Coexpression cluster:C17
From FANTOM5_SSTAR
Full id: C17_Mast_CD14_Monocytederived_Lymphatic_Smooth_mesenchymal_Macrophage
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 0.00124779298866059 | 0.0239349382370349 | 8 | 268 | MAPK signaling pathway (KEGG):04010 |
| 0.000246091667564656 | 0.00819873818781196 | 9 | 265 | Cytokine-cytokine receptor interaction (KEGG):04060 |
| 0.00371878601028399 | 0.0444149348020711 | 6 | 189 | Chemokine signaling pathway (KEGG):04062 |
| 0.000361949834961592 | 0.0104142838877585 | 5 | 78 | Phosphatidylinositol signaling system (KEGG):04070 |
| 4.99456752868316e-06 | 0.000632312249131288 | 7 | 86 | Apoptosis (KEGG):04210 |
| 4.05843748451846e-07 | 8.56330309233395e-05 | 10 | 155 | Jak-STAT signaling pathway (KEGG):04630 |
| 0.000729035865778493 | 0.0159791572739039 | 6 | 137 | Natural killer cell mediated cytotoxicity (KEGG):04650 |
| 0.000204481794359506 | 0.00761393975468042 | 6 | 108 | T cell receptor signaling pathway (KEGG):04660 |
| 0.00281083337266371 | 0.0378565430828963 | 4 | 75 | B cell receptor signaling pathway (KEGG):04662 |
| 3.5805963714335e-05 | 0.00203228521885661 | 6 | 79 | Fc epsilon RI signaling pathway (KEGG):04664 |
| 0.000757306031938572 | 0.0159791572739039 | 6 | 138 | Insulin signaling pathway (KEGG):04910 |
| 0.00403371365693327 | 0.0472840878673845 | 5 | 134 | Measles (KEGG):05162 |
| 0.000538205022820236 | 0.0141951574768837 | 5 | 85 | Small cell lung cancer (KEGG):05222 |
| 0.00177612724028162 | 0.026768774835673 | 3 | 31 | Asthma (KEGG):05310 |
| 0.00207288482596526 | 0.030514792903163 | 4 | 69 | IL-5 Signaling Pathway (Wikipathways):WP127 |
| 0.00294917098572649 | 0.0388921923742681 | 4 | 76 | miRNA regulation of DNA Damage Response (Wikipathways):WP1530 |
| 0.00133561700665514 | 0.0242746166278486 | 6 | 154 | Integrated Breast Cancer Pathway (Wikipathways):WP1984 |
| 0.00167483002330178 | 0.0266813321502795 | 6 | 161 | B Cell Receptor Signaling Pathway (Wikipathways):WP23 |
| 0.000538205022820236 | 0.0141951574768837 | 5 | 85 | Apoptosis (Wikipathways):WP254 |
| 0.00122859107900529 | 0.0239349382370349 | 5 | 102 | IL-3 Signaling Pathway (Wikipathways):WP286 |
| 0.000203899994200851 | 0.00761393975468042 | 5 | 69 | Kit Receptor Signaling Pathway (Wikipathways):WP304 |
| 0.00345004075042703 | 0.042821094020006 | 3 | 39 | FAS pathway and Stress induction of HSP regulation (Wikipathways):WP314 |
| 0.00138054691722362 | 0.0242746166278486 | 6 | 155 | TGF-beta Receptor Signaling Pathway (Wikipathways):WP366 |
| 4.17372951739905e-05 | 0.00203228521885661 | 8 | 162 | MAPK signaling pathway (Wikipathways):WP382 |
| 1.51651132194547e-06 | 0.00023998791669787 | 10 | 179 | EGFR1 Signaling Pathway (Wikipathways):WP437 |
| 0.0017281747522298 | 0.0266813321502795 | 6 | 162 | Insulin Signaling (Wikipathways):WP481 |
| 0.000732557511091659 | 0.0159791572739039 | 3 | 23 | Cytokines and Inflammatory Response (Wikipathways):WP530 |
| 0.00056785417462837 | 0.0143780677015903 | 5 | 86 | Delta-Notch Signaling Pathway (Wikipathways):WP61 |
| 0.00254761049248362 | 0.0358363875942695 | 4 | 73 | DNA damage response (Wikipathways):WP707 |
| 0.000719424134689446 | 0.0159791572739039 | 4 | 52 | Signaling by EGFR (Reactome):REACT_9417 |
| 6.04810813960922e-05 | 0.00273460889455188 | 9 | 220 | Signalling by NGF (Reactome):REACT_11061 |
| 1.80554295798147e-05 | 0.00141996560032503 | 11 | 289 | Metabolism of lipids and lipoproteins (Reactome):REACT_22258 |
| 0.00260427125753411 | 0.0358370370873716 | 5 | 121 | Signaling by Rho GTPases (Reactome):REACT_11044 |
| 0.00157190196285191 | 0.0261845774338225 | 6 | 159 | EGFR1 up reg. targets (Netpath):NetPath_4 |
| 0.00102710354601971 | 0.0209727917622733 | 5 | 98 | EGFR1 down reg. targets (Netpath):NetPath_4 |
| 0.00024178615016423 | 0.00819873818781196 | 16 | 740 | TGF beta receptor down reg. targets (Netpath):NetPath_7 |
| 1.75985085726702e-05 | 0.00141996560032503 | 18 | 728 | TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9 |
| 0.0017281747522298 | 0.0266813321502795 | 6 | 162 | TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9 |
| 0.00251447745448274 | 0.0358363875942695 | 10 | 441 | AR up reg. targets (Netpath):NetPath_2 |
| 0.000301542916174582 | 0.00908936504469098 | 5 | 75 | Kit Receptor up reg. targets (Netpath):NetPath_6 |
| 0.00324901386207623 | 0.0411325154938851 | 7 | 246 | B Cell Receptor up reg. targets (Netpath):NetPath_12 |
| 0.00309068090530608 | 0.0399265512869132 | 6 | 182 | B Cell Receptor down reg. targets (Netpath):NetPath_12 |
| 0.00138054691722362 | 0.0242746166278486 | 6 | 155 | IL-1 up reg. targets (Netpath):NetPath_13 |
| 9.90748172455031e-09 | 3.13571796582017e-06 | 18 | 433 | IL-2 up reg. targets (Netpath):NetPath_14 |
| 2.18217086101158e-05 | 0.00141996560032503 | 11 | 295 | IL-2 down reg. targets (Netpath):NetPath_14 |
| 0.000261207063319163 | 0.00826720355405149 | 4 | 40 | IL-3 up reg. targets (Netpath):NetPath_15 |
| 7.72229736813956e-05 | 0.00325880948935489 | 7 | 131 | IL-5 up reg. targets (Netpath):NetPath_17 |
| 0.00354907148778234 | 0.0432031202262734 | 4 | 80 | IL-6 up reg. targets (Netpath):NetPath_18 |
| 3.961352320522e-05 | 0.00203228521885661 | 4 | 25 | IL-9 up reg. targets (Netpath):NetPath_20 |
| 5.38941749608794e-10 | 3.41150127502366e-07 | 19 | 406 | {GRB2,414} (Static Module):NA |
| 2.2432315960901e-05 | 0.00141996560032503 | 7 | 108 | {HDAC1,108} (Static Module):NA |
| 0.00146041748967547 | 0.0249849802963397 | 3 | 29 | {PRKACA,33} (Static Module):NA |
| 0.000599702707363254 | 0.0146004543754208 | 6 | 132 | {RAC1,133} (Static Module):NA |
| 6.76472710977526e-06 | 0.00071367871008129 | 7 | 90 | {TRAF2,90} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005515 | protein binding | 1.43471854481016e-21 |
| GO:0065007 | biological regulation | 2.70148917475752e-12 |
| GO:0050794 | regulation of cellular process | 2.70148917475752e-12 |
| GO:0050789 | regulation of biological process | 6.1654349701466e-12 |
| GO:0007242 | intracellular signaling cascade | 8.12171012160566e-11 |
| GO:0044424 | intracellular part | 9.58920727803267e-11 |
| GO:0032502 | developmental process | 5.99754367163212e-09 |
| GO:0007243 | protein kinase cascade | 1.94517935355767e-08 |
| GO:0048522 | positive regulation of cellular process | 2.27745696992692e-08 |
| GO:0005622 | intracellular | 9.05349168309335e-08 |
| GO:0043231 | intracellular membrane-bound organelle | 1.10152245824923e-07 |
| GO:0043227 | membrane-bound organelle | 1.10152245824923e-07 |
| GO:0043283 | biopolymer metabolic process | 1.68527057609241e-07 |
| GO:0007165 | signal transduction | 1.76830563157703e-07 |
| GO:0019222 | regulation of metabolic process | 3.50936002400616e-07 |
| GO:0048518 | positive regulation of biological process | 5.0046301317108e-07 |
| GO:0005634 | nucleus | 6.94907866201002e-07 |
| GO:0007154 | cell communication | 6.94907866201002e-07 |
| GO:0006366 | transcription from RNA polymerase II promoter | 6.94907866201002e-07 |
| GO:0031323 | regulation of cellular metabolic process | 1.13227088374774e-06 |
| GO:0006351 | transcription, DNA-dependent | 2.59746625018308e-06 |
| GO:0032774 | RNA biosynthetic process | 2.63072016942865e-06 |
| GO:0005125 | cytokine activity | 2.7560084531967e-06 |
| GO:0005737 | cytoplasm | 3.39620628253114e-06 |
| GO:0043405 | regulation of MAP kinase activity | 4.73143743042192e-06 |
| GO:0048869 | cellular developmental process | 4.83546462699307e-06 |
| GO:0030154 | cell differentiation | 4.83546462699307e-06 |
| GO:0016070 | RNA metabolic process | 8.34054812015311e-06 |
| GO:0006355 | regulation of transcription, DNA-dependent | 1.01415722365403e-05 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 1.06338906169925e-05 |
| GO:0012505 | endomembrane system | 1.06338906169925e-05 |
| GO:0043229 | intracellular organelle | 1.46420035034932e-05 |
| GO:0043226 | organelle | 1.46420035034932e-05 |
| GO:0010468 | regulation of gene expression | 3.15208512384853e-05 |
| GO:0044464 | cell part | 3.93110302812265e-05 |
| GO:0006350 | transcription | 6.99606449241021e-05 |
| GO:0006915 | apoptosis | 7.64342517955896e-05 |
| GO:0006796 | phosphate metabolic process | 7.64342517955896e-05 |
| GO:0006793 | phosphorus metabolic process | 7.64342517955896e-05 |
| GO:0012501 | programmed cell death | 8.41245944185825e-05 |
| GO:0005102 | receptor binding | 8.41245944185825e-05 |
| GO:0009967 | positive regulation of signal transduction | 0.000126757689607934 |
| GO:0045449 | regulation of transcription | 0.000137336866537242 |
| GO:0009966 | regulation of signal transduction | 0.000185623206999147 |
| GO:0007275 | multicellular organismal development | 0.000186338527525231 |
| GO:0016568 | chromatin modification | 0.000204100076610728 |
| GO:0008219 | cell death | 0.00022129485105174 |
| GO:0016265 | death | 0.00022129485105174 |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.000254033916317086 |
| GO:0016310 | phosphorylation | 0.000287605243858205 |
| GO:0043687 | post-translational protein modification | 0.000287605243858205 |
| GO:0043407 | negative regulation of MAP kinase activity | 0.000314529791029521 |
| GO:0045859 | regulation of protein kinase activity | 0.00033374980260196 |
| GO:0043549 | regulation of kinase activity | 0.000386738268325921 |
| GO:0005615 | extracellular space | 0.000428677157423216 |
| GO:0044237 | cellular metabolic process | 0.000428679757630672 |
| GO:0051338 | regulation of transferase activity | 0.000428679757630672 |
| GO:0006629 | lipid metabolic process | 0.000428679757630672 |
| GO:0048523 | negative regulation of cellular process | 0.000457693886499556 |
| GO:0065008 | regulation of biological quality | 0.000480798720033574 |
| GO:0048468 | cell development | 0.000512637764711985 |
| GO:0000165 | MAPKKK cascade | 0.000735945517160157 |
| GO:0048856 | anatomical structure development | 0.000780108152220961 |
| GO:0043412 | biopolymer modification | 0.000840478787443906 |
| GO:0048519 | negative regulation of biological process | 0.000926111677597757 |
| GO:0000267 | cell fraction | 0.00101392486295289 |
| GO:0032501 | multicellular organismal process | 0.00101392486295289 |
| GO:0031090 | organelle membrane | 0.00127824208259349 |
| GO:0044446 | intracellular organelle part | 0.00135643725733871 |
| GO:0044422 | organelle part | 0.00143595999408309 |
| GO:0008284 | positive regulation of cell proliferation | 0.00155445016471634 |
| GO:0016563 | transcription activator activity | 0.00193378567019544 |
| GO:0006464 | protein modification process | 0.00238053592738431 |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 0.00252926571495382 |
| GO:0042981 | regulation of apoptosis | 0.00294005066218012 |
| GO:0010467 | gene expression | 0.00296914907575118 |
| GO:0044238 | primary metabolic process | 0.00303993494118298 |
| GO:0006468 | protein amino acid phosphorylation | 0.0030612719814928 |
| GO:0043067 | regulation of programmed cell death | 0.00307391132520232 |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | 0.00325532400761453 |
| GO:0044255 | cellular lipid metabolic process | 0.00347092702465748 |
| GO:0005624 | membrane fraction | 0.00384150067245826 |
| GO:0016023 | cytoplasmic membrane-bound vesicle | 0.0039920521565183 |
| GO:0016043 | cellular component organization and biogenesis | 0.00401216376128665 |
| GO:0031988 | membrane-bound vesicle | 0.00433098319838842 |
| GO:0008134 | transcription factor binding | 0.00433508288846662 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00491987430997247 |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | 0.00503999653347358 |
| GO:0044428 | nuclear part | 0.00515715370212118 |
| GO:0044421 | extracellular region part | 0.00516075778098251 |
| GO:0042327 | positive regulation of phosphorylation | 0.00516075778098251 |
| GO:0043507 | positive regulation of JNK activity | 0.00516075778098251 |
| GO:0031325 | positive regulation of cellular metabolic process | 0.00516075778098251 |
| GO:0006469 | negative regulation of protein kinase activity | 0.00550323202722075 |
| GO:0033673 | negative regulation of kinase activity | 0.00550323202722075 |
| GO:0006950 | response to stress | 0.00556302786083585 |
| GO:0005126 | hematopoietin/interferon-class (D200-domain) cytokine receptor binding | 0.0060908492450283 |
| GO:0051348 | negative regulation of transferase activity | 0.0060908492450283 |
| GO:0043506 | regulation of JNK activity | 0.00611573042144862 |
| GO:0045937 | positive regulation of phosphate metabolic process | 0.00611573042144862 |
| GO:0007267 | cell-cell signaling | 0.00622911657309422 |
| GO:0043170 | macromolecule metabolic process | 0.00633438439660024 |
| GO:0043122 | regulation of I-kappaB kinase/NF-kappaB cascade | 0.00643211445553293 |
| GO:0019899 | enzyme binding | 0.0065923004911574 |
| GO:0042127 | regulation of cell proliferation | 0.00676375864182426 |
| GO:0048513 | organ development | 0.00700926845199446 |
| GO:0006916 | anti-apoptosis | 0.0070098645900419 |
| GO:0033240 | positive regulation of amine metabolic process | 0.0070098645900419 |
| GO:0045764 | positive regulation of amino acid metabolic process | 0.0070098645900419 |
| GO:0001934 | positive regulation of protein amino acid phosphorylation | 0.0070098645900419 |
| GO:0009893 | positive regulation of metabolic process | 0.00710284508636211 |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 0.00764598832536406 |
| GO:0007254 | JNK cascade | 0.00764598832536406 |
| GO:0043406 | positive regulation of MAP kinase activity | 0.00803122225966411 |
| GO:0004672 | protein kinase activity | 0.00818042924014066 |
| GO:0031098 | stress-activated protein kinase signaling pathway | 0.00883765695344431 |
| GO:0006952 | defense response | 0.00894213255689516 |
| GO:0048731 | system development | 0.00894213255689516 |
| GO:0003713 | transcription coactivator activity | 0.0105922926021146 |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 0.0107175565121335 |
| GO:0030695 | GTPase regulator activity | 0.0111256029703367 |
| GO:0045885 | positive regulation of survival gene product activity | 0.0111256029703367 |
| GO:0004691 | cAMP-dependent protein kinase activity | 0.0111256029703367 |
| GO:0004908 | interleukin-1 receptor activity | 0.0111256029703367 |
| GO:0016192 | vesicle-mediated transport | 0.0112728103494936 |
| GO:0031410 | cytoplasmic vesicle | 0.0112728103494936 |
| GO:0031982 | vesicle | 0.0125296088304987 |
| GO:0030099 | myeloid cell differentiation | 0.0126847434849667 |
| GO:0010324 | membrane invagination | 0.0126847434849667 |
| GO:0006897 | endocytosis | 0.0126847434849667 |
| GO:0048583 | regulation of response to stimulus | 0.012725043451102 |
| GO:0040008 | regulation of growth | 0.0138471814000258 |
| GO:0051276 | chromosome organization and biogenesis | 0.014642102900278 |
| GO:0019722 | calcium-mediated signaling | 0.014642102900278 |
| GO:0006325 | establishment and/or maintenance of chromatin architecture | 0.0156036491650916 |
| GO:0048770 | pigment granule | 0.0156036491650916 |
| GO:0042470 | melanosome | 0.0156036491650916 |
| GO:0002705 | positive regulation of leukocyte mediated immunity | 0.0156036491650916 |
| GO:0019966 | interleukin-1 binding | 0.0156036491650916 |
| GO:0048146 | positive regulation of fibroblast proliferation | 0.0156036491650916 |
| GO:0002708 | positive regulation of lymphocyte mediated immunity | 0.0156036491650916 |
| GO:0007259 | JAK-STAT cascade | 0.016112612798943 |
| GO:0006323 | DNA packaging | 0.0161386559445924 |
| GO:0051247 | positive regulation of protein metabolic process | 0.0163842703174174 |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 0.0169855481371956 |
| GO:0043086 | negative regulation of catalytic activity | 0.0176044272305888 |
| GO:0016301 | kinase activity | 0.0179776597762854 |
| GO:0005159 | insulin-like growth factor receptor binding | 0.0179776597762854 |
| GO:0002699 | positive regulation of immune effector process | 0.0179776597762854 |
| GO:0018108 | peptidyl-tyrosine phosphorylation | 0.0189152810166851 |
| GO:0003712 | transcription cofactor activity | 0.0205258343600017 |
| GO:0048145 | regulation of fibroblast proliferation | 0.0205258343600017 |
| GO:0002706 | regulation of lymphocyte mediated immunity | 0.0205258343600017 |
| GO:0002703 | regulation of leukocyte mediated immunity | 0.0205258343600017 |
| GO:0004690 | cyclic nucleotide-dependent protein kinase activity | 0.0205258343600017 |
| GO:0048144 | fibroblast proliferation | 0.0205258343600017 |
| GO:0018212 | peptidyl-tyrosine modification | 0.0206707071012574 |
| GO:0043066 | negative regulation of apoptosis | 0.0213752993457399 |
| GO:0001932 | regulation of protein amino acid phosphorylation | 0.0217750266888544 |
| GO:0043069 | negative regulation of programmed cell death | 0.0223950651717772 |
| GO:0009653 | anatomical structure morphogenesis | 0.0223950651717772 |
| GO:0033238 | regulation of amine metabolic process | 0.0226253720848198 |
| GO:0006521 | regulation of amino acid metabolic process | 0.0226253720848198 |
| GO:0045453 | bone resorption | 0.0229857019454805 |
| GO:0002376 | immune system process | 0.0232208672059544 |
| GO:0030097 | hemopoiesis | 0.0236350079559576 |
| GO:0001558 | regulation of cell growth | 0.0241285231423306 |
| GO:0016566 | specific transcriptional repressor activity | 0.026077469622385 |
| GO:0002697 | regulation of immune effector process | 0.0297525889722221 |
| GO:0030659 | cytoplasmic vesicle membrane | 0.0297525889722221 |
| GO:0051240 | positive regulation of multicellular organismal process | 0.0297525889722221 |
| GO:0051246 | regulation of protein metabolic process | 0.0308342168848818 |
| GO:0048534 | hemopoietic or lymphoid organ development | 0.0308342168848818 |
| GO:0008610 | lipid biosynthetic process | 0.0308342168848818 |
| GO:0044433 | cytoplasmic vesicle part | 0.0311035181259561 |
| GO:0045884 | regulation of survival gene product activity | 0.0325729373780729 |
| GO:0005057 | receptor signaling protein activity | 0.0332225090732171 |
| GO:0007049 | cell cycle | 0.0340711798105801 |
| GO:0008217 | regulation of blood pressure | 0.0340711798105801 |
| GO:0030522 | intracellular receptor-mediated signaling pathway | 0.0340711798105801 |
| GO:0044453 | nuclear membrane part | 0.0342748916114095 |
| GO:0012506 | vesicle membrane | 0.0361406964183956 |
| GO:0002520 | immune system development | 0.0361406964183956 |
| GO:0000187 | activation of MAPK activity | 0.036857215194519 |
| GO:0000188 | inactivation of MAPK activity | 0.0389964434714144 |
| GO:0008290 | F-actin capping protein complex | 0.0389964434714144 |
| GO:0019932 | second-messenger-mediated signaling | 0.0400551816092555 |
| GO:0044451 | nucleoplasm part | 0.0400551816092555 |
| GO:0048871 | multicellular organismal homeostasis | 0.0400551816092555 |
| GO:0001894 | tissue homeostasis | 0.0400551816092555 |
| GO:0005157 | macrophage colony stimulating factor receptor binding | 0.0400551816092555 |
| GO:0048631 | regulation of skeletal muscle growth | 0.0400551816092555 |
| GO:0008917 | lipopolysaccharide N-acetylglucosaminyltransferase activity | 0.0400551816092555 |
| GO:0004506 | squalene monooxygenase activity | 0.0400551816092555 |
| GO:0031588 | AMP-activated protein kinase complex | 0.0400551816092555 |
| GO:0002032 | arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway | 0.0400551816092555 |
| GO:0008457 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity | 0.0400551816092555 |
| GO:0019131 | tripeptidyl-peptidase I activity | 0.0400551816092555 |
| GO:0043697 | cell dedifferentiation | 0.0400551816092555 |
| GO:0008449 | N-acetylglucosamine-6-sulfatase activity | 0.0400551816092555 |
| GO:0002355 | detection of tumor cell | 0.0400551816092555 |
| GO:0005688 | snRNP U6 | 0.0400551816092555 |
| GO:0035034 | histone acetyltransferase regulator activity | 0.0400551816092555 |
| GO:0048638 | regulation of developmental growth | 0.0400551816092555 |
| GO:0051927 | negative regulation of calcium ion transport via voltage-gated calcium channel | 0.0400551816092555 |
| GO:0005129 | granulocyte macrophage colony-stimulating factor receptor binding | 0.0400551816092555 |
| GO:0004051 | arachidonate 5-lipoxygenase activity | 0.0400551816092555 |
| GO:0005135 | interleukin-3 receptor binding | 0.0400551816092555 |
| GO:0048636 | positive regulation of muscle development | 0.0400551816092555 |
| GO:0035030 | phosphoinositide 3-kinase complex, class IA | 0.0400551816092555 |
| GO:0043696 | dedifferentiation | 0.0400551816092555 |
| GO:0048630 | skeletal muscle growth | 0.0400551816092555 |
| GO:0048633 | positive regulation of skeletal muscle growth | 0.0400551816092555 |
| GO:0004941 | beta2-adrenergic receptor activity | 0.0400551816092555 |
| GO:0048639 | positive regulation of developmental growth | 0.0400551816092555 |
| GO:0048643 | positive regulation of skeletal muscle development | 0.0400551816092555 |
| GO:0005942 | phosphoinositide 3-kinase complex | 0.0411909410440746 |
| GO:0042325 | regulation of phosphorylation | 0.0429925568688956 |
| GO:0005829 | cytosol | 0.0443799496400581 |
| GO:0007257 | activation of JNK activity | 0.0447338539757082 |
| GO:0016049 | cell growth | 0.0450488008073914 |
| GO:0016044 | membrane organization and biogenesis | 0.0450488008073914 |
| GO:0016307 | phosphatidylinositol phosphate kinase activity | 0.0477173031921382 |
| GO:0019370 | leukotriene biosynthetic process | 0.0477173031921382 |
| GO:0043450 | alkene biosynthetic process | 0.0477173031921382 |
| GO:0007131 | meiotic recombination | 0.0477173031921382 |
| GO:0008361 | regulation of cell size | 0.048717169772215 |
| GO:0003700 | transcription factor activity | 0.0488050587436444 |
| GO:0006954 | inflammatory response | 0.0489498151401395 |
| GO:0051174 | regulation of phosphorus metabolic process | 0.0495177760938287 |
| GO:0019220 | regulation of phosphate metabolic process | 0.0495177760938287 |
| GO:0051327 | M phase of meiotic cell cycle | 0.0495177760938287 |
| GO:0007126 | meiosis | 0.0495177760938287 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| histamine secreting cell | 2.45e-195 | 5 |
| biogenic amine secreting cell | 2.45e-195 | 5 |
| granulocytopoietic cell | 2.45e-195 | 5 |
| mast cell | 2.45e-195 | 5 |
| mast cell progenitor | 2.45e-195 | 5 |
| basophil mast progenitor cell | 2.45e-195 | 5 |
| endocrine cell | 4.60e-109 | 9 |
| secretory cell | 5.37e-28 | 36 |
| myeloid lineage restricted progenitor cell | 2.11e-15 | 66 |
| granulocyte monocyte progenitor cell | 3.48e-15 | 67 |
| myeloid leukocyte | 3.42e-14 | 72 |
| myeloid cell | 1.03e-09 | 108 |
| common myeloid progenitor | 1.03e-09 | 108 |
| hematopoietic lineage restricted progenitor cell | 8.28e-09 | 120 |
| leukocyte | 7.64e-08 | 136 |
| Ontology term | p-value | n |
|---|---|---|
| bone marrow | 1.72e-13 | 76 |
| bone element | 1.45e-12 | 82 |
| skeletal element | 1.62e-11 | 90 |
| immune system | 3.61e-11 | 93 |
| hematopoietic system | 1.23e-10 | 98 |
| blood island | 1.23e-10 | 98 |
| skeletal system | 1.95e-10 | 100 |
| hemolymphoid system | 1.03e-09 | 108 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.00106156 |
| MA0004.1 | 0.00057704 |
| MA0006.1 | 0.131407 |
| MA0007.1 | 0.0221124 |
| MA0009.1 | 0.0225844 |
| MA0014.1 | 0.0189046 |
| MA0017.1 | 0.3903 |
| MA0019.1 | 0.0452818 |
| MA0024.1 | 0.852575 |
| MA0025.1 | 0.0408929 |
| MA0027.1 | 0.585926 |
| MA0028.1 | 0.197302 |
| MA0029.1 | 1.0031 |
| MA0030.1 | 0.0252327 |
| MA0031.1 | 0.0111245 |
| MA0038.1 | 0.00244219 |
| MA0040.1 | 0.0934689 |
| MA0041.1 | 0.245352 |
| MA0042.1 | 0.169582 |
| MA0043.1 | 0.18168 |
| MA0046.1 | 0.319114 |
| MA0048.1 | 0.0179357 |
| MA0050.1 | 0.303669 |
| MA0051.1 | 0.935969 |
| MA0052.1 | 0.0208465 |
| MA0055.1 | 3.65093 |
| MA0056.1 | 0 |
| MA0057.1 | 4.90218 |
| MA0058.1 | 0.00331495 |
| MA0059.1 | 0.229569 |
| MA0060.1 | 2.15744e-07 |
| MA0061.1 | 0.02669 |
| MA0063.1 | 0 |
| MA0066.1 | 0.567468 |
| MA0067.1 | 0.388704 |
| MA0068.1 | 3.12435 |
| MA0069.1 | 0.151413 |
| MA0070.1 | 2.58701 |
| MA0071.1 | 1.35906 |
| MA0072.1 | 0.46163 |
| MA0073.1 | 48.4914 |
| MA0074.1 | 0.306052 |
| MA0076.1 | 0.189051 |
| MA0077.1 | 0.0702492 |
| MA0078.1 | 0.649025 |
| MA0081.1 | 1.8203 |
| MA0083.1 | 0.986503 |
| MA0084.1 | 0.695623 |
| MA0087.1 | 0.0760433 |
| MA0088.1 | 0.0286995 |
| MA0089.1 | 0 |
| MA0090.1 | 0.0690537 |
| MA0091.1 | 0.48388 |
| MA0092.1 | 0.0306008 |
| MA0093.1 | 8.05267e-05 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.182717 |
| MA0101.1 | 0.348593 |
| MA0103.1 | 0.0176842 |
| MA0105.1 | 1.25036 |
| MA0106.1 | 0.00199667 |
| MA0107.1 | 0.63921 |
| MA0108.2 | 1.14491 |
| MA0109.1 | 0 |
| MA0111.1 | 1.35088 |
| MA0113.1 | 0.117505 |
| MA0114.1 | 0.21863 |
| MA0115.1 | 0.913406 |
| MA0116.1 | 0.0103651 |
| MA0117.1 | 0.0744047 |
| MA0119.1 | 0.0153984 |
| MA0122.1 | 0.619284 |
| MA0124.1 | 0.717264 |
| MA0125.1 | 0.183803 |
| MA0130.1 | 0 |
| MA0131.1 | 0.140635 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.471918 |
| MA0136.1 | 0.832711 |
| MA0139.1 | 0.0251865 |
| MA0140.1 | 3.70326 |
| MA0141.1 | 0.654815 |
| MA0142.1 | 0.413005 |
| MA0143.1 | 0.00664493 |
| MA0144.1 | 0.0467386 |
| MA0145.1 | 0.000294699 |
| MA0146.1 | 0.0219295 |
| MA0147.1 | 0.017277 |
| MA0148.1 | 0.0035744 |
| MA0149.1 | 0.00431703 |
| MA0062.2 | 0.194655 |
| MA0035.2 | 8.12233 |
| MA0039.2 | 1.63816e-07 |
| MA0138.2 | 0.101904 |
| MA0002.2 | 3.02021 |
| MA0137.2 | 0.0423278 |
| MA0104.2 | 0.00290831 |
| MA0047.2 | 0.114318 |
| MA0112.2 | 0.000636275 |
| MA0065.2 | 1.45274 |
| MA0150.1 | 0.282871 |
| MA0151.1 | 0 |
| MA0152.1 | 2.23278 |
| MA0153.1 | 0.0515895 |
| MA0154.1 | 0.344611 |
| MA0155.1 | 1.59532 |
| MA0156.1 | 1.03213 |
| MA0157.1 | 0.00205965 |
| MA0158.1 | 0 |
| MA0159.1 | 1.86754 |
| MA0160.1 | 0.523291 |
| MA0161.1 | 0 |
| MA0162.1 | 9.97788 |
| MA0163.1 | 2.05572 |
| MA0164.1 | 0.0163738 |
| MA0080.2 | 0.579939 |
| MA0018.2 | 0.0847853 |
| MA0099.2 | 0.316725 |
| MA0079.2 | 7.87214 |
| MA0102.2 | 0.0590072 |
| MA0258.1 | 0.25672 |
| MA0259.1 | 0.162676 |
| MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| EGR1#1958 | 223 | 1.36152256810607 | 3.63570525363036e-07 | 1.79362031640955e-05 |
| GATA1#2623 | 124 | 2.05811286393054 | 2.43187547983098e-14 | 4.07023466727672e-12 |
| GATA2#2624 | 133 | 2.07475632871809 | 1.2506668101583e-15 | 2.33247126760934e-13 |
| TAL1#6886 | 44 | 1.60859135104941 | 0.0016760015986481 | 0.0104776685598713 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
