MCL coexpression mm9:1737

Phase1 CAGE Peaks

	Short description
Mm9::chr1:120524563..120524591,+	p2@Tfcp2l1
Mm9::chr1:120524622..120524637,+	p@chr1:120524622..120524637 +
Mm9::chr7:129008545..129008557,+	p3@Scnn1b
Mm9::chr7:129008565..129008579,+	p2@Scnn1b
Mm9::chr7:129008584..129008607,+	p1@Scnn1b

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015280	amiloride-sensitive sodium channel activity	0.0157234427217444
GO:0005272	sodium channel activity	0.0292006793403824
GO:0050909	sensory perception of taste	0.0310725177596377
GO:0031402	sodium ion binding	0.0310725177596377
GO:0015276	ligand-gated ion channel activity	0.0310725177596377
GO:0022834	ligand-gated channel activity	0.0310725177596377
GO:0006814	sodium ion transport	0.0359392976497014
GO:0031420	alkali metal ion binding	0.0496973100312277

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
renal system	3.08e-14	19
urinary system structure	1.44e-13	18
kidney	1.26e-10	14
kidney mesenchyme	1.26e-10	14
upper urinary tract	1.26e-10	14
kidney rudiment	1.26e-10	14
kidney field	1.26e-10	14
epithelial bud	1.27e-10	17
lung	1.87e-08	14
respiratory tube	1.87e-08	14
respiration organ	1.87e-08	14
pair of lungs	1.87e-08	14
lung primordium	1.87e-08	14
lung bud	1.87e-08	14
trunk region element	2.48e-08	79
epithelial fold	4.63e-08	20
anatomical space	5.13e-08	57
cavitated compound organ	4.79e-07	21
thoracic cavity element	5.61e-07	17
thoracic segment organ	5.61e-07	17
thoracic cavity	5.61e-07	17
thoracic segment of trunk	5.61e-07	17
respiratory primordium	5.61e-07	17
endoderm of foregut	5.61e-07	17
trunk	8.04e-07	90
female organism	9.56e-07	11

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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