Coexpression cluster:C910

Full id: C910_hepatic_smooth_Ewing_Adipocyte_left_Olfactory_umbilical

Phase1 CAGE Peaks

Hg19::chr15:63349229..63349248,-	p@chr15:63349229..63349248 -
Hg19::chr15:63349302..63349328,-	p@chr15:63349302..63349328 -
Hg19::chr15:63351782..63351815,-	p@chr15:63351782..63351815 -
Hg19::chr15:63351824..63351851,-	p@chr15:63351824..63351851 -
Hg19::chr15:63351866..63351889,-	p@chr15:63351866..63351889 -
Hg19::chr15:63353101..63353147,-	p@chr15:63353101..63353147 -
Hg19::chr15:63354440..63354463,-	p@chr15:63354440..63354463 -
Hg19::chr15:63354769..63354809,+	p8@TPM1
Hg19::chr15:63363279..63363308,+	p2@AL358752

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005862	muscle thin filament tropomyosin	0.00470976097963028
GO:0005865	striated muscle thin filament	0.00647592134699164
GO:0006937	regulation of muscle contraction	0.00685056142491677
GO:0008016	regulation of heart contraction	0.00685056142491677
GO:0008307	structural constituent of muscle	0.00685056142491677
GO:0003015	heart process	0.00685056142491677
GO:0060047	heart contraction	0.00685056142491677
GO:0030017	sarcomere	0.00685056142491677
GO:0030016	myofibril	0.00685056142491677
GO:0044449	contractile fiber part	0.00685056142491677
GO:0043292	contractile fiber	0.00685056142491677
GO:0008015	blood circulation	0.0129518426939833
GO:0003013	circulatory system process	0.0129518426939833
GO:0003012	muscle system process	0.0129518426939833
GO:0006936	muscle contraction	0.0129518426939833
GO:0051239	regulation of multicellular organismal process	0.0203844342399623
GO:0015629	actin cytoskeleton	0.0205013124995671
GO:0051674	localization of cell	0.0237347165157684
GO:0006928	cell motility	0.0237347165157684
GO:0003779	actin binding	0.0257859413634758
GO:0008092	cytoskeletal protein binding	0.0338093556037745
GO:0044430	cytoskeletal part	0.049131370219325

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	4.77e-20	180
mesodermal cell	2.94e-12	119
vascular associated smooth muscle cell	4.53e-11	32
smooth muscle cell	5.03e-11	42
smooth muscle myoblast	5.03e-11	42
muscle precursor cell	5.55e-11	57
myoblast	5.55e-11	57
multi-potent skeletal muscle stem cell	5.55e-11	57
muscle cell	2.42e-10	54
contractile cell	4.69e-10	59
electrically responsive cell	6.11e-10	60
electrically active cell	6.11e-10	60
embryonic cell	7.47e-10	248
fibroblast	7.87e-09	75

Uber Anatomy

Ontology term	p-value	n
multi-cellular organism	2.95e-14	659
trunk mesenchyme	1.04e-13	143
organism subdivision	2.62e-13	365
muscle tissue	3.18e-13	63
musculature	3.18e-13	63
musculature of body	3.18e-13	63
multi-tissue structure	1.12e-12	347
splanchnic layer of lateral plate mesoderm	1.21e-12	84
trunk	1.50e-12	216
skeletal muscle tissue	2.09e-12	61
striated muscle tissue	2.09e-12	61
myotome	2.09e-12	61
somite	3.64e-12	83
paraxial mesoderm	3.64e-12	83
presomitic mesoderm	3.64e-12	83
presumptive segmental plate	3.64e-12	83
trunk paraxial mesoderm	3.64e-12	83
presumptive paraxial mesoderm	3.64e-12	83
epithelial tube	1.07e-11	118
dermomyotome	1.11e-11	70
multilaminar epithelium	1.72e-11	82
artery	1.27e-10	42
arterial blood vessel	1.27e-10	42
arterial system	1.27e-10	42
vasculature	1.30e-10	79
vascular system	1.30e-10	79
circulatory system	3.28e-10	113
anatomical system	5.28e-10	625
anatomical group	7.90e-10	626
mesenchyme	1.02e-09	238
entire embryonic mesenchyme	1.02e-09	238
blood vessel	1.05e-09	60
epithelial tube open at both ends	1.05e-09	60
blood vasculature	1.05e-09	60
vascular cord	1.05e-09	60
unilaminar epithelium	2.19e-09	138
systemic artery	3.13e-09	33
systemic arterial system	3.13e-09	33
cardiovascular system	3.84e-09	110
epithelium	4.43e-09	309
cell layer	6.86e-09	312
vessel	1.29e-08	69
anatomical cluster	6.66e-08	286
primary circulatory organ	6.78e-08	27
compound organ	9.03e-07	69

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.