MCL coexpression mm9:1519

Phase1 CAGE Peaks

	Short description
Mm9::chr10:57857109..57857128,+	p2@Lims1
Mm9::chr10:57857129..57857143,+	p5@Lims1
Mm9::chr10:6979950..6980034,-	p1@Ppp1r14c
Mm9::chr10:87842901..87842925,-	p@chr10:87842901..87842925 -
Mm9::chr5:98459746..98459784,-	p7@Antxr2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004865	type 1 serine/threonine specific protein phosphatase inhibitor activity	0.0318987207226612
GO:0004864	protein phosphatase inhibitor activity	0.0318987207226612
GO:0019212	phosphatase inhibitor activity	0.0318987207226612
GO:0007163	establishment and/or maintenance of cell polarity	0.0318987207226612
GO:0005925	focal adhesion	0.0318987207226612
GO:0005924	cell-substrate adherens junction	0.0318987207226612
GO:0019888	protein phosphatase regulator activity	0.0318987207226612
GO:0030055	cell-matrix junction	0.0318987207226612
GO:0019208	phosphatase regulator activity	0.0318987207226612
GO:0005912	adherens junction	0.0440827641309891
GO:0007160	cell-matrix adhesion	0.0440827641309891
GO:0031589	cell-substrate adhesion	0.0440827641309891
GO:0016323	basolateral plasma membrane	0.0440827641309891

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
primary circulatory organ	2.35e-09	18
heart	2.35e-09	18
primitive heart tube	2.35e-09	18
primary heart field	2.35e-09	18
anterior lateral plate mesoderm	2.35e-09	18
heart tube	2.35e-09	18
heart primordium	2.35e-09	18
cardiac mesoderm	2.35e-09	18
cardiogenic plate	2.35e-09	18
heart rudiment	2.35e-09	18
multi-cellular organism	3.53e-09	333
lung	1.00e-08	14
respiratory tube	1.00e-08	14
respiration organ	1.00e-08	14
pair of lungs	1.00e-08	14
lung primordium	1.00e-08	14
lung bud	1.00e-08	14

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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