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Coexpression cluster:C1429

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Full id: C1429_CD14_Basophils_Natural_immature_Peripheral_CD14CD16_CD4



Phase1 CAGE Peaks

Hg19::chr17:17743452..17743466,-p@chr17:17743452..17743466
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Hg19::chr19:39892249..39892258,-p@chr19:39892249..39892258
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Hg19::chr19:39892296..39892314,-p@chr19:39892296..39892314
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Hg19::chr2:235217404..235217432,-p@chr2:235217404..235217432
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Hg19::chr6:109704348..109704364,+p3@BC030091
Hg19::chr9:134553955..134553973,-p@chr9:134553955..134553973
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte2.01e-51140
hematopoietic stem cell1.97e-43172
angioblastic mesenchymal cell1.97e-43172
hematopoietic lineage restricted progenitor cell8.42e-43124
hematopoietic cell2.13e-42182
hematopoietic oligopotent progenitor cell1.44e-40165
hematopoietic multipotent progenitor cell1.44e-40165
nongranular leukocyte1.79e-40119
myeloid leukocyte6.07e-3176
granulocyte monocyte progenitor cell6.60e-2871
myeloid lineage restricted progenitor cell1.32e-2670
CD14-positive, CD16-negative classical monocyte1.12e-2542
classical monocyte1.14e-2545
macrophage dendritic cell progenitor3.81e-2565
myeloid cell1.02e-24112
common myeloid progenitor1.02e-24112
monopoietic cell6.60e-2463
monocyte6.60e-2463
monoblast6.60e-2463
promonocyte6.60e-2463
lymphocyte2.79e-1453
common lymphoid progenitor2.79e-1453
lymphoid lineage restricted progenitor cell2.90e-1452
mesenchymal cell1.36e-08358
connective tissue cell9.72e-08365
motile cell1.15e-07390
intermediate monocyte1.53e-079
CD14-positive, CD16-positive monocyte1.53e-079
lymphocyte of B lineage1.60e-0724
pro-B cell1.60e-0724
Uber Anatomy
Ontology termp-valuen
hematopoietic system8.17e-27102
blood island8.17e-27102
bone marrow1.07e-2680
bone element2.70e-2386
hemolymphoid system4.53e-23112
immune system4.63e-19115
skeletal element6.87e-17101
skeletal system6.87e-17101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203344.515961150815470.005543980051953740.0250956888282766
FOSL2#2355411.28680040304110.0001656657722157630.0020376831450291
GATA1#262336.780154071900220.006765763983348560.0287531892027239
HDAC2#306636.707810118313130.006973940027962660.0294891016875336
JUN#372536.256414596168170.008486346850954870.0324155357606202
JUNB#3726315.30531632991060.0006470753298141560.00530287981563565
MEF2C#4208213.77045149754130.008235596942270060.0324682914595048
NFKB1#479043.658708949462560.01207927289015230.0438311160230219
NR3C1#2908512.47751944264427.52342219908436e-060.000214917585079369
PAX5#507944.446377020785220.005874733519240790.0263632232207274
RFX5#599348.03194055146340.0006204615428381410.0051108433687572
RXRA#6256413.38307809275558.51052088844461e-050.0012763214978005
SMARCC1#6599214.55445310654380.007398079383140510.0305648171484557
SP1#666765.69838137814092.91961319085282e-050.000609721019874981
SREBF2#6721172.82387706855790.01365361575289130.048171406513621
TAF1#687252.785871904787740.01078636340290410.0397935994714012
TBP#690853.088975572580320.006645448275786930.0282890671099255
TCF12#693835.317232451093210.013367345733860.0472460056549664
TCF7L2#693435.385088281568670.01290488779931040.0464077397173809
TFAP2A#702038.259317186522480.003860738477055590.0190454709652453
TFAP2C#702235.404614304930110.01277576166695870.0460623389628027
USF1#739144.240999518138640.007005367750829420.0296052119341591
USF2#739236.49609869253480.007634319815300560.0314574578706768
ZBTB33#10009210.55490834332710.01374250737140590.0483885818874029



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.