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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,

Latest revision as of 11:50, 17 September 2013


Full id: C1693_Mast_leukemia_acute_chronic_Dendritic_mature_immature



Phase1 CAGE Peaks

Hg19::chr12:93966313..93966323,+p30@SOCS2
Hg19::chr19:52029102..52029142,+p@chr19:52029102..52029142
+
Hg19::chr1:71512983..71513015,-p2@PTGER3
Hg19::chr6:66360833..66360849,+p@chr6:66360833..66360849
+
Hg19::chr7:91184269..91184309,-p@chr7:91184269..91184309
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005148prolactin receptor binding0.00600468009881598
GO:0008269JAK pathway signal transduction adaptor activity0.00600468009881598
GO:0008268receptor signaling protein tyrosine kinase signaling protein activity0.00600468009881598
GO:0005131growth hormone receptor binding0.00600468009881598
GO:0005159insulin-like growth factor receptor binding0.010398383262844
GO:0016265death0.010398383262844
GO:0008219cell death0.010398383262844
GO:0004957prostaglandin E receptor activity0.0127575036184426
GO:0004955prostaglandin receptor activity0.013505956381168
GO:0048468cell development0.013505956381168
GO:0004953icosanoid receptor activity0.013505956381168
GO:0004954prostanoid receptor activity0.013505956381168
GO:0007259JAK-STAT cascade0.0180047600390056
GO:0048869cellular developmental process0.0183771524647308
GO:0030154cell differentiation0.0183771524647308
GO:0005070SH3/SH2 adaptor activity0.0183771524647308
GO:0005126hematopoietin/interferon-class (D200-domain) cytokine receptor binding0.0199991020939335
GO:0060090molecular adaptor activity0.0199991020939335
GO:0030674protein binding, bridging0.0287224293463737
GO:0009968negative regulation of signal transduction0.0311783771436525
GO:0004879ligand-dependent nuclear receptor activity0.0397834287141932
GO:0001558regulation of cell growth0.0397834287141932
GO:0032502developmental process0.0397834287141932
GO:0006916anti-apoptosis0.0397834287141932
GO:0005057receptor signaling protein activity0.0397834287141932
GO:0005635nuclear envelope0.0397834287141932
GO:0016049cell growth0.0397834287141932
GO:0040008regulation of growth0.0397834287141932
GO:0060089molecular transducer activity0.0397834287141932
GO:0004871signal transducer activity0.0397834287141932
GO:0008361regulation of cell size0.0397834287141932
GO:0043066negative regulation of apoptosis0.0417115834356573
GO:0043069negative regulation of programmed cell death0.0417115834356573



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>

Disease
Ontology termp-valuen
chronic leukemia2.41e-198
chronic myeloid leukemia5.26e-181
myeloid leukemia1.64e-1331
leukemia9.43e-1139
hematologic cancer3.19e-0851
immune system cancer3.19e-0851


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.481059
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.0418333
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.12.33564
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.11.44118
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.111822
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.520776
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.11.65391
MA0141.12.22808
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.442008
MA0146.10.143081
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.21.65235
MA0039.20.311551
MA0138.20.837782
MA0002.20.83106
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.514087
MA0155.10.130813
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.382496
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.0198381
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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