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|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002346!3.57e-31!64;UBERON:0003075!3.57e-31!64;UBERON:0007284!3.57e-31!64;UBERON:0003056!2.26e-28!49;UBERON:0010371!6.95e-26!73;UBERON:0004121!1.56e-25!95;UBERON:0000924!1.56e-25!95;UBERON:0006601!1.56e-25!95;UBERON:0000073!1.75e-21!54;UBERON:0001049!5.99e-21!52;UBERON:0005068!5.99e-21!52;UBERON:0006241!5.99e-21!52;UBERON:0007135!5.99e-21!52;UBERON:0000955!8.46e-21!47;UBERON:0006238!8.46e-21!47;UBERON:0001017!3.07e-20!73;UBERON:0002616!1.12e-19!46;UBERON:0001016!2.04e-19!75;UBERON:0010314!3.75e-18!92;UBERON:0003080!2.41e-16!40;UBERON:0000970!2.17e-15!9;UBERON:0000019!2.17e-15!9;UBERON:0000047!2.17e-15!9;UBERON:0010312!2.17e-15!9;UBERON:0004088!2.17e-15!9;UBERON:0002104!2.17e-15!9;UBERON:0001456!2.17e-15!9;UBERON:0003072!2.17e-15!9;UBERON:0004128!2.17e-15!9;UBERON:0003071!2.17e-15!9;UBERON:0002780!2.60e-15!39;UBERON:0001890!2.60e-15!39;UBERON:0006240!2.60e-15!39;UBERON:0001444!3.83e-12!11;UBERON:0000020!6.26e-11!12;UBERON:0001032!6.26e-11!12;UBERON:0004456!6.26e-11!12;UBERON:0000033!6.63e-10!13;UBERON:0005085!6.63e-10!13;UBERON:0002020!3.83e-09!34;UBERON:0003528!7.23e-09!29;UBERON:0002791!7.23e-09!29;UBERON:0001893!7.23e-09!29;UBERON:0001894!2.74e-08!10;UBERON:0006222!2.74e-08!10
|ontology_enrichment_uberon=UBERON:0002346!3.57e-31!64;UBERON:0003075!3.57e-31!64;UBERON:0007284!3.57e-31!64;UBERON:0003056!2.26e-28!49;UBERON:0010371!6.95e-26!73;UBERON:0004121!1.56e-25!95;UBERON:0000924!1.56e-25!95;UBERON:0006601!1.56e-25!95;UBERON:0000073!1.75e-21!54;UBERON:0001049!5.99e-21!52;UBERON:0005068!5.99e-21!52;UBERON:0006241!5.99e-21!52;UBERON:0007135!5.99e-21!52;UBERON:0000955!8.46e-21!47;UBERON:0006238!8.46e-21!47;UBERON:0001017!3.07e-20!73;UBERON:0002616!1.12e-19!46;UBERON:0001016!2.04e-19!75;UBERON:0010314!3.75e-18!92;UBERON:0003080!2.41e-16!40;UBERON:0000970!2.17e-15!9;UBERON:0000019!2.17e-15!9;UBERON:0000047!2.17e-15!9;UBERON:0010312!2.17e-15!9;UBERON:0004088!2.17e-15!9;UBERON:0002104!2.17e-15!9;UBERON:0001456!2.17e-15!9;UBERON:0003072!2.17e-15!9;UBERON:0004128!2.17e-15!9;UBERON:0003071!2.17e-15!9;UBERON:0002780!2.60e-15!39;UBERON:0001890!2.60e-15!39;UBERON:0006240!2.60e-15!39;UBERON:0001444!3.83e-12!11;UBERON:0000020!6.26e-11!12;UBERON:0001032!6.26e-11!12;UBERON:0004456!6.26e-11!12;UBERON:0000033!6.63e-10!13;UBERON:0005085!6.63e-10!13;UBERON:0002020!3.83e-09!34;UBERON:0003528!7.23e-09!29;UBERON:0002791!7.23e-09!29;UBERON:0001893!7.23e-09!29;UBERON:0001894!2.74e-08!10;UBERON:0006222!2.74e-08!10
|tfbs_overrepresentation_for_novel_motifs=0.149902,0.327473,0.415689,1.01095,0.531164,0.551286,0.708527,0.308279,0.596432,0.0966197,0.631542,0.687282,0.564861,0.264234,1.44548,0,0.42315,0.511529,0.514215,0.245228,0.111207,0.0677113,0.728683,0.900615,0.427698,0.285776,0.782488,0.202945,0.313062,0.353285,0.192916,0.512187,1.3105,0.424507,0.272437,2.09107,0.222359,0.680922,0.194199,2.46941,0.0689912,0.196576,0.617892,0.274585,0.0590634,0.170437,0.935739,0.614044,0.190171,0.653986,0.408111,0.828085,0.167462,0.641205,0.657376,0.269785,0.330626,0.664869,0.242162,0.739389,0.494318,0.314847,0.637374,0.398468,0.278491,0.433342,0.785371,1.12243,0.490165,2.24371,0.12178,0.58423,0.167713,0.6886,0.0918517,0.018158,0.0199002,0.346003,0.479091,0.364953,1.32755,0.438213,0.842599,0.0300873,0.582029,0.0422746,0.697707,0.590279,1.68475,1.2816,0.851763,0.586575,0.523661,0.0737837,0.0506699,0.380698,0.127918,0.526183,0.355664,0.498538,0.061865,0.511936,1.51382,0.408622,1.85099,0.570967,0.459578,0.607107,1.22812,0.361235,0.875636,0.626748,0.366686,0.640523,0.858505,1.33236,0.14458,0.533284,0.424276,0.0601654,0.693645,0.380657,0.287218,0.345253,0.910454,0.482363,1.33126,0.517583,0.783932,0.939532,0.609469,0.5148,0.75595,0.280468,2.03941,0.149536,0.471259,0.197578,0.832159,1.64606,1.25025,0.789841,0.296788,0.521565,0.402166,0.572489,0.358053,1.60668,2.12104,0.0717633,0.360841,0.130124,0.642658,0.0459937,0.27974,0.718834,0.30804,0.603495,0.888165,0.470802,0.841238,0.581248,0.482758,2.01823,0.39934,0.273933,0.0613242,0.684489,0.0148726
}}
}}

Revision as of 18:18, 26 November 2012


Phase1 CAGE Peaks

 Short description
Mm9::chr12:45540065..45540076,+p9@Nrcam
Mm9::chr13:54431398..54431402,+p@chr13:54431398..54431402
+
Mm9::chr13:54467800..54467801,+p@chr13:54467800..54467801
+
Mm9::chr14:122874424..122874441,-p1@2610035F20Rik
Mm9::chr14:65208698..65208735,+p3@ENSMUST00000164162
Mm9::chr16:16560211..16560238,-p6@Fgd4
Mm9::chr16:16560239..16560290,-p3@Fgd4
Mm9::chr16:16560294..16560316,-p4@Fgd4
Mm9::chr17:26088998..26089027,-p1@ENSMUST00000162431
p1@uc008bcv.1
Mm9::chr2:105514700..105514715,+p13@Pax6
Mm9::chr2:79231715..79231718,-p6@Cerkl
Mm9::chr2:79292080..79292119,-p@chr2:79292080..79292119
-
Mm9::chr2:79294073..79294117,-p@chr2:79294073..79294117
-
Mm9::chr2:79294856..79294867,-p@chr2:79294856..79294867
-
Mm9::chr2:79295107..79295119,-p@chr2:79295107..79295119
-
Mm9::chr2:79296458..79296461,-p@chr2:79296458..79296461
-
Mm9::chr2:79296783..79296801,-p1@Neurod1
Mm9::chr2:79296907..79296918,-p2@Neurod1
Mm9::chr6:104443214..104443224,+p10@Cntn6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0007417central nervous system development0.00179441931292426
GO:0032990cell part morphogenesis0.00179441931292426
GO:0048858cell projection morphogenesis0.00179441931292426
GO:0030030cell projection organization and biogenesis0.00179441931292426
GO:0000902cell morphogenesis0.00543333884663067
GO:0032989cellular structure morphogenesis0.00543333884663067
GO:0043010camera-type eye development0.00543333884663067
GO:0007411axon guidance0.00543333884663067
GO:0009952anterior/posterior pattern formation0.00579654942489049
GO:0021902commitment of a neuronal cell to a specific type of neuron in the forebrain0.00579654942489049
GO:0021877forebrain neuron fate commitment0.00579654942489049
GO:0045165cell fate commitment0.00579654942489049
GO:0001654eye development0.00579654942489049
GO:0007399nervous system development0.00621337240759742
GO:0048856anatomical structure development0.00854992126284358
GO:0003002regionalization0.00939158937203724
GO:0007409axonogenesis0.00969655818258358
GO:0048667neuron morphogenesis during differentiation0.00971344345791167
GO:0048812neurite morphogenesis0.00971344345791167
GO:0019227action potential propagation0.00973599120688521
GO:0007420brain development0.00995764535848094
GO:0000904cellular morphogenesis during differentiation0.00995764535848094
GO:0007423sensory organ development0.00995764535848094
GO:0009950dorsal/ventral axis specification0.00995764535848094
GO:0021798forebrain dorsal/ventral pattern formation0.00995764535848094
GO:0031175neurite development0.00995764535848094
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.00995764535848094
GO:0005515protein binding0.0100964278780441
GO:0048666neuron development0.0113321223092617
GO:0007389pattern specification process0.0114503423936315
GO:0045893positive regulation of transcription, DNA-dependent0.0114503423936315
GO:0022612gland morphogenesis0.0114503423936315
GO:0021871forebrain regionalization0.0114503423936315
GO:0007435salivary gland morphogenesis0.0114503423936315
GO:0021879forebrain neuron differentiation0.0129756327257196
GO:0009653anatomical structure morphogenesis0.0134212707117066
GO:0016477cell migration0.0135297673807931
GO:0021872generation of neurons in the forebrain0.0135297673807931
GO:0030182neuron differentiation0.0135297673807931
GO:0045941positive regulation of transcription0.0135699617528827
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0137588549566502
GO:0032502developmental process0.0137588549566502
GO:0030035microspike biogenesis0.0147401905676848
GO:0007257activation of JNK activity0.0147401905676848
GO:0048699generation of neurons0.0149698395928933
GO:0043507positive regulation of JNK activity0.0149698395928933
GO:0006928cell motility0.0149698395928933
GO:0051674localization of cell0.0149698395928933
GO:0007431salivary gland development0.0156176295143254
GO:0022008neurogenesis0.0156176295143254
GO:0031325positive regulation of cellular metabolic process0.0161895943822009
GO:0030175filopodium0.0161895943822009
GO:0042995cell projection0.0161895943822009
GO:0021543pallium development0.0161895943822009
GO:0035272exocrine system development0.0161895943822009
GO:0042462eye photoreceptor cell development0.0161895943822009
GO:0009893positive regulation of metabolic process0.0161895943822009
GO:0043506regulation of JNK activity0.0163791565715026
GO:0030032lamellipodium biogenesis0.0163791565715026
GO:0006357regulation of transcription from RNA polymerase II promoter0.0163791565715026
GO:0045665negative regulation of neuron differentiation0.0167262475532054
GO:0001754eye photoreceptor cell differentiation0.0167262475532054
GO:0009798axis specification0.0172143878295004
GO:0042461photoreceptor cell development0.0172143878295004
GO:0021983pituitary gland development0.0179446169784669
GO:0006366transcription from RNA polymerase II promoter0.0181984630979
GO:0021536diencephalon development0.0193390463751049
GO:0048663neuron fate commitment0.0197152584466631
GO:0046530photoreceptor cell differentiation0.0197152584466631
GO:0048731system development0.0209800527282815
GO:0021537telencephalon development0.0209800527282815
GO:0001709cell fate determination0.0215107127193711
GO:0048869cellular developmental process0.0215107127193711
GO:0030154cell differentiation0.0215107127193711
GO:0045664regulation of neuron differentiation0.0233050062515438
GO:0022610biological adhesion0.0298487604054241
GO:0007155cell adhesion0.0298487604054241
GO:0000187activation of MAPK activity0.0298487604054241
GO:0043406positive regulation of MAP kinase activity0.0334792427771437
GO:0030902hindbrain development0.0334792427771437
GO:0007254JNK cascade0.0334792427771437
GO:0009953dorsal/ventral pattern formation0.0334792427771437
GO:0048592eye morphogenesis0.0334792427771437
GO:0050767regulation of neurogenesis0.0346117301328483
GO:0031098stress-activated protein kinase signaling pathway0.0349608027389977
GO:0030031cell projection biogenesis0.0355554181013376
GO:0035270endocrine system development0.0355554181013376
GO:0007275multicellular organismal development0.0355554181013376
GO:0030027lamellipodium0.0355554181013376
GO:0007219Notch signaling pathway0.0358739848435849
GO:0030334regulation of cell migration0.0367876692441853
GO:0048522positive regulation of cellular process0.0367876692441853
GO:0005089Rho guanyl-nucleotide exchange factor activity0.0367876692441853
GO:0001764neuron migration0.0377614798551938
GO:0035023regulation of Rho protein signal transduction0.0380391672205281
GO:0005088Ras guanyl-nucleotide exchange factor activity0.039237748839414
GO:0051270regulation of cell motility0.039237748839414
GO:0043405regulation of MAP kinase activity0.0394912962577309
GO:0016043cellular component organization and biogenesis0.0398863744207733
GO:0030424axon0.0399827555688522
GO:0040012regulation of locomotion0.0402209771220318
GO:0048518positive regulation of biological process0.0437803629891882
GO:0048732gland development0.0462705259130253
GO:0031252leading edge0.0470538335527206
GO:0007266Rho protein signal transduction0.0490371344115926



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
CNS neuron (sensu Vertebrata)1.38e-1023
neuroblast (sensu Vertebrata)1.38e-1023

Uber Anatomy
Ontology termp-valuen
neurectoderm3.57e-3164
neural plate3.57e-3164
presumptive neural plate3.57e-3164
pre-chordal neural plate2.26e-2849
ecto-epithelium6.95e-2673
ectoderm-derived structure1.56e-2595
ectoderm1.56e-2595
presumptive ectoderm1.56e-2595
regional part of nervous system1.75e-2154
neural tube5.99e-2152
neural rod5.99e-2152
future spinal cord5.99e-2152
neural keel5.99e-2152
brain8.46e-2147
future brain8.46e-2147
central nervous system3.07e-2073
regional part of brain1.12e-1946
nervous system2.04e-1975
structure with developmental contribution from neural crest3.75e-1892
anterior neural tube2.41e-1640
eye2.17e-159
camera-type eye2.17e-159
simple eye2.17e-159
immature eye2.17e-159
ocular region2.17e-159
visual system2.17e-159
face2.17e-159
optic cup2.17e-159
optic vesicle2.17e-159
eye primordium2.17e-159
regional part of forebrain2.60e-1539
forebrain2.60e-1539
future forebrain2.60e-1539
subdivision of head3.83e-1211
sense organ6.26e-1112
sensory system6.26e-1112
entire sense organ system6.26e-1112
head6.63e-1013
ectodermal placode6.63e-1013
gray matter3.83e-0934
brain grey matter7.23e-0929
regional part of telencephalon7.23e-0929
telencephalon7.23e-0929
diencephalon2.74e-0810
future diencephalon2.74e-0810


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}