Coexpression cluster:C217

Full id: C217_carcinoid_neuroectodermal_mature_mesodermal_colon_acute_occipital

Phase1 CAGE Peaks

Hg19::chr10:1608256..1608259,-	p@chr10:1608256..1608259 -
Hg19::chr10:4832445..4832452,-	p@chr10:4832445..4832452 -
Hg19::chr12:119551986..119552003,+	p@chr12:119551986..119552003 +
Hg19::chr12:54995823..54995832,+	p@chr12:54995823..54995832 +
Hg19::chr15:78110669..78110682,-	p@chr15:78110669..78110682 -
Hg19::chr15:90017749..90017754,+	p@chr15:90017749..90017754 +
Hg19::chr19:49607884..49607918,+	p8@SNRNP70
Hg19::chr1:62644259..62644263,-	p@chr1:62644259..62644263 -
Hg19::chr1:91173989..91173995,-	p@chr1:91173989..91173995 -
Hg19::chr1:91182854..91182860,-	p1@BARHL2
Hg19::chr1:91183462..91183477,-	p@chr1:91183462..91183477 -
Hg19::chr20:61408204..61408211,-	p@chr20:61408204..61408211 -
Hg19::chr2:288759..288775,-	p5@FAM150B
Hg19::chr3:163217650..163217656,+	p@chr3:163217650..163217656 +
Hg19::chr3:163246025..163246029,+	p@chr3:163246025..163246029 +
Hg19::chr3:164914157..164914179,-	p1@SLITRK3
Hg19::chr3:164914186..164914209,-	p2@SLITRK3
Hg19::chr3:164924775..164924801,+	p1@ENST00000494915
Hg19::chr3:164978158..164978160,+	p@chr3:164978158..164978160 +
Hg19::chr3:165528391..165528411,+	p@chr3:165528391..165528411 +
Hg19::chr4:107889427..107889438,-	p@chr4:107889427..107889438 -
Hg19::chr4:164245890..164245892,-	p@chr4:164245890..164245892 -
Hg19::chr4:164253724..164253729,-	p6@NPY1R
Hg19::chr4:164253738..164253756,-	p1@NPY1R
Hg19::chr4:164265035..164265079,+	p1@NPY5R
Hg19::chr6:140362987..140362992,-	p@chr6:140362987..140362992 -
Hg19::chr7:100963860..100963864,+	p@chr7:100963860..100963864 +
Hg19::chr7:108255447..108255485,-	p@chr7:108255447..108255485 -
Hg19::chr7:16761415..16761424,+	p@chr7:16761415..16761424 +
Hg19::chr7:8110627..8110644,+	p@chr7:8110627..8110644 +
Hg19::chr8:128736275..128736278,+	p@chr8:128736275..128736278 +
Hg19::chr8:128740714..128740717,+	p@chr8:128740714..128740717 +
Hg19::chr8:128744545..128744550,+	p@chr8:128744545..128744550 +
Hg19::chr8:128750912..128750928,-	p@chr8:128750912..128750928 -
Hg19::chr8:128753103..128753122,-	p@chr8:128753103..128753122 -
Hg19::chr8:128808429..128808430,+	p@chr8:128808429..128808430 +
Hg19::chr8:128808502..128808513,+	p@chr8:128808502..128808513 +
Hg19::chr8:128816803..128816806,+	p@chr8:128816803..128816806 +
Hg19::chr8:128838281..128838284,+	p@chr8:128838281..128838284 +
Hg19::chr8:128854517..128854521,+	p@chr8:128854517..128854521 +
Hg19::chr8:128871079..128871082,+	p@chr8:128871079..128871082 +
Hg19::chr8:128913834..128913842,+	p@chr8:128913834..128913842 +
Hg19::chr8:128914686..128914701,+	p@chr8:128914686..128914701 +
Hg19::chr8:128941462..128941471,+	p@chr8:128941462..128941471 +
Hg19::chr8:128966560..128966563,+	p@chr8:128966560..128966563 +
Hg19::chr8:128997045..128997048,+	p@chr8:128997045..128997048 +
Hg19::chr8:129008161..129008165,+	p@chr8:129008161..129008165 +
Hg19::chr8:129009316..129009319,+	p@chr8:129009316..129009319 +
Hg19::chr8:129010478..129010491,+	p@chr8:129010478..129010491 +
Hg19::chr8:129010495..129010500,+	p@chr8:129010495..129010500 +
Hg19::chr8:129010508..129010517,+	p@chr8:129010508..129010517 +
Hg19::chr8:129010544..129010566,+	p@chr8:129010544..129010566 +
Hg19::chr8:129010580..129010588,+	p@chr8:129010580..129010588 +
Hg19::chr8:129010639..129010644,+	p@chr8:129010639..129010644 +
Hg19::chr8:129010662..129010678,+	p@chr8:129010662..129010678 +
Hg19::chr8:129010681..129010688,+	p@chr8:129010681..129010688 +
Hg19::chr8:129010691..129010716,+	p@chr8:129010691..129010716 +
Hg19::chr8:129010718..129010746,+	p@chr8:129010718..129010746 +
Hg19::chr8:130552836..130552878,+	p@chr8:130552836..130552878 +
Hg19::chr8:130561090..130561130,+	p@chr8:130561090..130561130 +
Hg19::chr8:130561422..130561452,+	p@chr8:130561422..130561452 +
Hg19::chr8:130561498..130561517,+	p@chr8:130561498..130561517 +
Hg19::chr8:130597061..130597068,+	p@chr8:130597061..130597068 +
Hg19::chr8:130605044..130605052,+	p@chr8:130605044..130605052 +
Hg19::chr8:130619499..130619504,+	p@chr8:130619499..130619504 +
Hg19::chr8:130695085..130695088,+	p@chr8:130695085..130695088 +
Hg19::chr9:15868281..15868293,+	p@chr9:15868281..15868293 +
Hg19::chrX:2716941..2716946,+	p@chrX:2716941..2716946 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001602	pancreatic polypeptide receptor activity	4.55398731382268e-06
GO:0001601	peptide YY receptor activity	4.55398731382268e-06
GO:0004983	neuropeptide Y receptor activity	3.33854210183063e-05
GO:0008188	neuropeptide receptor activity	0.000356402276119086
GO:0042923	neuropeptide binding	0.000356402276119086
GO:0007409	axonogenesis	0.00117282651970566
GO:0048667	neuron morphogenesis during differentiation	0.00117282651970566
GO:0048812	neurite morphogenesis	0.00117282651970566
GO:0000904	cellular morphogenesis during differentiation	0.00117282651970566
GO:0031175	neurite development	0.00117282651970566
GO:0030594	neurotransmitter receptor activity	0.00117282651970566
GO:0042165	neurotransmitter binding	0.00117282651970566
GO:0001653	peptide receptor activity	0.00117282651970566
GO:0008528	peptide receptor activity, G-protein coupled	0.00117282651970566
GO:0048666	neuron development	0.00118522585057282
GO:0032501	multicellular organismal process	0.00145984201655562
GO:0032990	cell part morphogenesis	0.00157350799159451
GO:0048858	cell projection morphogenesis	0.00157350799159451
GO:0030030	cell projection organization and biogenesis	0.00157350799159451
GO:0042277	peptide binding	0.00157350799159451
GO:0030182	neuron differentiation	0.00157350799159451
GO:0048699	generation of neurons	0.00199335571415066
GO:0022008	neurogenesis	0.00223381212475117
GO:0000902	cell morphogenesis	0.0067941250701111
GO:0032989	cellular structure morphogenesis	0.0067941250701111
GO:0030516	regulation of axon extension	0.00793028288399281
GO:0019233	sensory perception of pain	0.00954444637888664
GO:0048675	axon extension	0.0104297952116351
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	0.0106620378517675
GO:0040014	regulation of multicellular organism growth	0.0120228164603318
GO:0007399	nervous system development	0.0121866909190908
GO:0035264	multicellular organism growth	0.01287988259275
GO:0050770	regulation of axonogenesis	0.0135291867260136
GO:0001709	cell fate determination	0.0146444756340622
GO:0001764	neuron migration	0.0176264153211654
GO:0007631	feeding behavior	0.0176264153211654
GO:0050767	regulation of neurogenesis	0.0176264153211654
GO:0009653	anatomical structure morphogenesis	0.0209891357403477
GO:0045727	positive regulation of translation	0.0233080356963457
GO:0008217	regulation of blood pressure	0.023580811498767
GO:0001584	rhodopsin-like receptor activity	0.0240144591641738
GO:0031328	positive regulation of cellular biosynthetic process	0.0244941344852801
GO:0048468	cell development	0.0259020651756324
GO:0050877	neurological system process	0.0263977756741457
GO:0009891	positive regulation of biosynthetic process	0.026451459743057
GO:0045165	cell fate commitment	0.026451459743057
GO:0005887	integral to plasma membrane	0.0270803626016344
GO:0031226	intrinsic to plasma membrane	0.027140803467409
GO:0004930	G-protein coupled receptor activity	0.0285449509077174
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.0285449509077174
GO:0051247	positive regulation of protein metabolic process	0.0285449509077174
GO:0019933	cAMP-mediated signaling	0.0286522076736371
GO:0003008	system process	0.0318891306803883
GO:0048731	system development	0.0339510465476914
GO:0007186	G-protein coupled receptor protein signaling pathway	0.0357325844498906
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.0357325844498906
GO:0019935	cyclic-nucleotide-mediated signaling	0.0365978547929813
GO:0048869	cellular developmental process	0.0391952391971702
GO:0030154	cell differentiation	0.0391952391971702
GO:0008015	blood circulation	0.0447745868544492
GO:0003013	circulatory system process	0.0447745868544492
GO:0048856	anatomical structure development	0.0454101387301649
GO:0004888	transmembrane receptor activity	0.0454622754135308
GO:0007626	locomotory behavior	0.0482321915530359
GO:0006417	regulation of translation	0.0482708870795632
GO:0006006	glucose metabolic process	0.0495889089312643

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

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Uber Anatomy

Ontology term	p-value	n
sympathetic nervous system	7.49e-08	5
autonomic nervous system	7.49e-08	5

Disease

Ontology term	p-value	n
neuroectodermal tumor	8.32e-82	10
germ cell and embryonal cancer	1.25e-37	22
germ cell cancer	1.25e-37	22
neuroendocrine tumor	9.49e-07	6

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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