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{{Coexpression_clusters
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|full_id=C3658_anaplastic_granulocyte_spinal_CD34_seminal_pineal_merkel
|id=C3658
|ontology_enrichment_celltype=CL:0000542!2.78e-12!53;CL:0000051!2.78e-12!53;CL:0000838!4.51e-12!52;CL:0000791!2.14e-07!18;CL:0000789!2.14e-07!18;CL:0002420!2.14e-07!18;CL:0002419!2.14e-07!18;CL:0000790!2.14e-07!18;CL:0000084!2.81e-07!25;CL:0000827!2.81e-07!25
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0007023!1.94e-11!115;UBERON:0000073!2.25e-11!94;UBERON:0001016!2.25e-11!94;UBERON:0001017!3.43e-11!82;UBERON:0005743!5.96e-11!86;UBERON:0001049!1.41e-10!57;UBERON:0005068!1.41e-10!57;UBERON:0006241!1.41e-10!57;UBERON:0007135!1.41e-10!57;UBERON:0000955!1.72e-09!69;UBERON:0006238!1.72e-09!69;UBERON:0002616!3.16e-09!59;UBERON:0003075!4.39e-09!86;UBERON:0007284!4.39e-09!86;UBERON:0002346!3.06e-08!90;UBERON:0003080!3.38e-07!42;UBERON:0002780!5.31e-07!41;UBERON:0001890!5.31e-07!41;UBERON:0006240!5.31e-07!41
}}

Latest revision as of 12:30, 17 September 2013


Full id: C3658_anaplastic_granulocyte_spinal_CD34_seminal_pineal_merkel



Phase1 CAGE Peaks

Hg19::chr17:55333876..55333939,+p1@MSI2
Hg19::chr17:55333945..55333971,+p4@MSI2
Hg19::chr17:55333997..55334044,+p2@MSI2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
lymphocyte1.47e-1153
common lymphoid progenitor1.47e-1153
lymphoid lineage restricted progenitor cell2.34e-1152
nucleate cell2.50e-1055
mature alpha-beta T cell1.62e-0718
alpha-beta T cell1.62e-0718
immature T cell1.62e-0718
mature T cell1.62e-0718
immature alpha-beta T cell1.62e-0718
T cell2.99e-0725
pro-T cell2.99e-0725
Uber Anatomy
Ontology termp-valuen
adult organism9.20e-12114
nervous system1.51e-1189
central nervous system6.40e-1181
neural tube2.87e-1056
neural rod2.87e-1056
future spinal cord2.87e-1056
neural keel2.87e-1056
neural plate3.09e-0982
presumptive neural plate3.09e-0982
brain3.64e-0968
future brain3.64e-0968
regional part of nervous system5.08e-0953
regional part of brain5.08e-0953
neurectoderm2.78e-0886
regional part of forebrain4.62e-0741
forebrain4.62e-0741
anterior neural tube4.62e-0741
future forebrain4.62e-0741
pre-chordal neural plate8.33e-0761


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.05336
MA0004.14.60201
MA0006.10.639288
MA0007.11.88666
MA0009.11.3275
MA0014.13.14798
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.12.94978
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.16.48547
MA0058.12.8588
MA0059.11.70014
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.11.04561
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.124.8599
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.12.03569
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.17.91707
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.707589
MA0147.14.68342
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.23.37171
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.24.26635
MA0047.20.973066
MA0112.20.264678
MA0065.21.39232
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.15.63764
MA0164.11.01792
MA0080.20.643061
MA0018.23.70709
MA0099.20.902716
MA0079.252.3088
MA0102.21.88331
MA0258.10.519674
MA0259.12.40872
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0324945520585546
E2F6#187635.017155731697390.00791769806886330.0321744861528351
EGR1#195834.988179094810140.008056488137383440.0320269322693434
JUN#3725312.51282919233630.0005103313992726250.004437843547763
JUND#372736.994663941871030.002921845042734990.0156577851310072
MAX#414936.452555509007120.003721913834265510.0186334767718161
MYC#460935.22228187160940.007020843755740150.0294170705691144
NR3C1#2908314.9730233311730.0002978331194675480.00308615866296967
SIN3A#2594235.408884726815140.006318961977991520.0276347753452308
USF1#739136.361499277207960.00388404057290560.019006902511184
USF2#7392312.99219738506960.0004558979393427810.00421284063767658
ZBTB7A#5134137.35190930787590.002516255860282270.0140023042301801
ZNF263#1012738.221841637010680.001799043925565870.010930212247945



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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