MCL coexpression mm9:1589

Phase1 CAGE Peaks

	Short description
Mm9::chr11:87391886..87391972,+	p1@Sept4
Mm9::chr14:70930626..70930654,+	p2@Lgi3
Mm9::chr14:70930656..70930686,+	p1@Lgi3
Mm9::chr14:70930803..70930810,+	p4@Lgi3
Mm9::chr3:102538826..102538875,+	p2@Tspan2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030382	sperm mitochondrion organization and biogenesis	0.0167616121174166
GO:0048240	sperm capacitation	0.0167616121174166

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	1.07e-13	54
structure with developmental contribution from neural crest	1.09e-13	92
central nervous system	6.10e-13	73
tube	9.25e-13	114
anatomical conduit	1.17e-12	122
neural tube	1.56e-12	52
neural rod	1.56e-12	52
future spinal cord	1.56e-12	52
neural keel	1.56e-12	52
nervous system	1.66e-12	75
neurectoderm	5.48e-11	64
neural plate	5.48e-11	64
presumptive neural plate	5.48e-11	64
brain	1.78e-10	47
future brain	1.78e-10	47
regional part of brain	4.87e-10	46
ectoderm-derived structure	6.19e-10	95
ectoderm	6.19e-10	95
presumptive ectoderm	6.19e-10	95
ecto-epithelium	1.50e-09	73
multi-cellular organism	1.59e-09	333
lung	7.31e-09	14
respiratory tube	7.31e-09	14
respiration organ	7.31e-09	14
pair of lungs	7.31e-09	14
lung primordium	7.31e-09	14
lung bud	7.31e-09	14
epithelial bud	5.53e-08	17
anterior neural tube	8.92e-08	40
regional part of forebrain	2.66e-07	39
forebrain	2.66e-07	39
future forebrain	2.66e-07	39
epithelial fold	5.30e-07	20
pre-chordal neural plate	5.83e-07	49

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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