MCL coexpression mm9:1747

Phase1 CAGE Peaks

	Short description
Mm9::chr1:181890115..181890211,+	p1@Cdc42bpa
Mm9::chr5:8567093..8567110,+	p@chr5:8567093..8567110 +
Mm9::chr5:8567113..8567123,+	p@chr5:8567113..8567123 +
Mm9::chr5:8606564..8606568,+	p@chr5:8606564..8606568 +
Mm9::chr9:42914037..42914109,-	p1@Arhgef12

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005083	small GTPase regulator activity	0.00509899699284794
GO:0030695	GTPase regulator activity	0.00821737696392652
GO:0007097	nuclear migration	0.00821737696392652
GO:0040023	establishment of nucleus localization	0.00986004192010371
GO:0051647	nucleus localization	0.00986004192010371
GO:0051656	establishment of organelle localization	0.027715412429569
GO:0007242	intracellular signaling cascade	0.027715412429569
GO:0051640	organelle localization	0.027715412429569
GO:0019992	diacylglycerol binding	0.0403401200135352
GO:0005089	Rho guanyl-nucleotide exchange factor activity	0.0403401200135352
GO:0035023	regulation of Rho protein signal transduction	0.0403401200135352
GO:0005088	Ras guanyl-nucleotide exchange factor activity	0.0403401200135352
GO:0000226	microtubule cytoskeleton organization and biogenesis	0.0403871732472332
GO:0007266	Rho protein signal transduction	0.0468573864306494

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
anatomical conduit	1.60e-16	122
tube	1.73e-15	114
structure with developmental contribution from neural crest	1.86e-11	92
multi-cellular organism	2.27e-10	333
regional part of nervous system	5.30e-10	54
neurectoderm	4.27e-09	64
neural plate	4.27e-09	64
presumptive neural plate	4.27e-09	64
neural tube	5.03e-09	52
neural rod	5.03e-09	52
future spinal cord	5.03e-09	52
neural keel	5.03e-09	52
ecto-epithelium	5.37e-09	73
ectoderm-derived structure	1.21e-08	95
ectoderm	1.21e-08	95
presumptive ectoderm	1.21e-08	95
brain	2.69e-08	47
future brain	2.69e-08	47
central nervous system	6.90e-08	73
regional part of brain	8.23e-08	46
nervous system	8.56e-08	75
tissue	2.31e-07	349
pre-chordal neural plate	4.17e-07	49
lung	6.52e-07	14
respiratory tube	6.52e-07	14
respiration organ	6.52e-07	14
pair of lungs	6.52e-07	14
lung primordium	6.52e-07	14
lung bud	6.52e-07	14

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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