MCL coexpression mm9:3088

Phase1 CAGE Peaks

	Short description
Mm9::chr17:27693887..27693908,+	p2@Hmga1-rs1 p2@Hmga1
Mm9::chr2:103810272..103810331,+	p4@Lmo2
Mm9::chr2:103810378..103810400,+	p7@Lmo2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045647	negative regulation of erythrocyte differentiation	0.00964225058894429
GO:0045646	regulation of erythrocyte differentiation	0.0108475319125623
GO:0045638	negative regulation of myeloid cell differentiation	0.0152668967658284
GO:0045637	regulation of myeloid cell differentiation	0.0178381635895469
GO:0030218	erythrocyte differentiation	0.0178381635895469
GO:0045596	negative regulation of cell differentiation	0.0313373144140689
GO:0030099	myeloid cell differentiation	0.0313373144140689
GO:0051093	negative regulation of developmental process	0.0313373144140689
GO:0045595	regulation of cell differentiation	0.0409795650030132
GO:0030097	hemopoiesis	0.0474695413609565
GO:0048534	hemopoietic or lymphoid organ development	0.0474695413609565
GO:0002520	immune system development	0.0474695413609565
GO:0050793	regulation of developmental process	0.0474695413609565

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
common myeloid progenitor	1.39e-08	19
myeloid cell	9.66e-07	16

Uber Anatomy

Ontology term	p-value	n
bone marrow	1.19e-10	16
bone element	1.34e-09	22
skeletal element	1.34e-09	22
skeletal system	1.34e-09	22
musculoskeletal system	4.70e-07	32

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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