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Coexpression cluster:C4818: Difference between revisions

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|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0003081!8.90e-20!216;UBERON:0002193!2.73e-14!112;UBERON:0000926!4.47e-14!448;UBERON:0004120!4.47e-14!448;UBERON:0006603!4.47e-14!448;UBERON:0002390!4.11e-13!102;UBERON:0003061!4.11e-13!102;UBERON:0002405!7.59e-13!115;UBERON:0002371!4.73e-11!80;UBERON:0001474!5.82e-09!86;UBERON:0004765!8.40e-08!101;UBERON:0001434!8.40e-08!101;UBERON:0002204!5.09e-07!167
|ontology_enrichment_uberon=UBERON:0003081!8.90e-20!216;UBERON:0002193!2.73e-14!112;UBERON:0000926!4.47e-14!448;UBERON:0004120!4.47e-14!448;UBERON:0006603!4.47e-14!448;UBERON:0002390!4.11e-13!102;UBERON:0003061!4.11e-13!102;UBERON:0002405!7.59e-13!115;UBERON:0002371!4.73e-11!80;UBERON:0001474!5.82e-09!86;UBERON:0004765!8.40e-08!101;UBERON:0001434!8.40e-08!101;UBERON:0002204!5.09e-07!167
|tf_chipseq_enrich=CCNT2#905;3:6.33620157696263:0.00393075003576489:0.0191413066156222!CTCF#10664;3:5.36025637307503:0.006492509252767:0.0281754829988255!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0328216338699378!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0324764931511277!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0322887127126977!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0465379794160973!HMGN3#9324;3:8.17854772335059:0.00182776694216421:0.0109361301445253!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.0128852075318774!MAX#4149;3:6.45255550900712:0.00372191383426551:0.0187602779409679!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0296454233446166!NRF1#4899;3:12.2102794477109:0.000549217240102001:0.00473929598769007!PAX5#5079;3:6.66956553117783:0.00337029099967726:0.017378780572494!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.00669560025666452!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0278587559635044!SP1#6667;3:5.6983813781409:0.00540396270171217:0.024815743771891!SPI1#6688;3:8.20432350852273:0.00181059318941052:0.0109487894220859!TFAP2A#7020;3:16.518634373045:0.000221803388076634:0.00249837403444085!TFAP2C#7022;3:10.8092286098602:0.000791674657575313:0.00619663565633726!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0331559666958673!ZBTB7A#51341;3:7.3519093078759:0.00251625586028227:0.0141098118546051!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0110257818521316
|tfbs_overrepresentation=0.147255,0.0586687,0.00948065,0.0477154,0.199763,0.287811,0.0430074,0.414564,0.03272,0.0257057,0.139423,0.225367,0.188771,0.125978,0.148679,0.0619003,0.140982,0.0982016,0.0528514,0.108057,0.188635,0.132577,0.081977,0.0948982,0.0415721,0.215492,0.209392,0.0907212,0.143747,0.0933697,0.204953,0.114046,0.0180314,0.208242,0.0665252,0.0844722,0.0308399,0.0429682,0.120351,0.0667043,0.0964797,0.0246116,0.140039,0.184019,0.120917,0.0362416,0.0380166,0.18151,0.111283,0.121201,0.154071,0.0541794,0.0701653,0.0929951,0.198787,0.0384161,0.107455,0.212709,0.0783235,0.105572,0.0294301,0.149417,0.108602,0.0759481,0.054569,0.0504887,0.352278,0.0600088,0.0860723,0.167053,0.378921,0.067678,0.089036,0.119383,0.00747605,0.0171177,0.0964936,0.0436945,0.0372495,0.00725252,0.0956287,0.226912,0.0425,0.114846,0.291327,0.251834,0.064341,0.209032,0.0693924,0.062747,0.0857568,0.0495878,0.0953825,0.0473737,0.0853887,0.115028,0.0124566,0.153631,0.0927458,0.27413,0.0574857,0.276221,0.141874,0.0370665,0.219088,0.0409286,0.0669887,0.338096,0.144217,0.269326,0.182599,0.0339971,0.149552,0.0176855,0.101221,0.0337525,0.0203386,0.0566549,0.139021,0.0838393,0.16671,0.214708,0.140123,0.0857827,0.102368,0.176912,0.0906875,0.0147934,0.0843604,0.134932,0.0595773,0.0748346,0.0572164,0.0227861,0.125792,0.108101,0.0648644,0.0553359,0.0330399,0.00395526,0.022776,0.127606,0.203923,0.155998,0.0641358,0.0693171,0.0988228,0.0842275,0.0389418,0.120833,0.200647,0.143677,0.180712,0.0265818,0.0427088,0.117549,0.0747594,0.228385,0.0516985,0.0337251,0.227719,0.0952829,0.116642,0.147788,0.273479,0.114283,0.0400322,0.127369,0.0403542,0.312091,0.179689,0.137725,0.00384591,0.0541353,0.0799324,0.090079,0.140334,0.181817,0.178449,0.0356339,0.158844,0.122474,0.0274061,0.115574,0.0737247,0.118847,0.183031,0.0401756,0.0828697,0.173562,0.107145,0.187297,0.122935,0.228812,0.112671,0.0470731,0.0782523,0.0602859,0.0676496,0.109673,0.0893019,0.060398,0.0308319,0.0606036,0.136451,0.259411,0.27358,0.15185,0.206299,0.178359,0.0458667,0.104357,0.121154,0.1129,0.312578,0.169057,0.164202,0.100942,0.062995,0.10299,0.14193,0.37245,0.15606,0.161026,0.0738599,0.126611,0.138852,0.085973,0.060453,0.059896,0.0538541,0.0133328,0.0418404,0.0765029,0.0959204,0.0931946,0.0472272,0.263087,0.163502,0.214803,0.182472,0.348993,0.0983991,0.0830921,0.116283,0.136838,0.0815104,0.111647,0.372804,0.117027,0.159052,0.185164,0.185743,0.0980288,0.0980899,0.159674,0.107242,0.201859,0.0695832,0.0585224,0.0619218,0.1751,0.0141386,0.128096,0.0345133,0.0810678,0.0811639,0.0920653,0.118078,0.0755168,0.278352,0.063292,0.254773,0.446759,0.0865903,0.0380459,0.130174,0.584917,0.0381789,0.0199061,0.635872,0.563047,0.517782,1.82637e-07,0.335423,0.629514,0.261553,0.446302,0.373681,0.309233,0.49143,0.330703,0.395854,0.329568,0.53472,0.615744,0.271958,0.292154,0.405773,0.39729,0.581713,0.597171,0.187251,0.362792,0.181715,0.423979,0.109988,0.330894,0.218329,0.427027,0.376924,0.463191,0.647576,0.528324,0.520763,0.370782,0.415647,0.484505,0.253571,0.276829,0.301787,0.481778,0.316882,0.223503,0.503224,0.603208,0.283727,0.314747,0.577664,0.291709,0.448095,0.0563639,0.416816,0.292835,0.137839,0.439556,0.373868,0.57762,0.608919,0.18237,0.0359955,2.91154e-07,0.0512465,0.275351,0.236471,0.185661,0.346319,0.535598,0.270984,0.625945,0.503058,0.513852,0.522083,0.248634,0.281576,0.472384,0.163244,0.0670502,0.0730934,0.184794,0.230427,0.176034,0.581837,0.1002,0.671377,0.546839,0.551561,0.448039,0.218623,0.312808,0.695172,0.0451077,0.0747529,0.229003,0.00449125,0.061213,0.50215,0.294698,0.34331,0.0282052,0.289204,0.327108,0.0295492,0.278044,0.490301,0.428671,0.228096,0.336314,0.19763,0.15631,0.567452,0.421464,0.48267,0.420626,0.516462,2.25312e-08,0.335105,0.144809,0.145539,0.0134194,0.376191,0.447325,0.459928,0.252232,0.152681,0.0465712,0.137098,0.259235,0.134788,0.0985856,0.546222,0.293698,0.284593,0.343734,0.306556,0.305777,0.601433,0.503082,0.522888,0.284629,0.262537,0.359455,0.226257,0.405955,0.41707,0.363685,0.464871,0.0142811,0.206222,0.525396,0.284166,0.437176,0.269226,0.339277,0.0479524,0.281425,0.141758,0.455379,0.520495,0.159617,0.238587,0.372281,0.232251,0.189515,0.0891382,0.0595618,0.524997,0.625309,0.347298,0.539392,0.34988,0.475069,0.404569,0.6408,0.262389,0.316179,0.0697683,0.0556835,0.192544,0.0779981,0.0575676,0.144322,0.223391,0.203656,0.442884,0.0214618,0.191777,0.111931,0.28934,0.0435386,0.303336,0.126478,0.134852,0.10689,0.0413156,0.0627924,0.0129363,0.0179103,0.303939,0.279795,0.390395,0.0464827,0.169603,0.114583,0.104559,0.0899537,0.0866966,0.15983,0.107111,0.0438639,0.00389058,0.123593,0.129156,0.210369,0.193675,0.346372,0.0499762,0.0828956,0.0666953,0.182185,0.111277,0.219383,0.332809,0.19559,0.132201,0.188694,0.0481795,0.199971,0.406014,0.127758,0.175785,0.184486,0.169234,0.0876426,0.0952322,0.0112557,0.222432,0.107043,0.275244,0.00481323,0.173708,0.141119,0.211595,0.0300692,0.131551,0.0445237,0.052362,0.208866,0.153187,0.0797897,0.0974211,0.160149,0.00796449,0.0906475,0.0558058,0.04434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26,0.00662343,0.137332,0.0145999,0.0656973,0.211746,0.220538,0.0801488,0.0757897,0.161801,0.193215,0.0549034,0.0779715,0.0561838,0.0417636,0.0345419,0.0388736,0.254674,0.170307,0.201033,0.0488949,0.174921,0.0117175,0.0330727,5.99252e-06,0.219556,0.0394698,0.0596469,0.419264,0.122476,0.108872,0.11002,0.26144,0.0286025,0.0470027,0.144567,0.038848,0.0874516,0.0550279,0.144067,0.253693,0.217069,0.190048,0.131088,0.394069,0.237101,0.286988,0.0761239,0.172491,0.0818785,0.182701,0.335058,0.147698,0.141463,0.167267,0.140622,0.0889592,0.309588,0.28711,0.0473033,0.094881,0.118532,0.132886,0.0774373,0.109194,0.128564,0.131452,4.37081e-09,0.0226843,0.051838,0.0993999,0.0500365,0.061829,0.0755121,0.0936516,0.144075,0.0340203,0.0741807,0.277091,8.15339e-05,0.655293,0.21727,0.289306,0.119215,0.192475,0.177967,0.547859,0.057571,0.047591,0.0899568,0.0608699,0.175319,0.300597,0.0713214,0.223874,0.291114,0.0355833,0.125606,0.175094,2.54891e-17,2.32492e-07,0.206454,0.218192,0.108277,0.0673484,0.108748,0.0494066,0.0958493,0.205732,0.0755808,0.045654,0.110216,0.070276,0.226171,0.153469,0.0376916,0.13262,0.0450031,0.0539144,0.114242,0.0929549,0.172425,0.104948,0.221645,0.057168,0.234298,0.0759837,0.286863,0.152372,0.194941,0.218271,0.101607,0.327067,0.172982,0.340936,0.151597,0.0626744,0.191335,0.148574,9.07794e-06,0.155821,0.0718905,0.0919008,0.0602373,0.144304,0.15063,0.0973823,0.15503,0.170295,0.193653,0.137219,0.228144,0.251466,0.0050797,0.11903,0.0838874,0.331451,0.113145,0.112651,0.186638,0.174776,0.0948451,0.264079,0.249049,0.140533,0.0997756,0.257598,0.103667,0.113069,0.025556,0.16791,0.09066,0.585505,0.166967,0.188651,0.0813902,0.184948,0.156261,0.311847,0.0362615,0.0590944,0.0334734,0.178389,0.218229,0.0290303,0.0972686,6.78596e-05,0.0360851,0.0168763,0.131093,0.0434602,0.133616,0.103051,0.36927,0.449036,0.407369,0.231447,0.544776,0.43956,0.37006,0.42622,0.448797,0.197484,0.396996,0.36145,0.406019,0.381071,0.580441,0.643768,0.432035,0.366326,0.390366,0.48809,0.00559336,0.443185,0.522904,1.06392e-10,3.95207e-08,0.227104,0.518585,0.0167433,0.38649,0.284625,0.0344717,0.55194,0.144318,0.28907,0.164197,0.462688,0.287881,0.21103,0.478174,0.336276,0.132529,0.258219,0.446557,0.243383,5.59455e-07,0.390974,7.41696e-05,0.109758,0.161598,0.0527155,0.00422412,0.150692,7.35021e-06,0.37357,8.87042e-08,0.477353,9.94932e-09,0.000558506,2.48085e-05,0.20342,0.200493,0.20558,0.300504,0.25656,0.425963,0.349197,0.383291,0.156104,0.141318,0.411941,0.0961477,0.314438,0.354789,0.163828,0.230581,0.120226,0.28424,0.562405,0.314429,0.181415,0.282286,0.00465874,0.24884,0.408413,0.516511,0.322213,0.28903,0.33942,0.61031,0.387276,0.522605,2.34371e-10,0.537348,0.222037,0.416621,0.416292,0.462712,0.00246111,0.215157,0.204817,0.452428,0.138871,0.00583733,0.166905,0.19783,0.0833851,0.316453,0.48065,0.175199,0.332919,0.373557,0.523625,0.408861,0.0768488,0.534741,0.39088,0.363192,0.236011,0.203486,0.273398,0.375787,0.4466,0.351067,0.275347,0.637444,0.305885,0.241132,0.371414,0.30666,0.303709,0.495883,0.0867777,0.508064,0.250964,0.383276,0.457886,0.504711,0.220231,0.509064,0.196976,0.191517,0.463751,0.601877,0.307334,0.459728,0.283463,0.563586,0.472935,0.399569,0.273281,0.368095,0.275089,0.384593,0.47795,0.0740334,0.339729,0.197805,0.24107,0.387069,0.332774,0.000131919,0.299887,0.634365,0.205413,0.17639,0.0779009,0.276869,0.205298,0.0337138,0.18966,0.258854,0.188263,0.0719199,0.264884,0.162568,0.19104,0.163057,0.219428,0.208013,0.0900729,0.0953646,0.166124,0.252184,0.378361,0.255516,0.20753,0.447185,0.179412,0.193601,0.220904,0.222977,0.341681,0.310674,0.21801,0.198614,0.186804,0.123324,0.199468,0.0325925,0.0933115,0.12405,0.179889,0.226869,0.27872,0.0855609,0.131118,0.20837,0.247588,0.222339,0.0673329,0.20847,0.266544,0.113092,0.145701,0.229428,0.162145,0.228955,0.168748,0.0384949,0.0660995,0.0521984,0.0455518,0.268741,0.201602,0.350452,0.154941,0.120196,0.0986735,0.108462,0.0595618,0.21593,0.158479,0.220319,0.195218,0.124213,0.259632,0.30793,0.180606,0.159884,0.257294,0.150733,0.217112,0.123917,0.184317,0.185335,0.0723291,0.258496,0.261744,0.203781,0.21382,0.207559,0.141867,0.193031,0.249101,0.115972,0.224568,0.246105,0.173026,0.200432,0.139785,0.197112,0.240478,0.156465,0.13108,0.256963,0.222798,0.172134,0.176789,0.0969345,0.202137,0.310405,0.280943,0.218161,0.0822373,0.202065,0.00591081,0.0536053,0.0537737,0.15113,0.078016,0.0407233,0.0537355,0.319922,0.261724,0.211332,0.187731,0.233626,0.189559,0.0812887,0.0981146,0.064145,0.121913,0.0638699,0.104603,0.0663259,0.0762523,0.128736,0.109171,0.04411,0.066952,0.089609,0.0367455,0.13497,0.204393,0.295769,0.286691,0.347036,0.141729,0.263159,0.255956,0.200105,0.227491,0.29837,0.253509,0.177664,0.28365,0.264413,0.131761,0.160658,0.206239,0.19924,0.28689,0.236464,0.325148,0.115817,0.218052,0.223831,0.11528,0.194982,0.190993,0.281727,0.283218,0.249955,0.164638,0.224257,0.0935776,0.327622,0.225752,0.207791,0.0958756,0.0859274,0.316866,0.171683,0.158847,0.271275,0.071111,0.270604,0.101021,0.222548,0.175934,0.157274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}}
}}

Revision as of 12:03, 5 September 2012


Full id: C4818_Eosinophils_Neutrophils_CD19_CD14_Dendritic_CD8_Natural



Phase1 CAGE Peaks

Hg19::chr9:33167255..33167266,-p6@B4GALT1
Hg19::chr9:33167293..33167307,-p5@B4GALT1
Hg19::chr9:33167308..33167378,-p2@B4GALT1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.31e-19140
myeloid leukocyte1.88e-1776
nongranular leukocyte1.12e-16119
CD14-positive, CD16-negative classical monocyte1.64e-1442
hematopoietic lineage restricted progenitor cell3.32e-14124
classical monocyte4.65e-1445
monopoietic cell3.62e-1363
monocyte3.62e-1363
monoblast3.62e-1363
promonocyte3.62e-1363
granulocyte monocyte progenitor cell6.77e-1371
macrophage dendritic cell progenitor1.57e-1265
myeloid lineage restricted progenitor cell6.38e-1270
somatic cell2.34e-11591
animal cell5.99e-11679
eukaryotic cell5.99e-11679
epithelial cell1.06e-08254
native cell3.73e-08722
hematopoietic stem cell3.94e-08172
angioblastic mesenchymal cell3.94e-08172
hematopoietic cell5.62e-08182
hematopoietic oligopotent progenitor cell2.19e-07165
hematopoietic multipotent progenitor cell2.19e-07165
Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm8.90e-20216
hemolymphoid system2.73e-14112
mesoderm4.47e-14448
mesoderm-derived structure4.47e-14448
presumptive mesoderm4.47e-14448
hematopoietic system4.11e-13102
blood island4.11e-13102
immune system7.59e-13115
bone marrow4.73e-1180
bone element5.82e-0986
skeletal element8.40e-08101
skeletal system8.40e-08101
musculoskeletal system5.09e-07167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0191413066156222
CTCF#1066435.360256373075030.0064925092527670.0281754829988255
E2F1#186934.907389214879320.008460985347239390.0328216338699378
E2F6#187635.017155731697390.00791769806886330.0324764931511277
EGR1#195834.988179094810140.008056488137383440.0322887127126977
ELF1#199734.258097958807540.01295179875054610.0465379794160973
HMGN3#932438.178547723350590.001827766942164210.0109361301445253
IRF1#365937.63716375356390.002244692747297240.0128852075318774
MAX#414936.452555509007120.003721913834265510.0187602779409679
MYC#460935.22228187160940.007020843755740150.0296454233446166
NRF1#4899312.21027944771090.0005492172401020010.00473929598769007
PAX5#507936.669565531177830.003370290999677260.017378780572494
RAD21#5885310.35503389545630.0009004912073565420.00669560025666452
SIN3A#2594235.408884726815140.006318961977991520.0278587559635044
SP1#666735.69838137814090.005403962701712170.024815743771891
SPI1#668838.204323508522730.001810593189410520.0109487894220859
TFAP2A#7020316.5186343730450.0002218033880766340.00249837403444085
TFAP2C#7022310.80922860986020.0007916746575753130.00619663565633726
YY1#752834.911170749853860.008441455341808260.0331559666958673
ZBTB7A#5134137.35190930787590.002516255860282270.0141098118546051
ZNF263#1012738.221841637010680.001799043925565870.0110257818521316



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.