MCL coexpression mm9:865

Phase1 CAGE Peaks

	Short description
Mm9::chr10:57834341..57834352,+	p@chr10:57834341..57834352 +
Mm9::chr10:57834358..57834375,+	p@chr10:57834358..57834375 +
Mm9::chr16:95479917..95479940,+	p7@Kcnj15
Mm9::chr16:95479946..95479978,+	p3@Kcnj15
Mm9::chr16:95479979..95480004,+	p8@Kcnj15
Mm9::chr16:95481305..95481317,-	p2@uc008abr.1
Mm9::chr6:125271351..125271378,+	p1@Scnn1a
Mm9::chr9:62345663..62345675,-	p@chr9:62345663..62345675 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0031420	alkali metal ion binding	0.00925754197162571
GO:0005261	cation channel activity	0.00925754197162571
GO:0022836	gated channel activity	0.00925754197162571
GO:0046873	metal ion transmembrane transporter activity	0.00925754197162571
GO:0015672	monovalent inorganic cation transport	0.00925754197162571
GO:0005216	ion channel activity	0.00925754197162571
GO:0022838	substrate specific channel activity	0.00925754197162571
GO:0015280	amiloride-sensitive sodium channel activity	0.00925754197162571
GO:0022803	passive transmembrane transporter activity	0.00925754197162571
GO:0015267	channel activity	0.00925754197162571
GO:0030001	metal ion transport	0.00925754197162571
GO:0008324	cation transmembrane transporter activity	0.0108821324932122
GO:0006812	cation transport	0.0108821324932122
GO:0005242	inward rectifier potassium channel activity	0.0124822025107478
GO:0015075	ion transmembrane transporter activity	0.0169669351270431
GO:0007163	establishment and/or maintenance of cell polarity	0.0169669351270431
GO:0006811	ion transport	0.0169669351270431
GO:0005272	sodium channel activity	0.0169669351270431
GO:0005925	focal adhesion	0.0169669351270431
GO:0022891	substrate-specific transmembrane transporter activity	0.0169669351270431
GO:0005924	cell-substrate adherens junction	0.0178595483766892
GO:0043169	cation binding	0.0178595483766892
GO:0030055	cell-matrix junction	0.0188918977019955
GO:0022857	transmembrane transporter activity	0.0188918977019955
GO:0046872	metal ion binding	0.0195826589729386
GO:0043167	ion binding	0.0195826589729386
GO:0022892	substrate-specific transporter activity	0.0195826589729386
GO:0050909	sensory perception of taste	0.0195826589729386
GO:0005912	adherens junction	0.0261422989106417
GO:0007160	cell-matrix adhesion	0.0261422989106417
GO:0031589	cell-substrate adhesion	0.0268993818387301
GO:0016323	basolateral plasma membrane	0.0272211068508857
GO:0031402	sodium ion binding	0.0286697266025328
GO:0005249	voltage-gated potassium channel activity	0.0286697266025328
GO:0015276	ligand-gated ion channel activity	0.0286697266025328
GO:0022834	ligand-gated channel activity	0.0286697266025328
GO:0030955	potassium ion binding	0.0365924190780974
GO:0006814	sodium ion transport	0.0365924190780974
GO:0022843	voltage-gated cation channel activity	0.036919405717662
GO:0005267	potassium channel activity	0.0378458342033089
GO:0006813	potassium ion transport	0.0462260026767222
GO:0022832	voltage-gated channel activity	0.0480720549348637
GO:0005244	voltage-gated ion channel activity	0.0480720549348637

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
respiratory system	4.08e-12	42
respiratory tract	1.64e-11	41
lung	1.26e-09	14
respiratory tube	1.26e-09	14
respiration organ	1.26e-09	14
pair of lungs	1.26e-09	14
lung primordium	1.26e-09	14
lung bud	1.26e-09	14
epithelial bud	2.85e-09	17
foregut	5.86e-09	80
thoracic cavity element	3.56e-07	17
thoracic segment organ	3.56e-07	17
thoracic cavity	3.56e-07	17
thoracic segment of trunk	3.56e-07	17
respiratory primordium	3.56e-07	17
endoderm of foregut	3.56e-07	17
epithelial fold	3.61e-07	20

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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