MCL coexpression mm9:348

Phase1 CAGE Peaks

	Short description
Mm9::chr10:79785809..79785833,-	p5@Pcsk4
Mm9::chr10:79785866..79785878,-	p4@Pcsk4
Mm9::chr11:100721732..100721742,+	p3@Stat5a
Mm9::chr11:23671230..23671264,-	p6@Rel
Mm9::chr11:70051512..70051533,+	p@chr11:70051512..70051533 +
Mm9::chr12:114067359..114067372,+	p@chr12:114067359..114067372 +
Mm9::chr13:69673043..69673069,-	p1@Papd7
Mm9::chr14:32308146..32308171,-	p2@Mettl6
Mm9::chr17:57129821..57129833,+	p@chr17:57129821..57129833 +
Mm9::chr19:10600074..10600095,+	p@chr19:10600074..10600095 +
Mm9::chr19:53496109..53496137,+	p@chr19:53496109..53496137 +
Mm9::chr1:174306731..174306755,+	p2@Pigm
Mm9::chr2:132073579..132073599,+	p@chr2:132073579..132073599 +
Mm9::chr3:87734359..87734371,+	p4@Isg20l2
Mm9::chr3:90058266..90058285,+	p3@Crtc2
Mm9::chr4:129488152..129488163,-	p@chr4:129488152..129488163 -
Mm9::chr4:148478345..148478356,+	p3@Dffa
Mm9::chr6:100621086..100621106,-	p2@Shq1
Mm9::chr7:30638614..30638628,-	p2@Zfp940
Mm9::chr7:71081571..71081581,+	p@chr7:71081571..71081581 +
Mm9::chr9:120480504..120480537,-	p@chr9:120480504..120480537 -
Mm9::chr9:20692745..20692756,+	p4@Ppan

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0046544	development of secondary male sexual characteristics	0.0428620973140022
GO:0046543	development of secondary female sexual characteristics	0.0428620973140022
GO:0001560	regulation of cell growth by extracellular stimulus	0.0428620973140022
GO:0045136	development of secondary sexual characteristics	0.0428620973140022
GO:0001553	luteinization	0.0428620973140022
GO:0040008	regulation of growth	0.0428620973140022
GO:0001779	natural killer cell differentiation	0.0428620973140022
GO:0045647	negative regulation of erythrocyte differentiation	0.0428620973140022
GO:0045931	positive regulation of progression through mitotic cell cycle	0.0428620973140022
GO:0045579	positive regulation of B cell differentiation	0.0428620973140022
GO:0045885	positive regulation of survival gene product activity	0.0428620973140022
GO:0006309	DNA fragmentation during apoptosis	0.0428620973140022
GO:0019218	regulation of steroid metabolic process	0.0428620973140022
GO:0030856	regulation of epithelial cell differentiation	0.0428620973140022
GO:0000030	mannosyltransferase activity	0.0428620973140022
GO:0042104	positive regulation of activated T cell proliferation	0.0428620973140022
GO:0045086	positive regulation of interleukin-2 biosynthetic process	0.0428620973140022
GO:0006921	cell structure disassembly during apoptosis	0.0428620973140022
GO:0046006	regulation of activated T cell proliferation	0.0428620973140022
GO:0045577	regulation of B cell differentiation	0.0428620973140022
GO:0030262	apoptotic nuclear changes	0.0428620973140022
GO:0045646	regulation of erythrocyte differentiation	0.0428620973140022
GO:0031668	cellular response to extracellular stimulus	0.0428620973140022
GO:0019915	sequestering of lipid	0.0438073878106892
GO:0043029	T cell homeostasis	0.0438073878106892
GO:0045884	regulation of survival gene product activity	0.0455952132937886
GO:0045787	positive regulation of progression through cell cycle	0.0455952132937886
GO:0030101	natural killer cell activation	0.0455952132937886
GO:0045076	regulation of interleukin-2 biosynthetic process	0.0455952132937886
GO:0006308	DNA catabolic process	0.0455952132937886
GO:0050798	activated T cell proliferation	0.0455952132937886
GO:0004289	subtilase activity	0.0455952132937886
GO:0045621	positive regulation of lymphocyte differentiation	0.0455952132937886
GO:0009991	response to extracellular stimulus	0.0455952132937886
GO:0042094	interleukin-2 biosynthetic process	0.0455952132937886
GO:0007595	lactation	0.0455952132937886
GO:0032623	interleukin-2 production	0.0462434538972172
GO:0050729	positive regulation of inflammatory response	0.0462434538972172
GO:0031349	positive regulation of defense response	0.0462434538972172
GO:0019216	regulation of lipid metabolic process	0.0462434538972172
GO:0002260	lymphocyte homeostasis	0.0462434538972172
GO:0045638	negative regulation of myeloid cell differentiation	0.0462434538972172
GO:0051716	cellular response to stimulus	0.0462434538972172
GO:0007346	regulation of progression through mitotic cell cycle	0.0462434538972172
GO:0046489	phosphoinositide biosynthetic process	0.0462434538972172
GO:0006506	GPI anchor biosynthetic process	0.0462434538972172
GO:0042981	regulation of apoptosis	0.0462434538972172
GO:0043067	regulation of programmed cell death	0.0462434538972172
GO:0006505	GPI anchor metabolic process	0.0462434538972172
GO:0040018	positive regulation of multicellular organism growth	0.0462434538972172
GO:0030879	mammary gland development	0.0462434538972172
GO:0022411	cellular component disassembly	0.0462434538972172
GO:0045619	regulation of lymphocyte differentiation	0.0474254577769673
GO:0045927	positive regulation of growth	0.048877223103783
GO:0050871	positive regulation of B cell activation	0.048877223103783
GO:0006997	nuclear organization and biogenesis	0.048877223103783
GO:0001776	leukocyte homeostasis	0.048877223103783
GO:0046661	male sex differentiation	0.048877223103783
GO:0042102	positive regulation of T cell proliferation	0.048877223103783
GO:0007259	JAK-STAT cascade	0.048877223103783
GO:0048872	homeostasis of number of cells	0.048877223103783
GO:0031347	regulation of defense response	0.048877223103783
GO:0050727	regulation of inflammatory response	0.048877223103783
GO:0022601	menstrual cycle phase	0.048877223103783
GO:0009605	response to external stimulus	0.048877223103783
GO:0046474	glycerophospholipid biosynthetic process	0.048877223103783
GO:0022602	menstrual cycle process	0.048877223103783

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	2.38e-12	32
hematopoietic oligopotent progenitor cell	2.38e-12	32
hematopoietic stem cell	2.38e-12	32
angioblastic mesenchymal cell	2.38e-12	32
hematopoietic multipotent progenitor cell	2.38e-12	32
nucleate cell	6.66e-11	16
hematopoietic lineage restricted progenitor cell	5.63e-10	25
lymphoid lineage restricted progenitor cell	1.32e-09	12
T cell	7.22e-09	11
pro-T cell	7.22e-09	11
lymphocyte	1.27e-08	13
common lymphoid progenitor	1.27e-08	13
mature alpha-beta T cell	2.19e-08	9
alpha-beta T cell	2.19e-08	9
immature T cell	2.19e-08	9
mature T cell	2.19e-08	9
immature alpha-beta T cell	2.19e-08	9
CD4-positive, alpha-beta T cell	1.23e-07	8
connective tissue cell	4.63e-07	46
mesenchymal cell	4.63e-07	46

Uber Anatomy

Ontology term	p-value	n
hemopoietic organ	2.45e-09	29
immune organ	2.45e-09	29
hemolymphoid system	3.86e-09	48
immune system	3.86e-09	48
hematopoietic system	5.66e-09	45
blood island	5.66e-09	45
mixed endoderm/mesoderm-derived structure	1.74e-08	35
segment of respiratory tract	3.91e-08	27
thymus	5.69e-08	23
neck	5.69e-08	23
respiratory system epithelium	5.69e-08	23
hemolymphoid system gland	5.69e-08	23
pharyngeal epithelium	5.69e-08	23
thymic region	5.69e-08	23
pharyngeal gland	5.69e-08	23
entire pharyngeal arch endoderm	5.69e-08	23
thymus primordium	5.69e-08	23
early pharyngeal endoderm	5.69e-08	23
pharynx	1.87e-07	24
upper respiratory tract	1.87e-07	24
chordate pharynx	1.87e-07	24
pharyngeal arch system	1.87e-07	24
pharyngeal region of foregut	1.87e-07	24
connective tissue	4.63e-07	46
gland of gut	7.52e-07	24

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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