MCL coexpression mm9:568

Phase1 CAGE Peaks

	Short description
Mm9::chr12:111326146..111326190,-	p@chr12:111326146..111326190 -
Mm9::chr13:54891345..54891350,+	p@chr13:54891345..54891350 +
Mm9::chr15:43002727..43002745,-	p5@Rspo2
Mm9::chr16:25865862..25865871,+	p8@Trp63
Mm9::chr16:25865901..25865908,+	p@chr16:25865901..25865908 +
Mm9::chr18:52718847..52718852,+	p@chr18:52718847..52718852 +
Mm9::chr2:24192402..24192413,+	p6@Il1rn
Mm9::chr2:24192424..24192445,+	p3@Il1rn
Mm9::chr2:24192453..24192465,+	p5@Il1rn
Mm9::chr2:46298201..46298233,-	p1@ENSMUST00000123911
Mm9::chr3:83578591..83578595,-	p@chr3:83578591..83578595 -
Mm9::chr6:117124183..117124190,+	p@chr6:117124183..117124190 +
Mm9::chr8:113861783..113861814,-	p2@Mlkl

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0060157	urinary bladder development	0.0227907741193229
GO:0007499	ectoderm and mesoderm interaction	0.0227907741193229
GO:0030353	fibroblast growth factor receptor antagonist activity	0.0256227681126851
GO:0005152	interleukin-1 receptor antagonist activity	0.0256227681126851
GO:0048745	smooth muscle development	0.0256227681126851
GO:0048019	receptor antagonist activity	0.0256227681126851
GO:0030547	receptor inhibitor activity	0.0256227681126851
GO:0030859	polarized epithelial cell differentiation	0.0256227681126851
GO:0001736	establishment of planar polarity	0.0256227681126851
GO:0007164	establishment of tissue polarity	0.0256227681126851
GO:0002347	response to tumor cell	0.0256227681126851
GO:0030545	receptor regulator activity	0.0256227681126851
GO:0007267	cell-cell signaling	0.0256227681126851
GO:0010464	regulation of mesenchymal cell proliferation	0.0256227681126851
GO:0002053	positive regulation of mesenchymal cell proliferation	0.0256227681126851
GO:0010463	mesenchymal cell proliferation	0.0256227681126851
GO:0001738	morphogenesis of a polarized epithelium	0.0294697120049581
GO:0005149	interleukin-1 receptor binding	0.0303602380595734
GO:0030308	negative regulation of cell growth	0.031156630686983
GO:0031069	hair follicle morphogenesis	0.0318730099422934
GO:0045792	negative regulation of cell size	0.039307685169038
GO:0005104	fibroblast growth factor receptor binding	0.039307685169038
GO:0030216	keratinocyte differentiation	0.0436033990801299
GO:0030073	insulin secretion	0.0436033990801299
GO:0045926	negative regulation of growth	0.0440452218976995
GO:0004672	protein kinase activity	0.0440452218976995
GO:0006468	protein amino acid phosphorylation	0.0454767631410165
GO:0030072	peptide hormone secretion	0.0454767631410165
GO:0002790	peptide secretion	0.0454767631410165
GO:0016773	phosphotransferase activity, alcohol group as acceptor	0.0465059855234204
GO:0016310	phosphorylation	0.0465059855234204
GO:0042475	odontogenesis of dentine-containing teeth	0.0465059855234204
GO:0030855	epithelial cell differentiation	0.0465059855234204
GO:0042476	odontogenesis	0.0465059855234204
GO:0015833	peptide transport	0.0465059855234204
GO:0022404	molting cycle process	0.0465059855234204
GO:0001942	hair follicle development	0.0465059855234204
GO:0022405	hair cycle process	0.0465059855234204
GO:0007166	cell surface receptor linked signal transduction	0.0465059855234204
GO:0046879	hormone secretion	0.0465059855234204
GO:0042633	hair cycle	0.0465059855234204
GO:0042303	molting cycle	0.0465059855234204
GO:0006793	phosphorus metabolic process	0.0482960797623162
GO:0006796	phosphate metabolic process	0.0482960797623162
GO:0007498	mesoderm development	0.0482960797623162
GO:0048730	epidermis morphogenesis	0.0482960797623162
GO:0007219	Notch signaling pathway	0.0482960797623162

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
smooth muscle cell	8.11e-12	3
vascular associated smooth muscle cell	8.11e-12	3
aortic smooth muscle cell	8.11e-12	3
smooth muscle myoblast	8.11e-12	3

Uber Anatomy

Ontology term	p-value	n
smooth muscle tissue	8.11e-12	3
blood vessel smooth muscle	8.11e-12	3
arterial system smooth muscle	8.11e-12	3
artery smooth muscle tissue	8.11e-12	3
aorta smooth muscle tissue	8.11e-12	3
zone of skin	1.38e-11	5
skin epidermis	1.38e-11	5
skin of body	1.38e-11	5
integument	1.38e-11	5
surface	1.38e-11	5
outer epithelium	1.38e-11	5
integumental system	1.38e-11	5
enveloping layer of ectoderm	1.38e-11	5
aorta	5.64e-09	4
artery	5.64e-09	4
systemic artery	5.64e-09	4
arterial blood vessel	5.64e-09	4
systemic arterial system	5.64e-09	4
aortic system	5.64e-09	4
arterial system	5.64e-09	4
vessel	2.92e-07	5
epithelial tube open at both ends	2.92e-07	5
blood vessel	2.92e-07	5
vasculature	2.92e-07	5
vascular system	2.92e-07	5
blood vasculature	2.92e-07	5
vascular cord	2.92e-07	5

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}