MCL coexpression mm9:2584

Phase1 CAGE Peaks

	Short description
Mm9::chr10:79459224..79459250,+	p1@Abca7
Mm9::chr19:7093830..7093905,-	p1@Fermt3
Mm9::chr8:72520162..72520197,-	p4@Gatad2a

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0021995	neuropore closure	0.0117228154558162
GO:0021506	anterior neuropore closure	0.0117228154558162
GO:0001842	neural fold formation	0.0117228154558162
GO:0010172	embryonic body morphogenesis	0.0117228154558162
GO:0010171	body morphogenesis	0.0117228154558162

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	6.64e-12	32
hematopoietic oligopotent progenitor cell	6.64e-12	32
hematopoietic stem cell	6.64e-12	32
angioblastic mesenchymal cell	6.64e-12	32
hematopoietic multipotent progenitor cell	6.64e-12	32
common myeloid progenitor	3.77e-11	19
hematopoietic lineage restricted progenitor cell	6.36e-10	25
myeloid cell	6.65e-10	16
myeloid lineage restricted progenitor cell	1.46e-08	13
connective tissue cell	9.29e-08	46
mesenchymal cell	9.29e-08	46
motile cell	4.61e-07	54

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	3.71e-16	48
immune system	3.71e-16	48
hematopoietic system	5.37e-15	45
blood island	5.37e-15	45
bone marrow	6.11e-10	16
bone element	3.66e-08	22
skeletal element	3.66e-08	22
skeletal system	3.66e-08	22
musculoskeletal system	6.86e-08	32
connective tissue	9.29e-08	46
mixed endoderm/mesoderm-derived structure	3.87e-07	35
endoderm-derived structure	6.93e-07	118
endoderm	6.93e-07	118
presumptive endoderm	6.93e-07	118
hemopoietic organ	7.28e-07	29
immune organ	7.28e-07	29

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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