Coexpression cluster:C2705

Full id: C2705_kidney_brain_occipital_duodenum_Neurons_Renal_temporal

Phase1 CAGE Peaks

Hg19::chr2:73144617..73144654,+	p1@EMX1
Hg19::chr2:73144668..73144679,+	p5@EMX1
Hg19::chr2:73144683..73144697,+	p3@EMX1
Hg19::chr2:73144739..73144750,+	p4@EMX1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
neuronal stem cell	7.53e-13	8
neural cell	3.15e-12	25
neuron	2.82e-09	6
neuroblast	2.82e-09	6
electrically signaling cell	2.82e-09	6
astrocyte of the cerebral cortex	4.22e-07	3

Uber Anatomy

Ontology term	p-value	n
cerebral cortex	3.79e-50	25
pallium	3.79e-50	25
cerebral hemisphere	1.02e-44	32
telencephalon	1.28e-44	34
regional part of cerebral cortex	1.46e-44	22
regional part of telencephalon	4.43e-41	32
neocortex	5.91e-41	20
brain grey matter	2.96e-38	34
gray matter	2.96e-38	34
central nervous system	1.37e-36	81
regional part of forebrain	1.09e-35	41
forebrain	1.09e-35	41
anterior neural tube	1.09e-35	41
future forebrain	1.09e-35	41
nervous system	9.11e-32	89
brain	2.12e-26	68
future brain	2.12e-26	68
regional part of nervous system	8.25e-26	53
regional part of brain	8.25e-26	53
neural tube	5.34e-24	56
neural rod	5.34e-24	56
future spinal cord	5.34e-24	56
neural keel	5.34e-24	56
pre-chordal neural plate	4.63e-23	61
organ system subdivision	1.84e-16	223
neural plate	4.52e-15	82
presumptive neural plate	4.52e-15	82
neurectoderm	5.31e-14	86
gyrus	9.09e-14	6
ectoderm-derived structure	7.31e-13	171
ectoderm	7.31e-13	171
presumptive ectoderm	7.31e-13	171
occipital lobe	1.63e-12	5
ecto-epithelium	3.64e-12	104
parietal lobe	3.96e-12	5
temporal lobe	1.08e-11	6
limbic system	5.27e-11	5
adult organism	1.70e-09	114
structure with developmental contribution from neural crest	2.44e-09	132
anatomical cluster	3.19e-08	373
frontal cortex	1.07e-07	3

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F6#1876	4	5.01715573169739	0.0015780219347306	0.00998104607808436
JUND#3727	4	6.99466394187103	0.00041768421781858	0.00392112557525885
NFKB1#4790	4	5.48806342419384	0.00110219956630198	0.00768647305722571
SIN3A#25942	4	5.40888472681514	0.00116817238488516	0.00797455753350028
SP1#6667	4	5.6983813781409	0.000948260606533398	0.00685081554273254
SUZ12#23512	4	50.1157809110629	1.5827390373096e-07	8.8348306957551e-06
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0322795010561154
YY1#7528	4	4.91117074985386	0.0017187183805544	0.0106986070417643
ZEB1#6935	4	16.8884320175439	1.22862303393937e-05	0.000304933842779453

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.