MCL coexpression mm9:926

Phase1 CAGE Peaks

	Short description
Mm9::chr11:98909393..98909430,+	p@chr11:98909393..98909430 +
Mm9::chr17:64212390..64212429,+	p@chr17:64212390..64212429 +
Mm9::chr19:7613621..7613623,+	p@chr19:7613621..7613623 +
Mm9::chr1:40496487..40496494,+	p3@Il1rl1
Mm9::chr1:40496612..40496633,+	p1@Il1rl1
Mm9::chr3:151668462..151668472,-	p@chr3:151668462..151668472 -
Mm9::chr5:99372782..99372792,-	p6@Prkg2
Mm9::chr8:87160297..87160316,+	p@chr8:87160297..87160316 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004692	cGMP-dependent protein kinase activity	0.00971838531944563
GO:0004690	cyclic nucleotide-dependent protein kinase activity	0.00971838531944563
GO:0004908	interleukin-1 receptor activity	0.00971838531944563
GO:0019966	interleukin-1 binding	0.00971838531944563
GO:0019002	GMP binding	0.00971838531944563
GO:0030553	cGMP binding	0.00971838531944563
GO:0005952	cAMP-dependent protein kinase complex	0.00971838531944563
GO:0008603	cAMP-dependent protein kinase regulator activity	0.0113371842039205
GO:0030551	cyclic nucleotide binding	0.0159529763788705
GO:0004907	interleukin receptor activity	0.0247194069537288
GO:0019965	interleukin binding	0.0247194069537288
GO:0019838	growth factor binding	0.0308310436698183
GO:0004896	hematopoietin/interferon-class (D200-domain) cytokine receptor activity	0.0313591463294665
GO:0019887	protein kinase regulator activity	0.0337087347741023
GO:0019955	cytokine binding	0.0337087347741023
GO:0019207	kinase regulator activity	0.0348969287172017
GO:0045087	innate immune response	0.0394855055171229

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
smooth muscle cell	4.75e-10	3
vascular associated smooth muscle cell	4.75e-10	3
aortic smooth muscle cell	4.75e-10	3
smooth muscle myoblast	4.75e-10	3
muscle precursor cell	1.64e-08	6
contractile cell	1.64e-08	6
muscle cell	1.64e-08	6
myoblast	1.64e-08	6
mesodermal cell	2.75e-07	7

Uber Anatomy

Ontology term	p-value	n
zone of skin	1.15e-13	5
skin epidermis	1.15e-13	5
skin of body	1.15e-13	5
integument	1.15e-13	5
surface	1.15e-13	5
outer epithelium	1.15e-13	5
integumental system	1.15e-13	5
enveloping layer of ectoderm	1.15e-13	5
smooth muscle tissue	4.75e-10	3
blood vessel smooth muscle	4.75e-10	3
arterial system smooth muscle	4.75e-10	3
artery smooth muscle tissue	4.75e-10	3
aorta smooth muscle tissue	4.75e-10	3
aorta	1.27e-07	4
artery	1.27e-07	4
systemic artery	1.27e-07	4
arterial blood vessel	1.27e-07	4
systemic arterial system	1.27e-07	4
aortic system	1.27e-07	4
arterial system	1.27e-07	4
surface structure	5.37e-07	22

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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