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MCL coexpression mm9:785: Difference between revisions

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{{MCL_coexpression_mm9|gostat_on_MCL_coexpression=GO:0050851;antigen receptor-mediated signaling pathway;4.98032272369071e-06;22637,77647,19264!GO:0002429;immune response-activating cell surface receptor signaling pathway;4.98032272369071e-06;22637,77647,19264!GO:0002768;immune response-regulating cell surface receptor signaling pathway;4.98032272369071e-06;22637,77647,19264!GO:0002757;immune response-activating signal transduction;4.98032272369071e-06;22637,77647,19264!GO:0002764;immune response-regulating signal transduction;4.98032272369071e-06;22637,77647,19264!GO:0050857;positive regulation of antigen receptor-mediated signaling pathway;9.00386442255923e-06;77647,19264!GO:0002253;activation of immune response;3.07476650178131e-05;22637,77647,19264!GO:0050778;positive regulation of immune response;4.96385487923431e-05;22637,77647,19264!GO:0002684;positive regulation of immune system process;4.96385487923431e-05;22637,77647,19264!GO:0042101;T cell receptor complex;5.7239151266756e-05;22637,77647!GO:0050776;regulation of immune response;5.7239151266756e-05;22637,77647,19264!GO:0002682;regulation of immune system process;5.7239151266756e-05;22637,77647,19264!GO:0051240;positive regulation of multicellular organismal process;5.86826780191044e-05;22637,77647,19264!GO:0050854;regulation of antigen receptor-mediated signaling pathway;7.06826458685156e-05;77647,19264!GO:0050850;positive regulation of calcium-mediated signaling;8.76915106603675e-05;22637,77647!GO:0050848;regulation of calcium-mediated signaling;8.76915106603675e-05;22637,77647!GO:0050852;T cell receptor signaling pathway;0.00016180330444394;22637,77647!GO:0001772;immunological synapse;0.000181633193691871;22637,77647!GO:0002376;immune system process;0.000181633193691871;16822,22637,77647,19264!GO:0019722;calcium-mediated signaling;0.000188708441611194;22637,77647!GO:0045321;leukocyte activation;0.000199043110945394;16822,22637,19264!GO:0001775;cell activation;0.000234537227246329;16822,22637,19264!GO:0042102;positive regulation of T cell proliferation;0.000274091506438314;22637,19264!GO:0051239;regulation of multicellular organismal process;0.000427113906584292;22637,77647,19264!GO:0032946;positive regulation of mononuclear cell proliferation;0.000434765238743307;22637,19264!GO:0050671;positive regulation of lymphocyte proliferation;0.000434765238743307;22637,19264!GO:0042129;regulation of T cell proliferation;0.000571796048606228;22637,19264!GO:0050870;positive regulation of T cell activation;0.000578207652799299;22637,19264!GO:0009966;regulation of signal transduction;0.000595041323197565;22637,77647,19264!GO:0032944;regulation of mononuclear cell proliferation;0.000796095387164107;22637,19264!GO:0050670;regulation of lymphocyte proliferation;0.000796095387164107;22637,19264!GO:0042098;T cell proliferation;0.000830919090127141;22637,19264!GO:0051251;positive regulation of lymphocyte activation;0.000963093465642323;22637,19264!GO:0030217;T cell differentiation;0.000963093465642323;22637,19264!GO:0050863;regulation of T cell activation;0.000998240347442248;22637,19264!GO:0009967;positive regulation of signal transduction;0.00103339512010087;22637,77647!GO:0043235;receptor complex;0.00123461326090412;22637,77647!GO:0032943;mononuclear cell proliferation;0.00123747495275673;22637,19264!GO:0046651;lymphocyte proliferation;0.00123747495275673;22637,19264!GO:0006955;immune response;0.0012790080426787;22637,77647,19264!GO:0051249;regulation of lymphocyte activation;0.00148158064106413;22637,19264!GO:0050865;regulation of cell activation;0.00155289535336506;22637,19264!GO:0030098;lymphocyte differentiation;0.00173599562815789;22637,19264!GO:0001920;negative regulation of receptor recycling;0.00178648417532317;77647!GO:0001915;negative regulation of T cell mediated cytotoxicity;0.00178648417532317;19264!GO:0050862;positive regulation of T cell receptor signaling pathway;0.00178648417532317;77647!GO:0042110;T cell activation;0.00261166190151548;22637,19264!GO:0019932;second-messenger-mediated signaling;0.00277799786397229;22637,77647!GO:0002521;leukocyte differentiation;0.0029006502973153;22637,19264!GO:0043366;beta selection;0.00322232420445744;22637!GO:0001960;negative regulation of cytokine and chemokine mediated signaling pathway;0.00322232420445744;19264!GO:0048522;positive regulation of cellular process;0.00330859469213209;22637,77647,19264!GO:0001916;positive regulation of T cell mediated cytotoxicity;0.00391239349282106;19264!GO:0051283;negative regulation of sequestering of calcium ion;0.00391239349282106;19264!GO:0051208;sequestering of calcium ion;0.00391239349282106;19264!GO:0001919;regulation of receptor recycling;0.00391239349282106;77647!GO:0002711;positive regulation of T cell mediated immunity;0.00391239349282106;19264!GO:0046638;positive regulation of alpha-beta T cell differentiation;0.00391239349282106;22637!GO:0001959;regulation of cytokine and chemokine mediated signaling pathway;0.00391239349282106;19264!GO:0001914;regulation of T cell mediated cytotoxicity;0.00391239349282106;19264!GO:0051238;sequestering of metal ion;0.00391239349282106;19264!GO:0051282;regulation of sequestering of calcium ion;0.00391239349282106;19264!GO:0051209;release of sequestered calcium ion into cytosol;0.00391239349282106;19264!GO:0048518;positive regulation of biological process;0.00409896873080155;22637,77647,19264!GO:0008284;positive regulation of cell proliferation;0.00418613191979287;22637,19264!GO:0046649;lymphocyte activation;0.00469435774122956;22637,19264!GO:0046637;regulation of alpha-beta T cell differentiation;0.00469435774122956;22637!GO:0002709;regulation of T cell mediated immunity;0.00469435774122956;19264!GO:0001911;negative regulation of leukocyte mediated cytotoxicity;0.00469435774122956;19264!GO:0001913;T cell mediated cytotoxicity;0.00469435774122956;19264!GO:0030097;hemopoiesis;0.00533850869155248;22637,19264!GO:0001881;receptor recycling;0.00570432351252845;77647!GO:0007242;intracellular signaling cascade;0.00593092495019197;16822,22637,77647!GO:0048534;hemopoietic or lymphoid organ development;0.00635863346583675;22637,19264!GO:0050663;cytokine secretion;0.00639999410461072;16822!GO:0007032;endosome organization and biogenesis;0.00639999410461072;58244!GO:0001784;phosphotyrosine binding;0.00639999410461072;22637!GO:0002520;immune system development;0.00692614222053051;22637,19264!GO:0051179;localization;0.00692614222053051;16822,58244,77647,19264!GO:0050853;B cell receptor signaling pathway;0.00692614222053051;19264!GO:0043368;positive T cell selection;0.00692614222053051;22637!GO:0045059;positive thymic T cell selection;0.00692614222053051;22637!GO:0046641;positive regulation of alpha-beta T cell proliferation;0.00692614222053051;22637!GO:0045060;negative thymic T cell selection;0.00746502352963415;22637!GO:0002456;T cell mediated immunity;0.00746502352963415;19264!GO:0043383;negative T cell selection;0.00746502352963415;22637!GO:0045309;protein phosphorylated amino acid binding;0.00746502352963415;22637!GO:0046635;positive regulation of alpha-beta T cell activation;0.00746502352963415;22637!GO:0046640;regulation of alpha-beta T cell proliferation;0.00812039942774404;22637!GO:0051607;defense response to virus;0.00812039942774404;19264!GO:0050856;regulation of T cell receptor signaling pathway;0.00812039942774404;77647!GO:0042127;regulation of cell proliferation;0.00947061860720167;22637,19264!GO:0046634;regulation of alpha-beta T cell activation;0.00970936502612786;22637!GO:0045576;mast cell activation;0.0101541368611683;16822!GO:0045582;positive regulation of T cell differentiation;0.0101541368611683;22637!GO:0046633;alpha-beta T cell proliferation;0.0101541368611683;22637!GO:0001912;positive regulation of leukocyte mediated cytotoxicity;0.0101541368611683;19264!GO:0051219;phosphoprotein binding;0.0108868737395942;22637!GO:0045061;thymic T cell selection;0.0116046262952258;22637!GO:0045621;positive regulation of lymphocyte differentiation;0.0117217562736301;22637!GO:0002705;positive regulation of leukocyte mediated immunity;0.0117217562736301;19264!GO:0051235;maintenance of localization;0.0117217562736301;19264!GO:0031341;regulation of cell killing;0.0117217562736301;19264!GO:0002708;positive regulation of lymphocyte mediated immunity;0.0117217562736301;19264!GO:0001910;regulation of leukocyte mediated cytotoxicity;0.0117217562736301;19264!GO:0002699;positive regulation of immune effector process;0.0123838947730921;19264!GO:0044459;plasma membrane part;0.0124516367663656;22637,77647,19264!GO:0045058;T cell selection;0.0124516367663656;22637!GO:0007204;elevation of cytosolic calcium ion concentration;0.0124516367663656;19264!GO:0045580;regulation of T cell differentiation;0.0124516367663656;22637!GO:0002703;regulation of leukocyte mediated immunity;0.0124516367663656;19264!GO:0002706;regulation of lymphocyte mediated immunity;0.0124516367663656;19264!GO:0002824;positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;0.0128387463247149;19264!GO:0051051;negative regulation of transport;0.0128387463247149;77647!GO:0002821;positive regulation of adaptive immune response;0.0128387463247149;19264!GO:0002697;regulation of immune effector process;0.0133188921147921;19264!GO:0051480;cytosolic calcium ion homeostasis;0.0133188921147921;19264!GO:0046632;alpha-beta T cell differentiation;0.0145929289081716;22637!GO:0007165;signal transduction;0.0146620771487547;16822,22637,77647,19264!GO:0001909;leukocyte mediated cytotoxicity;0.014664766672504;19264!GO:0001906;cell killing;0.014664766672504;19264!GO:0002819;regulation of adaptive immune response;0.014664766672504;19264!GO:0002822;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.;0.014664766672504;19264!GO:0008283;cell proliferation;0.0147016628458098;22637,19264!GO:0045619;regulation of lymphocyte differentiation;0.0150843923413467;22637!GO:0043112;receptor metabolic process;0.01613433618561;77647!GO:0033077;T cell differentiation in the thymus;0.01613433618561;22637!GO:0007154;cell communication;0.0168893175076412;16822,22637,77647,19264!GO:0002274;myeloid leukocyte activation;0.0168893175076412;16822!GO:0005925;focal adhesion;0.0168893175076412;19264!GO:0042100;B cell proliferation;0.0168893175076412;19264!GO:0009306;protein secretion;0.0186176208445451;16822!GO:0005924;cell-substrate adherens junction;0.0189489941709148;19264!GO:0046631;alpha-beta T cell activation;0.0189489941709148;22637!GO:0005802;trans-Golgi network;0.0194132338169768;58244!GO:0046777;protein amino acid autophosphorylation;0.0198705146588119;22637!GO:0032501;multicellular organismal process;0.0199297434493292;16822,22637,77647,19264!GO:0005886;plasma membrane;0.0203230007642845;22637,77647,19264!GO:0030055;cell-matrix junction;0.0203230007642845;19264!GO:0030183;B cell differentiation;0.0203230007642845;19264!GO:0016540;protein autoprocessing;0.0203230007642845;22637!GO:0006469;negative regulation of protein kinase activity;0.0206090405561041;19264!GO:0033673;negative regulation of kinase activity;0.0206090405561041;19264!GO:0048193;Golgi vesicle transport;0.0213023182680741;58244!GO:0004715;non-membrane spanning protein tyrosine kinase activity;0.0213023182680741;22637!GO:0051348;negative regulation of transferase activity;0.0213023182680741;19264!GO:0045184;establishment of protein localization;0.0244848945667967;16822,58244!GO:0019221;cytokine and chemokine mediated signaling pathway;0.0248664499757035;19264!GO:0043086;negative regulation of catalytic activity;0.0257916660588895;19264!GO:0019901;protein kinase binding;0.0261619550246218;19264!GO:0009615;response to virus;0.026527221150298;19264!GO:0019900;kinase binding;0.0268875635902952;19264!GO:0008104;protein localization;0.0272167319733423;16822,58244!GO:0051649;establishment of cellular localization;0.0272167319733423;16822,58244!GO:0051641;cellular localization;0.0279261139065417;16822,58244!GO:0033036;macromolecule localization;0.028415053329007;16822,58244!GO:0018212;peptidyl-tyrosine modification;0.0289514571859491;22637!GO:0018108;peptidyl-tyrosine phosphorylation;0.0289514571859491;22637!GO:0006874;cellular calcium ion homeostasis;0.0303006260442891;19264!GO:0005912;adherens junction;0.0307587697235578;19264!GO:0055074;calcium ion homeostasis;0.0307587697235578;19264!GO:0051234;establishment of localization;0.0307587697235578;16822,58244,77647!GO:0006793;phosphorus metabolic process;0.0307587697235578;22637,19264!GO:0006796;phosphate metabolic process;0.0307587697235578;22637,19264!GO:0006875;cellular metal ion homeostasis;0.0324413878071201;19264!GO:0016485;protein processing;0.0324413878071201;22637!GO:0048523;negative regulation of cellular process;0.0329202248070333;77647,19264!GO:0055065;metal ion homeostasis;0.0330193124676124;19264!GO:0016323;basolateral plasma membrane;0.0337819370700022;19264!GO:0007166;cell surface receptor linked signal transduction;0.0348292371106258;22637,77647,19264!GO:0048519;negative regulation of biological process;0.0368739864133545;77647,19264!GO:0051049;regulation of transport;0.0397702004545595;77647!GO:0042113;B cell activation;0.0399286764495899;19264!GO:0044267;cellular protein metabolic process;0.0399286764495899;22637,77647,19264!GO:0004725;protein tyrosine phosphatase activity;0.0400103326163405;19264!GO:0002250;adaptive immune response;0.0407521510522234;19264!GO:0002460;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;0.0407521510522234;19264!GO:0044260;cellular macromolecule metabolic process;0.0407521510522234;22637,77647,19264!GO:0009968;negative regulation of signal transduction;0.040917668044181;19264!GO:0002449;lymphocyte mediated immunity;0.041585462606662;19264!GO:0018193;peptidyl-amino acid modification;0.0418006464084082;22637!GO:0030005;cellular di-, tri-valent inorganic cation homeostasis;0.0424556661987694;19264!GO:0019538;protein metabolic process;0.0425542198268073;22637,77647,19264!GO:0055066;di-, tri-valent inorganic cation homeostasis;0.0432728331933592;19264!GO:0002443;leukocyte mediated immunity;0.0432728331933592;19264!GO:0001816;cytokine production;0.0432728331933592;16822!GO:0030003;cellular cation homeostasis;0.0451904702019235;19264!GO:0006470;protein amino acid dephosphorylation;0.0458044805498022;19264!GO:0055080;cation homeostasis;0.0459869206282985;19264!}}
{{MCL_coexpression_mm9|coexpression_dpi_cluster_scores_mean=0.0264798433358094,0.0333414567052139,0.0112318553753863,0.000582559907755624,0.00627229510580353,-0.00131739582113634,-0.00770966142035684,0.528094296555984,1.07321381679663,1.05219095764166,1.07856739008988,1.02456132377239,0.584468123872316,0.496633945754266,0.00531313549354889,0.0470281863483162,-0.0279784938378616,0.205047201854177,0.164529690304541,0.108580123728678,0.10770986464242,0.0660762922136758,0.0399001852707602,-0.0169613023814381,0.00331146978678836,-0.00129161709439068,0.00665591899877853,0.00123317924804751,0.00452094365287967,0.0333677540205872,-0.004886341663615,-0.00887428572315819,-0.0377414229753876,-0.0216521498228419,-0.00858907325828276,-0.0279149337695266,-0.0226104729493202,0.0480056349162279,-0.0222906438520871,0.0606177993657721,0.0758538140556461,0.118445607751192,0.0705576227160881,0.017613077980441,0.0230695474703584,0.0239266905372151,0.00735031503970564,0.0274065142158334,0.0118484485072224,0.00828367909558509,0.0191160560483526,0.0143126496382242,0.00818514074143267,0.430827583656694,0.502335333510778,-0.0114634793455897,-0.00833345491095205,-0.00626921193890803,0.0267250555510024,0.0227245310748554,0.0342008468998723,0.0134677649606423,0.00382887888756373,0.0150234327895852,0.0144615415245664,0.000343173784669772,0.0154573319456117,0.0169575323099536,0.0291229186291414,0.0323104554899575,0.0241026502971657,0.0120149869495197,0.0174495319307129,0.000827823366159559,0.0167314250134511,0.00968377654763978,0.00186323552336633,3.80836237897271e-05,0.00301137867816103,0.0228966368217479,0.0327777306239223,0.0292723657496036,0.0190153731656374,0.0117152154283107,0.00819522882614926,0.00149967805895182,0.0053357774444103,0.0228606504749477,0.0408608364657116,0.00789153034578301,0.010192444968328,0.0142795047535307,-0.0263684212868467,-0.038862062382653,-0.0405170541228401,-0.049236318895186,0.0829996644232045,-0.00157418947654074,0.00956526099532732,0.0019908945165836,0.0461036366495863,0.00899806804248679,0.0535124024008683,0.0485059340114389,0.0187078309940597,0.0156131407675411,0.0181120893727446,0.0584805021094525,0.35868201914882,0.02694692549333,0.0385728515158011,0.00602820702726977,-0.00399508990061304,-0.0109166860918019,0.00429649497797296,0.00930241244192965,0.00350599789314074,0.0234363653859448,0.0223840283444941,0.00930294526755883,-0.0172068297376902,-0.00798524806526655,0.026360585037714,0.00325194685095386,0.00898336294725204,0.0404840145570141,0.0423596020931868,-0.00261662460346189,0.0222721623874238,-0.000688621240832971,0.016494405938725,-0.0107825475182292,0.0386123562812014,0.0566515320429794,0.0101754962614848,0.0240395420752965,0.0259722498500093,0.0412779980506997,0.048188579047551,0.0307066689759479,0.00658347173091313,0.00650554687636048,0.00992531014930227,0.00176731176171497,0.0104212935695178,0.020770244372029,0.022170611365434,0.00738173565976226,0.00635207615887868,0.0233239492802826,0.00735795978902126,0.0050159966765849,0.0264969625828142,0.00431965550403388,0.0225148111899102,0.046731585070334,-0.00144857178760833,0.0179179376279996,0.0106572187856333,0.00414323602033851,0.01215930405849,0.00161850625316042,0.0166341411844402,0.0251712145440145,0.00444039972835396,0.00592138828405207,-0.0039005868109906,0.0612987410659798,-0.00483334844194416,0.0531682427575495,0.0151591042002034,0.0384225422052794,0.0356491368294319,-0.00373485053147757,0.0265519671522716,0.0341656999977549,0.0957050389900274,0.00842979370592566,0.00886913888337867,0.00194615098910537,0.0052367854377384,0.00909578124679576,-0.0175379004856852,0.00161447475079338,-0.0215951517567308,0.00797249114168643,0.0224838887511853,0.0240459557986251,0.00117687544663164,-0.0182535570236484,-0.0188933908514266,0.0150145921703026,0.0184094291504512,0.00640285323424577,-0.0078770628310054,0.000123219451385579,0.00993278144164757,0.00382083554762492,0.0124311445288453,0.0124826267939196,0.00362895735334689,-0.00272690366098479,-0.014506384704558,-0.000638722906972669,-0.0213483160596333,-0.0192373319957956,-0.0278791413309994,-0.0382541017200494,-0.0229419614183013,-0.0118962077852606,-0.0222109048596431,-0.0467128681366271,0.106204093288149,0.0205589648641267,0.00938080336171989,-0.013423458171822,-0.0404805380488684,0.0176525629408409,0.129209725374845,0.0420307084124258,0.0048728681126685,0.0388384431374093,0.0120246392268368,0.147052301569584,0.0285222885322561,0.0532013300833854,0.0780188962026641,0.118474983442493,0.0703951409229975,0.0910898147739658,0.110764164715742,0.102929019347616,-0.0156114908079446,0.0487639845952173,0.0641115312226725,0.0467025278804172,0.0113623531076145,0.0149196274904167,0.0289723360787883,-0.0175898050307825,-0.00645348139124542,-0.0112242952706514,-0.00900620788157146,-0.0142544604101166,0.00225130529257553,-0.00706070856184793,-0.0184555649543828,-0.0218425635420137,-0.00553046749269649,0.0205291045067192,0.0192685055993846,0.0100774008137885,0.0272321435300682,0.0327587611590031,-0.021420004792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receptor-mediated signaling pathway;4.98032272369071e-06;22637,77647,19264!GO:0002429;immune response-activating cell surface receptor signaling pathway;4.98032272369071e-06;22637,77647,19264!GO:0002768;immune response-regulating cell surface receptor signaling pathway;4.98032272369071e-06;22637,77647,19264!GO:0002757;immune response-activating signal transduction;4.98032272369071e-06;22637,77647,19264!GO:0002764;immune response-regulating signal transduction;4.98032272369071e-06;22637,77647,19264!GO:0050857;positive regulation of antigen receptor-mediated signaling pathway;9.00386442255923e-06;77647,19264!GO:0002253;activation of immune response;3.07476650178131e-05;22637,77647,19264!GO:0050778;positive regulation of immune response;4.96385487923431e-05;22637,77647,19264!GO:0002684;positive regulation of immune system process;4.96385487923431e-05;22637,77647,19264!GO:0042101;T cell receptor complex;5.7239151266756e-05;22637,77647!GO:0050776;regulation of immune response;5.7239151266756e-05;22637,77647,19264!GO:0002682;regulation of immune system process;5.7239151266756e-05;22637,77647,19264!GO:0051240;positive regulation of multicellular organismal process;5.86826780191044e-05;22637,77647,19264!GO:0050854;regulation of antigen receptor-mediated signaling pathway;7.06826458685156e-05;77647,19264!GO:0050850;positive regulation of calcium-mediated signaling;8.76915106603675e-05;22637,77647!GO:0050848;regulation of calcium-mediated signaling;8.76915106603675e-05;22637,77647!GO:0050852;T cell receptor signaling pathway;0.00016180330444394;22637,77647!GO:0001772;immunological synapse;0.000181633193691871;22637,77647!GO:0002376;immune system process;0.000181633193691871;16822,22637,77647,19264!GO:0019722;calcium-mediated signaling;0.000188708441611194;22637,77647!GO:0045321;leukocyte activation;0.000199043110945394;16822,22637,19264!GO:0001775;cell activation;0.000234537227246329;16822,22637,19264!GO:0042102;positive regulation of T cell proliferation;0.000274091506438314;22637,19264!GO:0051239;regulation of multicellular organismal process;0.000427113906584292;22637,77647,19264!GO:0032946;positive regulation of mononuclear cell proliferation;0.000434765238743307;22637,19264!GO:0050671;positive regulation of lymphocyte proliferation;0.000434765238743307;22637,19264!GO:0042129;regulation of T cell proliferation;0.000571796048606228;22637,19264!GO:0050870;positive regulation of T cell activation;0.000578207652799299;22637,19264!GO:0009966;regulation of signal transduction;0.000595041323197565;22637,77647,19264!GO:0032944;regulation of mononuclear cell proliferation;0.000796095387164107;22637,19264!GO:0050670;regulation of lymphocyte proliferation;0.000796095387164107;22637,19264!GO:0042098;T cell proliferation;0.000830919090127141;22637,19264!GO:0051251;positive regulation of lymphocyte activation;0.000963093465642323;22637,19264!GO:0030217;T cell differentiation;0.000963093465642323;22637,19264!GO:0050863;regulation of T cell activation;0.000998240347442248;22637,19264!GO:0009967;positive regulation of signal transduction;0.00103339512010087;22637,77647!GO:0043235;receptor complex;0.00123461326090412;22637,77647!GO:0032943;mononuclear cell proliferation;0.00123747495275673;22637,19264!GO:0046651;lymphocyte proliferation;0.00123747495275673;22637,19264!GO:0006955;immune response;0.0012790080426787;22637,77647,19264!GO:0051249;regulation of lymphocyte activation;0.00148158064106413;22637,19264!GO:0050865;regulation of cell activation;0.00155289535336506;22637,19264!GO:0030098;lymphocyte differentiation;0.00173599562815789;22637,19264!GO:0001920;negative regulation of receptor recycling;0.00178648417532317;77647!GO:0001915;negative regulation of T cell mediated cytotoxicity;0.00178648417532317;19264!GO:0050862;positive regulation of T cell receptor signaling pathway;0.00178648417532317;77647!GO:0042110;T cell activation;0.00261166190151548;22637,19264!GO:0019932;second-messenger-mediated signaling;0.00277799786397229;22637,77647!GO:0002521;leukocyte differentiation;0.0029006502973153;22637,19264!GO:0043366;beta selection;0.00322232420445744;22637!GO:0001960;negative regulation of cytokine and chemokine mediated signaling pathway;0.00322232420445744;19264!GO:0048522;positive regulation of cellular process;0.00330859469213209;22637,77647,19264!GO:0001916;positive regulation of T cell mediated cytotoxicity;0.00391239349282106;19264!GO:0051283;negative regulation of sequestering of calcium ion;0.00391239349282106;19264!GO:0051208;sequestering of calcium ion;0.00391239349282106;19264!GO:0001919;regulation of receptor recycling;0.00391239349282106;77647!GO:0002711;positive regulation of T cell mediated immunity;0.00391239349282106;19264!GO:0046638;positive regulation of alpha-beta T cell differentiation;0.00391239349282106;22637!GO:0001959;regulation of cytokine and chemokine mediated signaling pathway;0.00391239349282106;19264!GO:0001914;regulation of T cell mediated cytotoxicity;0.00391239349282106;19264!GO:0051238;sequestering of metal ion;0.00391239349282106;19264!GO:0051282;regulation of sequestering of calcium ion;0.00391239349282106;19264!GO:0051209;release of sequestered calcium ion into cytosol;0.00391239349282106;19264!GO:0048518;positive regulation of biological process;0.00409896873080155;22637,77647,19264!GO:0008284;positive regulation of cell proliferation;0.00418613191979287;22637,19264!GO:0046649;lymphocyte activation;0.00469435774122956;22637,19264!GO:0046637;regulation of alpha-beta T cell differentiation;0.00469435774122956;22637!GO:0002709;regulation of T cell mediated immunity;0.00469435774122956;19264!GO:0001911;negative regulation of leukocyte mediated cytotoxicity;0.00469435774122956;19264!GO:0001913;T cell mediated cytotoxicity;0.00469435774122956;19264!GO:0030097;hemopoiesis;0.00533850869155248;22637,19264!GO:0001881;receptor recycling;0.00570432351252845;77647!GO:0007242;intracellular signaling cascade;0.00593092495019197;16822,22637,77647!GO:0048534;hemopoietic or lymphoid organ development;0.00635863346583675;22637,19264!GO:0050663;cytokine secretion;0.00639999410461072;16822!GO:0007032;endosome organization and biogenesis;0.00639999410461072;58244!GO:0001784;phosphotyrosine binding;0.00639999410461072;22637!GO:0002520;immune system development;0.00692614222053051;22637,19264!GO:0051179;localization;0.00692614222053051;16822,58244,77647,19264!GO:0050853;B cell receptor signaling pathway;0.00692614222053051;19264!GO:0043368;positive T cell selection;0.00692614222053051;22637!GO:0045059;positive thymic T cell selection;0.00692614222053051;22637!GO:0046641;positive regulation of alpha-beta T cell proliferation;0.00692614222053051;22637!GO:0045060;negative thymic T cell selection;0.00746502352963415;22637!GO:0002456;T cell mediated immunity;0.00746502352963415;19264!GO:0043383;negative T cell selection;0.00746502352963415;22637!GO:0045309;protein phosphorylated amino acid binding;0.00746502352963415;22637!GO:0046635;positive regulation of alpha-beta T cell activation;0.00746502352963415;22637!GO:0046640;regulation of alpha-beta T cell proliferation;0.00812039942774404;22637!GO:0051607;defense response to virus;0.00812039942774404;19264!GO:0050856;regulation of T cell receptor signaling pathway;0.00812039942774404;77647!GO:0042127;regulation of cell proliferation;0.00947061860720167;22637,19264!GO:0046634;regulation of alpha-beta T cell activation;0.00970936502612786;22637!GO:0045576;mast cell activation;0.0101541368611683;16822!GO:0045582;positive regulation of T cell differentiation;0.0101541368611683;22637!GO:0046633;alpha-beta T cell proliferation;0.0101541368611683;22637!GO:0001912;positive regulation of leukocyte mediated cytotoxicity;0.0101541368611683;19264!GO:0051219;phosphoprotein binding;0.0108868737395942;22637!GO:0045061;thymic T cell selection;0.0116046262952258;22637!GO:0045621;positive regulation of lymphocyte differentiation;0.0117217562736301;22637!GO:0002705;positive regulation of leukocyte mediated immunity;0.0117217562736301;19264!GO:0051235;maintenance of localization;0.0117217562736301;19264!GO:0031341;regulation of cell killing;0.0117217562736301;19264!GO:0002708;positive regulation of lymphocyte mediated immunity;0.0117217562736301;19264!GO:0001910;regulation of leukocyte mediated cytotoxicity;0.0117217562736301;19264!GO:0002699;positive regulation of immune effector process;0.0123838947730921;19264!GO:0044459;plasma membrane part;0.0124516367663656;22637,77647,19264!GO:0045058;T cell selection;0.0124516367663656;22637!GO:0007204;elevation of cytosolic calcium ion concentration;0.0124516367663656;19264!GO:0045580;regulation of T cell differentiation;0.0124516367663656;22637!GO:0002703;regulation of leukocyte mediated immunity;0.0124516367663656;19264!GO:0002706;regulation of lymphocyte mediated immunity;0.0124516367663656;19264!GO:0002824;positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;0.0128387463247149;19264!GO:0051051;negative regulation of transport;0.0128387463247149;77647!GO:0002821;positive regulation of adaptive immune response;0.0128387463247149;19264!GO:0002697;regulation of immune effector process;0.0133188921147921;19264!GO:0051480;cytosolic calcium ion homeostasis;0.0133188921147921;19264!GO:0046632;alpha-beta T cell differentiation;0.0145929289081716;22637!GO:0007165;signal transduction;0.0146620771487547;16822,22637,77647,19264!GO:0001909;leukocyte mediated cytotoxicity;0.014664766672504;19264!GO:0001906;cell killing;0.014664766672504;19264!GO:0002819;regulation of adaptive immune response;0.014664766672504;19264!GO:0002822;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.;0.014664766672504;19264!GO:0008283;cell proliferation;0.0147016628458098;22637,19264!GO:0045619;regulation of lymphocyte differentiation;0.0150843923413467;22637!GO:0043112;receptor metabolic process;0.01613433618561;77647!GO:0033077;T cell differentiation in the thymus;0.01613433618561;22637!GO:0007154;cell communication;0.0168893175076412;16822,22637,77647,19264!GO:0002274;myeloid leukocyte activation;0.0168893175076412;16822!GO:0005925;focal adhesion;0.0168893175076412;19264!GO:0042100;B cell proliferation;0.0168893175076412;19264!GO:0009306;protein secretion;0.0186176208445451;16822!GO:0005924;cell-substrate adherens junction;0.0189489941709148;19264!GO:0046631;alpha-beta T cell activation;0.0189489941709148;22637!GO:0005802;trans-Golgi network;0.0194132338169768;58244!GO:0046777;protein amino acid autophosphorylation;0.0198705146588119;22637!GO:0032501;multicellular organismal process;0.0199297434493292;16822,22637,77647,19264!GO:0005886;plasma membrane;0.0203230007642845;22637,77647,19264!GO:0030055;cell-matrix junction;0.0203230007642845;19264!GO:0030183;B cell differentiation;0.0203230007642845;19264!GO:0016540;protein autoprocessing;0.0203230007642845;22637!GO:0006469;negative regulation of protein kinase activity;0.0206090405561041;19264!GO:0033673;negative regulation of kinase activity;0.0206090405561041;19264!GO:0048193;Golgi vesicle transport;0.0213023182680741;58244!GO:0004715;non-membrane spanning protein tyrosine kinase activity;0.0213023182680741;22637!GO:0051348;negative regulation of transferase activity;0.0213023182680741;19264!GO:0045184;establishment of protein localization;0.0244848945667967;16822,58244!GO:0019221;cytokine and chemokine mediated signaling pathway;0.0248664499757035;19264!GO:0043086;negative regulation of catalytic activity;0.0257916660588895;19264!GO:0019901;protein kinase binding;0.0261619550246218;19264!GO:0009615;response to virus;0.026527221150298;19264!GO:0019900;kinase binding;0.0268875635902952;19264!GO:0008104;protein localization;0.0272167319733423;16822,58244!GO:0051649;establishment of cellular localization;0.0272167319733423;16822,58244!GO:0051641;cellular localization;0.0279261139065417;16822,58244!GO:0033036;macromolecule localization;0.028415053329007;16822,58244!GO:0018212;peptidyl-tyrosine modification;0.0289514571859491;22637!GO:0018108;peptidyl-tyrosine phosphorylation;0.0289514571859491;22637!GO:0006874;cellular calcium ion homeostasis;0.0303006260442891;19264!GO:0005912;adherens junction;0.0307587697235578;19264!GO:0055074;calcium ion homeostasis;0.0307587697235578;19264!GO:0051234;establishment of localization;0.0307587697235578;16822,58244,77647!GO:0006793;phosphorus metabolic process;0.0307587697235578;22637,19264!GO:0006796;phosphate metabolic process;0.0307587697235578;22637,19264!GO:0006875;cellular metal ion homeostasis;0.0324413878071201;19264!GO:0016485;protein processing;0.0324413878071201;22637!GO:0048523;negative regulation of cellular process;0.0329202248070333;77647,19264!GO:0055065;metal ion homeostasis;0.0330193124676124;19264!GO:0016323;basolateral plasma membrane;0.0337819370700022;19264!GO:0007166;cell surface receptor linked signal transduction;0.0348292371106258;22637,77647,19264!GO:0048519;negative regulation of biological process;0.0368739864133545;77647,19264!GO:0051049;regulation of transport;0.0397702004545595;77647!GO:0042113;B cell activation;0.0399286764495899;19264!GO:0044267;cellular protein metabolic process;0.0399286764495899;22637,77647,19264!GO:0004725;protein tyrosine phosphatase activity;0.0400103326163405;19264!GO:0002250;adaptive immune response;0.0407521510522234;19264!GO:0002460;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;0.0407521510522234;19264!GO:0044260;cellular macromolecule metabolic process;0.0407521510522234;22637,77647,19264!GO:0009968;negative regulation of signal transduction;0.040917668044181;19264!GO:0002449;lymphocyte mediated immunity;0.041585462606662;19264!GO:0018193;peptidyl-amino acid modification;0.0418006464084082;22637!GO:0030005;cellular di-, tri-valent inorganic cation homeostasis;0.0424556661987694;19264!GO:0019538;protein metabolic process;0.0425542198268073;22637,77647,19264!GO:0055066;di-, tri-valent inorganic cation homeostasis;0.0432728331933592;19264!GO:0002443;leukocyte mediated immunity;0.0432728331933592;19264!GO:0001816;cytokine production;0.0432728331933592;16822!GO:0030003;cellular cation homeostasis;0.0451904702019235;19264!GO:0006470;protein amino acid dephosphorylation;0.0458044805498022;19264!GO:0055080;cation homeostasis;0.0459869206282985;19264!|ontology_enrichment_celltype=CL:0000791!2.14e-18!9;CL:0000789!2.14e-18!9;CL:0002420!2.14e-18!9;CL:0002419!2.14e-18!9;CL:0000790!2.14e-18!9;CL:0000084!1.24e-17!11;CL:0000827!1.24e-17!11;CL:0000624!1.14e-16!8;CL:0000838!5.77e-16!12;CL:0000542!1.48e-14!13;CL:0000051!1.48e-14!13;CL:0000893!2.96e-13!6;CL:0002489!2.96e-13!6;CL:0000898!2.96e-13!6;CL:0000809!2.96e-13!6;CL:0000810!2.96e-13!6;CL:0000895!2.96e-13!6;CL:0000808!2.96e-13!6;CL:0000894!2.96e-13!6;CL:0000806!2.96e-13!6;CL:0000807!2.96e-13!6;CL:0000805!2.96e-13!6;CL:0002425!2.96e-13!6;CL:0002436!2.96e-13!6;CL:0002427!2.96e-13!6;CL:0002428!2.96e-13!6;CL:0002429!2.96e-13!6;CL:0002433!2.96e-13!6;CL:0002431!2.96e-13!6;CL:0002432!2.96e-13!6;CL:0002242!2.17e-11!16;CL:0002031!3.85e-11!25;CL:0000738!1.39e-10!17;CL:0002087!1.39e-10!17;CL:0000988!5.06e-08!32;CL:0002032!5.06e-08!32;CL:0000037!5.06e-08!32;CL:0000566!5.06e-08!32;CL:0000837!5.06e-08!32|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0004177!6.61e-34!29;UBERON:0005057!6.61e-34!29;UBERON:0002370!2.02e-30!23;UBERON:0000974!2.02e-30!23;UBERON:0004807!2.02e-30!23;UBERON:0005058!2.02e-30!23;UBERON:0003351!2.02e-30!23;UBERON:0009113!2.02e-30!23;UBERON:0003295!2.02e-30!23;UBERON:0009722!2.02e-30!23;UBERON:0005562!2.02e-30!23;UBERON:0007690!2.02e-30!23;UBERON:0006562!6.30e-29!24;UBERON:0003408!6.30e-29!24;UBERON:0001557!6.30e-29!24;UBERON:0001042!6.30e-29!24;UBERON:0008814!6.30e-29!24;UBERON:0009145!6.30e-29!24;UBERON:0000077!5.49e-27!35;UBERON:0000065!4.36e-26!41;UBERON:0002193!1.09e-25!48;UBERON:0002405!1.09e-25!48;UBERON:0002390!1.20e-25!45;UBERON:0003061!1.20e-25!45;UBERON:0001004!2.65e-25!42;UBERON:0000072!4.14e-25!27;UBERON:0000063!3.55e-20!35;UBERON:0007811!1.71e-17!36;UBERON:0001041!1.20e-14!80;UBERON:0000153!8.58e-14!43;UBERON:0005911!8.86e-13!69;UBERON:0003081!7.14e-11!87;UBERON:0004921!8.82e-10!114;UBERON:0003929!1.12e-09!55;UBERON:0001007!1.76e-09!116;UBERON:0001555!1.76e-09!116;UBERON:0007026!1.76e-09!116;UBERON:0002368!1.80e-09!60;UBERON:0004119!3.44e-09!118;UBERON:0000925!3.44e-09!118;UBERON:0006595!3.44e-09!118;UBERON:0002530!2.38e-08!65;UBERON:0000064!6.29e-08!99;UBERON:0000490!2.93e-07!66;UBERON:0000949!4.72e-07!72|tfbs_overrepresentation_for_novel_motifs=0.354643,0.0909519,0.330161,0.394491,0.645379,0.40827,0.495658,0.146465,0.468136,0.133458,0.453212,0.484001,0.449446,0.507558,0.24249,0,0.696644,0.62892,0.829774,0.0703872,0.802917,0.047629,0.50668,0.226287,0.337218,0.534339,0.128175,0.428336,0.268347,0.0963992,0.414842,0.796599,0.218674,0.364174,0.242923,0.281474,0.210533,0.480503,0.559915,0.167387,0.637027,0.419787,0.663794,0.684206,0.317317,0.383899,0.618203,0.443479,1.30029,0.271021,0.679429,0.560572,0.0915709,0.937018,0.954342,0.514504,0.279148,0.471658,0.12126,0.512521,0.776777,0.569793,0.163832,0.668331,0.525334,0.708248,1.08987,1.43807,0.772155,1.29123,0.31262,0.900535,0.0512949,0.987652,0.116281,0.107966,0.113315,0.607043,0.759798,0.299972,0.90463,1.6986,0.568383,1.38499,0.873141,0.0800961,0.231102,0.319367,0.623015,1.60001,1.15927,0.878077,0.809272,0.232894,0.188213,0.17334,0.444003,0.812053,0.618454,0.987389,1.13987,0.796322,0.919715,0.680015,0.678976,0.419366,0.737915,0.439611,0.30446,0.297733,0.348012,0.921485,0.301014,0.458194,1.16629,0.222515,0.10952,0.398075,0.697928,0.597328,0.993019,0.647706,1.3263,0.606154,1.22022,0.763454,0.503569,0.802564,1.08836,0.235546,0.90286,0.387557,1.05894,0.527782,1.18781,3.21543,0.362565,1.0797,1.13883,1.96797,1.5682,1.09456,0.547855,0.806961,0.672593,0.420221,0.621266,1.92834,0.364791,0.229209,0.32395,0.041769,0.938577,0.178329,0.526881,1.01974,0.561556,0.705025,0.352329,0.362302,1.1483,0.872292,0.763895,0.345891,0.669337,0.519673,0.209556,0.482466,0.0435162|tfbs_overrepresentation_jaspar=MA0003.1;0.00972621,MA0004.1;1.02263,MA0006.1;0.238555,MA0007.1;0.38073,MA0009.1;0.82278,MA0014.1;0.119217,MA0017.1;0.26239,MA0019.1;0.642876,MA0024.1;0.779446,MA0025.1;1.05446,MA0027.1;2.46647,MA0028.1;0.24786,MA0029.1;0.757957,MA0030.1;0.764448,MA0031.1;0.729293,MA0038.1;0.534262,MA0040.1;0.835181,MA0041.1;0.323687,MA0042.1;0.311486,MA0043.1;0.918718,MA0046.1;0.858391,MA0048.1;0.0824771,MA0050.1;0.431976,MA0051.1;0.542972,MA0052.1;0.84317,MA0055.1;0.221677,MA0056.1;0,MA0057.1;0.258928,MA0058.1;1.49242,MA0059.1;0.849123,MA0060.1;0.505012,MA0061.1;0.194456,MA0063.1;0,MA0066.1;0.523573,MA0067.1;1.16502,MA0068.1;0.077274,MA0069.1;0.843506,MA0070.1;0.833895,MA0071.1;1.10147,MA0072.1;0.825495,MA0073.1;0.0431817,MA0074.1;0.488775,MA0076.1;0.279739,MA0077.1;0.804033,MA0078.1;0.575205,MA0081.1;0.897217,MA0083.1;0.917931,MA0084.1;1.49188,MA0087.1;0.87515,MA0088.1;0.0492918,MA0089.1;0,MA0090.1;0.362551,MA0091.1;0.407455,MA0092.1;0.362847,MA0093.1;1.30984,MA0095.1;0,MA0098.1;0,MA0100.1;0.477594,MA0101.1;0.324888,MA0103.1;0.272167,MA0105.1;0.35523,MA0106.1;0.582805,MA0107.1;0.266586,MA0108.2;0.665343,MA0109.1;0,MA0111.1;0.375908,MA0113.1;0.555251,MA0114.1;0.561811,MA0115.1;0.921497,MA0116.1;0.238371,MA0117.1;0.88947,MA0119.1;0.325434,MA0122.1;0.909168,MA0124.1;1.11203,MA0125.1;1.03833,MA0130.1;0,MA0131.1;0.638414,MA0132.1;0,MA0133.1;0,MA0135.1;0.954884,MA0136.1;0.508047,MA0139.1;0.143341,MA0140.1;0.477483,MA0141.1;1.43798,MA0142.1;0.714976,MA0143.1;0.571221,MA0144.1;0.195095,MA0145.1;0.200183,MA0146.1;0.0548413,MA0147.1;0.205697,MA0148.1;1.05634,MA0149.1;0.330018,MA0062.2;0.365726,MA0035.2;1.21101,MA0039.2;0.043355,MA0138.2;0.630612,MA0002.2;0.145685,MA0137.2;0.287486,MA0104.2;0.157347,MA0047.2;1.32079,MA0112.2;0.442124,MA0065.2;0.773848,MA0150.1;0.991233,MA0151.1;0,MA0152.1;0.53362,MA0153.1;0.971406,MA0154.1;0.0809407,MA0155.1;0.490492,MA0156.1;0.278949,MA0157.1;0.683365,MA0158.1;0,MA0159.1;0.214506,MA0160.1;0.413266,MA0161.1;0,MA0162.1;0.0672805,MA0163.1;0.0124565,MA0164.1;0.508398,MA0080.2;0.737531,MA0018.2;0.51781,MA0099.2;0.624421,MA0079.2;0.000240419,MA0102.2;1.5442,MA0258.1;2.30311,MA0259.1;0.196451,MA0442.1;0}}

Latest revision as of 15:53, 17 September 2013


Phase1 CAGE Peaks

 Short description
Mm9::chr11:33947078..33947093,+p2@Lcp2
Mm9::chr14:54843390..54843408,+p@chr14:54843390..54843408
+
Mm9::chr16:48772258..48772270,-p5@Trat1
Mm9::chr1:140072473..140072489,-p@chr1:140072473..140072489
-
Mm9::chr1:140072490..140072513,-p@chr1:140072490..140072513
-
Mm9::chr1:157005834..157005906,+p1@Stx6
Mm9::chr1:36827266..36827270,+p@chr1:36827266..36827270
+
Mm9::chr6:41492719..41492776,+p1@ENSMUST00000103293
p1@uc009bpq.1
Mm9::chr6:41494508..41494519,+p@chr6:41494508..41494519
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0050851antigen receptor-mediated signaling pathway4.98032272369071e-06
GO:0002429immune response-activating cell surface receptor signaling pathway4.98032272369071e-06
GO:0002768immune response-regulating cell surface receptor signaling pathway4.98032272369071e-06
GO:0002757immune response-activating signal transduction4.98032272369071e-06
GO:0002764immune response-regulating signal transduction4.98032272369071e-06
GO:0050857positive regulation of antigen receptor-mediated signaling pathway9.00386442255923e-06
GO:0002253activation of immune response3.07476650178131e-05
GO:0050778positive regulation of immune response4.96385487923431e-05
GO:0002684positive regulation of immune system process4.96385487923431e-05
GO:0042101T cell receptor complex5.7239151266756e-05
GO:0050776regulation of immune response5.7239151266756e-05
GO:0002682regulation of immune system process5.7239151266756e-05
GO:0051240positive regulation of multicellular organismal process5.86826780191044e-05
GO:0050854regulation of antigen receptor-mediated signaling pathway7.06826458685156e-05
GO:0050850positive regulation of calcium-mediated signaling8.76915106603675e-05
GO:0050848regulation of calcium-mediated signaling8.76915106603675e-05
GO:0050852T cell receptor signaling pathway0.00016180330444394
GO:0001772immunological synapse0.000181633193691871
GO:0002376immune system process0.000181633193691871
GO:0019722calcium-mediated signaling0.000188708441611194
GO:0045321leukocyte activation0.000199043110945394
GO:0001775cell activation0.000234537227246329
GO:0042102positive regulation of T cell proliferation0.000274091506438314
GO:0051239regulation of multicellular organismal process0.000427113906584292
GO:0032946positive regulation of mononuclear cell proliferation0.000434765238743307
GO:0050671positive regulation of lymphocyte proliferation0.000434765238743307
GO:0042129regulation of T cell proliferation0.000571796048606228
GO:0050870positive regulation of T cell activation0.000578207652799299
GO:0009966regulation of signal transduction0.000595041323197565
GO:0032944regulation of mononuclear cell proliferation0.000796095387164107
GO:0050670regulation of lymphocyte proliferation0.000796095387164107
GO:0042098T cell proliferation0.000830919090127141
GO:0051251positive regulation of lymphocyte activation0.000963093465642323
GO:0030217T cell differentiation0.000963093465642323
GO:0050863regulation of T cell activation0.000998240347442248
GO:0009967positive regulation of signal transduction0.00103339512010087
GO:0043235receptor complex0.00123461326090412
GO:0032943mononuclear cell proliferation0.00123747495275673
GO:0046651lymphocyte proliferation0.00123747495275673
GO:0006955immune response0.0012790080426787
GO:0051249regulation of lymphocyte activation0.00148158064106413
GO:0050865regulation of cell activation0.00155289535336506
GO:0030098lymphocyte differentiation0.00173599562815789
GO:0001920negative regulation of receptor recycling0.00178648417532317
GO:0001915negative regulation of T cell mediated cytotoxicity0.00178648417532317
GO:0050862positive regulation of T cell receptor signaling pathway0.00178648417532317
GO:0042110T cell activation0.00261166190151548
GO:0019932second-messenger-mediated signaling0.00277799786397229
GO:0002521leukocyte differentiation0.0029006502973153
GO:0043366beta selection0.00322232420445744
GO:0001960negative regulation of cytokine and chemokine mediated signaling pathway0.00322232420445744
GO:0048522positive regulation of cellular process0.00330859469213209
GO:0001916positive regulation of T cell mediated cytotoxicity0.00391239349282106
GO:0051283negative regulation of sequestering of calcium ion0.00391239349282106
GO:0051208sequestering of calcium ion0.00391239349282106
GO:0001919regulation of receptor recycling0.00391239349282106
GO:0002711positive regulation of T cell mediated immunity0.00391239349282106
GO:0046638positive regulation of alpha-beta T cell differentiation0.00391239349282106
GO:0001959regulation of cytokine and chemokine mediated signaling pathway0.00391239349282106
GO:0001914regulation of T cell mediated cytotoxicity0.00391239349282106
GO:0051238sequestering of metal ion0.00391239349282106
GO:0051282regulation of sequestering of calcium ion0.00391239349282106
GO:0051209release of sequestered calcium ion into cytosol0.00391239349282106
GO:0048518positive regulation of biological process0.00409896873080155
GO:0008284positive regulation of cell proliferation0.00418613191979287
GO:0046649lymphocyte activation0.00469435774122956
GO:0046637regulation of alpha-beta T cell differentiation0.00469435774122956
GO:0002709regulation of T cell mediated immunity0.00469435774122956
GO:0001911negative regulation of leukocyte mediated cytotoxicity0.00469435774122956
GO:0001913T cell mediated cytotoxicity0.00469435774122956
GO:0030097hemopoiesis0.00533850869155248
GO:0001881receptor recycling0.00570432351252845
GO:0007242intracellular signaling cascade0.00593092495019197
GO:0048534hemopoietic or lymphoid organ development0.00635863346583675
GO:0050663cytokine secretion0.00639999410461072
GO:0007032endosome organization and biogenesis0.00639999410461072
GO:0001784phosphotyrosine binding0.00639999410461072
GO:0002520immune system development0.00692614222053051
GO:0051179localization0.00692614222053051
GO:0050853B cell receptor signaling pathway0.00692614222053051
GO:0043368positive T cell selection0.00692614222053051
GO:0045059positive thymic T cell selection0.00692614222053051
GO:0046641positive regulation of alpha-beta T cell proliferation0.00692614222053051
GO:0045060negative thymic T cell selection0.00746502352963415
GO:0002456T cell mediated immunity0.00746502352963415
GO:0043383negative T cell selection0.00746502352963415
GO:0045309protein phosphorylated amino acid binding0.00746502352963415
GO:0046635positive regulation of alpha-beta T cell activation0.00746502352963415
GO:0046640regulation of alpha-beta T cell proliferation0.00812039942774404
GO:0051607defense response to virus0.00812039942774404
GO:0050856regulation of T cell receptor signaling pathway0.00812039942774404
GO:0042127regulation of cell proliferation0.00947061860720167
GO:0046634regulation of alpha-beta T cell activation0.00970936502612786
GO:0045576mast cell activation0.0101541368611683
GO:0045582positive regulation of T cell differentiation0.0101541368611683
GO:0046633alpha-beta T cell proliferation0.0101541368611683
GO:0001912positive regulation of leukocyte mediated cytotoxicity0.0101541368611683
GO:0051219phosphoprotein binding0.0108868737395942
GO:0045061thymic T cell selection0.0116046262952258
GO:0045621positive regulation of lymphocyte differentiation0.0117217562736301
GO:0002705positive regulation of leukocyte mediated immunity0.0117217562736301
GO:0051235maintenance of localization0.0117217562736301
GO:0031341regulation of cell killing0.0117217562736301
GO:0002708positive regulation of lymphocyte mediated immunity0.0117217562736301
GO:0001910regulation of leukocyte mediated cytotoxicity0.0117217562736301
GO:0002699positive regulation of immune effector process0.0123838947730921
GO:0044459plasma membrane part0.0124516367663656
GO:0045058T cell selection0.0124516367663656
GO:0007204elevation of cytosolic calcium ion concentration0.0124516367663656
GO:0045580regulation of T cell differentiation0.0124516367663656
GO:0002703regulation of leukocyte mediated immunity0.0124516367663656
GO:0002706regulation of lymphocyte mediated immunity0.0124516367663656
GO:0002824positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0128387463247149
GO:0051051negative regulation of transport0.0128387463247149
GO:0002821positive regulation of adaptive immune response0.0128387463247149
GO:0002697regulation of immune effector process0.0133188921147921
GO:0051480cytosolic calcium ion homeostasis0.0133188921147921
GO:0046632alpha-beta T cell differentiation0.0145929289081716
GO:0007165signal transduction0.0146620771487547
GO:0001909leukocyte mediated cytotoxicity0.014664766672504
GO:0001906cell killing0.014664766672504
GO:0002819regulation of adaptive immune response0.014664766672504
GO:0002822regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.0.014664766672504
GO:0008283cell proliferation0.0147016628458098
GO:0045619regulation of lymphocyte differentiation0.0150843923413467
GO:0043112receptor metabolic process0.01613433618561
GO:0033077T cell differentiation in the thymus0.01613433618561
GO:0007154cell communication0.0168893175076412
GO:0002274myeloid leukocyte activation0.0168893175076412
GO:0005925focal adhesion0.0168893175076412
GO:0042100B cell proliferation0.0168893175076412
GO:0009306protein secretion0.0186176208445451
GO:0005924cell-substrate adherens junction0.0189489941709148
GO:0046631alpha-beta T cell activation0.0189489941709148
GO:0005802trans-Golgi network0.0194132338169768
GO:0046777protein amino acid autophosphorylation0.0198705146588119
GO:0032501multicellular organismal process0.0199297434493292
GO:0005886plasma membrane0.0203230007642845
GO:0030055cell-matrix junction0.0203230007642845
GO:0030183B cell differentiation0.0203230007642845
GO:0016540protein autoprocessing0.0203230007642845
GO:0006469negative regulation of protein kinase activity0.0206090405561041
GO:0033673negative regulation of kinase activity0.0206090405561041
GO:0048193Golgi vesicle transport0.0213023182680741
GO:0004715non-membrane spanning protein tyrosine kinase activity0.0213023182680741
GO:0051348negative regulation of transferase activity0.0213023182680741
GO:0045184establishment of protein localization0.0244848945667967
GO:0019221cytokine and chemokine mediated signaling pathway0.0248664499757035
GO:0043086negative regulation of catalytic activity0.0257916660588895
GO:0019901protein kinase binding0.0261619550246218
GO:0009615response to virus0.026527221150298
GO:0019900kinase binding0.0268875635902952
GO:0008104protein localization0.0272167319733423
GO:0051649establishment of cellular localization0.0272167319733423
GO:0051641cellular localization0.0279261139065417
GO:0033036macromolecule localization0.028415053329007
GO:0018212peptidyl-tyrosine modification0.0289514571859491
GO:0018108peptidyl-tyrosine phosphorylation0.0289514571859491
GO:0006874cellular calcium ion homeostasis0.0303006260442891
GO:0005912adherens junction0.0307587697235578
GO:0055074calcium ion homeostasis0.0307587697235578
GO:0051234establishment of localization0.0307587697235578
GO:0006793phosphorus metabolic process0.0307587697235578
GO:0006796phosphate metabolic process0.0307587697235578
GO:0006875cellular metal ion homeostasis0.0324413878071201
GO:0016485protein processing0.0324413878071201
GO:0048523negative regulation of cellular process0.0329202248070333
GO:0055065metal ion homeostasis0.0330193124676124
GO:0016323basolateral plasma membrane0.0337819370700022
GO:0007166cell surface receptor linked signal transduction0.0348292371106258
GO:0048519negative regulation of biological process0.0368739864133545
GO:0051049regulation of transport0.0397702004545595
GO:0042113B cell activation0.0399286764495899
GO:0044267cellular protein metabolic process0.0399286764495899
GO:0004725protein tyrosine phosphatase activity0.0400103326163405
GO:0002250adaptive immune response0.0407521510522234
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0407521510522234
GO:0044260cellular macromolecule metabolic process0.0407521510522234
GO:0009968negative regulation of signal transduction0.040917668044181
GO:0002449lymphocyte mediated immunity0.041585462606662
GO:0018193peptidyl-amino acid modification0.0418006464084082
GO:0030005cellular di-, tri-valent inorganic cation homeostasis0.0424556661987694
GO:0019538protein metabolic process0.0425542198268073
GO:0055066di-, tri-valent inorganic cation homeostasis0.0432728331933592
GO:0002443leukocyte mediated immunity0.0432728331933592
GO:0001816cytokine production0.0432728331933592
GO:0030003cellular cation homeostasis0.0451904702019235
GO:0006470protein amino acid dephosphorylation0.0458044805498022
GO:0055080cation homeostasis0.0459869206282985



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
mature alpha-beta T cell2.14e-189
alpha-beta T cell2.14e-189
immature T cell2.14e-189
mature T cell2.14e-189
immature alpha-beta T cell2.14e-189
T cell1.24e-1711
pro-T cell1.24e-1711
CD4-positive, alpha-beta T cell1.14e-168
lymphoid lineage restricted progenitor cell5.77e-1612
lymphocyte1.48e-1413
common lymphoid progenitor1.48e-1413
thymocyte2.96e-136
double negative thymocyte2.96e-136
naive T cell2.96e-136
double-positive, alpha-beta thymocyte2.96e-136
CD4-positive, alpha-beta thymocyte2.96e-136
naive thymus-derived CD4-positive, alpha-beta T cell2.96e-136
DN4 thymocyte2.96e-136
DN1 thymic pro-T cell2.96e-136
DN2 thymocyte2.96e-136
DN3 thymocyte2.96e-136
immature single positive thymocyte2.96e-136
early T lineage precursor2.96e-136
mature CD4 single-positive thymocyte2.96e-136
resting double-positive thymocyte2.96e-136
double-positive blast2.96e-136
CD69-positive double-positive thymocyte2.96e-136
CD69-positive, CD4-positive single-positive thymocyte2.96e-136
CD4-positive, CD8-intermediate double-positive thymocyte2.96e-136
CD24-positive, CD4 single-positive thymocyte2.96e-136
nucleate cell2.17e-1116
hematopoietic lineage restricted progenitor cell3.85e-1125
leukocyte1.39e-1017
nongranular leukocyte1.39e-1017
hematopoietic cell5.06e-0832
hematopoietic oligopotent progenitor cell5.06e-0832
hematopoietic stem cell5.06e-0832
angioblastic mesenchymal cell5.06e-0832
hematopoietic multipotent progenitor cell5.06e-0832

Uber Anatomy
Ontology termp-valuen
hemopoietic organ6.61e-3429
immune organ6.61e-3429
thymus2.02e-3023
neck2.02e-3023
respiratory system epithelium2.02e-3023
hemolymphoid system gland2.02e-3023
pharyngeal epithelium2.02e-3023
thymic region2.02e-3023
pharyngeal gland2.02e-3023
entire pharyngeal arch endoderm2.02e-3023
thymus primordium2.02e-3023
early pharyngeal endoderm2.02e-3023
pharynx6.30e-2924
gland of gut6.30e-2924
upper respiratory tract6.30e-2924
chordate pharynx6.30e-2924
pharyngeal arch system6.30e-2924
pharyngeal region of foregut6.30e-2924
mixed endoderm/mesoderm-derived structure5.49e-2735
respiratory tract4.36e-2641
hemolymphoid system1.09e-2548
immune system1.09e-2548
hematopoietic system1.20e-2545
blood island1.20e-2545
respiratory system2.65e-2542
segment of respiratory tract4.14e-2527
organ segment3.55e-2035
craniocervical region1.71e-1736
foregut1.20e-1480
anterior region of body8.58e-1443
endo-epithelium8.86e-1369
lateral plate mesoderm7.14e-1187
subdivision of digestive tract8.82e-10114
gut epithelium1.12e-0955
digestive system1.76e-09116
digestive tract1.76e-09116
primitive gut1.76e-09116
endocrine gland1.80e-0960
endoderm-derived structure3.44e-09118
endoderm3.44e-09118
presumptive endoderm3.44e-09118
gland2.38e-0865
organ part6.29e-0899
unilaminar epithelium2.93e-0766
endocrine system4.72e-0772


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.00972621
MA0004.11.02263
MA0006.10.238555
MA0007.10.38073
MA0009.10.82278
MA0014.10.119217
MA0017.10.26239
MA0019.10.642876
MA0024.10.779446
MA0025.11.05446
MA0027.12.46647
MA0028.10.24786
MA0029.10.757957
MA0030.10.764448
MA0031.10.729293
MA0038.10.534262
MA0040.10.835181
MA0041.10.323687
MA0042.10.311486
MA0043.10.918718
MA0046.10.858391
MA0048.10.0824771
MA0050.10.431976
MA0051.10.542972
MA0052.10.84317
MA0055.10.221677
MA0056.10
MA0057.10.258928
MA0058.11.49242
MA0059.10.849123
MA0060.10.505012
MA0061.10.194456
MA0063.10
MA0066.10.523573
MA0067.11.16502
MA0068.10.077274
MA0069.10.843506
MA0070.10.833895
MA0071.11.10147
MA0072.10.825495
MA0073.10.0431817
MA0074.10.488775
MA0076.10.279739
MA0077.10.804033
MA0078.10.575205
MA0081.10.897217
MA0083.10.917931
MA0084.11.49188
MA0087.10.87515
MA0088.10.0492918
MA0089.10
MA0090.10.362551
MA0091.10.407455
MA0092.10.362847
MA0093.11.30984
MA0095.10
MA0098.10
MA0100.10.477594
MA0101.10.324888
MA0103.10.272167
MA0105.10.35523
MA0106.10.582805
MA0107.10.266586
MA0108.20.665343
MA0109.10
MA0111.10.375908
MA0113.10.555251
MA0114.10.561811
MA0115.10.921497
MA0116.10.238371
MA0117.10.88947
MA0119.10.325434
MA0122.10.909168
MA0124.11.11203
MA0125.11.03833
MA0130.10
MA0131.10.638414
MA0132.10
MA0133.10
MA0135.10.954884
MA0136.10.508047
MA0139.10.143341
MA0140.10.477483
MA0141.11.43798
MA0142.10.714976
MA0143.10.571221
MA0144.10.195095
MA0145.10.200183
MA0146.10.0548413
MA0147.10.205697
MA0148.11.05634
MA0149.10.330018
MA0062.20.365726
MA0035.21.21101
MA0039.20.043355
MA0138.20.630612
MA0002.20.145685
MA0137.20.287486
MA0104.20.157347
MA0047.21.32079
MA0112.20.442124
MA0065.20.773848
MA0150.10.991233
MA0151.10
MA0152.10.53362
MA0153.10.971406
MA0154.10.0809407
MA0155.10.490492
MA0156.10.278949
MA0157.10.683365
MA0158.10
MA0159.10.214506
MA0160.10.413266
MA0161.10
MA0162.10.0672805
MA0163.10.0124565
MA0164.10.508398
MA0080.20.737531
MA0018.20.51781
MA0099.20.624421
MA0079.20.000240419
MA0102.21.5442
MA0258.12.30311
MA0259.10.196451
MA0442.10
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