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Coexpression cluster:C587

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Full id: C587_Osteoblast_Monocytederived_CD14_Macrophage_leiomyoma_Adipocyte_Dendritic



Phase1 CAGE Peaks

Hg19::chr11:1774396..1774410,-p@chr11:1774396..1774410
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Hg19::chr11:1774555..1774567,-p@chr11:1774555..1774567
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Hg19::chr11:1774591..1774602,-p@chr11:1774591..1774602
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Hg19::chr11:1774626..1774637,-p@chr11:1774626..1774637
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Hg19::chr11:1774653..1774680,-p@chr11:1774653..1774680
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Hg19::chr11:1774731..1774765,-p@chr11:1774731..1774765
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Hg19::chr11:1778628..1778664,-p3@CTSD
Hg19::chr11:1780775..1780793,-p2@ENST00000427721
Hg19::chr11:1780825..1780859,-p@chr11:1780825..1780859
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Hg19::chr11:1782587..1782602,-p@chr11:1782587..1782602
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Hg19::chr17:42429493..42429515,+p@chr17:42429493..42429515
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Hg19::chr19:40872708..40872743,+p8@PLD3
Hg19::chr19:49469548..49469569,+p@chr19:49469548..49469569
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Hg19::chr2:85628961..85628975,-p10@CAPG
Hg19::chr7:97911681..97911696,+p@chr7:97911681..97911696
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0048770pigment granule0.000962696371097009
GO:0042470melanosome0.000962696371097009
GO:0004192cathepsin D activity0.00320852466737313
GO:0016023cytoplasmic membrane-bound vesicle0.00695351994664752
GO:0031988membrane-bound vesicle0.00695351994664752
GO:0031410cytoplasmic vesicle0.00721811799281055
GO:0031982vesicle0.00721811799281055
GO:0004630phospholipase D activity0.00721811799281055
GO:0008290F-actin capping protein complex0.0158032041510128
GO:0051693actin filament capping0.0158032041510128
GO:0051016barbed-end actin filament capping0.0158032041510128
GO:0030835negative regulation of actin filament depolymerization0.0158032041510128
GO:0030834regulation of actin filament depolymerization0.0158032041510128
GO:0030042actin filament depolymerization0.0158032041510128
GO:0004194pepsin A activity0.0166720528007639
GO:0044444cytoplasmic part0.0168152519673891
GO:0008064regulation of actin polymerization and/or depolymerization0.0215137929918326
GO:0051261protein depolymerization0.0215137929918326
GO:0030832regulation of actin filament length0.0215137929918326
GO:0032535regulation of cellular component size0.0215137929918326
GO:0032956regulation of actin cytoskeleton organization and biogenesis0.0215137929918326
GO:0030031cell projection biogenesis0.0215263959366968
GO:0051129negative regulation of cellular component organization and biogenesis0.0215263959366968
GO:0051493regulation of cytoskeleton organization and biogenesis0.0215263959366968
GO:0033043regulation of organelle organization and biogenesis0.0215263959366968
GO:0008154actin polymerization and/or depolymerization0.0225432140480013
GO:0004190aspartic-type endopeptidase activity0.0302278645094982
GO:0051128regulation of cellular component organization and biogenesis0.0342769630157552
GO:0051248negative regulation of protein metabolic process0.0344147421805016
GO:0004620phospholipase activity0.0375507630894644
GO:0005737cytoplasm0.0375507630894644
GO:0008081phosphoric diester hydrolase activity0.04095819083259
GO:0016298lipase activity0.04095819083259
GO:0016042lipid catabolic process0.0411571714271229
GO:0004091carboxylesterase activity0.0464739618400419
GO:0043231intracellular membrane-bound organelle0.0464739618400419
GO:0043227membrane-bound organelle0.0464739618400419
GO:0005764lysosome0.0464739618400419
GO:0000323lytic vacuole0.0464739618400419
GO:0032990cell part morphogenesis0.0464739618400419
GO:0030030cell projection organization and biogenesis0.0464739618400419
GO:0048858cell projection morphogenesis0.0464739618400419



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
mesoderm8.10e-14315
mesoderm-derived structure8.10e-14315
presumptive mesoderm8.10e-14315
bone marrow1.95e-1376
multi-cellular organism1.22e-12656
bone element2.00e-1282
skeletal element2.19e-1290
immune system5.83e-1293
skeletal system2.14e-11100
musculoskeletal system2.00e-10167
anatomical system2.18e-09624
anatomical group3.08e-09625
hemolymphoid system4.87e-09108
organ6.01e-09503
hematopoietic system2.19e-0898
blood island2.19e-0898
germ layer4.71e-08560
germ layer / neural crest4.71e-08560
embryonic tissue4.71e-08560
presumptive structure4.71e-08560
germ layer / neural crest derived structure4.71e-08560
epiblast (generic)4.71e-08560
embryonic structure1.18e-07564
lateral plate mesoderm1.80e-07203
developing anatomical structure5.82e-07581
embryo5.83e-07592


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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