MCL coexpression mm9:2063

Phase1 CAGE Peaks

	Short description
Mm9::chr13:31717418..31717433,-	p1@1700018A04Rik
Mm9::chr13:31717548..31717596,+	p1@Foxf2
Mm9::chr13:31717597..31717613,+	p2@Foxf2
Mm9::chr13:31717614..31717628,+	p3@Foxf2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042249	establishment of polarity of embryonic epithelium	0.0082178272064866
GO:0007164	establishment of tissue polarity	0.0082178272064866
GO:0001736	establishment of planar polarity	0.0082178272064866
GO:0001738	morphogenesis of a polarized epithelium	0.0106831753684326
GO:0048566	embryonic gut development	0.0106831753684326
GO:0048565	gut development	0.0123267408097299
GO:0048568	embryonic organ development	0.0217185433314289
GO:0030198	extracellular matrix organization and biogenesis	0.0292760094231085
GO:0003713	transcription coactivator activity	0.0310451250022827
GO:0003702	RNA polymerase II transcription factor activity	0.0312277433846491
GO:0043062	extracellular structure organization and biogenesis	0.0369802224291897
GO:0002009	morphogenesis of an epithelium	0.0421163644332438
GO:0003712	transcription cofactor activity	0.0429855576954684
GO:0016563	transcription activator activity	0.0480229277379061
GO:0008134	transcription factor binding	0.0480229277379061
GO:0045892	negative regulation of transcription, DNA-dependent	0.0480229277379061

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
lung	2.09e-11	14
respiratory tube	2.09e-11	14
respiration organ	2.09e-11	14
pair of lungs	2.09e-11	14
lung primordium	2.09e-11	14
lung bud	2.09e-11	14
epithelial bud	6.07e-09	17
thoracic cavity element	4.21e-08	17
thoracic segment organ	4.21e-08	17
thoracic cavity	4.21e-08	17
thoracic segment of trunk	4.21e-08	17
respiratory primordium	4.21e-08	17
endoderm of foregut	4.21e-08	17
neurectoderm	3.09e-07	64
neural plate	3.09e-07	64
presumptive neural plate	3.09e-07	64

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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