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Coexpression cluster:C299

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Full id: C299_CD14CD16_Eosinophils_Neutrophils_CD14_Whole_Basophils_blood



Phase1 CAGE Peaks

Hg19::chr11:67051096..67051110,+p@chr11:67051096..67051110
+
Hg19::chr11:67051146..67051171,+p@chr11:67051146..67051171
+
Hg19::chr11:67056068..67056080,+p4@ANKRD13D
Hg19::chr11:73097322..73097366,+p@chr11:73097322..73097366
+
Hg19::chr12:110888103..110888172,-p1@ARPC3
Hg19::chr15:40600028..40600061,-p2@PLCB2
Hg19::chr15:85259803..85259821,+p@chr15:85259803..85259821
+
Hg19::chr16:50059183..50059199,+p2@TMEM188
Hg19::chr17:38480637..38480649,+p@chr17:38480637..38480649
+
Hg19::chr17:43487729..43487738,-p1@uc002iiy.1
Hg19::chr17:72462766..72462831,+p1@CD300A
Hg19::chr19:18508396..18508460,-p1@LRRC25
Hg19::chr19:51920837..51920848,-p3@SIGLEC10
Hg19::chr19:51920861..51920864,-p6@SIGLEC10
Hg19::chr19:51920873..51920906,-p1@SIGLEC10
Hg19::chr19:51920954..51920971,-p2@SIGLEC10
Hg19::chr19:55084417..55084428,+p4@LILRA2
Hg19::chr1:236028436..236028467,-p@chr1:236028436..236028467
-
Hg19::chr1:244979057..244979081,+p@chr1:244979057..244979081
+
Hg19::chr20:1472009..1472020,-p4@SIRPB2
Hg19::chr20:1472029..1472032,-p5@SIRPB2
Hg19::chr20:48892848..48892884,+p1@ENST00000422459
Hg19::chr20:55950074..55950095,+p@chr20:55950074..55950095
+
Hg19::chr20:62708506..62708524,-p9@RGS19
Hg19::chr20:62710772..62710783,-p4@RGS19
Hg19::chr22:44577612..44577668,+p1@PARVG
Hg19::chr22:50968798..50968830,+p@chr22:50968798..50968830
+
Hg19::chr22:50968897..50968915,+p@chr22:50968897..50968915
+
Hg19::chr2:20624862..20624875,+p@chr2:20624862..20624875
+
Hg19::chr2:45795104..45795144,-p2@SRBD1
Hg19::chr3:72149553..72149577,-p1@ENST00000468646
p1@uc003dpb.1
Hg19::chr4:154387777..154387789,+p@chr4:154387777..154387789
+
Hg19::chr5:176735063..176735088,-p2@MXD3
Hg19::chr5:180229951..180229996,+p@chr5:180229951..180229996
+
Hg19::chr6:167370025..167370046,-p1@RNASET2
Hg19::chr6:42897260..42897305,+p2@CNPY3
Hg19::chr7:106505807..106505839,+p3@PIK3CG
Hg19::chr7:139529081..139529084,+p6@TBXAS1
Hg19::chr7:139529085..139529115,+p2@TBXAS1
Hg19::chr7:26331470..26331517,+p2@SNX10
Hg19::chr7:99750250..99750284,+p6@C7orf59
Hg19::chr9:130540938..130540952,-p2@SH2D3C


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell4.29e-62172
angioblastic mesenchymal cell4.29e-62172
hematopoietic oligopotent progenitor cell2.18e-58165
hematopoietic multipotent progenitor cell2.18e-58165
hematopoietic cell6.72e-58182
leukocyte2.77e-54140
hematopoietic lineage restricted progenitor cell3.18e-45124
nongranular leukocyte5.39e-44119
myeloid cell1.39e-41112
common myeloid progenitor1.39e-41112
myeloid leukocyte3.04e-3576
granulocyte monocyte progenitor cell2.74e-3171
myeloid lineage restricted progenitor cell8.30e-3070
macrophage dendritic cell progenitor1.36e-2865
monopoietic cell1.04e-2763
monocyte1.04e-2763
monoblast1.04e-2763
promonocyte1.04e-2763
CD14-positive, CD16-negative classical monocyte1.33e-2642
classical monocyte1.49e-2345
lymphocyte2.94e-1453
common lymphoid progenitor2.94e-1453
lymphoid lineage restricted progenitor cell5.59e-1452
lymphocyte of B lineage5.59e-0824
pro-B cell5.59e-0824
intermediate monocyte2.74e-079
CD14-positive, CD16-positive monocyte2.74e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.36e-36102
blood island1.36e-36102
hemolymphoid system6.39e-34112
bone marrow1.08e-2680
immune system4.28e-24115
adult organism8.78e-24115
bone element5.23e-2386
skeletal element1.55e-15101
skeletal system1.55e-15101
lateral plate mesoderm6.39e-09216
blood2.96e-0815
haemolymphatic fluid2.96e-0815
organism substance2.96e-0815
Disease
Ontology termp-valuen
leukemia7.97e-0839
hematologic cancer8.32e-0851
immune system cancer8.32e-0851
myeloid leukemia3.60e-0731


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#1879122.544704813305430.001731100097627140.010656275085234
ELF1#1997252.534582118337826.20505328922612e-072.8448180881189e-05
MAX#4149131.997219562311730.008989734168348840.0340840356787986
POLR2A#5430361.840674151335491.58595236861894e-078.8010244115937e-06
POU2F2#5452112.384937253218280.004681702869844110.0220905559782981
SPI1#6688275.274207969764613.13703166424514e-155.62935481068898e-13



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


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