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Coexpression cluster:C890

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Full id: C890_CD19_CD4_Peripheral_CD8_Natural_Dendritic_Mast



Phase1 CAGE Peaks

Hg19::chr12:12510270..12510289,+p5@LOH12CR1
Hg19::chr12:133065939..133065959,+p6@FBRSL1
Hg19::chr17:76356237..76356282,-p2@SOCS3
Hg19::chr19:54041603..54041615,+p10@ZNF331
Hg19::chr19:54041645..54041661,+p5@ZNF331
Hg19::chr20:34203794..34203818,+p8@SPAG4
Hg19::chrX:110924471..110924482,+p5@ALG13
Hg19::chrX:110924562..110924571,+p8@ALG13
Hg19::chrX:110924578..110924589,+p9@ALG13


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004577N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity0.0150712351348169
GO:0046627negative regulation of insulin receptor signaling pathway0.0188357167392016
GO:0030259lipid glycosylation0.0188357167392016
GO:0046626regulation of insulin receptor signaling pathway0.0188357167392016



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte2.12e-36140
hematopoietic lineage restricted progenitor cell1.22e-28124
nongranular leukocyte4.43e-28119
hematopoietic stem cell5.16e-26172
angioblastic mesenchymal cell5.16e-26172
hematopoietic cell1.22e-25182
myeloid leukocyte4.62e-2476
hematopoietic oligopotent progenitor cell2.04e-23165
hematopoietic multipotent progenitor cell2.04e-23165
CD14-positive, CD16-negative classical monocyte1.13e-2242
classical monocyte2.02e-2245
granulocyte monocyte progenitor cell3.19e-2171
myeloid lineage restricted progenitor cell9.76e-1970
macrophage dendritic cell progenitor9.94e-1965
monopoietic cell1.05e-1763
monocyte1.05e-1763
monoblast1.05e-1763
promonocyte1.05e-1763
myeloid cell3.97e-14112
common myeloid progenitor3.97e-14112
lymphoid lineage restricted progenitor cell3.32e-0952
lymphocyte3.60e-0953
common lymphoid progenitor3.60e-0953
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.02e-23102
blood island2.02e-23102
bone element3.60e-1986
bone marrow4.15e-1980
hemolymphoid system9.91e-19112
skeletal element4.10e-12101
skeletal system4.10e-12101
adult organism4.25e-12115
immune system2.75e-10115
regional part of forebrain1.93e-0841
forebrain1.93e-0841
future forebrain1.93e-0841
anterior neural tube2.47e-0842
neural tube2.49e-0857
neural rod2.49e-0857
future spinal cord2.49e-0857
neural keel2.49e-0857
regional part of brain4.72e-0759
gray matter6.07e-0734
brain grey matter6.07e-0734
telencephalon8.28e-0734


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066463.573504248716680.002103883629372150.0121651811741777
CTCFL#14069048.776210826210820.0006740680382610040.00543915567086001
E2F6#187673.902232235764630.0003067423599492730.00316185011160108
EGR1#195884.433936973164571.92853122912633e-050.000435395315691148
ELK4#200547.215858514874680.001409539058987380.0091651631043197
GABPB1#255353.926491020101210.004337976092287310.0205840020491774
GTF2F1#296257.077589375976470.0002865435853580450.00304686677980135
HEY1#2346273.142308589082220.001258763462843770.0084575397128114
JUND#372764.663109294580680.0004849682005391460.00433755193081338
MYC#460963.48152124773960.002423669811459260.0136551573306896
PAX5#507964.446377020785220.0006322700088175870.00519091639422215
POLR2A#543081.908847268051620.0116612289598830.0425789984037065
POU2F2#545244.047166247885570.01161426156153230.0424342089636127
RAD21#588544.602237286869480.007351242900196250.0303953623363394
SETDB1#9869313.44000872600350.001144723251466790.00783702075778038
SMARCB1#659836.084238593719140.01075671401246010.0396968358567958
TAF1#687282.971596698440260.0004233749951234810.00395853725297236
TFAP2C#702244.804101604382320.006299303434747120.0277861617359274
USF1#739164.240999518138640.0008220017441944160.00625949982952392
ZEB1#693535.629477339181290.01330488236341950.0470347835071986
ZNF143#770257.500486973459950.0002177465175801830.00249137034942558



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.