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{{Coexpression_clusters
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A0059.1;0.522232,MA0060.1;0.321781,MA0061.1;0.291022,MA0063.1;0,MA0066.1;0.736721,MA0067.1;1.43651,MA0068.1;0.692739,MA0069.1;1.09737,MA0070.1;1.08584,MA0071.1;0.695094,MA0072.1;1.0812,MA0073.1;0.0140295,MA0074.1;1.73427,MA0076.1;3.37477,MA0077.1;1.07324,MA0078.1;0.836493,MA0081.1;0.522409,MA0083.1;1.12028,MA0084.1;1.62584,MA0087.1;1.07867,MA0088.1;0.132006,MA0089.1;0,MA0090.1;0.556637,MA0091.1;0.629594,MA0092.1;0.588959,MA0093.1;0.456342,MA0095.1;0,MA0098.1;0,MA0100.1;0.750974,MA0101.1;0.459973,MA0103.1;0.442769,MA0105.1;1.00065,MA0106.1;0.779931,MA0107.1;0.378225,MA0108.2;0.94238,MA0109.1;0,MA0111.1;0.5713,MA0113.1;0.797251,MA0114.1;0.973423,MA0115.1;1.35895,MA0116.1;0.994489,MA0117.1;1.1512,MA0119.1;0.504689,MA0122.1;1.17777,MA0124.1;1.31673,MA0125.1;1.23103,MA0130.1;0,MA0131.1;0.855546,MA0132.1;0,MA0133.1;0,MA0135.1;1.14377,MA0136.1;0.743749,MA0139.1;2.96863,MA0140.1;0.692258,MA0141.1;0.520334,MA0142.1;0.912455,MA0143.1;0.797437,MA0144.1;0.356507,MA0145.1;1.39943,MA0146.1;0.333008,MA0147.1;0.386018,MA0148.1;0.653474,MA0149.1;0.681935,MA0062.2;3.94248,MA0035.2;0.691506,MA0039.2;0.0118463,MA0138.2;0.837782,MA0002.2;0.30855,MA0137.2;0.47779,MA0104.2;0.320919,MA0047.2;0.767096,MA0112.2;1.96224,MA0065.2;0.146576,MA0150.1;0.550239,MA0151.1;0,MA0152.1;0.69926,MA0153.1;1.21379,MA0154.1;0.514087,MA0155.1;1.3196,MA0156.1;0.480289,MA0157.1;0.883854,MA0158.1;0,MA0159.1;0.386729,MA0160.1;0.669748,MA0161.1;0,MA0162.1;1.72541,MA0163.1;1.49262,MA0164.1;0.810347,MA0080.2;0.456437,MA0018.2;0.781393,MA0099.2;0.699641,MA0079.2;0.0198381,MA0102.2;1.66336,MA0258.1;0.914277,MA0259.1;0.395396,MA0442.1;0}}
|full_id=C1809_CD4_Peripheral_normal_Neutrophils_CD8_Natural_CD14
|id=C1809
|ontology_enrichment_celltype=CL:0000738!9.95e-30!140;CL:0002087!1.85e-25!119;CL:0002031!1.27e-24!124;CL:0000766!7.40e-24!76;CL:0002057!2.01e-20!42;CL:0002009!2.72e-20!65;CL:0000557!4.49e-20!71;CL:0000860!7.65e-20!45;CL:0002194!1.31e-19!63;CL:0000576!1.31e-19!63;CL:0000040!1.31e-19!63;CL:0000559!1.31e-19!63;CL:0000839!2.63e-19!70;CL:0000037!9.62e-19!172;CL:0000566!9.62e-19!172;CL:0000988!1.83e-17!182;CL:0002032!6.02e-17!165;CL:0000837!6.02e-17!165;CL:0000763!3.13e-11!112;CL:0000049!3.13e-11!112
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002390!8.01e-25!102;UBERON:0003061!8.01e-25!102;UBERON:0002193!1.35e-21!112;UBERON:0002371!3.07e-18!80;UBERON:0001474!4.63e-16!86;UBERON:0004765!5.09e-13!101;UBERON:0001434!5.09e-13!101;UBERON:0002405!1.55e-12!115;UBERON:0000178!1.01e-07!15;UBERON:0000179!1.01e-07!15;UBERON:0000463!1.01e-07!15
}}

Latest revision as of 11:52, 17 September 2013


Full id: C1809_CD4_Peripheral_normal_Neutrophils_CD8_Natural_CD14



Phase1 CAGE Peaks

Hg19::chr19:12902603..12902655,-p@chr19:12902603..12902655
-
Hg19::chr19:12902681..12902688,-p@chr19:12902681..12902688
-
Hg19::chr19:12903127..12903178,-p1@CU678639
p1@CU679368
Hg19::chr19:12903214..12903252,-p3@CU678639
p3@CU679368
Hg19::chr19:12903367..12903458,-p2@CU678639
p2@CU679368


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte7.90e-24136
myeloid leukocyte4.29e-2372
defensive cell1.32e-2048
phagocyte1.32e-2048
macrophage dendritic cell progenitor3.13e-1961
nongranular leukocyte3.22e-19115
granulocyte monocyte progenitor cell9.77e-1967
classical monocyte1.17e-1842
CD14-positive, CD16-negative classical monocyte1.17e-1842
monopoietic cell1.18e-1859
monocyte1.18e-1859
monoblast1.18e-1859
promonocyte1.18e-1859
hematopoietic lineage restricted progenitor cell1.20e-18120
myeloid lineage restricted progenitor cell2.08e-1866
hematopoietic stem cell2.77e-15168
angioblastic mesenchymal cell2.77e-15168
hematopoietic cell6.94e-15177
hematopoietic oligopotent progenitor cell1.40e-13161
hematopoietic multipotent progenitor cell1.40e-13161
myeloid cell1.33e-11108
common myeloid progenitor1.33e-11108
stuff accumulating cell4.47e-1087
intermediate monocyte9.45e-079
CD14-positive, CD16-positive monocyte9.45e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system9.81e-2498
blood island9.81e-2498
hemolymphoid system3.84e-21108
bone marrow2.51e-1776
skeletal element9.65e-1690
bone element1.12e-1582
immune system4.23e-1593
skeletal system6.52e-14100
blood5.27e-0815
haemolymphatic fluid5.27e-0815
organism substance5.27e-0815
lateral plate mesoderm3.15e-07203


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.13.23705
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.11.45664
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.11.18667
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.13.196
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.11.5062
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.692739
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.0140295
MA0074.11.73427
MA0076.13.37477
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.11.00065
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.973423
MA0115.11.35895
MA0116.10.994489
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.12.96863
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.11.39943
MA0146.10.333008
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.23.94248
MA0035.20.691506
MA0039.20.0118463
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.21.96224
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.514087
MA0155.11.3196
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.11.72541
MA0163.11.49262
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.0198381
MA0102.21.66336
MA0258.10.914277
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ETS1#211359.728760922202341.14685159850452e-050.000292207938756315
GABPB1#255357.067683836182175.6685482528729e-050.000948290102485652
MAX#414945.16204440720570.002526309009485180.0139985773897295
NANOG#79923317.54686708860760.0003794200090681830.00376139025411219
NR2C2#7182319.56876654314450.0002750171700966610.00293146746557717
TAF7#687936.859841642954350.005843286407019040.0262469136408181
TCF12#693836.380678941311850.007185168653258840.0298315177490638
TCF7L2#693436.462105937882410.006930108755689190.0293227577010664
USF1#739145.089199421766370.00266867775360040.0147195160236743
USF2#7392410.39375790805570.0001646179728687530.00202646587322486



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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