Coexpression cluster:C1693

Full id: C1693_Mast_leukemia_acute_chronic_Dendritic_mature_immature

Phase1 CAGE Peaks

Hg19::chr12:93966313..93966323,+	p30@SOCS2
Hg19::chr19:52029102..52029142,+	p@chr19:52029102..52029142 +
Hg19::chr1:71512983..71513015,-	p2@PTGER3
Hg19::chr6:66360833..66360849,+	p@chr6:66360833..66360849 +
Hg19::chr7:91184269..91184309,-	p@chr7:91184269..91184309 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0005148	prolactin receptor binding	0.00600468009881598
GO:0008269	JAK pathway signal transduction adaptor activity	0.00600468009881598
GO:0008268	receptor signaling protein tyrosine kinase signaling protein activity	0.00600468009881598
GO:0005131	growth hormone receptor binding	0.00600468009881598
GO:0005159	insulin-like growth factor receptor binding	0.010398383262844
GO:0016265	death	0.010398383262844
GO:0008219	cell death	0.010398383262844
GO:0004957	prostaglandin E receptor activity	0.0127575036184426
GO:0004955	prostaglandin receptor activity	0.013505956381168
GO:0048468	cell development	0.013505956381168
GO:0004953	icosanoid receptor activity	0.013505956381168
GO:0004954	prostanoid receptor activity	0.013505956381168
GO:0007259	JAK-STAT cascade	0.0180047600390056
GO:0048869	cellular developmental process	0.0183771524647308
GO:0030154	cell differentiation	0.0183771524647308
GO:0005070	SH3/SH2 adaptor activity	0.0183771524647308
GO:0005126	hematopoietin/interferon-class (D200-domain) cytokine receptor binding	0.0199991020939335
GO:0060090	molecular adaptor activity	0.0199991020939335
GO:0030674	protein binding, bridging	0.0287224293463737
GO:0009968	negative regulation of signal transduction	0.0311783771436525
GO:0004879	ligand-dependent nuclear receptor activity	0.0397834287141932
GO:0001558	regulation of cell growth	0.0397834287141932
GO:0032502	developmental process	0.0397834287141932
GO:0006916	anti-apoptosis	0.0397834287141932
GO:0005057	receptor signaling protein activity	0.0397834287141932
GO:0005635	nuclear envelope	0.0397834287141932
GO:0016049	cell growth	0.0397834287141932
GO:0040008	regulation of growth	0.0397834287141932
GO:0060089	molecular transducer activity	0.0397834287141932
GO:0004871	signal transducer activity	0.0397834287141932
GO:0008361	regulation of cell size	0.0397834287141932
GO:0043066	negative regulation of apoptosis	0.0417115834356573
GO:0043069	negative regulation of programmed cell death	0.0417115834356573

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>

---

Cell Type

Ontology term	p-value	n
histamine secreting cell	3.48e-82	5
biogenic amine secreting cell	3.48e-82	5
granulocytopoietic cell	3.48e-82	5
mast cell	3.48e-82	5
mast cell progenitor	3.48e-82	5
basophil mast progenitor cell	3.48e-82	5
endocrine cell	7.85e-46	9
myeloid cell	1.84e-14	108
common myeloid progenitor	1.84e-14	108
secretory cell	1.41e-11	36
hematopoietic oligopotent progenitor cell	1.87e-09	161
hematopoietic multipotent progenitor cell	1.87e-09	161
hematopoietic stem cell	5.03e-09	168
angioblastic mesenchymal cell	5.03e-09	168
hematopoietic cell	1.60e-08	177

Disease

Ontology term	p-value	n
chronic leukemia	2.41e-19	8
chronic myeloid leukemia	5.26e-18	1
myeloid leukemia	1.64e-13	31
leukemia	9.43e-11	39
hematologic cancer	3.19e-08	51
immune system cancer	3.19e-08	51

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.