Coexpression cluster:C385
From FANTOM5_SSTAR
Full id: C385_Mesenchymal_Alveolar_Osteoblast_Smooth_Renal_Placental_Fibroblast
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0005739 | mitochondrion | 0.00620645344517677 |
GO:0005737 | cytoplasm | 0.00761501180775182 |
GO:0044444 | cytoplasmic part | 0.00761501180775182 |
GO:0006915 | apoptosis | 0.00761501180775182 |
GO:0012501 | programmed cell death | 0.00761501180775182 |
GO:0016265 | death | 0.00761501180775182 |
GO:0008219 | cell death | 0.00761501180775182 |
GO:0043231 | intracellular membrane-bound organelle | 0.00772619952853591 |
GO:0043227 | membrane-bound organelle | 0.00772619952853591 |
GO:0044429 | mitochondrial part | 0.012211775933763 |
GO:0010269 | response to selenium ion | 0.0180924827404877 |
GO:0048468 | cell development | 0.0180924827404877 |
GO:0004601 | peroxidase activity | 0.0180924827404877 |
GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | 0.0180924827404877 |
GO:0005741 | mitochondrial outer membrane | 0.019637546591411 |
GO:0033598 | mammary gland epithelial cell proliferation | 0.019637546591411 |
GO:0008539 | proteasome inhibitor activity | 0.019637546591411 |
GO:0033599 | regulation of mammary gland epithelial cell proliferation | 0.019637546591411 |
GO:0008969 | phosphohistidine phosphatase activity | 0.019637546591411 |
GO:0008632 | apoptotic program | 0.019637546591411 |
GO:0007005 | mitochondrion organization and biogenesis | 0.019637546591411 |
GO:0031968 | organelle outer membrane | 0.019637546591411 |
GO:0019867 | outer membrane | 0.019637546591411 |
GO:0044424 | intracellular part | 0.019637546591411 |
GO:0042579 | microbody | 0.019637546591411 |
GO:0005777 | peroxisome | 0.019637546591411 |
GO:0031966 | mitochondrial membrane | 0.019637546591411 |
GO:0043295 | glutathione binding | 0.019637546591411 |
GO:0017057 | 6-phosphogluconolactonase activity | 0.019637546591411 |
GO:0000266 | mitochondrial fission | 0.019637546591411 |
GO:0019307 | mannose biosynthetic process | 0.019637546591411 |
GO:0004615 | phosphomannomutase activity | 0.019637546591411 |
GO:0005740 | mitochondrial envelope | 0.021381196836168 |
GO:0006979 | response to oxidative stress | 0.0226387669961546 |
GO:0044455 | mitochondrial membrane part | 0.0226387669961546 |
GO:0008631 | induction of apoptosis by oxidative stress | 0.0226387669961546 |
GO:0031307 | integral to mitochondrial outer membrane | 0.0226387669961546 |
GO:0031306 | intrinsic to mitochondrial outer membrane | 0.0272464569702817 |
GO:0043229 | intracellular organelle | 0.0272464569702817 |
GO:0043226 | organelle | 0.0272464569702817 |
GO:0048869 | cellular developmental process | 0.0272988937719487 |
GO:0030154 | cell differentiation | 0.0272988937719487 |
GO:0009650 | UV protection | 0.0272988937719487 |
GO:0016559 | peroxisome fission | 0.0272988937719487 |
GO:0051920 | peroxiredoxin activity | 0.0272988937719487 |
GO:0032592 | integral to mitochondrial membrane | 0.0272988937719487 |
GO:0048285 | organelle fission | 0.034862420969153 |
GO:0030503 | regulation of cell redox homeostasis | 0.034862420969153 |
GO:0043154 | negative regulation of caspase activity | 0.0384090722914862 |
GO:0031967 | organelle envelope | 0.0388818993684594 |
GO:0031975 | envelope | 0.0388818993684594 |
GO:0006368 | RNA elongation from RNA polymerase II promoter | 0.0402033875658268 |
GO:0006917 | induction of apoptosis | 0.0431027183745183 |
GO:0012502 | induction of programmed cell death | 0.0431027183745183 |
GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | 0.0431027183745183 |
GO:0042744 | hydrogen peroxide catabolic process | 0.0431027183745183 |
GO:0044446 | intracellular organelle part | 0.0431027183745183 |
GO:0044422 | organelle part | 0.0431027183745183 |
GO:0005794 | Golgi apparatus | 0.0431027183745183 |
GO:0001836 | release of cytochrome c from mitochondria | 0.0431027183745183 |
GO:0006740 | NADPH regeneration | 0.0431027183745183 |
GO:0006098 | pentose-phosphate shunt | 0.0431027183745183 |
GO:0042743 | hydrogen peroxide metabolic process | 0.0431027183745183 |
GO:0005515 | protein binding | 0.0443883691234917 |
GO:0006013 | mannose metabolic process | 0.0443883691234917 |
GO:0005762 | mitochondrial large ribosomal subunit | 0.0443883691234917 |
GO:0030663 | COPI coated vesicle membrane | 0.0443883691234917 |
GO:0000315 | organellar large ribosomal subunit | 0.0443883691234917 |
GO:0030126 | COPI vesicle coat | 0.0443883691234917 |
GO:0005779 | integral to peroxisomal membrane | 0.0443883691234917 |
GO:0031231 | intrinsic to peroxisomal membrane | 0.0443883691234917 |
GO:0004602 | glutathione peroxidase activity | 0.0443883691234917 |
GO:0065003 | macromolecular complex assembly | 0.0443883691234917 |
GO:0043065 | positive regulation of apoptosis | 0.0443883691234917 |
GO:0005622 | intracellular | 0.0443883691234917 |
GO:0006891 | intra-Golgi vesicle-mediated transport | 0.0443883691234917 |
GO:0030137 | COPI-coated vesicle | 0.0443883691234917 |
GO:0006739 | NADP metabolic process | 0.0443883691234917 |
GO:0005680 | anaphase-promoting complex | 0.0443883691234917 |
GO:0043068 | positive regulation of programmed cell death | 0.0443883691234917 |
GO:0030178 | negative regulation of Wnt receptor signaling pathway | 0.0457598392455279 |
GO:0006354 | RNA elongation | 0.0457598392455279 |
GO:0031090 | organelle membrane | 0.0457598392455279 |
GO:0019318 | hexose metabolic process | 0.0457863884821124 |
GO:0006749 | glutathione metabolic process | 0.0457888876222452 |
GO:0008637 | apoptotic mitochondrial changes | 0.0457888876222452 |
GO:0005996 | monosaccharide metabolic process | 0.0457888876222452 |
GO:0022607 | cellular component assembly | 0.0463276222825077 |
GO:0042542 | response to hydrogen peroxide | 0.0463276222825077 |
GO:0017124 | SH3 domain binding | 0.0463276222825077 |
GO:0000152 | nuclear ubiquitin ligase complex | 0.0476122033922862 |
GO:0006732 | coenzyme metabolic process | 0.0476122033922862 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
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Ontology term | p-value | n |
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Ontology term | p-value | n |
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Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.