Coexpression cluster:C1750

Full id: C1750_Monocytederived_Fibroblast_Mesenchymal_Smooth_Macrophage_CD14_Pericytes

Phase1 CAGE Peaks

Hg19::chr15:72668281..72668373,-	p1@HEXA
Hg19::chr17:42422629..42422636,+	p3@GRN
Hg19::chr17:42422637..42422655,+	p2@GRN
Hg19::chr20:44519948..44519986,+	p1@CTSA
Hg19::chr20:44519987..44519999,+	p3@CTSA

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004186	carboxypeptidase C activity	0.00430137713279296
GO:0005764	lysosome	0.00430137713279296
GO:0000323	lytic vacuole	0.00430137713279296
GO:0005773	vacuole	0.00430137713279296
GO:0004563	beta-N-acetylhexosaminidase activity	0.00620624403326304
GO:0006689	ganglioside catabolic process	0.00620624403326304
GO:0050884	neuromuscular process controlling posture	0.00620624403326304
GO:0046479	glycosphingolipid catabolic process	0.00678787958567052
GO:0019377	glycolipid catabolic process	0.00723976547420677
GO:0019915	sequestering of lipid	0.00723976547420677
GO:0001573	ganglioside metabolic process	0.00723976547420677
GO:0007628	adult walking behavior	0.00723976547420677
GO:0004185	serine carboxypeptidase activity	0.00918812158171093
GO:0007267	cell-cell signaling	0.00922311555031341
GO:0008344	adult locomotory behavior	0.0101338814539278
GO:0030149	sphingolipid catabolic process	0.0101788223163941
GO:0015929	hexosaminidase activity	0.0108558122730047
GO:0050885	neuromuscular process controlling balance	0.0108558122730047
GO:0006687	glycosphingolipid metabolic process	0.0108558122730047
GO:0007040	lysosome organization and biogenesis	0.0108558122730047
GO:0007033	vacuole organization and biogenesis	0.0113264700810796
GO:0050905	neuromuscular process	0.0113264700810796
GO:0046466	membrane lipid catabolic process	0.0113264700810796
GO:0042552	myelination	0.0117218610643795
GO:0030534	adult behavior	0.0117218610643795
GO:0006664	glycolipid metabolic process	0.0119745955732875
GO:0007272	ensheathment of neurons	0.0119745955732875
GO:0008366	axon ensheathment	0.0119745955732875
GO:0006672	ceramide metabolic process	0.0119745955732875
GO:0046519	sphingoid metabolic process	0.0126595217242665
GO:0001508	regulation of action potential	0.0139992529683599
GO:0044242	cellular lipid catabolic process	0.0159503329124385
GO:0030203	glycosaminoglycan metabolic process	0.0159503329124385
GO:0006022	aminoglycan metabolic process	0.0159503329124385
GO:0006665	sphingolipid metabolic process	0.0210614992510894
GO:0004180	carboxypeptidase activity	0.0219788420698607
GO:0046982	protein heterodimerization activity	0.0307300006956865
GO:0050954	sensory perception of mechanical stimulus	0.0366217204028624
GO:0007605	sensory perception of sound	0.0366217204028624
GO:0016042	lipid catabolic process	0.0394769015844559
GO:0007626	locomotory behavior	0.047697623954621
GO:0008238	exopeptidase activity	0.0477278536872717
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	0.0477278536872717

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
somatic cell	6.75e-15	591
monopoietic cell	3.81e-13	63
monocyte	3.81e-13	63
monoblast	3.81e-13	63
promonocyte	3.81e-13	63
animal cell	1.23e-12	679
eukaryotic cell	1.23e-12	679
macrophage dendritic cell progenitor	5.32e-12	65
non-terminally differentiated cell	6.18e-12	180
mesodermal cell	8.09e-12	119
granulocyte monocyte progenitor cell	2.39e-09	71
myeloid lineage restricted progenitor cell	3.11e-09	70
fibroblast	4.30e-09	75
multi fate stem cell	1.01e-08	430
CD14-positive, CD16-negative classical monocyte	2.06e-08	42
classical monocyte	6.87e-08	45
somatic stem cell	7.64e-08	436
myeloid leukocyte	9.46e-08	76
lining cell	1.17e-07	57
barrier cell	1.17e-07	57
meso-epithelial cell	6.60e-07	44

Uber Anatomy

Ontology term	p-value	n
mesoderm	5.06e-19	448
mesoderm-derived structure	5.06e-19	448
presumptive mesoderm	5.06e-19	448
lateral plate mesoderm	3.04e-17	216
multi-cellular organism	8.29e-14	659
musculoskeletal system	1.66e-13	167
anatomical group	1.01e-11	626
immune system	1.11e-11	115
anatomical system	1.15e-11	625
bone marrow	3.10e-10	80
bone element	1.41e-09	86
skeletal element	4.03e-09	101
skeletal system	4.03e-09	101
epithelial tube	1.98e-08	118
organ	3.36e-08	511
hemolymphoid system	9.48e-08	112
splanchnic layer of lateral plate mesoderm	3.11e-07	84
germ layer	6.58e-07	604
embryonic tissue	6.58e-07	604
presumptive structure	6.58e-07	604
epiblast (generic)	6.58e-07	604
embryonic structure	7.45e-07	605
developing anatomical structure	7.45e-07	605
circulatory system	9.28e-07	113

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.