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Coexpression cluster:C3317: Difference between revisions

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{{Coexpression_clusters
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|full_id=C3317_smallcell_lung_merkel_small_kidney_bronchioalveolar_Renal
|id=C3317
}}

Latest revision as of 12:23, 17 September 2013


Full id: C3317_smallcell_lung_merkel_small_kidney_bronchioalveolar_Renal



Phase1 CAGE Peaks

Hg19::chr12:6484605..6484629,-p1@SCNN1A
Hg19::chr12:6484687..6484698,-p6@SCNN1A
Hg19::chr12:6484722..6484736,-p2@SCNN1A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
endoderm-derived structure4.19e-24160
endoderm4.19e-24160
presumptive endoderm4.19e-24160
subdivision of digestive tract1.64e-19118
digestive system5.21e-19145
digestive tract5.21e-19145
primitive gut5.21e-19145
trunk region element1.06e-15101
anatomical space2.54e-1595
immaterial anatomical entity4.19e-15117
renal system1.48e-1448
urinary system structure6.58e-1447
endo-epithelium5.84e-1382
respiratory system2.06e-1274
epithelial bud4.08e-1237
thoracic cavity element1.34e-1134
thoracic cavity1.34e-1134
foregut1.50e-1187
respiratory tract3.88e-1154
organ4.68e-11503
thoracic segment organ4.86e-1135
lung1.22e-0922
respiratory tube1.22e-0922
respiration organ1.22e-0922
pair of lungs1.22e-0922
lung primordium1.22e-0922
lung bud1.22e-0922
epithelial fold2.24e-0947
reproductive structure6.44e-0959
reproductive system6.44e-0959
nephron tubule epithelium6.52e-0910
subdivision of trunk1.58e-08112
organ system subdivision2.18e-08223
respiratory primordium3.63e-0838
endoderm of foregut3.63e-0838
embryo4.47e-08592
multi-cellular organism5.44e-08656
organism subdivision5.86e-08264
male organism6.33e-0822
male reproductive system6.33e-0822
organ part8.31e-08218
reproductive organ1.30e-0748
male reproductive organ1.33e-0711
kidney1.34e-0726
kidney mesenchyme1.34e-0726
upper urinary tract1.34e-0726
kidney rudiment1.34e-0726
kidney field1.34e-0726
orifice2.08e-0736
cavitated compound organ2.15e-0731
respiratory tract epithelium2.75e-0719
lung epithelium2.75e-0719
segment of respiratory tract3.52e-0747
multi-tissue structure3.54e-07342
excretory tube3.71e-0716
kidney epithelium3.71e-0716
respiratory system epithelium3.74e-0728
organ segment8.18e-0798
Disease
Ontology termp-valuen
carcinoma1.14e-16106
cell type cancer1.67e-11143
adenocarcinoma1.55e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.11.59304
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.12.5782
MA0105.10.846801
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.12.53618
MA0143.11.00455
MA0144.10.531867
MA0145.12.94723
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.21.62945
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.12.02721
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.12.37721
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.23.14419
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488362.71700033932814.049570681927e-060.000129139881664053
EP300#203336.77394172622320.003216880500103790.0167073341563648
ESR1#2099330.76860329615453.43136389821584e-050.000674638957390369
HDAC2#3066313.41562023662630.0004140761399857210.00390268910603454
JUN#3725312.51282919233630.0005103313992726250.00443415149822244
JUND#372736.994663941871030.002921845042734990.015635321740954
NANOG#79923329.24477848101273.99627955670032e-050.000735319662829854
NR3C1#2908314.9730233311730.0002978331194675480.00308248866951455
POU5F1#54603335.4392014519062.63510205045339e-081.82015491433401e-06
RXRA#6256320.07461713913330.0001235730348432220.00164930916114905
SIN3A#2594235.408884726815140.006318961977991520.0275816470940551
SP1#666735.69838137814090.005403962701712170.0245758528458139
TAF7#6879311.43306940492390.0006690181981945830.00541346491061006
TCF12#6938310.63446490218640.0008313523990202070.00628215130607564
USF1#739136.361499277207960.00388404057290560.0189748953781312



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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