Coexpression cluster:C351

Full id: C351_Fibroblast_Smooth_mesenchymal_Adipocyte_tenocyte_Synoviocyte_Hair

Phase1 CAGE Peaks

Hg19::chr14:75070388..75070409,-	p@chr14:75070388..75070409 -
Hg19::chr16:4431001..4431014,+	p4@VASN
Hg19::chr16:55513074..55513088,+	p2@MMP2
Hg19::chr16:55513101..55513124,+	p1@MMP2
Hg19::chr16:55516814..55516833,+	p@chr16:55516814..55516833 +
Hg19::chr16:55516984..55517009,+	p@chr16:55516984..55517009 +
Hg19::chr16:55519282..55519295,+	p@chr16:55519282..55519295 +
Hg19::chr16:55519314..55519342,-	p@chr16:55519314..55519342 -
Hg19::chr16:55519541..55519560,+	p@chr16:55519541..55519560 +
Hg19::chr16:55519569..55519597,+	p@chr16:55519569..55519597 +
Hg19::chr16:55519605..55519627,+	p@chr16:55519605..55519627 +
Hg19::chr16:55522512..55522527,+	p6@MMP2
Hg19::chr16:55522536..55522599,+	p4@MMP2
Hg19::chr16:55523690..55523729,-	p@chr16:55523690..55523729 -
Hg19::chr16:55525707..55525728,+	p@chr16:55525707..55525728 +
Hg19::chr16:55525755..55525774,+	p@chr16:55525755..55525774 +
Hg19::chr16:55525781..55525812,+	p@chr16:55525781..55525812 +
Hg19::chr16:55527062..55527078,+	p7@MMP2
Hg19::chr16:55527084..55527124,+	p5@MMP2
Hg19::chr16:55532232..55532249,+	p@chr16:55532232..55532249 +
Hg19::chr16:55536741..55536782,+	p@chr16:55536741..55536782 +
Hg19::chr16:55539240..55539261,+	p@chr16:55539240..55539261 +
Hg19::chr16:55539265..55539280,+	p@chr16:55539265..55539280 +
Hg19::chr16:55539338..55539366,+	p@chr16:55539338..55539366 +
Hg19::chr16:55539371..55539383,+	p@chr16:55539371..55539383 +
Hg19::chr16:55539430..55539443,+	p@chr16:55539430..55539443 +
Hg19::chr16:55539539..55539552,+	p@chr16:55539539..55539552 +
Hg19::chr16:55539559..55539581,+	p@chr16:55539559..55539581 +
Hg19::chr16:55539785..55539877,+	p@chr16:55539785..55539877 +
Hg19::chr16:55539883..55539894,+	p@chr16:55539883..55539894 +
Hg19::chr16:55539899..55539914,+	p@chr16:55539899..55539914 +
Hg19::chr16:55540311..55540323,+	p@chr16:55540311..55540323 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001955	blood vessel maturation	0.00182503237960673
GO:0004228	gelatinase A activity	0.00182503237960673
GO:0030574	collagen catabolic process	0.00762948231814427
GO:0044256	protein digestion	0.00762948231814427
GO:0044254	multicellular organismal protein catabolic process	0.00762948231814427
GO:0044266	multicellular organismal macromolecule catabolic process	0.00762948231814427
GO:0044259	multicellular organismal macromolecule metabolic process	0.00762948231814427
GO:0044268	multicellular organismal protein metabolic process	0.00762948231814427
GO:0032963	collagen metabolic process	0.00762948231814427
GO:0044243	multicellular organismal catabolic process	0.00762948231814427
GO:0044236	multicellular organismal metabolic process	0.00762948231814427
GO:0030017	sarcomere	0.0138075264980836
GO:0021700	developmental maturation	0.0138075264980836
GO:0030016	myofibril	0.0138075264980836
GO:0044449	contractile fiber part	0.014586720778938
GO:0043292	contractile fiber	0.014586720778938
GO:0007586	digestion	0.0203692002083057
GO:0001568	blood vessel development	0.031812593175251
GO:0001944	vasculature development	0.031812593175251
GO:0004222	metalloendopeptidase activity	0.0360308646701287

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	2.31e-42	180
fibroblast	3.19e-19	75
muscle precursor cell	2.35e-18	57
myoblast	2.35e-18	57
multi-potent skeletal muscle stem cell	2.35e-18	57
contractile cell	1.67e-17	59
muscle cell	5.11e-17	54
electrically responsive cell	6.88e-16	60
electrically active cell	6.88e-16	60
mesodermal cell	1.25e-15	119
smooth muscle cell	2.47e-15	42
smooth muscle myoblast	2.47e-15	42
vascular associated smooth muscle cell	5.94e-12	32
embryonic cell	1.10e-11	248
skin fibroblast	7.55e-08	23
preadipocyte	1.20e-07	12
somatic cell	3.91e-07	591

Uber Anatomy

Ontology term	p-value	n
somite	7.14e-21	83
paraxial mesoderm	7.14e-21	83
presomitic mesoderm	7.14e-21	83
presumptive segmental plate	7.14e-21	83
trunk paraxial mesoderm	7.14e-21	83
presumptive paraxial mesoderm	7.14e-21	83
multilaminar epithelium	3.62e-20	82
dermomyotome	7.96e-20	70
splanchnic layer of lateral plate mesoderm	2.98e-19	84
muscle tissue	1.13e-18	63
musculature	1.13e-18	63
musculature of body	1.13e-18	63
skeletal muscle tissue	1.27e-18	61
striated muscle tissue	1.27e-18	61
myotome	1.27e-18	61
blood vessel	5.02e-16	60
epithelial tube open at both ends	5.02e-16	60
blood vasculature	5.02e-16	60
vascular cord	5.02e-16	60
trunk mesenchyme	5.17e-16	143
vasculature	5.21e-16	79
vascular system	5.21e-16	79
artery	4.16e-15	42
arterial blood vessel	4.16e-15	42
arterial system	4.16e-15	42
vessel	3.77e-14	69
systemic artery	5.13e-13	33
systemic arterial system	5.13e-13	33
epithelial tube	7.62e-13	118
organism subdivision	1.31e-12	365
multi-cellular organism	1.46e-12	659
unilaminar epithelium	1.95e-12	138
trunk	9.09e-12	216
circulatory system	3.42e-11	113
cardiovascular system	5.21e-11	110
surface structure	6.69e-10	95
cell layer	1.81e-09	312
epithelium	2.12e-09	309
integument	2.90e-09	45
integumental system	2.90e-09	45
aorta	3.73e-09	21
aortic system	3.73e-09	21
anatomical system	5.01e-09	625
anatomical group	8.88e-09	626
heart	2.63e-07	24
primitive heart tube	2.63e-07	24
primary heart field	2.63e-07	24
anterior lateral plate mesoderm	2.63e-07	24
heart tube	2.63e-07	24
heart primordium	2.63e-07	24
cardiac mesoderm	2.63e-07	24
cardiogenic plate	2.63e-07	24
heart rudiment	2.63e-07	24
primary circulatory organ	2.80e-07	27
skin of body	3.15e-07	40
smooth muscle tissue	3.38e-07	15

Disease

Ontology term	p-value	n
ovarian cancer	7.08e-07	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.