MCL coexpression mm9:1015

Phase1 CAGE Peaks

	Short description
Mm9::chr10:128185557..128185594,+	p1@Wibg
Mm9::chr10:79727687..79727778,+	p1@Dazap1
Mm9::chr10:79862089..79862129,-	p2@Mbd3
Mm9::chr10:79862134..79862173,-	p3@Mbd3
Mm9::chr12:81744845..81744856,-	p2@Erh
Mm9::chr17:57074836..57074927,-	p1@Mllt1
Mm9::chr2:128793732..128793766,-	p2@ENSMUST00000099385

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006346	methylation-dependent chromatin silencing	0.0478431093363871
GO:0016581	NuRD complex	0.0478431093363871
GO:0016573	histone acetylation	0.0478431093363871
GO:0006473	protein amino acid acetylation	0.0478431093363871
GO:0006342	chromatin silencing	0.0478431093363871
GO:0031507	heterochromatin formation	0.0478431093363871
GO:0045814	negative regulation of gene expression, epigenetic	0.0478431093363871

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
ectodermal cell	4.50e-12	44
neurectodermal cell	4.50e-12	44
neural cell	1.15e-11	43
neuron	2.84e-10	33
neuronal stem cell	2.84e-10	33
neuroblast	2.84e-10	33
electrically signaling cell	2.84e-10	33
non-terminally differentiated cell	4.51e-10	49
electrically responsive cell	1.52e-08	39
electrically active cell	1.52e-08	39
CNS neuron (sensu Vertebrata)	2.27e-07	23
neuroblast (sensu Vertebrata)	2.27e-07	23

Uber Anatomy

Ontology term	p-value	n
central nervous system	2.04e-08	73
nervous system	2.14e-08	75
ectoderm-derived structure	2.17e-07	95
ectoderm	2.17e-07	95
presumptive ectoderm	2.17e-07	95

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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