MCL coexpression mm9:1585

Phase1 CAGE Peaks

	Short description
Mm9::chr11:74537834..74537895,-	p1@Pafah1b1
Mm9::chr16:91011274..91011314,-	p1@Synj1
Mm9::chr16:93712169..93712182,+	p2@Dopey2
Mm9::chr1:37356727..37356782,+	p1@Inpp4a
Mm9::chr4:120689806..120689866,-	p1@Smap2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0042577	lipid phosphatase activity	0.000375173200338662
GO:0004437	inositol or phosphatidylinositol phosphatase activity	0.00180936514812023
GO:0006797	polyphosphate metabolic process	0.00761518654467758
GO:0017120	polyphosphoinositide phosphatase activity	0.00761518654467758
GO:0006798	polyphosphate catabolic process	0.00761518654467758
GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	0.0126905868252215
GO:0001675	acrosome formation	0.0142753457569309
GO:0008090	retrograde axon cargo transport	0.0142753457569309
GO:0047496	vesicle transport along microtubule	0.0186535788948009
GO:0004439	phosphoinositide 5-phosphatase activity	0.0186535788948009
GO:0016791	phosphoric monoester hydrolase activity	0.0186535788948009
GO:0042578	phosphoric ester hydrolase activity	0.0272791496909187
GO:0008088	axon cargo transport	0.0292603068847647

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	6.74e-10	23
neuroblast (sensu Vertebrata)	6.74e-10	23

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	1.21e-13	54
neural tube	1.31e-12	52
neural rod	1.31e-12	52
future spinal cord	1.31e-12	52
neural keel	1.31e-12	52
gray matter	1.57e-12	34
brain	2.99e-10	47
future brain	2.99e-10	47
brain grey matter	3.22e-10	29
regional part of telencephalon	3.22e-10	29
telencephalon	3.22e-10	29
regional part of brain	6.99e-10	46
anterior neural tube	3.89e-09	40
neurectoderm	8.25e-09	64
neural plate	8.25e-09	64
presumptive neural plate	8.25e-09	64
regional part of forebrain	1.35e-08	39
forebrain	1.35e-08	39
future forebrain	1.35e-08	39
central nervous system	1.74e-08	73
nervous system	1.14e-07	75
ecto-epithelium	2.06e-07	73
organ part	3.35e-07	99
pre-chordal neural plate	4.29e-07	49

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}