MCL coexpression mm9:1466

Phase1 CAGE Peaks

	Short description
Mm9::chr5:137970903..137970920,-	p11@Gnb2
Mm9::chr5:143667121..143667159,-	p@chr5:143667121..143667159 -
Mm9::chr5:143667272..143667304,-	p@chr5:143667272..143667304 -
Mm9::chr9:107518129..107518160,-	p@chr9:107518129..107518160 -
Mm9::chrX:163645344..163645469,-	p@chrX:163645344..163645469 -
Mm9::chrX:163645903..163645995,-	p@chrX:163645903..163645995 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003924	GTPase activity	0.0232053893554618
GO:0007213	acetylcholine receptor signaling, muscarinic pathway	0.0319868529172063
GO:0005829	cytosol	0.0354393021358382
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	0.0354393021358382
GO:0017111	nucleoside-triphosphatase activity	0.0354393021358382
GO:0016462	pyrophosphatase activity	0.0354393021358382
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0354393021358382
GO:0016817	hydrolase activity, acting on acid anhydrides	0.0354393021358382
GO:0005515	protein binding	0.0371944056098492

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
somatic cell	1.49e-25	118
animal cell	1.67e-23	115
eukaryotic cell	1.67e-23	115
somatic stem cell	9.54e-20	91
multi fate stem cell	9.54e-20	91
stem cell	3.79e-19	97
non-terminally differentiated cell	1.83e-16	49
neural cell	7.52e-14	43
ectodermal cell	4.28e-13	44
neurectodermal cell	4.28e-13	44
embryonic cell	2.44e-12	70
electrically responsive cell	5.05e-12	39
electrically active cell	5.05e-12	39
motile cell	6.65e-10	54
neuron	1.40e-09	33
neuronal stem cell	1.40e-09	33
neuroblast	1.40e-09	33
electrically signaling cell	1.40e-09	33
CNS neuron (sensu Vertebrata)	1.81e-09	23
neuroblast (sensu Vertebrata)	1.81e-09	23
connective tissue cell	3.22e-07	46
mesenchymal cell	3.22e-07	46

Uber Anatomy

Ontology term	p-value	n
bone marrow	2.89e-08	16
gray matter	3.57e-08	34
musculoskeletal system	1.61e-07	32
hemolymphoid system	3.19e-07	48
immune system	3.19e-07	48
connective tissue	3.22e-07	46
nervous system	9.45e-07	75

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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