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Coexpression cluster:C569

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Full id: C569_CD14_immature_CD19_Basophils_migratory_Dendritic_Peripheral



Phase1 CAGE Peaks

Hg19::chr16:87498643..87498677,+p@chr16:87498643..87498677
+
Hg19::chr5:149792614..149792625,+p@chr5:149792614..149792625
+
Hg19::chr6:30227370..30227387,+p2@HLA-L
Hg19::chr6:32441310..32441322,-p2@HLA-DRB9
Hg19::chr6:32441341..32441365,-p1@HLA-DRB9
Hg19::chr6:32572499..32572517,+p@chr6:32572499..32572517
+
Hg19::chr6:32577605..32577616,-p@chr6:32577605..32577616
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Hg19::chr6:32577619..32577667,-p@chr6:32577619..32577667
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Hg19::chr6:32577678..32577698,-p@chr6:32577678..32577698
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Hg19::chr6:32577917..32577935,+p@chr6:32577917..32577935
+
Hg19::chr6:32997441..32997457,+p@chr6:32997441..32997457
+
Hg19::chr6:32997459..32997492,+p@chr6:32997459..32997492
+
Hg19::chr6:32997495..32997511,+p@chr6:32997495..32997511
+
Hg19::chr6:33043568..33043579,-p@chr6:33043568..33043579
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Hg19::chr7:140017476..140017487,-p@chr7:140017476..140017487
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Hg19::chr7:39664276..39664287,-p@chr7:39664276..39664287
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.83e-52140
nongranular leukocyte1.13e-43119
hematopoietic lineage restricted progenitor cell4.32e-42124
hematopoietic stem cell5.50e-36172
angioblastic mesenchymal cell5.50e-36172
hematopoietic cell3.96e-34182
hematopoietic oligopotent progenitor cell2.37e-33165
hematopoietic multipotent progenitor cell2.37e-33165
myeloid leukocyte2.94e-2876
CD14-positive, CD16-negative classical monocyte1.41e-2642
granulocyte monocyte progenitor cell8.59e-2671
macrophage dendritic cell progenitor4.52e-2565
monopoietic cell9.62e-2463
monocyte9.62e-2463
monoblast9.62e-2463
promonocyte9.62e-2463
classical monocyte4.74e-2345
myeloid lineage restricted progenitor cell1.99e-2270
lymphoid lineage restricted progenitor cell2.26e-1752
lymphocyte3.09e-1753
common lymphoid progenitor3.09e-1753
myeloid cell3.60e-16112
common myeloid progenitor3.60e-16112
lymphocyte of B lineage4.67e-1224
pro-B cell4.67e-1224
mesenchymal cell1.04e-11358
connective tissue cell2.12e-10365
B cell8.90e-0914
motile cell1.36e-08390
dendritic cell2.08e-0710
intermediate monocyte5.49e-079
CD14-positive, CD16-positive monocyte5.49e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system8.63e-31102
blood island8.63e-31102
hemolymphoid system2.50e-27112
bone marrow2.01e-2380
bone element2.10e-2186
skeletal element1.23e-16101
skeletal system1.23e-16101
immune system5.09e-15115
adult organism9.61e-11115
connective tissue1.19e-09375
lateral plate mesoderm1.51e-09216
blood3.00e-0715
haemolymphatic fluid3.00e-0715
organism substance3.00e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538710.65653828413281.61542932578931e-066.13281800640166e-05
BCL11A#5333547.092363775901760.001996726919506420.0116104984547815
BCL3#60236.477581775700930.0102327923622150.0380971981148357
EBF1#187984.45323342328450.0001406612198143210.00183402211438051
FOS#2353137.310838688476711.58896378173251e-101.67288093145526e-08
FOSL1#806149.928394929093250.0005732096671019780.0048399583169588
GATA1#262365.085115553925160.0006728445994713830.00542970306940131
IRF4#366245.478628171686030.005068546010533350.0235992098789217
JUN#372564.692310947126130.001030862620745210.00729270888356089
JUNB#372659.56582270619410.0001199540053341380.00162615217589461
MEF2A#420544.685807727411010.008783099930456450.033363576548954
NFKB1#4790124.116047568145381.1672690224261e-064.76204724348277e-05
NFYA#480066.909592762436450.0001272357021845650.00169278592362469
NFYB#480155.237435391730140.001892131820411660.0111469063172368
PAX5#507972.91793491989030.005570360390464740.0252096402833881
POLR2A#5430162.147453176558074.88536678567824e-060.000151087598972298
POU2F2#5452126.829593043306893.64282080840165e-092.99568946778472e-07
RFX5#5993139.788927547096023.88993456139909e-125.14254272984759e-10
SP1#6667103.561488361338067.84823393273076e-050.00120290828250729
SPI1#668894.614931973544033.01826774164688e-050.000620765783122998
STAT1#677256.470808592874750.0007317668712721070.00582774136562357
STAT3#677463.944799373932840.002544236462237630.0140874515894198
TAF1#6872142.925165500027132.86208202997623e-069.84237685639406e-05
TAL1#688659.333942711700060.0001345934653965960.00176460041834736
TBP#6908143.243424351209347.26082897616864e-073.23374719591504e-05
TRIM28#1015544.647631261315630.009036390425926160.0342584427070314
USF2#739254.060061682834250.005732377623791920.0258354026949987
YY1#752892.762533546792790.001686710741936190.0105408319277809



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.