-4
GO:0009220	pyrimidine ribonucleotide biosynthetic process	5.797397e-4
GO:0006228	UTP biosynthetic process	5.881840e-4
GO:0006165	nucleoside diphosphate phosphorylation	5.881840e-4
GO:0006183	GTP biosynthetic process	5.881840e-4
GO:0046007	negative regulation of activated T cell proliferation	5.989107e-4
GO:0006306	DNA methylation	6.136483e-4
GO:0018160	peptidyl-pyrromethane cofactor linkage	6.215665e-4
GO:0031118	rRNA pseudouridine synthesis	6.215665e-4
GO:0031619	homologous chromosome orientation involved in meiotic metaphase I plate congression	6.215665e-4
GO:0023035	CD40 signaling pathway	6.215665e-4
GO:0045905	positive regulation of translational termination	6.246152e-4
GO:0006452	translational frameshifting	6.246152e-4
GO:0045901	positive regulation of translational elongation	6.246152e-4
GO:0090130	tissue migration	6.297954e-4
GO:0030853	negative regulation of granulocyte differentiation	6.338802e-4
GO:0009164	nucleoside catabolic process	6.483328e-4
GO:0006085	acetyl-CoA biosynthetic process	6.641005e-4
GO:0046697	decidualization	6.723365e-4
GO:0006007	glucose catabolic process	6.795537e-4
GO:0060084	synaptic transmission involved in micturition	6.912986e-4
GO:0061180	mammary gland epithelium development	6.982176e-4
GO:0043086	negative regulation of catalytic activity	6.992383e-4
GO:0045835	negative regulation of meiosis	7.037468e-4
GO:0030046	parallel actin filament bundle assembly	7.176191e-4
GO:0030952	establishment or maintenance of cytoskeleton polarity	7.188198e-4
GO:0015904	tetracycline transport	7.257477e-4
GO:0010987	negative regulation of high-density lipoprotein particle clearance	7.257477e-4
GO:0010897	negative regulation of triglyceride catabolic process	7.257477e-4
GO:0070489	T cell aggregation	7.424736e-4
GO:0006767	water-soluble vitamin metabolic process	7.465425e-4
GO:0090083	regulation of inclusion body assembly	7.573602e-4
GO:0046164	alcohol catabolic process	7.582524e-4
GO:0060406	positive regulation of penile erection	7.816136e-4
GO:0006402	mRNA catabolic process	7.850348e-4
GO:0009895	negative regulation of catabolic process	7.874635e-4
GO:0030035	microspike assembly	7.908043e-4
GO:0009259	ribonucleotide metabolic process	7.977267e-4
GO:0009972	cytidine deamination	7.980999e-4
GO:0071803	positive regulation of podosome assembly	7.993605e-4
GO:0072126	positive regulation of glomerular mesangial cell proliferation	8.006105e-4
GO:0071506	cellular response to mycophenolic acid	8.006105e-4
GO:0072676	lymphocyte migration	8.012309e-4
GO:0050957	equilibrioception	8.060864e-4
GO:0048872	homeostasis of number of cells	8.130886e-4
GO:0000413	protein peptidyl-prolyl isomerization	8.174406e-4
GO:0030004	cellular monovalent inorganic cation homeostasis	8.213966e-4
GO:0007265	Ras protein signal transduction	8.326870e-4
GO:0033687	osteoblast proliferation	8.565368e-4
GO:0007042	lysosomal lumen acidification	8.565368e-4
GO:0033233	regulation of protein sumoylation	8.579009e-4
GO:0043241	protein complex disassembly	8.621772e-4
GO:0006000	fructose metabolic process	8.633511e-4
GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine	8.749406e-4
GO:0032786	positive regulation of transcription elongation, DNA-dependent	8.789306e-4
GO:0009987	cellular process	8.792337e-4
GO:0014043	negative regulation of neuron maturation	8.928892e-4
GO:0046483	heterocycle metabolic process	9.096666e-4
GO:0055086	nucleobase-containing small molecule metabolic process	9.479885e-4
GO:0045351	type I interferon biosynthetic process	9.482791e-4
GO:0046314	phosphocreatine biosynthetic process	9.622665e-4
GO:0060435	bronchiole development	1.002873e-3
GO:0045616	regulation of keratinocyte differentiation	1.016814e-3
GO:0032984	macromolecular complex disassembly	1.023048e-3
GO:0080111	DNA demethylation	1.036534e-3
GO:0035335	peptidyl-tyrosine dephosphorylation	1.043359e-3
GO:0001782	B cell homeostasis	1.043849e-3
GO:0071340	skeletal muscle nicotinic acetylcholine receptor clustering	1.054965e-3
GO:0007208	activation of phospholipase C activity by serotonin receptor signaling pathway	1.054965e-3
GO:0009218	pyrimidine ribonucleotide metabolic process	1.071690e-3
GO:0019344	cysteine biosynthetic process	1.074999e-3
GO:0003093	regulation of glomerular filtration	1.087850e-3
GO:0048871	multicellular organismal homeostasis	1.088044e-3
GO:0035247	peptidyl-arginine omega-N-methylation	1.093977e-3
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	1.100875e-3
GO:0045936	negative regulation of phosphate metabolic process	1.138333e-3
GO:0032736	positive regulation of interleukin-13 production	1.153482e-3
GO:0051180	vitamin transport	1.195183e-3
GO:0040029	regulation of gene expression, epigenetic	1.198598e-3
GO:0046292	formaldehyde metabolic process	1.219616e-3
GO:0030573	bile acid catabolic process	1.219616e-3
GO:0060307	regulation of ventricular cardiomyocyte membrane repolarization	1.238699e-3
GO:0032782	bile acid secretion	1.238699e-3
GO:0072529	pyrimidine-containing compound catabolic process	1.255417e-3
GO:0031641	regulation of myelination	1.256269e-3
GO:0045630	positive regulation of T-helper 2 cell differentiation	1.283237e-3
GO:0002432	granuloma formation	1.288696e-3
GO:0008360	regulation of cell shape	1.291113e-3
GO:0060319	primitive erythrocyte differentiation	1.314902e-3
GO:0002575	basophil chemotaxis	1.314902e-3
GO:0071816	tail-anchored membrane protein insertion into ER membrane	1.338750e-3
GO:0045713	low-density lipoprotein particle receptor biosynthetic process	1.352408e-3
GO:0034441	plasma lipoprotein particle oxidation	1.352408e-3
GO:0060249	anatomical structure homeostasis	1.353443e-3
GO:0070383	DNA cytosine deamination	1.372408e-3
GO:0060457	negative regulation of digestive system process	1.372408e-3
GO:0070664	negative regulation of leukocyte proliferation	1.379807e-3
GO:0061014	positive regulation of mRNA catabolic process	1.384141e-3
GO:0012501	programmed cell death	1.385474e-3
GO:0014829	vascular smooth muscle contraction	1.406422e-3
GO:0009258	10-formyltetrahydrofolate catabolic process	1.407431e-3
GO:0061048	negative regulation of branching involved in lung morphogenesis	1.407431e-3
GO:0032753	positive regulation of interleukin-4 production	1.414405e-3
GO:0009226	nucleotide-sugar biosynthetic process	1.471629e-3
GO:0060339	negative regulation of type I interferon-mediated signaling pathway	1.472473e-3
GO:0019402	galactitol metabolic process	1.472473e-3
GO:0015728	mevalonate transport	1.472473e-3
GO:0008217	regulation of blood pressure	1.478981e-3
GO:0071281	cellular response to iron ion	1.485251e-3
GO:0010944	negative regulation of transcription by competitive promoter binding	1.493138e-3
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	1.493138e-3
GO:0002478	antigen processing and presentation of exogenous peptide antigen	1.493138e-3
GO:0034219	carbohydrate transmembrane transport	1.494333e-3
GO:0007271	synaptic transmission, cholinergic	1.496381e-3
GO:0000212	meiotic spindle organization	1.518199e-3
GO:0009150	purine ribonucleotide metabolic process	1.535806e-3
GO:0051972	regulation of telomerase activity	1.554559e-3
GO:0031347	regulation of defense response	1.578511e-3
GO:0006835	dicarboxylic acid transport	1.592916e-3
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	1.603707e-3
GO:0010869	regulation of receptor biosynthetic process	1.620054e-3
GO:0003073	regulation of systemic arterial blood pressure	1.622101e-3
GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway	1.623956e-3
GO:0000185	activation of MAPKKK activity	1.650946e-3
GO:0070972	protein localization in endoplasmic reticulum	1.686725e-3
GO:0046034	ATP metabolic process	1.700398e-3
GO:0030502	negative regulation of bone mineralization	1.712504e-3
GO:0044092	negative regulation of molecular function	1.725903e-3
GO:0051186	cofactor metabolic process	1.775409e-3
GO:0046680	response to DDT	1.784736e-3
GO:0060623	regulation of chromosome condensation	1.784736e-3
GO:0071283	cellular response to iron(III) ion	1.784736e-3
GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	1.784736e-3
GO:0015761	mannose transport	1.784736e-3
GO:0019413	acetate biosynthetic process	1.784736e-3
GO:0019542	propionate biosynthetic process	1.784736e-3
GO:0019752	carboxylic acid metabolic process	1.798474e-3
GO:0071299	cellular response to vitamin A	1.818053e-3
GO:0060716	labyrinthine layer blood vessel development	1.851448e-3
GO:0002316	follicular B cell differentiation	1.856066e-3
GO:0033033	negative regulation of myeloid cell apoptosis	1.862899e-3
GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine	1.862899e-3
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	1.891425e-3
GO:0048708	astrocyte differentiation	1.905828e-3
GO:0061024	membrane organization	1.924323e-3
GO:0031444	slow-twitch skeletal muscle fiber contraction	1.928096e-3
GO:0071217	cellular response to external biotic stimulus	1.958593e-3
GO:0016142	O-glycoside catabolic process	1.958593e-3
GO:0042270	protection from natural killer cell mediated cytotoxicity	1.958593e-3
GO:2000774	positive regulation of cellular senescence	2.011402e-3
GO:0035986	senescence-associated heterochromatin focus formation	2.011402e-3
GO:0016044	cellular membrane organization	2.018505e-3
GO:0045415	negative regulation of interleukin-8 biosynthetic process	2.028721e-3
GO:0001890	placenta development	2.030271e-3
GO:0046847	filopodium assembly	2.039642e-3
GO:0060351	cartilage development involved in endochondral bone morphogenesis	2.043561e-3
GO:0043534	blood vessel endothelial cell migration	2.052074e-3
GO:0071316	cellular response to nicotine	2.064116e-3
GO:0009147	pyrimidine nucleoside triphosphate metabolic process	2.070532e-3
GO:0032914	positive regulation of transforming growth factor beta1 production	2.080943e-3
GO:0060693	regulation of branching involved in salivary gland morphogenesis	2.084306e-3
GO:0006082	organic acid metabolic process	2.113239e-3
GO:0035645	enteric smooth muscle cell differentiation	2.117369e-3
GO:0006700	C21-steroid hormone biosynthetic process	2.136604e-3
GO:0001933	negative regulation of protein phosphorylation	2.182438e-3
GO:0060080	regulation of inhibitory postsynaptic membrane potential	2.230897e-3
GO:0070168	negative regulation of biomineral tissue development	2.253603e-3
GO:0010624	regulation of Schwann cell proliferation	2.264623e-3
GO:0031077	post-embryonic camera-type eye development	2.272765e-3
GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	2.295916e-3
GO:0050901	leukocyte tethering or rolling	2.295969e-3
GO:0032471	reduction of endoplasmic reticulum calcium ion concentration	2.300320e-3
GO:0035814	negative regulation of renal sodium excretion	2.304158e-3
GO:0031365	N-terminal protein amino acid modification	2.340898e-3
GO:0048384	retinoic acid receptor signaling pathway	2.357393e-3
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	2.357491e-3
GO:0046185	aldehyde catabolic process	2.357866e-3
GO:0007202	activation of phospholipase C activity	2.360305e-3
GO:0050856	regulation of T cell receptor signaling pathway	2.389958e-3
GO:0006942	regulation of striated muscle contraction	2.398125e-3
GO:0006505	GPI anchor metabolic process	2.405941e-3
GO:0042180	cellular ketone metabolic process	2.407147e-3
GO:0009408	response to heat	2.441853e-3

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0035094	response to nicotine	5.162701e-12
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	6.456554e-11
GO:0048298	positive regulation of isotype switching to IgA isotypes	1.611057e-10
GO:0035691	macrophage migration inhibitory factor signaling pathway	8.584097e-10
GO:0002636	positive regulation of germinal center formation	1.758536e-9
GO:0006631	fatty acid metabolic process	2.194482e-9
GO:2001021	negative regulation of response to DNA damage stimulus	2.802214e-9
GO:2000107	negative regulation of leukocyte apoptosis	3.615392e-9
GO:0090083	regulation of inclusion body assembly	4.645765e-9
GO:0002906	negative regulation of mature B cell apoptosis	9.482727e-9
GO:0070229	negative regulation of lymphocyte apoptosis	1.089274e-8
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	1.159861e-8
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	1.254965e-8
GO:0002385	mucosal immune response	1.325824e-8
GO:0051006	positive regulation of lipoprotein lipase activity	1.618503e-8
GO:0019724	B cell mediated immunity	2.066811e-8
GO:0006206	pyrimidine base metabolic process	2.494748e-8
GO:0016064	immunoglobulin mediated immune response	2.677653e-8
GO:0002251	organ or tissue specific immune response	3.351730e-8
GO:0010898	positive regulation of triglyceride catabolic process	3.581972e-8
GO:0034442	regulation of lipoprotein oxidation	4.294882e-8
GO:0044255	cellular lipid metabolic process	5.527224e-8
GO:0060193	positive regulation of lipase activity	6.020695e-8
GO:0042790	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	6.434704e-8
GO:0002830	positive regulation of type 2 immune response	7.587367e-8
GO:0042180	cellular ketone metabolic process	9.012294e-8
GO:0006082	organic acid metabolic process	1.009537e-7
GO:0046889	positive regulation of lipid biosynthetic process	1.520028e-7
GO:0006952	defense response	1.626452e-7
GO:0090084	negative regulation of inclusion body assembly	1.750380e-7
GO:0007586	digestion	1.816381e-7
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	2.318265e-7
GO:0019752	carboxylic acid metabolic process	2.343868e-7
GO:0006629	lipid metabolic process	2.420127e-7
GO:0006982	response to lipid hydroperoxide	2.425350e-7
GO:0002903	negative regulation of B cell apoptosis	2.587477e-7
GO:0034445	negative regulation of plasma lipoprotein particle oxidation	3.106184e-7
GO:0050746	regulation of lipoprotein metabolic process	7.271057e-7
GO:0002443	leukocyte mediated immunity	7.956467e-7
GO:0032700	negative regulation of interleukin-17 production	8.548444e-7
GO:0021564	vagus nerve development	8.935345e-7
GO:0001516	prostaglandin biosynthetic process	9.244984e-7
GO:0051085	chaperone mediated protein folding requiring cofactor	1.017072e-6
GO:0045368	positive regulation of interleukin-13 biosynthetic process	1.040733e-6
GO:0034393	positive regulation of smooth muscle cell apoptosis	1.062136e-6
GO:0051135	positive regulation of NK T cell activation	1.120209e-6
GO:0045940	positive regulation of steroid metabolic process	1.375322e-6
GO:0006693	prostaglandin metabolic process	1.675481e-6
GO:0010896	regulation of triglyceride catabolic process	1.745486e-6
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling	1.895533e-6
GO:2001020	regulation of response to DNA damage stimulus	1.913727e-6
GO:0055114	oxidation-reduction process	1.919094e-6
GO:0044281	small molecule metabolic process	2.029727e-6
GO:0072529	pyrimidine-containing compound catabolic process	2.039649e-6
GO:0002227	innate immune response in mucosa	2.102707e-6
GO:0050748	negative regulation of lipoprotein metabolic process	2.839428e-6
GO:0035082	axoneme assembly	2.988974e-6
GO:0030300	regulation of intestinal cholesterol absorption	3.087093e-6
GO:0002449	lymphocyte mediated immunity	3.227429e-6
GO:0072376	protein activation cascade	3.270998e-6
GO:0015781	pyrimidine nucleotide-sugar transport	3.374257e-6
GO:0006956	complement activation	3.468378e-6
GO:0045834	positive regulation of lipid metabolic process	3.545714e-6
GO:0001961	positive regulation of cytokine-mediated signaling pathway	3.735329e-6
GO:0032787	monocarboxylic acid metabolic process	3.782239e-6
GO:0046456	icosanoid biosynthetic process	3.881989e-6
GO:0032846	positive regulation of homeostatic process	4.148324e-6
GO:0006707	cholesterol catabolic process	4.865246e-6
GO:0021563	glossopharyngeal nerve development	5.293193e-6
GO:0061077	chaperone-mediated protein folding	5.790894e-6
GO:0006360	transcription from RNA polymerase I promoter	5.878231e-6
GO:0015914	phospholipid transport	6.554124e-6
GO:0046394	carboxylic acid biosynthetic process	6.804506e-6
GO:0002579	positive regulation of antigen processing and presentation	6.912489e-6
GO:0019229	regulation of vasoconstriction	8.414748e-6
GO:0002604	regulation of dendritic cell antigen processing and presentation	9.278867e-6
GO:0070228	regulation of lymphocyte apoptosis	1.064389e-5
GO:0006208	pyrimidine base catabolic process	1.106589e-5
GO:0009719	response to endogenous stimulus	1.250532e-5
GO:0006636	unsaturated fatty acid biosynthetic process	1.288452e-5
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	1.506100e-5
GO:0046890	regulation of lipid biosynthetic process	1.509301e-5
GO:0001562	response to protozoan	1.597030e-5
GO:0043279	response to alkaloid	1.612045e-5
GO:0006633	fatty acid biosynthetic process	1.690882e-5
GO:0009725	response to hormone stimulus	1.810060e-5
GO:0008203	cholesterol metabolic process	2.190411e-5
GO:0090208	positive regulation of triglyceride metabolic process	2.367042e-5
GO:0072329	monocarboxylic acid catabolic process	2.388613e-5
GO:0046037	GMP metabolic process	2.502270e-5
GO:0045087	innate immune response	2.507340e-5
GO:0006690	icosanoid metabolic process	2.657760e-5
GO:0048486	parasympathetic nervous system development	2.758894e-5
GO:0006991	response to sterol depletion	2.878621e-5
GO:0071316	cellular response to nicotine	2.900911e-5
GO:0019218	regulation of steroid metabolic process	3.029004e-5
GO:0044243	multicellular organismal catabolic process	3.190560e-5
GO:0051588	regulation of neurotransmitter transport	3.243968e-5
GO:0010661	positive regulation of muscle cell apoptosis	3.263171e-5
GO:0030574	collagen catabolic process	3.287569e-5
GO:0046395	carboxylic acid catabolic process	3.336713e-5
GO:0032729	positive regulation of interferon-gamma production	3.402662e-5
GO:0030157	pancreatic juice secretion	3.853519e-5
GO:0015816	glycine transport	3.853519e-5
GO:0016074	snoRNA metabolic process	3.874173e-5
GO:0009112	nucleobase metabolic process	3.877831e-5
GO:0060760	positive regulation of response to cytokine stimulus	4.046781e-5
GO:0035986	senescence-associated heterochromatin focus formation	4.302576e-5
GO:0090402	oncogene-induced senescence	4.302576e-5
GO:2000774	positive regulation of cellular senescence	4.302576e-5
GO:0045082	positive regulation of interleukin-10 biosynthetic process	4.302576e-5
GO:0008610	lipid biosynthetic process	4.419178e-5
GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	4.870897e-5
GO:0007288	sperm axoneme assembly	4.941412e-5
GO:2000251	positive regulation of actin cytoskeleton reorganization	4.984466e-5
GO:0035036	sperm-egg recognition	5.342367e-5
GO:0009062	fatty acid catabolic process	5.373366e-5
GO:0021783	preganglionic parasympathetic nervous system development	5.541558e-5
GO:0032642	regulation of chemokine production	5.571265e-5
GO:0003050	regulation of systemic arterial blood pressure by atrial natriuretic peptide	6.320929e-5
GO:0044058	regulation of digestive system process	6.325605e-5
GO:0006953	acute-phase response	6.519271e-5
GO:0045980	negative regulation of nucleotide metabolic process	7.009864e-5
GO:0016125	sterol metabolic process	7.150018e-5
GO:0033344	cholesterol efflux	7.314602e-5
GO:0002833	positive regulation of response to biotic stimulus	7.500201e-5
GO:0009071	serine family amino acid catabolic process	7.533356e-5
GO:0015790	UDP-xylose transport	7.874582e-5
GO:0015788	UDP-N-acetylglucosamine transport	7.874582e-5
GO:0071874	cellular response to norepinephrine stimulus	8.095649e-5
GO:0048016	inositol phosphate-mediated signaling	8.494418e-5
GO:0002455	humoral immune response mediated by circulating immunoglobulin	8.741211e-5
GO:0006378	mRNA polyadenylation	9.133450e-5
GO:0018342	protein prenylation	1.042257e-4
GO:0002821	positive regulation of adaptive immune response	1.091800e-4
GO:0090086	negative regulation of protein deubiquitination	1.149052e-4
GO:0030818	negative regulation of cAMP biosynthetic process	1.159164e-4
GO:0019430	removal of superoxide radicals	1.219436e-4
GO:0006066	alcohol metabolic process	1.242211e-4
GO:0045907	positive regulation of vasoconstriction	1.286445e-4
GO:0006954	inflammatory response	1.305910e-4
GO:0002699	positive regulation of immune effector process	1.310905e-4
GO:0046113	nucleobase catabolic process	1.479980e-4
GO:0002577	regulation of antigen processing and presentation	1.664261e-4
GO:0001578	microtubule bundle formation	1.848569e-4
GO:0048630	skeletal muscle tissue growth	1.909918e-4
GO:0034370	triglyceride-rich lipoprotein particle remodeling	1.920397e-4
GO:0097035	regulation of membrane lipid distribution	2.022947e-4
GO:0051001	negative regulation of nitric-oxide synthase activity	2.022947e-4
GO:0090023	positive regulation of neutrophil chemotaxis	2.130776e-4
GO:0015761	mannose transport	2.250246e-4
GO:0042744	hydrogen peroxide catabolic process	2.276377e-4
GO:0042832	defense response to protozoan	2.291035e-4
GO:0070244	negative regulation of thymocyte apoptosis	2.340901e-4
GO:0042663	regulation of endodermal cell fate specification	2.340901e-4
GO:0051702	interaction with symbiont	2.388841e-4
GO:2000106	regulation of leukocyte apoptosis	2.395074e-4
GO:0051897	positive regulation of protein kinase B signaling cascade	2.460404e-4
GO:0043627	response to estrogen stimulus	2.490772e-4
GO:0071242	cellular response to ammonium ion	2.616899e-4
GO:0006578	betaine biosynthetic process	2.684645e-4
GO:0048242	epinephrine secretion	2.863242e-4
GO:0032229	negative regulation of synaptic transmission, GABAergic	2.863317e-4
GO:0010193	response to ozone	3.043868e-4
GO:0045780	positive regulation of bone resorption	3.085129e-4
GO:0010893	positive regulation of steroid biosynthetic process	3.104419e-4
GO:0065005	protein-lipid complex assembly	3.145886e-4
GO:0010466	negative regulation of peptidase activity	3.162225e-4
GO:0030817	regulation of cAMP biosynthetic process	3.179440e-4
GO:0001706	endoderm formation	3.299977e-4
GO:0090238	positive regulation of arachidonic acid secretion	3.475446e-4
GO:0006668	sphinganine-1-phosphate metabolic process	3.481058e-4
GO:0032722	positive regulation of chemokine production	3.575292e-4
GO:0010224	response to UV-B	3.730506e-4
GO:0008535	respiratory chain complex IV assembly	3.739339e-4
GO:0046475	glycerophospholipid catabolic process	3.859971e-4
GO:0002837	regulation of immune response to tumor cell	3.952537e-4
GO:0034372	very-low-density lipoprotein particle remodeling	3.975928e-4
GO:0006663	platelet activating factor biosynthetic process	4.040901e-4
GO:0042396	phosphagen biosynthetic process	4.042913e-4
GO:0070243	regulation of thymocyte apoptosis	4.086021e-4
GO:0030799	regulation of cyclic nucleotide metabolic process	4.275169e-4
GO:0007339	binding of sperm to zona pellucida	4.325492e-4
GO:0002839	positive regulation of immune response to tumor cell	4.359906e-4
GO:0001867	complement activation, lectin pathway	4.517416e-4
GO:0030802	regulation of cyclic nucleotide biosynthetic process	4.770874e-4
GO:0046314	phosphocreatine biosynthetic process	4.783432e-4
GO:0010949	negative regulation of intestinal phytosterol absorption	4.783432e-4
GO:0045796	negative regulation of intestinal cholesterol absorption	4.783432e-4
GO:0010518	positive regulation of phospholipase activity	4.982554e-4
GO:0042269	regulation of natural killer cell mediated cytotoxicity	5.009638e-4
GO:0042267	natural killer cell mediated cytotoxicity	5.234489e-4
GO:0042304	regulation of fatty acid biosynthetic process	5.331406e-4
GO:0048148	behavioral response to cocaine	5.380355e-4
GO:0046626	regulation of insulin receptor signaling pathway	5.577582e-4
GO:0043085	positive regulation of catalytic activity	5.848602e-4
GO:0071422	succinate transmembrane transport	5.879433e-4
GO:0006994	positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	5.879433e-4
GO:0015889	cobalamin transport	5.879433e-4
GO:0045908	negative regulation of vasodilation	6.112841e-4
GO:0050810	regulation of steroid biosynthetic process	6.242167e-4
GO:0070232	regulation of T cell apoptosis	6.381309e-4
GO:0035845	photoreceptor cell outer segment organization	6.430216e-4
GO:0045358	negative regulation of interferon-beta biosynthetic process	6.430216e-4
GO:0018344	protein geranylgeranylation	6.430216e-4
GO:0016140	O-glycoside metabolic process	6.430216e-4
GO:0030967	ER-nuclear sterol response pathway	6.477122e-4
GO:0006958	complement activation, classical pathway	6.497147e-4
GO:0034105	positive regulation of tissue remodeling	6.500310e-4
GO:0006108	malate metabolic process	6.669267e-4
GO:0046060	dATP metabolic process	6.829884e-4
GO:0046548	retinal rod cell development	6.845807e-4
GO:0000305	response to oxygen radical	7.072672e-4
GO:0030814	regulation of cAMP metabolic process	7.210434e-4
GO:0031649	heat generation	7.456666e-4
GO:0019932	second-messenger-mediated signaling	7.486610e-4
GO:0010524	positive regulation of calcium ion transport into cytosol	7.686131e-4
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	7.714351e-4
GO:0002069	columnar/cuboidal epithelial cell maturation	7.714351e-4
GO:0010873	positive regulation of cholesterol esterification	7.753088e-4
GO:0042662	negative regulation of mesodermal cell fate specification	7.875246e-4
GO:0033700	phospholipid efflux	7.891043e-4
GO:0090022	regulation of neutrophil chemotaxis	8.012837e-4
GO:0035987	endodermal cell differentiation	8.012837e-4
GO:0050778	positive regulation of immune response	8.017181e-4
GO:0001659	temperature homeostasis	8.029095e-4
GO:0046628	positive regulation of insulin receptor signaling pathway	8.264662e-4
GO:0032649	regulation of interferon-gamma production	8.450614e-4
GO:0002071	glandular epithelial cell maturation	8.471560e-4
GO:0008594	photoreceptor cell morphogenesis	8.471560e-4
GO:0006635	fatty acid beta-oxidation	8.525988e-4
GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter	8.700626e-4
GO:0072361	regulation of glycolysis by regulation of transcription from RNA polymerase II promoter	8.700626e-4
GO:0006546	glycine catabolic process	8.700626e-4
GO:0048240	sperm capacitation	8.871780e-4
GO:0008645	hexose transport	9.035732e-4
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	9.169618e-4
GO:0071702	organic substance transport	9.291681e-4
GO:0046928	regulation of neurotransmitter secretion	9.294826e-4
GO:0044236	multicellular organismal metabolic process	9.311265e-4
GO:0019216	regulation of lipid metabolic process	9.507762e-4
GO:0002426	immunoglobulin production in mucosal tissue	9.624078e-4
GO:0032868	response to insulin stimulus	1.036591e-3
GO:0052547	regulation of peptidase activity	1.036824e-3
GO:0042129	regulation of T cell proliferation	1.040964e-3
GO:0045404	positive regulation of interleukin-4 biosynthetic process	1.080549e-3
GO:0002077	acrosome matrix dispersal	1.105161e-3
GO:0051186	cofactor metabolic process	1.108646e-3
GO:0072593	reactive oxygen species metabolic process	1.109303e-3
GO:0009988	cell-cell recognition	1.142752e-3
GO:0006705	mineralocorticoid biosynthetic process	1.159237e-3
GO:0045723	positive regulation of fatty acid biosynthetic process	1.163688e-3
GO:0014819	regulation of skeletal muscle contraction	1.173793e-3
GO:0050790	regulation of catalytic activity	1.179668e-3
GO:0010976	positive regulation of neuron projection development	1.193198e-3
GO:0043094	cellular metabolic compound salvage	1.208581e-3
GO:0050766	positive regulation of phagocytosis	1.272027e-3
GO:0051444	negative regulation of ubiquitin-protein ligase activity	1.283795e-3
GO:0019882	antigen processing and presentation	1.284749e-3
GO:0019217	regulation of fatty acid metabolic process	1.354980e-3
GO:0043434	response to peptide hormone stimulus	1.376856e-3
GO:0006383	transcription from RNA polymerase III promoter	1.379894e-3
GO:0006734	NADH metabolic process	1.390113e-3
GO:0071340	skeletal muscle nicotinic acetylcholine receptor clustering	1.395255e-3
GO:0018206	peptidyl-methionine modification	1.436202e-3
GO:0006669	sphinganine-1-phosphate biosynthetic process	1.436202e-3
GO:0007493	endodermal cell fate determination	1.437873e-3
GO:0002513	tolerance induction to self antigen	1.444681e-3
GO:0035023	regulation of Rho protein signal transduction	1.448807e-3
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.499876e-3
GO:0042743	hydrogen peroxide metabolic process	1.504386e-3
GO:0048241	epinephrine transport	1.508632e-3
GO:0060913	cardiac cell fate determination	1.541039e-3
GO:0032571	response to vitamin K	1.541039e-3
GO:0072181	mesonephric duct formation	1.557877e-3
GO:0002902	regulation of B cell apoptosis	1.565652e-3
GO:0035104	positive regulation of transcription via sterol regulatory element binding	1.615306e-3
GO:0071705	nitrogen compound transport	1.627719e-3
GO:0010872	regulation of cholesterol esterification	1.634657e-3
GO:0045086	positive regulation of interleukin-2 biosynthetic process	1.660510e-3
GO:0050432	catecholamine secretion	1.672128e-3
GO:0072527	pyrimidine-containing compound metabolic process	1.712893e-3
GO:0050671	positive regulation of lymphocyte proliferation	1.714781e-3
GO:0032233	positive regulation of actin filament bundle assembly	1.732494e-3
GO:0043467	regulation of generation of precursor metabolites and energy	1.733845e-3
GO:0002684	positive regulation of immune system process	1.750021e-3
GO:0032859	activation of Ral GTPase activity	1.751342e-3
GO:0042157	lipoprotein metabolic process	1.760670e-3
GO:0006641	triglyceride metabolic process	1.762464e-3
GO:0046503	glycerolipid catabolic process	1.806844e-3
GO:0051345	positive regulation of hydrolase activity	1.822092e-3
GO:0072428	signal transduction involved in intra-S DNA damage checkpoint	1.837444e-3
GO:0006801	superoxide metabolic process	1.837609e-3
GO:0043922	negative regulation by host of viral transcription	1.853583e-3
GO:0006959	humoral immune response	1.876735e-3
GO:0007109	cytokinesis, completion of separation	1.894554e-3
GO:0055090	acylglycerol homeostasis	1.905977e-3
GO:0060947	cardiac vascular smooth muscle cell differentiation	1.929877e-3
GO:0043691	reverse cholesterol transport	1.944803e-3
GO:0006760	folic acid-containing compound metabolic process	1.952727e-3
GO:0070233	negative regulation of T cell apoptosis	1.969448e-3
GO:0044259	multicellular organismal macromolecule metabolic process	1.971314e-3
GO:0010033	response to organic substance	1.984817e-3
GO:0070059	apoptosis in response to endoplasmic reticulum stress	1.994814e-3
GO:0008202	steroid metabolic process	1.995054e-3
GO:0070374	positive regulation of ERK1 and ERK2 cascade	2.021025e-3
GO:0032218	riboflavin transport	2.036889e-3
GO:0033566	gamma-tubulin complex localization	2.036889e-3
GO:0016068	type I hypersensitivity	2.036889e-3
GO:0018230	peptidyl-L-cysteine S-palmitoylation	2.036889e-3
GO:0000053	argininosuccinate metabolic process	2.036889e-3
GO:0000303	response to superoxide	2.040369e-3
GO:0045332	phospholipid translocation	2.044049e-3
GO:0016042	lipid catabolic process	2.088597e-3
GO:0010901	regulation of very-low-density lipoprotein particle remodeling	2.106235e-3
GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation	2.151685e-3
GO:0032946	positive regulation of mononuclear cell proliferation	2.162166e-3
GO:0050999	regulation of nitric-oxide synthase activity	2.193912e-3
GO:0010522	regulation of calcium ion transport into cytosol	2.249080e-3
GO:0002526	acute inflammatory response	2.263373e-3
GO:0032368	regulation of lipid transport	2.273174e-3
GO:0030321	transepithelial chloride transport	2.288919e-3
GO:0031638	zymogen activation	2.321288e-3
GO:0033628	regulation of cell adhesion mediated by integrin	2.328421e-3
GO:0017004	cytochrome complex assembly	2.355629e-3
GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	2.355629e-3
GO:0032963	collagen metabolic process	2.368736e-3
GO:0070665	positive regulation of leukocyte proliferation	2.388471e-3
GO:0043631	RNA polyadenylation	2.406901e-3
GO:0032025	response to cobalt ion	2.461689e-3
GO:0045089	positive regulation of innate immune response	2.479711e-3
GO:0046185	aldehyde catabolic process	2.512528e-3
GO:0046333	octopamine metabolic process	2.512528e-3
GO:0035106	operant conditioning	2.512528e-3
GO:0042309	homoiothermy	2.512528e-3
GO:0030573	bile acid catabolic process	2.512528e-3
GO:0032277	negative regulation of gonadotropin secretion	2.512701e-3
GO:0042107	cytokine metabolic process	2.515505e-3
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade	2.515505e-3
GO:0032897	negative regulation of viral transcription	2.533450e-3
GO:0032276	regulation of gonadotropin secretion	2.533450e-3
GO:0045076	regulation of interleukin-2 biosynthetic process	2.542552e-3
GO:0009611	response to wounding	2.565038e-3
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	2.571150e-3
GO:0032768	regulation of monooxygenase activity	2.636134e-3
GO:0002703	regulation of leukocyte mediated immunity	2.646535e-3
GO:0009190	cyclic nucleotide biosynthetic process	2.655734e-3
GO:0006177	GMP biosynthetic process	2.665542e-3
GO:0015844	monoamine transport	2.681866e-3
GO:0015749	monosaccharide transport	2.702536e-3
GO:0006544	glycine metabolic process	2.735624e-3
GO:0045357	regulation of interferon-beta biosynthetic process	2.739537e-3
GO:0031124	mRNA 3'-end processing	2.766221e-3
GO:0044283	small molecule biosynthetic process	2.774237e-3
GO:0071375	cellular response to peptide hormone stimulus	2.785321e-3
GO:0010273	detoxification of copper ion	2.828909e-3
GO:0070328	triglyceride homeostasis	2.861328e-3
GO:0006706	steroid catabolic process	2.919332e-3
GO:0042742	defense response to bacterium	2.930034e-3
GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	2.934197e-3
GO:0070166	enamel mineralization	2.934197e-3
GO:0031999	negative regulation of fatty acid beta-oxidation	2.934197e-3
GO:0044093	positive regulation of molecular function	2.962842e-3
GO:0060051	negative regulation of protein glycosylation	3.032456e-3
GO:0032908	regulation of transforming growth factor beta1 production	3.034821e-3
GO:2000297	negative regulation of synapse maturation	3.090198e-3
GO:0039020	pronephric nephron tubule development	3.090198e-3
GO:0035565	regulation of pronephros size	3.090198e-3
GO:0000038	very long-chain fatty acid metabolic process	3.135266e-3
GO:0010288	response to lead ion	3.171407e-3
GO:0051251	positive regulation of lymphocyte activation	3.273104e-3
GO:0090031	positive regulation of steroid hormone biosynthetic process	3.334044e-3
GO:0006006	glucose metabolic process	3.371370e-3
GO:0045807	positive regulation of endocytosis	3.457847e-3
GO:0010935	regulation of macrophage cytokine production	3.512711e-3
GO:0035634	response to stilbenoid	3.527387e-3
GO:0010517	regulation of phospholipase activity	3.559702e-3
GO:0042840	D-glucuronate catabolic process	3.569001e-3
GO:0045751	negative regulation of Toll signaling pathway	3.569001e-3
GO:0060307	regulation of ventricular cardiomyocyte membrane repolarization	3.569001e-3
GO:0060299	negative regulation of sarcomere organization	3.569001e-3
GO:0042228	interleukin-8 biosynthetic process	3.569001e-3
GO:0000379	tRNA-type intron splice site recognition and cleavage	3.569001e-3
GO:0035582	negative regulation of BMP signaling pathway by extracellular sequestering of BMP	3.569001e-3
GO:0006780	uroporphyrinogen III biosynthetic process	3.569001e-3
GO:0031119	tRNA pseudouridine synthesis	3.569001e-3
GO:0017196	N-terminal peptidyl-methionine acetylation	3.569001e-3
GO:0035725	sodium ion transmembrane transport	3.603607e-3
GO:0042102	positive regulation of T cell proliferation	3.619060e-3
GO:0002697	regulation of immune effector process	3.628380e-3
GO:0031576	G2/M transition checkpoint	3.639715e-3
GO:0006821	chloride transport	3.691947e-3
GO:0008286	insulin receptor signaling pathway	3.787798e-3
GO:0051336	regulation of hydrolase activity	3.821106e-3
GO:0001909	leukocyte mediated cytotoxicity	3.823011e-3
GO:0006213	pyrimidine nucleoside metabolic process	3.836608e-3
GO:0015937	coenzyme A biosynthetic process	3.851012e-3
GO:0050830	defense response to Gram-positive bacterium	3.855532e-3
GO:0060674	placenta blood vessel development	3.872647e-3
GO:0051092	positive regulation of NF-kappaB transcription factor activity	3.988362e-3
GO:0046847	filopodium assembly	4.020279e-3
GO:0018345	protein palmitoylation	4.066897e-3
GO:0006725	cellular aromatic compound metabolic process	4.151556e-3
GO:0033085	negative regulation of T cell differentiation in thymus	4.201080e-3
GO:0014070	response to organic cyclic compound	4.231228e-3
GO:0009124	nucleoside monophosphate biosynthetic process	4.382140e-3
GO:0060191	regulation of lipase activity	4.490238e-3
GO:0072369	regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter	4.496834e-3
GO:0072366	regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter	4.496834e-3
GO:0072363	regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter	4.496834e-3
GO:0032869	cellular response to insulin stimulus	4.544167e-3
GO:0045625	regulation of T-helper 1 cell differentiation	4.552094e-3
GO:0046514	ceramide catabolic process	4.605051e-3
GO:0071731	response to nitric oxide	4.647272e-3
GO:0021554	optic nerve development	4.647272e-3
GO:0046880	regulation of follicle-stimulating hormone secretion	4.689603e-3
GO:0051856	adhesion to symbiont	4.754278e-3
GO:0051341	regulation of oxidoreductase activity	4.755639e-3
GO:0048545	response to steroid hormone stimulus	4.763832e-3
GO:0044282	small molecule catabolic process	4.772483e-3
GO:0007205	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	4.800754e-3
GO:0097152	mesenchymal cell apoptosis	4.818462e-3
GO:0003273	cell migration involved in endocardial cushion formation	4.818462e-3
GO:0015758	glucose transport	4.968027e-3
GO:0006030	chitin metabolic process	5.017002e-3
GO:0010876	lipid localization	5.021263e-3
GO:0010863	positive regulation of phospholipase C activity	5.024226e-3
GO:0042104	positive regulation of activated T cell proliferation	5.071282e-3
GO:0042094	interleukin-2 biosynthetic process	5.163251e-3
GO:0046882	negative regulation of follicle-stimulating hormone secretion	5.163251e-3
GO:0071257	cellular response to electrical stimulus	5.214030e-3
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	5.234443e-3
GO:0001895	retina homeostasis	5.234443e-3
GO:0061078	positive regulation of prostaglandin secretion involved in immune response	5.250442e-3
GO:0070430	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	5.250442e-3
GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	5.250442e-3
GO:0045362	positive regulation of interleukin-1 biosynthetic process	5.250442e-3
GO:0002365	gamma-delta T cell lineage commitment	5.250442e-3
GO:0016142	O-glycoside catabolic process	5.250442e-3
GO:0032620	interleukin-17 production	5.250442e-3
GO:0032707	negative regulation of interleukin-23 production	5.250442e-3
GO:0010951	negative regulation of endopeptidase activity	5.332064e-3
GO:0035025	positive regulation of Rho protein signal transduction	5.389509e-3
GO:0032863	activation of Rac GTPase activity	5.389509e-3
GO:0002858	regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	5.389509e-3
GO:0009314	response to radiation	5.428400e-3
GO:0044242	cellular lipid catabolic process	5.430510e-3
GO:0060564	negative regulation of mitotic anaphase-promoting complex activity	5.482167e-3
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	5.482167e-3
GO:0042089	cytokine biosynthetic process	5.489128e-3
GO:0006110	regulation of glycolysis	5.489270e-3
GO:0005996	monosaccharide metabolic process	5.491844e-3
GO:0070682	proteasome regulatory particle assembly	5.606087e-3
GO:0018158	protein oxidation	5.606087e-3
GO:0035129	post-embryonic hindlimb morphogenesis	5.606087e-3
GO:0006955	immune response	5.757267e-3
GO:0043248	proteasome assembly	5.875275e-3
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	5.990519e-3
GO:0001660	fever generation	6.009410e-3
GO:0050760	negative regulation of thymidylate synthase biosynthetic process	6.030945e-3
GO:0015732	prostaglandin transport	6.030945e-3
GO:0002706	regulation of lymphocyte mediated immunity	6.043150e-3
GO:0035066	positive regulation of histone acetylation	6.066982e-3
GO:0051084	'de novo' posttranslational protein folding	6.139544e-3
GO:0048268	clathrin coat assembly	6.148217e-3
GO:0071495	cellular response to endogenous stimulus	6.151896e-3
GO:0045329	carnitine biosynthetic process	6.163549e-3
GO:0033278	cell proliferation in midbrain	6.163549e-3
GO:0019585	glucuronate metabolic process	6.190537e-3
GO:0050909	sensory perception of taste	6.211293e-3
GO:0060056	mammary gland involution	6.223158e-3
GO:0003025	regulation of systemic arterial blood pressure by baroreceptor feedback	6.227930e-3
GO:0001711	endodermal cell fate commitment	6.251839e-3
GO:0001736	establishment of planar polarity	6.251839e-3
GO:0022614	membrane to membrane docking	6.256999e-3
GO:0042035	regulation of cytokine biosynthetic process	6.319637e-3
GO:0050714	positive regulation of protein secretion	6.406511e-3
GO:0051851	modification by host of symbiont morphology or physiology	6.444773e-3
GO:0035813	regulation of renal sodium excretion	6.483918e-3
GO:0006968	cellular defense response	6.499816e-3
GO:0006282	regulation of DNA repair	6.514379e-3
GO:0006555	methionine metabolic process	6.585091e-3
GO:0006869	lipid transport	6.618508e-3
GO:0042986	positive regulation of amyloid precursor protein biosynthetic process	6.628448e-3
GO:0021853	cerebral cortex GABAergic interneuron migration	6.628448e-3
GO:0032769	negative regulation of monooxygenase activity	6.660305e-3
GO:0007202	activation of phospholipase C activity	6.758829e-3
GO:0051496	positive regulation of stress fiber assembly	6.779554e-3
GO:0007164	establishment of tissue polarity	6.838907e-3
GO:0050994	regulation of lipid catabolic process	6.852678e-3
GO:0034391	regulation of smooth muscle cell apoptosis	6.866111e-3
GO:0060346	bone trabecula formation	6.885817e-3
GO:0002252	immune effector process	6.895114e-3
GO:0030168	platelet activation	7.036210e-3
GO:0009116	nucleoside metabolic process	7.066316e-3
GO:0043101	purine-containing compound salvage	7.168844e-3
GO:0019730	antimicrobial humoral response	7.168844e-3
GO:0015840	urea transport	7.168844e-3
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	7.244096e-3
GO:0034505	tooth mineralization	7.260578e-3