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|full_id=C3166_acute_biphenotypic_Basophils_myelodysplastic_CD34_CD133_leukemia
|full_id=C3166_acute_biphenotypic_Basophils_myelodysplastic_CD34_CD133_leukemia
|id=C3166
|id=C3166
|ontology_enrichment_celltype=CL:0000763!1.26e-44!112;CL:0000049!1.26e-44!112;CL:0000037!1.51e-36!172;CL:0000566!1.51e-36!172;CL:0000988!3.68e-33!182;CL:0002032!1.49e-32!165;CL:0000837!1.49e-32!165;CL:0000766!1.31e-21!76;CL:0000839!4.45e-16!70;CL:0000738!4.85e-15!140;CL:0000557!2.07e-14!71;CL:0000094!2.02e-12!8;CL:0002057!2.95e-11!42;CL:0002194!1.86e-10!63;CL:0000576!1.86e-10!63;CL:0000040!1.86e-10!63;CL:0000559!1.86e-10!63;CL:0000860!4.38e-10!45;CL:0002031!5.34e-10!124;CL:0002009!6.66e-10!65;CL:0000081!1.70e-08!11;CL:0002087!5.48e-08!119;CL:0002274!8.68e-08!5;CL:0000457!8.68e-08!5;CL:0002191!8.68e-08!5;CL:0000097!8.68e-08!5;CL:0000831!8.68e-08!5;CL:0002028!8.68e-08!5
|ontology_enrichment_disease=DOID:8692!5.53e-30!31;DOID:1240!6.42e-22!39;DOID:2531!1.09e-14!51;DOID:0060083!1.09e-14!51;DOID:1036!4.97e-09!8
|ontology_enrichment_uberon=UBERON:0002390!1.46e-24!102;UBERON:0003061!1.46e-24!102;UBERON:0002193!6.73e-22!112;UBERON:0000178!7.76e-14!15;UBERON:0000179!7.76e-14!15;UBERON:0000463!7.76e-14!15;UBERON:0002371!8.88e-13!80;UBERON:0001474!3.36e-11!86;UBERON:0002405!5.17e-10!115;UBERON:0007023!6.60e-09!115;UBERON:0004765!3.70e-08!101;UBERON:0001434!3.70e-08!101;UBERON:0003081!9.22e-08!216
}}
}}

Revision as of 14:33, 21 May 2012


Full id: C3166_acute_biphenotypic_Basophils_myelodysplastic_CD34_CD133_leukemia



Phase1 CAGE Peaks

Hg19::chr11:59824099..59824106,+p3@MS4A3
Hg19::chr11:59824113..59824125,+p2@MS4A3
Hg19::chr11:59824127..59824161,+p1@MS4A3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
myeloid cell1.26e-44112
common myeloid progenitor1.26e-44112
hematopoietic stem cell1.51e-36172
angioblastic mesenchymal cell1.51e-36172
hematopoietic cell3.68e-33182
hematopoietic oligopotent progenitor cell1.49e-32165
hematopoietic multipotent progenitor cell1.49e-32165
myeloid leukocyte1.31e-2176
myeloid lineage restricted progenitor cell4.45e-1670
leukocyte4.85e-15140
granulocyte monocyte progenitor cell2.07e-1471
granulocyte2.02e-128
CD14-positive, CD16-negative classical monocyte2.95e-1142
monopoietic cell1.86e-1063
monocyte1.86e-1063
monoblast1.86e-1063
promonocyte1.86e-1063
classical monocyte4.38e-1045
hematopoietic lineage restricted progenitor cell5.34e-10124
macrophage dendritic cell progenitor6.66e-1065
blood cell1.70e-0811
nongranular leukocyte5.48e-08119
histamine secreting cell8.68e-085
biogenic amine secreting cell8.68e-085
granulocytopoietic cell8.68e-085
mast cell8.68e-085
mast cell progenitor8.68e-085
basophil mast progenitor cell8.68e-085
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.46e-24102
blood island1.46e-24102
hemolymphoid system6.73e-22112
blood7.76e-1415
haemolymphatic fluid7.76e-1415
organism substance7.76e-1415
bone marrow8.88e-1380
bone element3.36e-1186
immune system5.17e-10115
adult organism6.60e-09115
skeletal element3.70e-08101
skeletal system3.70e-08101
lateral plate mesoderm9.22e-08216
Disease
Ontology termp-valuen
myeloid leukemia5.53e-3031
leukemia6.42e-2239
hematologic cancer1.09e-1451
immune system cancer1.09e-1451
chronic leukemia4.97e-098


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.