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{{Coexpression_clusters
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|full_id=C1645_temporal_non_occipital_parietal_duodenum_neuroblastoma_brain
|id=C1645
|ontology_enrichment_celltype=CL:0000055!1.64e-11!180;CL:0000393!1.55e-07!60;CL:0000211!1.55e-07!60;CL:0000183!4.55e-07!59
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000073!4.13e-32!94;UBERON:0001016!4.13e-32!94;UBERON:0005743!6.09e-30!86;UBERON:0004121!2.02e-29!169;UBERON:0003075!4.92e-29!86;UBERON:0007284!4.92e-29!86;UBERON:0001049!7.75e-29!57;UBERON:0005068!7.75e-29!57;UBERON:0006241!7.75e-29!57;UBERON:0007135!7.75e-29!57;UBERON:0001017!8.10e-29!82;UBERON:0000924!4.35e-27!173;UBERON:0006601!4.35e-27!173;UBERON:0002616!3.18e-26!59;UBERON:0002346!1.37e-25!90;UBERON:0000475!1.05e-24!365;UBERON:0003056!2.24e-24!61;UBERON:0000033!1.70e-23!123;UBERON:0000955!5.09e-23!69;UBERON:0006238!5.09e-23!69;UBERON:0000153!6.26e-23!129;UBERON:0007811!6.26e-23!129;UBERON:0002780!4.10e-22!41;UBERON:0001890!4.10e-22!41;UBERON:0006240!4.10e-22!41;UBERON:0003080!8.77e-22!42;UBERON:0002020!4.22e-21!34;UBERON:0003528!4.22e-21!34;UBERON:0001893!8.93e-21!34;UBERON:0002791!3.09e-20!33;UBERON:0001869!4.19e-20!32;UBERON:0000956!1.20e-16!25;UBERON:0000203!1.20e-16!25;UBERON:0000119!4.78e-15!312;UBERON:0002619!8.05e-15!22;UBERON:0000483!1.75e-14!309;UBERON:0007023!5.21e-14!115;UBERON:0001950!1.06e-13!20;UBERON:0000468!6.54e-13!659;UBERON:0000481!1.60e-12!347;UBERON:0000064!5.50e-12!219;UBERON:0000467!2.13e-11!625;UBERON:0000480!3.59e-11!626;UBERON:0000922!1.42e-09!612;UBERON:0002050!1.56e-08!605;UBERON:0005423!1.56e-08!605;UBERON:0000025!2.57e-08!194;UBERON:0000923!2.88e-08!604;UBERON:0005291!2.88e-08!604;UBERON:0006598!2.88e-08!604;UBERON:0002532!2.88e-08!604;UBERON:0003076!3.52e-08!15;UBERON:0003057!3.52e-08!15;UBERON:0000914!2.39e-07!83;UBERON:0002329!2.39e-07!83;UBERON:0003077!2.39e-07!83;UBERON:0003059!2.39e-07!83;UBERON:0007282!2.39e-07!83;UBERON:0009618!2.39e-07!83;UBERON:0007285!2.39e-07!83;UBERON:0004290!3.05e-07!70
}}

Latest revision as of 11:49, 17 September 2013


Full id: C1645_temporal_non_occipital_parietal_duodenum_neuroblastoma_brain



Phase1 CAGE Peaks

Hg19::chr11:79151822..79151890,-p1@ODZ4
Hg19::chr11:79151896..79151911,-p8@ODZ4
Hg19::chr11:79151994..79152022,-p2@ODZ4
Hg19::chr11:79152025..79152047,-p5@ODZ4
Hg19::chr11:79152060..79152082,-p4@ODZ4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
nervous system1.42e-3289
neural tube5.44e-3256
neural rod5.44e-3256
future spinal cord5.44e-3256
neural keel5.44e-3256
neural plate6.93e-3182
presumptive neural plate6.93e-3182
central nervous system7.31e-3181
regional part of nervous system1.20e-2953
regional part of brain1.20e-2953
ecto-epithelium3.09e-29104
neurectoderm7.72e-2886
ectoderm-derived structure2.42e-26171
ectoderm2.42e-26171
presumptive ectoderm2.42e-26171
pre-chordal neural plate9.49e-2661
brain5.98e-2568
future brain5.98e-2568
structure with developmental contribution from neural crest7.07e-25132
regional part of forebrain1.31e-2441
forebrain1.31e-2441
anterior neural tube1.31e-2441
future forebrain1.31e-2441
brain grey matter1.91e-2334
gray matter1.91e-2334
telencephalon6.64e-2334
cerebral hemisphere3.12e-2232
regional part of telencephalon4.19e-2232
cerebral cortex1.35e-1825
pallium1.35e-1825
regional part of cerebral cortex1.54e-1622
neocortex2.82e-1520
cell layer4.69e-14309
multi-tissue structure1.07e-13342
epithelium2.25e-13306
anatomical cluster1.47e-11373
adult organism3.73e-11114
multi-cellular organism6.36e-11656
organ part1.00e-10218
organ system subdivision2.68e-10223
anatomical system2.87e-10624
anatomical group4.08e-10625
embryo9.71e-10592
developing anatomical structure2.95e-09581
posterior neural tube1.70e-0815
chordal neural plate1.70e-0815
tube8.35e-08192
embryonic structure3.73e-07564
germ layer7.62e-07560
germ layer / neural crest7.62e-07560
embryonic tissue7.62e-07560
presumptive structure7.62e-07560
germ layer / neural crest derived structure7.62e-07560
epiblast (generic)7.62e-07560


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.04569
MA0004.10.626788
MA0006.18.98782
MA0007.10.606704
MA0009.11.11255
MA0014.13.71305
MA0017.10.496101
MA0019.11.84387
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.11.66737
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.15.50918
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.11.2972
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.11.12656
MA0105.10.520776
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.11.39016
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.868598
MA0146.10.0359558
MA0147.11.77656
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.527987
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.24.22271
MA0047.20.767096
MA0112.20.136971
MA0065.20.449243
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.514087
MA0155.10.130813
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.11.77901
MA0160.10.669748
MA0161.10
MA0162.14.22787
MA0163.10.680296
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.22.12087
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066455.360256373075030.0002259278299937090.00249478501128282
E2F1#186954.907389214879320.0003512818099256460.00352290387428697
MYC#460955.22228187160940.0002573944848850610.00276251388417541
RAD21#5885510.35503389545638.39503550283973e-060.000229220683106164
SPI1#668846.563458806818180.0009957429636454020.00714051080610836



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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