MCL coexpression mm9:1642

Phase1 CAGE Peaks

	Short description
Mm9::chr13:34744542..34744557,-	p1@1300014I06Rik
Mm9::chr16:92400312..92400328,-	p1@Rcan1
Mm9::chr3:89083505..89083516,-	p3@Efna1
Mm9::chr3:89083524..89083549,-	p1@Efna1
Mm9::chr3:89083555..89083569,-	p2@Efna1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0035091	phosphoinositide binding	0.0112294586646708
GO:0005543	phospholipid binding	0.0112294586646708
GO:0050790	regulation of catalytic activity	0.0112294586646708
GO:0048013	ephrin receptor signaling pathway	0.0112294586646708
GO:0043666	regulation of phosphoprotein phosphatase activity	0.0112294586646708
GO:0065009	regulation of a molecular function	0.0112294586646708
GO:0008289	lipid binding	0.0126774394364876
GO:0019722	calcium-mediated signaling	0.0340461036786531
GO:0050770	regulation of axonogenesis	0.0432118247404294
GO:0000187	activation of MAPK activity	0.0464345050491006
GO:0043406	positive regulation of MAP kinase activity	0.0464345050491006
GO:0050767	regulation of neurogenesis	0.0464345050491006
GO:0007242	intracellular signaling cascade	0.0464345050491006
GO:0007154	cell communication	0.0464345050491006
GO:0043405	regulation of MAP kinase activity	0.0464345050491006
GO:0048741	skeletal muscle fiber development	0.0464345050491006
GO:0048747	muscle fiber development	0.0464345050491006
GO:0048468	cell development	0.0464345050491006

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
epithelial cell	1.92e-07	25

Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	5.83e-15	118
endoderm	5.83e-15	118
presumptive endoderm	5.83e-15	118
digestive system	2.17e-14	116
digestive tract	2.17e-14	116
primitive gut	2.17e-14	116
subdivision of digestive tract	1.29e-13	114
intestine	3.13e-13	31
gastrointestinal system	1.22e-11	47
subdivision of trunk	2.53e-11	66
trunk region element	4.81e-10	79
mucosa	1.78e-07	15
lung	1.85e-07	14
respiratory tube	1.85e-07	14
respiration organ	1.85e-07	14
pair of lungs	1.85e-07	14
lung primordium	1.85e-07	14
lung bud	1.85e-07	14
thoracic cavity element	2.77e-07	17
thoracic segment organ	2.77e-07	17
thoracic cavity	2.77e-07	17
thoracic segment of trunk	2.77e-07	17
respiratory primordium	2.77e-07	17
endoderm of foregut	2.77e-07	17
immaterial anatomical entity	5.26e-07	79
epithelial bud	7.21e-07	17
intestinal mucosa	9.62e-07	13
anatomical wall	9.62e-07	13
wall of intestine	9.62e-07	13
gastrointestinal system mucosa	9.62e-07	13

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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