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Coexpression cluster:C2573

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Full id: C2573_cord_CD14_migratory_CD19_splenic_CD34_immature



Phase1 CAGE Peaks

Hg19::chr1:234978750..234978761,-p@chr1:234978750..234978761
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Hg19::chr3:119281446..119281491,-p@chr3:119281446..119281491
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Hg19::chr3:119281492..119281509,-p@chr3:119281492..119281509
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Hg19::chr9:21994161..21994189,+p@chr9:21994161..21994189
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
leukocyte2.88e-64140
hematopoietic lineage restricted progenitor cell1.68e-53124
hematopoietic cell2.94e-53182
hematopoietic stem cell1.58e-51172
angioblastic mesenchymal cell1.58e-51172
nongranular leukocyte1.97e-51119
hematopoietic oligopotent progenitor cell2.93e-48165
hematopoietic multipotent progenitor cell2.93e-48165
classical monocyte1.25e-3345
CD14-positive, CD16-negative classical monocyte1.93e-3242
myeloid leukocyte2.24e-3076
granulocyte monocyte progenitor cell2.32e-2971
myeloid lineage restricted progenitor cell4.24e-2870
macrophage dendritic cell progenitor1.35e-2665
monopoietic cell7.99e-2563
monocyte7.99e-2563
monoblast7.99e-2563
promonocyte7.99e-2563
myeloid cell1.83e-24112
common myeloid progenitor1.83e-24112
lymphocyte1.83e-2253
common lymphoid progenitor1.83e-2253
lymphoid lineage restricted progenitor cell8.32e-2252
lymphocyte of B lineage1.27e-1624
pro-B cell1.27e-1624
mesenchymal cell4.60e-15358
connective tissue cell5.62e-15365
motile cell4.19e-12390
dendritic cell6.13e-1110
intermediate monocyte4.82e-109
CD14-positive, CD16-positive monocyte4.82e-109
conventional dendritic cell2.22e-098
multi fate stem cell4.12e-09430
stem cell5.83e-09444
somatic stem cell7.34e-09436
B cell4.38e-0814
circulating cell7.86e-086
native cell1.99e-07722
Langerhans cell6.83e-075
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.42e-28102
blood island3.42e-28102
hemolymphoid system1.51e-26112
bone marrow3.73e-2680
bone element1.07e-2486
skeletal element1.97e-20101
skeletal system1.97e-20101
immune system3.30e-19115
connective tissue5.61e-14375
musculoskeletal system1.05e-07167
Disease
Ontology termp-valuen
lymphoma2.73e-0710


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.