Coexpression cluster:C1893

Full id: C1893_Mast_CD14_heart_Monocytederived_Melanocyte_Macrophage_left

Phase1 CAGE Peaks

Hg19::chr2:218770123..218770135,-	p15@TNS1
Hg19::chr2:218770139..218770150,-	p13@TNS1
Hg19::chr2:218770151..218770162,-	p12@TNS1
Hg19::chr2:218770168..218770198,-	p7@TNS1
Hg19::chr3:69435343..69435354,-	p32@FRMD4B

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008092	cytoskeletal protein binding	0.0100654764014699
GO:0005856	cytoskeleton	0.0219678857479727
GO:0004289	subtilase activity	0.0219678857479727
GO:0019898	extrinsic to membrane	0.0393900223864073
GO:0043232	intracellular non-membrane-bound organelle	0.0393900223864073
GO:0043228	non-membrane-bound organelle	0.0393900223864073

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
myeloid lineage restricted progenitor cell	7.53e-20	70
granulocyte monocyte progenitor cell	4.47e-17	71
myeloid leukocyte	7.50e-16	76
monopoietic cell	1.68e-14	63
monocyte	1.68e-14	63
monoblast	1.68e-14	63
promonocyte	1.68e-14	63
macrophage dendritic cell progenitor	1.19e-13	65
myeloid cell	1.78e-13	112
common myeloid progenitor	1.78e-13	112
CD14-positive, CD16-negative classical monocyte	7.03e-11	42
classical monocyte	1.45e-09	45
hematopoietic lineage restricted progenitor cell	1.30e-07	124
histamine secreting cell	4.14e-07	5
biogenic amine secreting cell	4.14e-07	5
granulocytopoietic cell	4.14e-07	5
mast cell	4.14e-07	5
mast cell progenitor	4.14e-07	5
basophil mast progenitor cell	4.14e-07	5
hematopoietic stem cell	7.39e-07	172
angioblastic mesenchymal cell	7.39e-07	172

Uber Anatomy

Ontology term	p-value	n
adult organism	2.09e-56	115
hematopoietic system	6.28e-19	102
blood island	6.28e-19	102
hemolymphoid system	4.15e-17	112
bone marrow	2.87e-14	80
neural tube	4.42e-14	57
neural rod	4.42e-14	57
future spinal cord	4.42e-14	57
neural keel	4.42e-14	57
bone element	6.41e-13	86
regional part of brain	2.04e-10	59
immune system	5.01e-10	115
anterior neural tube	5.84e-10	42
neural plate	1.70e-09	86
presumptive neural plate	1.70e-09	86
regional part of forebrain	2.51e-09	41
forebrain	2.51e-09	41
future forebrain	2.51e-09	41
neurectoderm	5.13e-09	90
skeletal element	6.65e-09	101
skeletal system	6.65e-09	101
central nervous system	8.03e-08	82
brain	8.04e-08	69
future brain	8.04e-08	69
brainstem	1.03e-07	8
gray matter	1.79e-07	34
brain grey matter	1.79e-07	34
telencephalon	3.52e-07	34
regional part of telencephalon	7.62e-07	33

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.