MCL coexpression mm9:76
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0065007 | biological regulation | 6.92642685468837e-08 |
| GO:0006355 | regulation of transcription, DNA-dependent | 9.84396779962737e-08 |
| GO:0006351 | transcription, DNA-dependent | 9.84396779962737e-08 |
| GO:0032774 | RNA biosynthetic process | 9.84396779962737e-08 |
| GO:0003677 | DNA binding | 9.84396779962737e-08 |
| GO:0019222 | regulation of metabolic process | 9.84396779962737e-08 |
| GO:0045449 | regulation of transcription | 9.84396779962737e-08 |
| GO:0050789 | regulation of biological process | 9.84396779962737e-08 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 1.1686848142673e-07 |
| GO:0006350 | transcription | 1.28526040306994e-07 |
| GO:0010468 | regulation of gene expression | 1.94151723713076e-07 |
| GO:0031323 | regulation of cellular metabolic process | 3.29084677911261e-07 |
| GO:0050794 | regulation of cellular process | 6.13238654211701e-07 |
| GO:0016070 | RNA metabolic process | 7.27563497338756e-07 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 1.20682343817744e-06 |
| GO:0010467 | gene expression | 1.28229738144171e-06 |
| GO:0043283 | biopolymer metabolic process | 3.34520698961319e-06 |
| GO:0003676 | nucleic acid binding | 1.16785624495997e-05 |
| GO:0003700 | transcription factor activity | 1.55499946371682e-05 |
| GO:0007275 | multicellular organismal development | 0.00010835014899739 |
| GO:0032501 | multicellular organismal process | 0.000115261877887468 |
| GO:0043170 | macromolecule metabolic process | 0.000271144404853417 |
| GO:0007420 | brain development | 0.000294810163091713 |
| GO:0030900 | forebrain development | 0.000481132545249111 |
| GO:0048666 | neuron development | 0.000612359123428026 |
| GO:0007417 | central nervous system development | 0.000775517727305473 |
| GO:0048856 | anatomical structure development | 0.000775517727305473 |
| GO:0044238 | primary metabolic process | 0.000905910292692037 |
| GO:0048731 | system development | 0.000915354416258053 |
| GO:0044237 | cellular metabolic process | 0.000915354416258053 |
| GO:0005667 | transcription factor complex | 0.0010319370587749 |
| GO:0007399 | nervous system development | 0.00105563528805409 |
| GO:0030182 | neuron differentiation | 0.00144262815090391 |
| GO:0032502 | developmental process | 0.00149242453091425 |
| GO:0007409 | axonogenesis | 0.00177430338629772 |
| GO:0048667 | neuron morphogenesis during differentiation | 0.00208792384673866 |
| GO:0048812 | neurite morphogenesis | 0.00208792384673866 |
| GO:0008038 | neuron recognition | 0.00217910028963226 |
| GO:0048699 | generation of neurons | 0.00222458909236768 |
| GO:0005634 | nucleus | 0.00226916841375991 |
| GO:0044451 | nucleoplasm part | 0.00262943763722978 |
| GO:0022008 | neurogenesis | 0.00286207671032103 |
| GO:0000904 | cellular morphogenesis during differentiation | 0.00291468213444351 |
| GO:0005654 | nucleoplasm | 0.00309812654676973 |
| GO:0048513 | organ development | 0.00309812654676973 |
| GO:0007411 | axon guidance | 0.0032570022222967 |
| GO:0031175 | neurite development | 0.0032570022222967 |
| GO:0048869 | cellular developmental process | 0.00353719730615721 |
| GO:0030154 | cell differentiation | 0.00353719730615721 |
| GO:0031981 | nuclear lumen | 0.00691639763886853 |
| GO:0032990 | cell part morphogenesis | 0.00937243738238856 |
| GO:0048858 | cell projection morphogenesis | 0.00937243738238856 |
| GO:0030030 | cell projection organization and biogenesis | 0.00937243738238856 |
| GO:0043233 | organelle lumen | 0.0117109348003719 |
| GO:0031974 | membrane-enclosed lumen | 0.0117109348003719 |
| GO:0031234 | extrinsic to internal side of plasma membrane | 0.0126582396021272 |
| GO:0031017 | exocrine pancreas development | 0.0126582396021272 |
| GO:0045780 | positive regulation of bone resorption | 0.0126582396021272 |
| GO:0005502 | 11-cis retinal binding | 0.0126582396021272 |
| GO:0007610 | behavior | 0.014656350765791 |
| GO:0045595 | regulation of cell differentiation | 0.0167368999207396 |
| GO:0030902 | hindbrain development | 0.0168607545440724 |
| GO:0050808 | synapse organization and biogenesis | 0.0179072174004843 |
| GO:0008037 | cell recognition | 0.0179072174004843 |
| GO:0016199 | axon midline choice point recognition | 0.0226121789953236 |
| GO:0021985 | neurohypophysis development | 0.0226121789953236 |
| GO:0040014 | regulation of multicellular organism growth | 0.0237680273215628 |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0262744348725975 |
| GO:0035264 | multicellular organism growth | 0.0306397961167397 |
| GO:0021854 | hypothalamus development | 0.0306397961167397 |
| GO:0014002 | astrocyte development | 0.0306397961167397 |
| GO:0021979 | hypothalamus cell differentiation | 0.0306397961167397 |
| GO:0017074 | procollagen N-endopeptidase activity | 0.0306397961167397 |
| GO:0006366 | transcription from RNA polymerase II promoter | 0.0346492066172554 |
| GO:0044428 | nuclear part | 0.0353018013867202 |
| GO:0016198 | axon choice point recognition | 0.0386979496977745 |
| GO:0060024 | rhythmic synaptic transmission | 0.0386979496977745 |
| GO:0032989 | cellular structure morphogenesis | 0.0441591472987605 |
| GO:0000902 | cell morphogenesis | 0.0441591472987605 |
| GO:0004994 | somatostatin receptor activity | 0.0459446533668452 |
| GO:0016188 | synaptic vesicle maturation | 0.0459446533668452 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| neuron of cerebral cortex | 1.87e-10 | 6 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
