MCL coexpression mm9:1503

Phase1 CAGE Peaks

	Short description
Mm9::chr10:17667803..17667904,-	p1@Heca
Mm9::chr11:77161761..77161771,+	p3@Ssh2
Mm9::chr11:77161774..77161794,+	p2@Ssh2
Mm9::chr12:85559785..85559840,-	p1@C130039O16Rik
Mm9::chr4:100937819..100937836,-	p1@Jak1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004718	Janus kinase activity	0.0399802800961384
GO:0004716	receptor signaling protein tyrosine kinase activity	0.0399802800961384

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
mesoderm	1.73e-12	120
mesoderm-derived structure	1.73e-12	120
presumptive mesoderm	1.73e-12	120
foregut	2.44e-12	80
primordium	6.22e-12	134
lateral plate mesoderm	2.23e-11	87
endo-epithelium	1.60e-10	69
mixed endoderm/mesoderm-derived structure	4.51e-09	35
organism subdivision	8.11e-09	150
hemopoietic organ	8.15e-09	29
immune organ	8.15e-09	29
hemolymphoid system	1.03e-08	48
immune system	1.03e-08	48
unilaminar epithelium	1.92e-08	66
respiratory system	1.96e-08	42
hematopoietic system	3.25e-08	45
blood island	3.25e-08	45
respiratory tract	4.46e-08	41
endoderm-derived structure	2.23e-07	118
endoderm	2.23e-07	118
presumptive endoderm	2.23e-07	118
digestive system	2.41e-07	116
digestive tract	2.41e-07	116
primitive gut	2.41e-07	116
gut epithelium	2.73e-07	55
subdivision of digestive tract	3.01e-07	114
gland of gut	3.63e-07	24
pharynx	3.77e-07	24
upper respiratory tract	3.77e-07	24
chordate pharynx	3.77e-07	24
pharyngeal arch system	3.77e-07	24
pharyngeal region of foregut	3.77e-07	24
thymus	8.49e-07	23
neck	8.49e-07	23
respiratory system epithelium	8.49e-07	23
hemolymphoid system gland	8.49e-07	23
pharyngeal epithelium	8.49e-07	23
thymic region	8.49e-07	23
pharyngeal gland	8.49e-07	23
entire pharyngeal arch endoderm	8.49e-07	23
thymus primordium	8.49e-07	23
early pharyngeal endoderm	8.49e-07	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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