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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.420797993194653,0

Latest revision as of 14:14, 17 September 2013


Full id: C4516_occipital_duodenum_temporal_Adipocyte_parietal_medial_mixed



Phase1 CAGE Peaks

Hg19::chr5:71504086..71504091,+p31@MAP1B
Hg19::chr5:71504109..71504117,+p28@MAP1B
Hg19::chr8:80567172..80567190,+p5@STMN2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0030182neuron differentiation0.00163934058036349
GO:0048699generation of neurons0.00163934058036349
GO:0022008neurogenesis0.00163934058036349
GO:0001578microtubule bundle formation0.00736372744328584
GO:0007399nervous system development0.00736372744328584
GO:0016358dendrite development0.00864232922638426
GO:0030426growth cone0.00864232922638426
GO:0030427site of polarized growth0.00864232922638426
GO:0007026negative regulation of microtubule depolymerization0.00864232922638426
GO:0031114regulation of microtubule depolymerization0.00864232922638426
GO:0048468cell development0.00864232922638426
GO:0007019microtubule depolymerization0.00864232922638426
GO:0031111negative regulation of microtubule polymerization or depolymerization0.00864232922638426
GO:0031110regulation of microtubule polymerization or depolymerization0.010117609612396
GO:0031109microtubule polymerization or depolymerization0.0104195146702293
GO:0048731system development0.011571990372739
GO:0051261protein depolymerization0.0123940198225719
GO:0048869cellular developmental process0.0123940198225719
GO:0030154cell differentiation0.0123940198225719
GO:0051129negative regulation of cellular component organization and biogenesis0.0126950436732381
GO:0048856anatomical structure development0.0137607290947746
GO:0007275multicellular organismal development0.017270899636267
GO:0051128regulation of cellular component organization and biogenesis0.0202965121797894
GO:0000226microtubule cytoskeleton organization and biogenesis0.0202965121797894
GO:0051248negative regulation of protein metabolic process0.0202965121797894
GO:0031175neurite development0.0253215333655514
GO:0048666neuron development0.0278076846485725
GO:0032502developmental process0.0287655222530471
GO:0005875microtubule associated complex0.0302493312433866
GO:0032990cell part morphogenesis0.0310575802307371
GO:0030030cell projection organization and biogenesis0.0310575802307371
GO:0048858cell projection morphogenesis0.0310575802307371
GO:0032501multicellular organismal process0.0318274926238275
GO:0005625soluble fraction0.0335144414387489
GO:0005874microtubule0.0414079775642464
GO:0042995cell projection0.0414079775642464
GO:0007017microtubule-based process0.0414079775642464



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
fibroblast3.03e-1376
skin fibroblast2.27e-0823
Uber Anatomy
Ontology termp-valuen
nervous system1.20e-2189
central nervous system5.94e-2181
neural tube3.42e-2056
neural rod3.42e-2056
future spinal cord3.42e-2056
neural keel3.42e-2056
regional part of nervous system1.52e-1953
regional part of brain1.52e-1953
brain grey matter1.99e-1834
gray matter1.99e-1834
brain2.67e-1868
future brain2.67e-1868
regional part of forebrain4.76e-1841
forebrain4.76e-1841
anterior neural tube4.76e-1841
future forebrain4.76e-1841
telencephalon8.20e-1834
regional part of telencephalon3.30e-1732
cerebral hemisphere3.64e-1732
neural plate1.63e-1582
presumptive neural plate1.63e-1582
cerebral cortex2.77e-1425
pallium2.77e-1425
neurectoderm5.96e-1486
pre-chordal neural plate1.11e-1361
structure with developmental contribution from neural crest2.45e-12132
regional part of cerebral cortex3.95e-1222
neocortex5.71e-1120
ecto-epithelium6.02e-11104
ectoderm-derived structure4.37e-10171
ectoderm4.37e-10171
presumptive ectoderm4.37e-10171
tube1.04e-07192


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.11.97353
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.21.20011
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.00160703
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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